BioPAX pathway converted from "factor V -> factor Va + factor V activation peptide" in the Reactome database. LEFT-TO-RIGHT 3.4.21.1 3.4.21.92 3.4.21.73 3.4.21.71 3.4.21.93 3.4.21.94 3.4.21.34 3.4.21.78 3.4.21.9 3.4.21.53 3.4.21.6 3.4.21.75 3.4.24.3 3.4.21.10 3.4.21.54 3.4.21.7 3.4.21.4 3.4.21.59 3.4.21.38 3.4.21.5 3.4.21.35 3.4.21.79 3.4.21.36 3.4.19.1 3.4.21.62 3.4.21.41 3.4.21.61 3.4.21.83 3.4.21.22 3.4.21.88 3.4.21.45 3.4.21.89 3.4.21.20 3.4.21.42 3.4.21.21 3.4.21.43 3.4.21.87 3.4.21.26 3.4.21.48 3.4.24.34 3.4.21.27 3.4.21.46 3.4.21.68 3.4.21.47 3.4.21.69 3.4.21.39 3.4.24.7 3.4.21.102 factor V -> factor Va + factor V activation peptide This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> O88783 factor V Reactome DB_ID: 9824609 extracellular region GENE ONTOLOGY GO:0005576 UniProt:O88783 Mus musculus NCBI Taxonomy 10090 UniProt O88783 29 EQUAL 2224 EQUAL Reactome Database ID Release 82 9824609 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824609 Reactome R-MMU-140697 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140697.1 Reactome http://www.reactome.org O88783 factor V activation peptide Reactome DB_ID: 9824611 738 EQUAL 1573 EQUAL Reactome Database ID Release 82 9824611 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824611 Reactome R-MMU-140787 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140787.1 factor Va Reactome DB_ID: 9824605 O88783 factor Va heavy chain Reactome DB_ID: 9824603 29 EQUAL 737 EQUAL Reactome Database ID Release 82 9824603 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824603 Reactome R-MMU-140691 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140691.1 1 O88783 factor Va light chain Reactome DB_ID: 9824601 1574 EQUAL 2224 EQUAL Reactome Database ID Release 82 9824601 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824601 Reactome R-MMU-140690 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140690.1 1 Ca2+ Calcium calcium(2+) Reactome DB_ID: 74112 calcium(2+) [ChEBI:29108] calcium(2+) ChEBI CHEBI:29108 Reactome Database ID Release 82 74112 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74112 Reactome R-ALL-74112 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74112.4 COMPOUND C00076 additional information MI MI:0361 1 Reactome Database ID Release 82 9824605 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824605 Reactome R-MMU-140692 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140692.1 ACTIVATION activated thrombin (factor IIa) Reactome DB_ID: 9824259 F2 thrombin light chain P19221 Reactome DB_ID: 9824257 UniProt:P19221 F2 UniProt P19221 328 EQUAL 363 EQUAL Reactome Database ID Release 82 9824257 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824257 Reactome R-MMU-140598 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140598.1 1 F2 thrombin heavy chain P19221 Reactome DB_ID: 9824255 364 EQUAL 622 EQUAL Reactome Database ID Release 82 9824255 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824255 Reactome R-MMU-140589 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140589.1 1 6 Reactome Database ID Release 82 9824259 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824259 Reactome R-MMU-156786 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-156786.1 GENE ONTOLOGY GO:0004252 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 9824260 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824260 Reactome Database ID Release 82 9824613 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824613 Reactome R-MMU-140696 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140696.1 Activated thrombin (factor IIa) catalyzes the conversion of factor V to factor Va (activated factor V). The activation peptide released in this reaction has no known function. 14982929 Pubmed 2004 The factor V activation paradox Orfeo, T Brufatto, N Nesheim, ME Xu, H Butenas, S Mann, KG J Biol Chem 279:19580-91 inferred from electronic annotation EVIDENCE CODE ECO:0000203 INHIBITION Reactome Database ID Release 82 9824541 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824541 Converted from EntitySet in Reactome Extracellular thrombin inactivating complexes Reactome DB_ID: 9824517 activated thrombin (factor IIa):SERPIND1 Reactome DB_ID: 9824482 P49182 Serpind1 SERPIND1 Reactome DB_ID: 9824480 UniProt:P49182 Serpind1 UniProt P49182 20 EQUAL 499 EQUAL Reactome Database ID Release 82 9824480 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824480 Reactome R-MMU-5578885 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5578885.1 1 1 Reactome Database ID Release 82 9824482 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824482 Reactome R-MMU-5578881 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5578881.1 thrombin:cleaved SERPINC1 Reactome DB_ID: 9824492 1 cleaved SERPINC1 Reactome DB_ID: 9824490 P32261 