BioPAX pathway converted from "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" in the Reactome database.Antigen Presentation: Folding, assembly and peptide loading of class I MHCUnlike other glycoproteins, correct folding of MHC class I molecules is not sufficient to trigger their exit from the ER, they exit only after peptide loading. Described here is the process of antigen presentation which consists of the folding, assembly, and peptide loading of MHC class I molecules. The newly synthesized MHC class I Heavy Chain (HC) is initially folded with the help of several chaperones (calnexin, BiP, ERp57) and then binds with Beta-2-microglobulin (B2M). This MHC:B2M heterodimer enters the peptide loading complex (PLC), a multiprotein complex that includes calreticulin, endoplasmic reticulum resident protein 57 (ERp57), transporter associated with antigen processing (TAP) and tapasin. Peptides generated from Ub-proteolysis are transported into the ER through TAP. These peptides are further trimmed by ER-associated aminopeptidase (ERAP) and loaded on to MHC class I molecules. Stable MHC class I trimers with high-affinity peptide are transported from the ER to the cell surface by the Golgi apparatus.Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29LEFT-TO-RIGHTBinding of newly synthesized MHC class I heavy chain (HC) with calnexinThe newly synthesized MHC class I heavy chain (HC) translocates into the endoplasmic reticulum (ER) and binds rapidly to calnexin (CNX), a transmembrane calcium-dependent lectin with chaperone activity. CNX recognizes and binds to an N-linked monoglycosylated Glc1Man9GlcNAc2 carbohydrate group found attached to the conserved Asn-86 in the HC. Interaction of HC with CNX promotes the formation of intrachain disulfide bonds. Another candidate ER chaperon protein is immunoglobulin binding protein (BiP), found to associate with HC in the absence of CNX. These chaperones can cooperate in protein folding and prevention of aggregation.Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29Converted from EntitySet in ReactomeChaperones calnexin/BiPReactome DB_ID: 983129CANXCalnexin (CANX)Reactome DB_ID: 983091integral component of lumenal side of endoplasmic reticulum membraneGENE ONTOLOGYGO:0071556UniProt:P27824 CANXCANXFUNCTION Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.SUBUNIT Interacts with MAPK3/ERK1 (By similarity). Interacts with KCNH2 (PubMed:16361248). Associates with ribosomes (By similarity). Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins (PubMed:22314232). Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1 (PubMed:23826168). Interacts with PPIB (PubMed:20801878). Interacts with ZNRF4 (PubMed:21205830). Interacts with SMIM22 (PubMed:29765154). Interacts with TMX2.SUBUNIT (Microbial infection) Interacts with HBV large envelope protein, isoform L.SUBUNIT (Microbial infection) Interacts with HBV large envelope protein, isoform M; this association may be essential for isoform M proper secretion.PTM Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).PTM Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins.PTM Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.SIMILARITY Belongs to the calreticulin family.Homo sapiensNCBI Taxonomy9606UniProtP2782421EQUAL592EQUALReactome Database ID Release 75983091Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983091ReactomeR-HSA-9830911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983091.1Reactomehttp://www.reactome.orgBiPHSPA578 kDa glucose-regulated proteinGRP78Reactome DB_ID: 985498UniProt:P11021 HSPA5HSPA5GRP78FUNCTION Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166).ACTIVITY REGULATION The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains. In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction (PubMed:26655470). In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates (PubMed:26655470). J domain-containing co-chaperones (DNAJB9/ERdj4 or DNAJC10/ERdj5) stimulate the ATPase activity and are required for efficient substrate recognition by HSPA5/BiP (By similarity). Homooligomerization inactivates participating HSPA5/BiP protomers and probably act as reservoirs to store HSPA5/BiP molecules when they are not needed by the cell (By similarity).SUBUNIT Monomer and homooligomer; homooligomerization via the interdomain linker inactivates the chaperone activity and acts as a storage of HSPA5/BiP molecules (By similarity). Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (By similarity). Interacts with TMEM132A and TRIM21 (PubMed:12699405). May form a complex with ERLEC1, OS9, SEL1L and SYVN1 (PubMed:18264092,PubMed:18502753). Interacts with DNAJC10 (PubMed:12411443, PubMed:23769672). Interacts with DNAJB9/ERdj4; leading to recruit HSPA5/BiP to ERN1/IRE1 (By similarity). Interacts with ERN1/IRE1; interaction takes place following interaction with DNAJB9/ERdj4 and leads to inactivate ERN1/IRE1 (By similarity). Interacts with MX1 (By similarity). Interacts with METTL23 (PubMed:23349634). Interacts with CEMIP; the interaction induces calcium leakage from the endoplasmic reticulum and cell migration (PubMed:23990668). Interacts with PCSK4 form; the interaction takes place in the endoplasmic reticulum (PubMed:21080038). Interacts with CIPC (PubMed:26657846). Interacts with CCDC88B (via C-terminus); the interaction opposes ERN1-mediated JNK activation, protecting against apoptosis (PubMed:21289099). Interacts with INPP5K; necessary for INPP5K localization at the endoplasmic reticulum (PubMed:26940976). Interacts with MANF; the interaction is direct (PubMed:22637475). Interacts with LOXL2; leading to activate the ERN1/IRE1-XBP1 pathway of the unfolded protein response (PubMed:28332555). Interacts with CLU under stressed condition; interaction increases CLU protein stability; facilitates its retrotranslocation and redistribution to the mitochondria; cooperatively suppress stress-induced apoptosis by stabilizing mitochondrial membrane integrity (PubMed:22689054). Interacts with CCDC47 (By similarity). Interacts with CLN3 (Probable). Interacts with KIAA1324; may regulate the function of HSPA5 in apoptosis and cell proliferation (PubMed:26045166). Interacts with CASP7 (PubMed:26045166).INDUCTION By endoplasmic reticulum stress.DOMAIN The interdomain linker regulates the chaperone activity by mediating the formation of homooligomers. Homooligomers are formed by engagement of the interdomain linker of one HSPA5/BiP molecule as a typical substrate of an adjacent HSPA5/BiP molecule. HSPA5/BiP oligomerization inactivates participating HSPA5/BiP protomers. HSPA5/BiP oligomers probably act as reservoirs to store HSPA5/BiP molecules when they are not needed by the cell. When the levels of unfolded proteins rise, cells can rapidly break up these oligomers to make active monomers.PTM AMPylated by FICD (PubMed:25601083). In unstressed cells, AMPylation at Thr-518 by FICD inactivates the chaperome activity: AMPylated form is locked in a relatively inert state and only weakly stimulated by J domain-containing proteins (By similarity). In response to endoplasmic reticulum stress, de-AMPylation by the same protein, FICD, restores the chaperone activity (By similarity).DISEASE Autoantigen in rheumatoid arthritis.SIMILARITY Belongs to the heat shock protein 70 family.CAUTION AMPylation was initially reported to take place at Ser-365 and Thr-366 in vitro, and promote activation of HSPA5/BiP (PubMed:25601083). However, it was later shown that AMPylation takes place at Thr-518 and leads to inactivation of HSPA5/BiP.UniProtP1102119EQUAL654EQUALReactome Database ID Release 75985498Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=985498ReactomeR-HSA-9854981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-985498.1Reactome Database ID Release 75983129Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983129ReactomeR-HSA-9831291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983129.1monoglucosylated MHC class I HC(Glc)1(Man)9(GlcNAc)2-MHC class I heavy chainReactome DB_ID: 983120Converted from EntitySet in ReactomeClass I MHC heavy chain (MHC HC)Reactome DB_ID: 983117HLA-AHLA class I histocompatibility antigen, A-1 alpha chain precursor1A01_HUMANReactome DB_ID: 983102UniProt:P30443 HLA-AHLA-AHLAAFUNCTION Antigen-presenting major histocompatibility complex class I (MHCI) molecule, HLA-A*01 serotype. