BioPAX pathway converted from "PA is converted to CDP-DAG by CDS1" in the Reactome database. LEFT-TO-RIGHT 2.7.7.41 PA is converted to CDP-DAG by CDS1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> CTP cytidine 5'-triphosphate Cytidine triphosphate CTP(4-) Reactome DB_ID: 110614 cytosol GENE ONTOLOGY GO:0005829 CTP(4-) [ChEBI:37563] CTP(4-) ctp cytidine 5'-triphosphate(4-) CTP ChEBI CHEBI:37563 Reactome Database ID Release 79 110614 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110614 Reactome R-ALL-110614 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-110614.3 Reactome http://www.reactome.org COMPOUND C00063 additional information MI MI:0361 PA phosphatidic acid Reactome DB_ID: 426755 endoplasmic reticulum membrane GENE ONTOLOGY GO:0005789 phosphatidic acid [ChEBI:16337] phosphatidic acid ChEBI CHEBI:16337 Reactome Database ID Release 79 426755 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426755 Reactome R-ALL-426755 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-426755.3 COMPOUND C00416 CDP-DAG Cytidine diphosphate diacylglycerol CDP-diacylglycerol Reactome DB_ID: 426955 CDP-diacylglycerol [ChEBI:17962] CDP-diacylglycerol ChEBI CHEBI:17962 Reactome Database ID Release 79 426955 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426955 Reactome R-ALL-426955 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-426955.3 COMPOUND C00269 PPi pyrophosphate diphosphoric acid pyrophosphoric acid diphosphate Reactome DB_ID: 111294 diphosphate(3-) [ChEBI:33019] diphosphate(3-) ChEBI CHEBI:33019 Reactome Database ID Release 79 111294 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111294 Reactome R-ALL-111294 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-111294.4 COMPOUND C00013 ACTIVATION CDS1:Mg2+ Reactome DB_ID: 9808226 Cds1 CDS1 P98191 Reactome DB_ID: 9808224 UniProt:P98191 Cds1 Mus musculus NCBI Taxonomy 10090 UniProt P98191 1 EQUAL 461 EQUAL Reactome Database ID Release 79 9808224 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9808224 Reactome R-MMU-1498762 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1498762.1 1 Mg2+ Magnesium magnesium(2+) Mg++ Reactome DB_ID: 217314 magnesium(2+) [ChEBI:18420] magnesium(2+) ChEBI CHEBI:18420 Reactome Database ID Release 79 217314 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=217314 Reactome R-ALL-217314 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-217314.3 COMPOUND C00305 1 Reactome Database ID Release 79 9808226 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9808226 Reactome R-MMU-1500651 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1500651.1 GENE ONTOLOGY GO:0004605 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 79 9808227 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9808227 Reactome Database ID Release 79 9808229 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9808229 Reactome R-MMU-1483121 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1483121.1 At the endoplasmic reticulum (ER) membrane, phosphatidate cytidylyltransferase 1 (CDS1) converts phosphatidic acid (PA) and cytidine triphosphate (CTP) into cytidine diphosphate-diacylglycerol (CDP-DAG). Both ER and mitochondrial membranes have the capability to synthesize cytidine diphosphate-diacylglycerol (CDP-DAG) with phosphatidate cytidylyltransferase 1 and 2 (CDS1 and CDS2) (Lykidis et al. 1997). However, transport of CDP-DAG between organelles cannot be ruled out (Stuhne-Sekalec et al. 1986). 3718705 Pubmed 1986 Participation of the microsomal CDP-diglycerides in the mitochondrial biosynthesis of phosphatidylglycerol Stuhne-Sekalec, L Chudzik, J Stanacev, NZ Biochem Cell Biol 64:309-14 9407135 Pubmed 1997 The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content Lykidis, A Jackson, PD Rock, CO Jackowski, S J Biol Chem 272:33402-9 inferred from electronic annotation EVIDENCE CODE ECO:0000203