SERPINC1(426-464) Reactome DB_ID: 9824488 UniProt:P32261 UniProt P32261 426 EQUAL 464 EQUAL Reactome Database ID Release 82 9824488 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824488 Reactome R-MMU-140817 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140817.1 1 P32261 SERPINC1(33-425) Reactome DB_ID: 9824486 33 EQUAL 425 EQUAL Reactome Database ID Release 82 9824486 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824486 Reactome R-MMU-140814 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140814.1 1 Reactome Database ID Release 82 9824490 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824490 Reactome R-MMU-140821 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140821.1 1 Reactome Database ID Release 82 9824492 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824492 Reactome R-MMU-140874 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140874.1 SERPINA5:Activated protein C Reactome DB_ID: 9824515 P70458 Serpina5 SERPINA5 Reactome DB_ID: 9824496 UniProt:P70458 Serpina5 UniProt P70458 26 EQUAL 406 EQUAL Reactome Database ID Release 82 9824496 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824496 Reactome R-MMU-5591085 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5591085.1 1 Activated protein C Reactome DB_ID: 9824513 Proc PROC(212-461) P33587 Reactome DB_ID: 9824511 UniProt:P33587 Proc UniProt P33587 212 EQUAL 461 EQUAL Reactome Database ID Release 82 9824511 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824511 Reactome R-MMU-141048 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-141048.1 1 Proc 8xCbxE-3D-PROC(43-197) P33587 Reactome DB_ID: 9824509 71 EQUAL L-gamma-carboxyglutamic acid MOD MOD:00041 68 EQUAL 67 EQUAL 62 EQUAL 61 EQUAL 58 EQUAL 56 EQUAL 49 EQUAL 113 EQUAL (2S,3R)-3-hydroxyaspartic acid MOD MOD:00036 43 EQUAL 197 EQUAL Reactome Database ID Release 82 9824509 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824509 Reactome R-MMU-141041 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-141041.1 1 1 Reactome Database ID Release 82 9824513 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824513 Reactome R-MMU-141050 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-141050.1 1 Reactome Database ID Release 82 9824515 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824515 Reactome R-MMU-5607007 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5607007.1 Reactome Database ID Release 82 9824517 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824517 Reactome R-MMU-5607050 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5607050.1 INHIBITION Reactome Database ID Release 82 9824542 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824542 SERPINE2:GAG:activated thrombin (factor IIa) Reactome DB_ID: 9824531 plasma membrane GENE ONTOLOGY GO:0005886 SERPINE2:GAG Reactome DB_ID: 9824529 GAG glycosaminoglycan Reactome DB_ID: 977180 glycosaminoglycan [ChEBI:18085] glycosaminoglycan ChEBI CHEBI:18085 Reactome Database ID Release 82 977180 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=977180 Reactome R-ALL-977180 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-977180.3 1 Q07235 Serpine2 SERPINE2 Reactome DB_ID: 9824527 UniProt:Q07235 Serpine2 UniProt Q07235 20 EQUAL 398 EQUAL Reactome Database ID Release 82 9824527 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824527 Reactome R-MMU-4127459 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4127459.1 2 Reactome Database ID Release 82 9824529 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824529 Reactome R-MMU-5607782 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5607782.1 1 activated thrombin (factor IIa) Reactome DB_ID: 9824523 F2 thrombin light chain P19221 Reactome DB_ID: 9824521 328 EQUAL 363 EQUAL Reactome Database ID Release 82 9824521 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824521 Reactome R-MMU-140810 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140810.1 1 Ca2+ Calcium calcium(2+) Reactome DB_ID: 140648 Reactome Database ID Release 82 140648 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=140648 Reactome R-ALL-140648 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-140648.4 COMPOUND C00076 6 F2 thrombin heavy chain P19221 Reactome DB_ID: 9824519 364 EQUAL 622 EQUAL Reactome Database ID Release 82 9824519 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824519 Reactome R-MMU-140809 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140809.1 1 Reactome Database ID Release 82 9824523 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824523 Reactome R-MMU-140811 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-140811.1 1 Reactome Database ID Release 82 9824531 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824531 Reactome R-MMU-5607781 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5607781.1