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A*01-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:1402688, PubMed:7504010, PubMed:17189421, PubMed:19177349, PubMed:26758806, PubMed:24395804). May also present self-peptides, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells. Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17189421, PubMed:20364150). Can bind different peptides that share a common structural motif defined by the nature of the peptide anchor residues. HLA-A*01:01 presents a restricted peptide repertoire including viral epitopes derived from IAV NP/nucleoprotein (CTELKLSDY), IAV PB1/polymerase basic protein 1 (VSDGGPNLY), HAdV-11 capsid L3/hexon protein (LTDLGQNLLY) as well as tumor peptide antigens including MAGE1 (EADPTGHSY), MAGEA3 (EVDPIGHLY) and WT1 (TSEKRPFMCAY), all having in common a canonical motif with a negatively charged Asp or Glu residue at position 3 and a Tyr anchor residue at C-terminal (PubMed:1402688, PubMed:7504010, PubMed:17189421, PubMed:20364150, PubMed:25880248, PubMed:30530481, PubMed:24395804, PubMed:26758806). A number of HLA-A*01:01-restricted peptides carry a post-translational modification with oxidation and N-terminal acetylation being the most frequent (PubMed:25880248). Fails to present highly immunogenic peptides from the EBV latent antigens (PubMed:18779413).SUBUNIT Heterotrimer that consists of an alpha chain HLA-A*01, a beta chain B2M and a peptide (peptide-HLA-A*01-B2M) (PubMed:19177349, PubMed:24395804, PubMed:26758806, PubMed:7504010, PubMed:7506728). Early in biogenesis, HLA-A-B2M dimer interacts with the components of the peptide-loading complex composed of TAPBP, TAP1-TAP2, TAPBPL, PDIA3/ERP57 and CALR. Interacts with TAP1-TAP2 transporter via TAPBP; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter. Interacts with TAPBPL; TAPBPL binds peptide-free HLA-A-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange for higher affinity peptides. Only optimally assembled peptide-HLA-A-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells. HLA-A (via polymorphic alpha-1 and alpha-2 domains) interacts with antigen-specific TCR (via CDR3 domains). One HLA-A molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop); this interaction insures peptide-HLA-A-B2M recognition by CD8-positive T cells only (By similarity).TISSUE SPECIFICITY Ubiquitous.DOMAIN The alpha-1 domain is a structural part of the peptide-binding cleft.DOMAIN The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:19177349, PubMed:26758806, PubMed:24395804). Mediates the interaction with TAP1-TAP2 complex (By similarity).DOMAIN The alpha-3 Ig-like domain mediates the interaction with CD8 coreceptor.POLYMORPHISM The HLA-A*01 allele group comprises at least 297 different alleles. Polymorphic residues encode for alpha-1 and alpha-2 domains of the peptide-binding cleft, where they contribute to variations in peptide binding and TCR recognition among different alleles. The sequence shown is that of HLA-A*01:01.SIMILARITY Belongs to the MHC class I family.UniProtP3044325EQUAL365EQUALReactome Database ID Release 75983102Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983102ReactomeR-HSA-9831021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983102.1HLA class I histocompatibility antigen, A-2 alpha chainReactome DB_ID: 983075UniProt:P01892 HLA-AHLA-AHLAAFUNCTION Antigen-presenting major histocompatibility complex class I (MHCI) molecule, HLA-A*02 serotype. