BioPAX pathway converted from "PLEKHA4,(5,6) bind PI3P" in the Reactome database.LEFT-TO-RIGHTPLEKHA4,(5,6) bind PI3PThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PI3P1-phosphatidyl-1D-myo-inositol 3-phosphateReactome DB_ID: 1806276plasma membraneGENE ONTOLOGYGO:00058861-phosphatidyl-1D-myo-inositol 3-phosphate [ChEBI:17283]1-phosphatidyl-1D-myo-inositol 3-phosphatePtdIns3PPtdIns-3-P1,2-Diacyl-sn-glycero-3-phospho-(1&apos;-myo-inositol-3&apos;-phosphate)Phosphatidylinositol 3-phosphateChEBICHEBI:17283Reactome Database ID Release 751806276Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806276ReactomeR-ALL-18062763Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1806276.3Reactomehttp://www.reactome.orgConverted from EntitySet in ReactomePLEKHA4,(5,6)Reactome DB_ID: 9807593Q8VC98Plekha4PLEKHA4Reactome DB_ID: 9807583UniProt:Q8VC98Plekha4Mus musculusNCBI Taxonomy10090UniProtQ8VC981EQUAL779EQUALReactome Database ID Release 759807583Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9807583ReactomeR-MMU-88703571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8870357.1E9Q6H8Plekha5PLEKHA5Reactome DB_ID: 9807587UniProt:E9Q6H8Plekha5UniProtE9Q6H82EQUAL1116EQUALReactome Database ID Release 759807587Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9807587ReactomeR-MMU-88704981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8870498.1Q7TQG1Plekha6PLEKHA6Reactome DB_ID: 9807591UniProt:Q7TQG1Plekha6UniProtQ7TQG11EQUAL1048EQUALReactome Database ID Release 759807591Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9807591ReactomeR-MMU-88704911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8870491.1Reactome Database ID Release 759807593Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9807593ReactomeR-MMU-88704961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8870496.1PLEKHA4,(5,6):PI3PReactome DB_ID: 980759511Reactome Database ID Release 759807595Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9807595ReactomeR-MMU-88705091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8870509.1Reactome Database ID Release 759807597Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9807597ReactomeR-MMU-88704891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8870489.1The second messenger phosphatidylinositol 3,4,5-trisphosphate (PIP3, PtdIns(3,4,5)P) is generated by the action of phosphoinositide 3-kinase (PI3K) in response to growth factors and insulin and regulates a range of cellular processes. Proteins containing the plekstrin homology (PH) domain can interact specifically with PIP3 or its immediate breakdown product, phosphatidylinositol 3,4-diphosphate (PIP2, PtdIns(3,4)P). Proteins with a PH domain have also been found to bind to PIs other than PIP3 or PIP2. Pleckstrin homology domain-containing family A member 4 (PLEKHA4 aka PEPP1) is able to specifically bind phosphatidylinositol 3-phosphate (PI3P) but not other phosphoinositides (Dowler et al. 2000). Two related isoforms of PLEKHA4, PLEKHA5 and 6 (PEPP2 and PEPP3), possess a very similar PH domain sequence, indicating that they may also interact with PI3P (Dowler et al. 2000, Yamada et al. 2012). These proteins may function as adaptor molecules since they possess no obvious catalytic moieties.11001876Pubmed2000Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificitiesDowler, SCurrie, R ACampbell, D GDeak, MKular, GDownes, C PAlessi, D RBiochem. J. 351:19-3122037487Pubmed2012Identification and characterization of splicing variants of PLEKHA5 (Plekha5) during brain developmentYamada, KenichiroNomura, NorikoYamano, ArisaYamada, YasukazuWakamatsu, NobuakiGene 492:270-5inferred from electronic annotationEVIDENCE CODEECO:0000203