BioPAX pathway converted from "INTL1 binds bacterial glycans" in the Reactome database.LEFT-TO-RIGHTINTL1 binds bacterial glycansThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ITLN1 trimer:Ca2+Reactome DB_ID: 9799014extracellular regionGENE ONTOLOGYGO:0005576ITLNY1:Ca2+Reactome DB_ID: 9799012Itln1ITLN1O88310Reactome DB_ID: 9799010UniProt:O88310Itln1Mus musculusNCBI Taxonomy10090UniProtO8831031EQUALL-cystine (cross-link)MODMOD:0003448EQUAL19EQUAL298EQUALReactome Database ID Release 759799010Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799010ReactomeR-MMU-68045151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6804515.1Reactomehttp://www.reactome.org1Ca2+Calciumcalcium(2+)Reactome DB_ID: 74112calcium(2+) [ChEBI:29108]calcium(2+)ChEBICHEBI:29108Reactome Database ID Release 7574112Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74112ReactomeR-ALL-741124Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74112.4COMPOUNDC00076additional informationMIMI:03613Reactome Database ID Release 759799012Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799012ReactomeR-MMU-68076281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6807628.13Reactome Database ID Release 759799014Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799014ReactomeR-MMU-68045091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6804509.1Converted from EntitySet in ReactomeINTL1 ligandsbacterial glycans recognized by INTL1Reactome DB_ID: 6804535KDO3-deoxy-α-D-manno-oct-2-ulosonate3-deoxy-alpha-D-manno-oct-2-ulosonateReactome DB_ID: 6804537cell wallGENE ONTOLOGYGO:00056183-deoxy-alpha-D-manno-oct-2-ulosonate [ChEBI:85986]3-deoxy-alpha-D-manno-oct-2-ulosonateChEBICHEBI:85986Reactome Database ID Release 756804537Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6804537ReactomeR-ALL-68045373Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6804537.3beta-Galfbeta-D-galactofuranosylbeta-D-galactofuranosyl groupReactome DB_ID: 6804501beta-D-galactofuranosyl group [ChEBI:59496]beta-D-galactofuranosyl groupβ-D-galactofuranosylChEBICHEBI:59496Reactome Database ID Release 756804501Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6804501ReactomeR-ALL-68045013Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6804501.3heptoseL, D-alpha-heptoseL-glycero-alpha-D-manno-heptopyranoseReactome DB_ID: 6804502L-glycero-alpha-D-manno-heptopyranose [ChEBI:42976]L-glycero-alpha-D-manno-heptopyranoseChEBICHEBI:42976Reactome Database ID Release 756804502Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6804502ReactomeR-ALL-68045023Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6804502.3Reactome Database ID Release 756804535Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6804535ReactomeR-ALL-68045351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6804535.1INTL1:bacterial glycanReactome DB_ID: 979901611Reactome Database ID Release 759799016Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799016ReactomeR-MMU-68045131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6804513.1Reactome Database ID Release 759799018Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799018ReactomeR-MMU-68045271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6804527.1Intelectin-1 (INTL1) is a 120-kDa secretory lectin that recognizes multiple glycan epitopes found exclusively on microbes: beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, heptoses, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (Tsuji S et al. 2001; Wesener DA et al. 2015). These glycan residues are widely distributed in bacteria, including S. pneumoniae, Proteus mirabilis, Proteus vulgaris, Yersinia pestis and K. pneumoniae (Wesener DA et al. 2015). The 1.6-A-resolution crystal structure of human INTL1 complexed with beta-Galf suggests that INTL1 binds its carbohydrate ligands bearing terminal 1,2-diols through calcium ion-dependent coordination (Wesener DA et al. 2015).<p>Secreted INTL1 functions as a disulfide-linked trimer (Tsuji S et al., 2001; Tsuji S et al., 2007; Wesener DA et al., 2015).17621593Pubmed2007Differential structure and activity between human and mouse intelectin-1: human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomerTsuji, ShoutaroYamashita, MakikoNishiyama, AkihitoShinohara, TsutomuLi, ZhongweiMyrvik, Quentin NHoffman, Donald RHenriksen, Ruth AnnShibata, YoshimiGlycobiology 17:1045-5111313366Pubmed2001Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wallTsuji, SUehori, JMatsumoto, MSuzuki, YMatsuhisa, AToyoshima, KSeya, TJ. Biol. Chem. 276:23456-6326148048Pubmed2015Recognition of microbial glycans by human intelectin-1Wesener, Darryl AWangkanont, KittikhunMcBride, RyanSong, XuezhengKraft, Matthew BHodges, Heather LZarling, Lucas CSplain, Rebecca ASmith, David FCummings, Richard DPaulson, James CForest, Katrina TKiessling, Laura LNat. Struct. Mol. Biol. 22:603-10inferred from electronic annotationEVIDENCE CODEECO:0000203