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A*02-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:7694806, PubMed:2784196, PubMed:12138174, PubMed:12796775, PubMed:28250417, PubMed:8906788, PubMed:19542454, PubMed:20619457). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7935798). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 11 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome (PubMed:17079320, PubMed:26929325). Can bind different peptides that share a common structural motif defined by the nature of the peptide anchor residues (PubMed:7935798, PubMed:8906788, PubMed:8805302, PubMed:8630735, PubMed:22245737). HLA-A*02:01, a major allele in human populations, presents immunodominant viral epitopes derived from IAV M/matrix protein 1 (GILGFVFTL), HIV-1 env (TLTSCNTSV), HIV-1 gag-pol (ILKEPVHGV), HTLV-1 Tax (LLFGYPVYV), HBV C/core antigen (FLPSDFFPS), HCMV UL83/pp65 (NLVPMVATV) as well as tumor peptide antigens including MAGEA4 (GVYDGREHTV), WT1 (RMFPNAPYL) and CTAG1A/NY-ESO-1 (SLLMWITQC), all having in common hydrophobic amino acids at position 2 and at C-terminal anchors (PubMed:12796775, PubMed:8805302, PubMed:8630735, PubMed:9177355, PubMed:20619457, PubMed:18275829, PubMed:28250417, PubMed:7694806, PubMed:8906788, PubMed:11502003, PubMed:19542454, PubMed:12138174).SUBUNIT Heterotrimer that consists of an alpha chain HLA-A*02, a beta chain B2M and a peptide (peptide-HLA-A*02-B2M) (PubMed:8805302, PubMed:7694806, PubMed:7935798, PubMed:9177355, PubMed:18275829, PubMed:22245737, PubMed:28250417, PubMed:11502003). Early in biogenesis, HLA-A*02-B2M dimer interacts with the components of the peptide-loading complex composed of TAPBP, TAP1-TAP2, TAPBPL, PDIA3/ERP57 and CALR (PubMed:21263072). Interacts with TAP1-TAP2 transporter via TAPBP; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:8805302, PubMed:8630735, PubMed:21263072). Interacts with TAPBPL; TAPBPL binds peptide-free HLA-A*02-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange for higher affinity peptides (PubMed:26869717). Only optimally assembled peptide-HLA-A*02-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells. HLA-A*02 (via polymorphic alpha-1 and alpha-2 domains) interacts with antigen-specific TCR (via CDR3 domains) (PubMed:22245737, PubMed:12796775, PubMed:18275829). One HLA-A*02 molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop); this interaction insures peptide-HLA-A*02-B2M recognition by CD8-positive T cells only (PubMed:9177355, PubMed:2784196).SUBUNIT (Microbial infection) Interacts with HHV-8 MIR1 protein.SUBUNIT (Microbial infection) Interacts with HTLV-1 accessory protein p12I.TISSUE SPECIFICITY Ubiquitous.INDUCTION Up-regulated by IFNG, and proinflammatory cytokines IL1B and TNF.DOMAIN The alpha-1 domain is a structural part of the peptide-binding cleft.DOMAIN The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:7694806, PubMed:8906788, PubMed:2784196, PubMed:28250417, PubMed:22245737, PubMed:19542454, PubMed:20619457). Mediates the interaction with TAP1-TAP2 complex (PubMed:8805302).DOMAIN The alpha-3 Ig-like domain mediates the interaction with CD8 coreceptor.PTM N-linked glycosylation at ASN-110.PTM (Microbial infection) Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system.POLYMORPHISM The HLA-A*02 allele group comprises at least 825 different alleles. Polymorphic residues encode for alpha-1 and alpha-2 domains of the peptide-binding cleft, where they contribute to variations in peptide binding and TCR recognition among different alleles. The sequence shown is that of HLA-A*02:01, which represents the major allele expressed in nearly half of the human population worldwide.DISEASE May act as a susceptibility gene in Diabetes mellitus, insulin-dependent (IDDM) (PubMed:22245737, PubMed:18802479). In a glucose-dependent way, HLA-A*02:01 may aberrantly present the signal peptide of preproinsulin (ALWGPDPAAA) on the surface of pancreatic beta cells to autoreactive CD8-positive T cells, potentially driving T-cell mediated