BioPAX pathway converted from "Inactive G alpha (z) reassociates with G beta:gamma" in the Reactome database. LEFT-TO-RIGHT Inactive G alpha (z) reassociates with G beta:gamma This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> G-protein beta-gamma complex Reactome DB_ID: 9781997 plasma membrane GENE ONTOLOGY GO:0005886 Converted from EntitySet in Reactome G-protein gamma subunit Reactome DB_ID: 9781988 Gng2 G-protein gamma 2 subunit GBG2_MOUSE Gng2 Reactome DB_ID: 428101 UniProt:P63213 Gng2 Gng2 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity).TISSUE SPECIFICITY Adrenal gland and brain.SIMILARITY Belongs to the G protein gamma family. Mus musculus NCBI Taxonomy 10090 UniProt P63213 2 EQUAL 68 EQUAL Reactome Database ID Release 81 428101 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428101 Reactome R-MMU-428101 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-428101.1 Reactome http://www.reactome.org Gng3 GNG3 P63216 Reactome DB_ID: 9781958 UniProt:P63216 Gng3 Gng3 Gngt3 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma. Interacts with SCN8A.TISSUE SPECIFICITY Abundantly expressed in brain. Low levels in testis.SIMILARITY Belongs to the G protein gamma family. UniProt P63216 1 EQUAL 72 EQUAL Reactome Database ID Release 81 9781958 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781958 Reactome R-MMU-164376 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-164376.1 Gng4 GNG4 P50153 Reactome DB_ID: 9781961 UniProt:P50153 Gng4 Gng4 Gngt4 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3 (By similarity). Interacts with KCNK1.TISSUE SPECIFICITY Brain.SIMILARITY Belongs to the G protein gamma family. UniProt P50153 1 EQUAL 72 EQUAL Reactome Database ID Release 81 9781961 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781961 Reactome R-MMU-164350 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-164350.1 Gng5 GNG5 Q80SZ7 Reactome DB_ID: 9781964 UniProt:Q80SZ7 Gng5 Gng5 Gngt5 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma.SIMILARITY Belongs to the G protein gamma family. UniProt Q80SZ7 2 EQUAL 65 EQUAL Reactome Database ID Release 81 9781964 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781964 Reactome R-MMU-164383 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-164383.1 Gng7 GNG7 Q61016 Reactome DB_ID: 9781967 UniProt:Q61016 Gng7 Gng7 Gngt7 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma.TISSUE SPECIFICITY Brain. Found in the hippocampus, striatum, midbrain and cortex.DISRUPTION PHENOTYPE Mice display increased startle response but normal prepulse inhibition of the startle response. No effect on survival to weaning, fertility and mortality.SIMILARITY Belongs to the G protein gamma family. UniProt Q61016 2 EQUAL 65 EQUAL Reactome Database ID Release 81 9781967 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781967 Reactome R-MMU-164325 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-164325.1 Gng8 GNG8 P63078 Reactome DB_ID: 9781970 UniProt:P63078 Gng8 Gng8 Gng9 Gngt9 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit may have a very specific role in the development and turnover of olfactory and vomeronasal neurons.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma.SIMILARITY Belongs to the G protein gamma family. UniProt P63078 1 EQUAL 67 EQUAL Reactome Database ID Release 81 9781970 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781970 Reactome R-MMU-164371 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-164371.1 Gngt2 GNGT2 Q61017 Reactome DB_ID: 9781973 UniProt:Q61017 Gngt2 Gngt2 Gng8 Gngt8 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma.SIMILARITY Belongs to the G protein gamma family. UniProt Q61017 1 EQUAL 66 EQUAL Reactome Database ID Release 81 9781973 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781973 Reactome R-MMU-167440 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167440.1 Gng10 GNG10 Q9CXP8 Reactome DB_ID: 9781976 UniProt:Q9CXP8 Gng10 Gng10 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3 (By similarity).SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma.SIMILARITY Belongs to the G protein gamma family. UniProt Q9CXP8 1 EQUAL 65 EQUAL Reactome Database ID Release 81 9781976 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781976 Reactome R-MMU-164344 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-164344.1 Gng11 GNG11 P61953 Reactome DB_ID: 9781979 UniProt:P61953 Gng11 Gng11 Gngt11 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2 (By similarity).SIMILARITY Belongs to the G protein gamma family. UniProt P61953 1 EQUAL 70 EQUAL Reactome Database ID Release 81 9781979 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781979 Reactome R-MMU-164329 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-164329.1 Gng12 GNG12 Q9DAS9 Reactome DB_ID: 9781982 UniProt:Q9DAS9 Gng12 Gng12 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma.SIMILARITY Belongs to the G protein gamma family. UniProt Q9DAS9 2 EQUAL 69 EQUAL Reactome Database ID Release 81 9781982 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781982 Reactome R-MMU-164367 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-164367.1 Gng13 G-protein gamma 13 subunit GBG13_MOUSE Gng13 Reactome DB_ID: 428090 UniProt:Q9JMF3 Gng13 Gng13 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma.SIMILARITY Belongs to the G protein gamma family. UniProt Q9JMF3 1 EQUAL 64 EQUAL Reactome Database ID Release 81 428090 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428090 Reactome R-MMU-428090 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-428090.1 Gngt1 GNGT1 Q61012 Reactome DB_ID: 9781986 UniProt:Q61012 Gngt1 Gngt1 Gng1 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma.TISSUE SPECIFICITY Retinal rod outer segment.MASS SPECTROMETRY Includes farnesylation and methylation.SIMILARITY Belongs to the G protein gamma family. UniProt Q61012 2 EQUAL 71 EQUAL Reactome Database ID