BioPAX pathway converted from "REG3A,REG3G binds bacterial peptidoglycan" in the Reactome database.LEFT-TO-RIGHTREG3A,REG3G binds bacterial peptidoglycanThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PGNGlcNac-(1-->4)MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2N-acetyl-beta-D-glycosaminyl-(1->4)-N-acetylmuramoyl peptidebeta-GlcNAc-(1->4)-MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2peptidoglycanReactome DB_ID: 6789198cell wallGENE ONTOLOGYGO:0005618beta-GlcNAc-(1->4)-MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2 [ChEBI:55424]beta-GlcNAc-(1->4)-MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2ChEBICHEBI:55424Reactome Database ID Release 756789198Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6789198ReactomeR-ALL-67891983Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6789198.3Reactomehttp://www.reactome.orgConverted from EntitySet in ReactomeREG3A,G(38-175)REG3A(38-175), REG3G(38-175)Reactome DB_ID: 9798759Converted from EntitySet in ReactomeHomologues of REG3A(38-175)Reactome DB_ID: 9798737Reg3aREG3A(38-175)O09037Reactome DB_ID: 9798723extracellular regionGENE ONTOLOGYGO:0005576UniProt:O09037Reg3aMus musculusNCBI Taxonomy10090UniProtO0903738EQUAL175EQUALReactome Database ID Release 759798723Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798723ReactomeR-MMU-68013521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352.1Reg3gREG3A(38-175)O09049Reactome DB_ID: 9798727UniProt:O09049Reg3gUniProtO0904938EQUAL175EQUALReactome Database ID Release 759798727Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798727ReactomeR-MMU-6801352-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352-2.1Reg3bREG3A(38-175)P35230Reactome DB_ID: 9798731UniProt:P35230Reg3bUniProtP3523038EQUAL175EQUALReactome Database ID Release 759798731Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798731ReactomeR-MMU-6801352-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352-3.1Reg3dREG3A(38-175)Q9QUS9Reactome DB_ID: 9798735UniProt:Q9QUS9Reg3dUniProtQ9QUS938EQUAL175EQUALReactome Database ID Release 759798735Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798735ReactomeR-MMU-6801352-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352-4.1Reactome Database ID Release 759798737Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798737ReactomeR-MMU-6801352-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352-5.1Reactome Database ID Release 759798759Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798759ReactomeR-MMU-68017941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801794.1REG3A(38-175), REG3G(38-175):peptidoglycanReactome DB_ID: 9798777PeptidoglycanGlcNAc(1-->4)MurNAc:L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2GlcNAc(1-->4)MurNAc:peptideReactome DB_ID: 6788957Reactome Database ID Release 756788957Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6788957ReactomeR-ALL-67889572Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6788957.2ChEBI8005additional informationMIMI:036111Reactome Database ID Release 759798777Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798777ReactomeR-MMU-68018091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801809.1Reactome Database ID Release 759798779Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798779ReactomeR-MMU-68018081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801808.1Regenerating islet-derived 3 (REG3) proteins belong to the family of C-type lectins (Cash HL et al. 2006a,b; Lehotzky RE et al. 2010). REG3A and REG3G are induced and expressed in the intestine where they function as antibacterial peptides by targeting the peptidoglycan moieties of bacteria. NMR spectroscopy revealed that human REG3A lectin recognized the peptidoglycan carbohydrate backbone in a calcium-independent manner via a conserved “EPN” motif that is critical for bacterial killing (Lehotzky RE et al. 2010). The antibacterial activities of REG3 proteins are restricted to Gram-positive bacteria and are tightly controlled by an inhibitory N-terminal pro-segment that is removed by trypsin in vivo (Cash HL et al. 2006; Mukherjee S et al. 2009; Medveczky P et al. 2009).19095652Pubmed2009Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegmentMukherjee, SohiniPartch, Carrie LLehotzky, Rebecca EWhitham, Cecilia VChu, HiutungBevins, Charles LGardner, Kevin HHooper, Lora VJ. Biol. Chem. 284:4881-816931762Pubmed2006Symbiotic bacteria direct expression of an intestinal bactericidal lectinCash, Heather LWhitham, Cecilia VBehrendt, Cassie LHooper, Lora VScience 313:1126-3020382864Pubmed2010Molecular basis for peptidoglycan recognition by a bactericidal lectinLehotzky, Rebecca EPartch, Carrie LMukherjee, SohiniCash, Heather LGoldman, William EGardner, Kevin HHooper, Lora VProc. Natl. Acad. Sci. U.S.A. 107:7722-719254208Pubmed2009Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregationMedveczky, PéterSzmola, RichárdSahin-Tóth, MiklósBiochem. J. 420:335-4316504538Pubmed2006Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coliCash, Heather LWhitham, Cecilia VHooper, Lora VProtein Expr. Purif. 48:151-9inferred from electronic annotationEVIDENCE CODEECO:0000203