Release 81 9781986 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781986 Reactome R-MMU-167428 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167428.1 Reactome Database ID Release 81 9781988 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781988 Reactome R-MMU-167442 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167442.1 1 Converted from EntitySet in Reactome GNB G-protein beta subunit Reactome DB_ID: 9781995 Gnb1 G-protein beta 1 subunit GBB1_MOUSE Gnb1 Reactome DB_ID: 4551475 cytosol GENE ONTOLOGY GO:0005829 UniProt:P62874 Gnb1 Gnb1 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity). Interacts with ARHGEF18 and RASD2 (By similarity).PTM Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.SIMILARITY Belongs to the WD repeat G protein beta family. UniProt P62874 2 EQUAL 340 EQUAL Reactome Database ID Release 81 4551475 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4551475 Reactome R-MMU-4551475 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4551475.1 Gnb2 G-protein beta 2 subunit GBB2_MOUSE Gnb2 Reactome DB_ID: 4551493 UniProt:P62880 Gnb2 Gnb2 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. Interacts with ATXN10. Interacts with SCN8A.DEVELOPMENTAL STAGE Expressed in meiotically incompetent oocytes. Expression increases in fully grown meiotically competent oocytes. Expression then decreases during metaphase-II arrested eggs, one-cell embryo, two-cell embryo and eight-cell embryo stages, and increases again during blastocyst stage.SIMILARITY Belongs to the WD repeat G protein beta family. UniProt P62880 2 EQUAL 340 EQUAL Reactome Database ID Release 81 4551493 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4551493 Reactome R-MMU-4551493 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4551493.1 Gnb3 G-protein beta 3 subunit GBB3_MOUSE Gnb3 Reactome DB_ID: 4551480 UniProt:Q61011 Gnb3 Gnb3 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2 (By similarity).SIMILARITY Belongs to the WD repeat G protein beta family. UniProt Q61011 1 EQUAL 340 EQUAL Reactome Database ID Release 81 4551480 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4551480 Reactome R-MMU-4551480 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4551480.1 Gnb4 G-protein beta 4 subunit Guanine nucleotide-binding protein subunit beta-4 GBB4_MOUSE Gnb4 Reactome DB_ID: 4551495 UniProt:P29387 Gnb4 Gnb4 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma.SIMILARITY Belongs to the WD repeat G protein beta family. UniProt P29387 2 EQUAL 340 EQUAL Reactome Database ID Release 81 4551495 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4551495 Reactome R-MMU-4551495 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4551495.1 Gnb5 G-protein beta 5 subunit Guanine nucleotide-binding protein subunit beta-5 GBB5_MOUSE Gnb5 Reactome DB_ID: 4551482 UniProt:P62881 Gnb5 Gnb5 FUNCTION Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).SUBUNIT Component of a complex composed of RGS9, GNB5 and RGS9BP; within this complex, the presence of GNB5 stabilizes both itself and RGS9 and increases RGS9 GTPase-activating protein (GAP) activity (By similarity) (PubMed:12119397, PubMed:16908407, PubMed:18204463). Interacts with RGS6 and RGS7 (By similarity).TISSUE SPECIFICITY Isoform 1 is only detected in retina (PubMed:8910430). Isoform 2 is detected in brain (at protein level) (PubMed:8071339). Isoform 2 is detected in brain (PubMed:8071339).SIMILARITY Belongs to the WD repeat G protein beta family. UniProt P62881 1 EQUAL 395 EQUAL Reactome Database ID Release 81 4551482 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4551482 Reactome R-MMU-4551482 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4551482.1 Reactome Database ID Release 81 9781995 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781995 Reactome R-MMU-6814413 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6814413.1 1 Reactome Database ID Release 81 9781997 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781997 Reactome R-MMU-167434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167434.1 G-protein alpha (z):GDP Reactome DB_ID: 9810332 GDP Guanosine 5'-diphosphate Guanosine diphosphate Reactome DB_ID: 114549 GDP [ChEBI:17552] GDP Guanosine 5'-diphosphate Guanosine diphosphate ChEBI CHEBI:17552 Reactome Database ID Release 81 114549 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114549 Reactome R-ALL-114549 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-114549.2 COMPOUND C00035 additional information MI MI:0361 1 Gnaz GNAZ O70443 Reactome DB_ID: 9803109 UniProt:O70443 Gnaz UniProt O70443 2 EQUAL 355 EQUAL Reactome Database ID Release 81 9803109 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9803109 Reactome R-MMU-167416 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167416.1 1 Reactome Database ID Release 81 9810332 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9810332 Reactome R-MMU-392006 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-392006.1 Heterotrimeric G-protein Gz (inactive) Reactome DB_ID: 9810334 1 1 Reactome Database ID Release 81 9810334 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9810334 Reactome R-MMU-391985 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-391985.1 Reactome Database ID Release 81 9810359 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9810359 Reactome R-MMU-750988 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-750988.1 The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active G alpha (z) subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (z):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates. 16923326 Pubmed 2006 Structural basis of function in heterotrimeric G proteins Oldham, WM Hamm, HE Q Rev Biophys 39:117-66 15951850 Pubmed 2005 The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits Siderovski, DP Willard, FS Int J Biol Sci 1:51-66 inferred from electronic annotation EVIDENCE CODE ECO:0000203