cytotoxicity in pancreatic islets (PubMed:22245737, PubMed:18802479).SIMILARITY Belongs to the MHC class I family.UniProtP0189225EQUAL365EQUALReactome Database ID Release 75983075Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983075ReactomeR-HSA-9830751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983075.1HLA-AHLA class I histocompatibility antigen, A-3 alpha chain precursor1A03_HUMANReactome DB_ID: 983100UniProt:P04439 HLA-AHLA-AHLAAFUNCTION Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:2456340, PubMed:2784196, PubMed:1402688, PubMed:7504010, PubMed:9862734, PubMed:10449296, PubMed:12138174, PubMed:12393434, PubMed:15893615, PubMed:17189421, PubMed:19543285, PubMed:21498667, PubMed:24192765, PubMed:7694806, PubMed:24395804, PubMed:28250417). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728, PubMed:7679507). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17189421, PubMed:20364150, PubMed:17079320, PubMed:26929325, PubMed:27049119). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:7504010, PubMed:9862734).FUNCTION Allele A*01:01: Presents a restricted peptide repertoire including viral epitopes derived from IAV NP/nucleoprotein (CTELKLSDY), IAV PB1/polymerase basic protein 1 (VSDGGPNLY), HAdV-11 capsid L3/hexon protein (LTDLGQNLLY) as well as tumor peptide antigens including MAGE1 (EADPTGHSY), MAGEA3 (EVDPIGHLY) and WT1 (TSEKRPFMCAY), all having in common a canonical motif with a negatively charged Asp or Glu residue at position 3 and a Tyr anchor residue at the C-terminus (PubMed:1402688, PubMed:7504010, PubMed:17189421, PubMed:20364150, PubMed:25880248, PubMed:30530481, PubMed:19177349, PubMed:24395804, PubMed:26758806). A number of HLA-A*01:01-restricted peptides carry a post-translational modification with oxidation and N-terminal acetylation being the most frequent (PubMed:25880248). Fails to present highly immunogenic peptides from the EBV latent antigens (PubMed:18779413).FUNCTION Allele A*02:01: A major allele in human populations, presents immunodominant viral epitopes derived from IAV M/matrix protein 1 (GILGFVFTL), HIV-1 env (TLTSCNTSV), HIV-1 gag-pol (ILKEPVHGV), HTLV-1 Tax (LLFGYPVYV), HBV C/core antigen (FLPSDFFPS), HCMV UL83/pp65 (NLVPMVATV) as well as tumor peptide antigens including MAGEA4 (GVYDGREHTV), WT1 (RMFPNAPYL) and CTAG1A/NY-ESO-1 (SLLMWITQC), all having in common hydrophobic amino acids at position 2 and at the C-terminal anchors.FUNCTION Allele A*03:01: Presents viral epitopes derived from IAV NP (ILRGSVAHK), HIV-1 nef (QVPLRPMTYK), HIV-1 gag-pol (AIFQSSMTK) as well as tumor peptide antigens including PMEL (LIYRRRLMK), NODAL (HAYIQSLLK), TRP-2 (RMYNMVPFF), all having in common hydrophobic amino acids at position 2 and Lys or Arg anchor residues at the C-terminus (PubMed:7504010, PubMed:7679507, PubMed:9862734, PubMed:19543285, PubMed:21943705, PubMed:2456340). May also display spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119).FUNCTION Allele A*11:01: Presents several immunodominant epitopes derived from HIV-1 gag-pol and HHV-4 EBNA4, containing the peptide motif with Val, Ile, Thr, Leu, Tyr or Phe at position 2 and Lys anchor residue at the C-terminus. Important in the control of HIV-1, EBV and HBV infections.FUNCTION Allele A*23:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response.FUNCTION Allele A*24:02: Presents viral epitopes derived from HIV-1 nef (RYPLTFGWCF), EBV lytic- and latent-cycle antigens BRLF1 (TYPVLEEMF), BMLF1 (DYNFVKQLF) and LMP2 (IYVLVMLVL), SARS-CoV nucleocapsid/N (QFKDNVILL), as well as tumor peptide antigens including PRAME (LYVDSLFFL), all sharing a common signature motif, namely an aromatic residue Tyr or Phe at position 2 and a nonhydrophobic anchor residue Phe, Leu or Iso at the C-terminus (PubMed:9047241, PubMed:12393434, PubMed:24192765, PubMed:20844028). Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response (PubMed:17182537, PubMed:18502829).FUNCTION Allele A*26:01: Presents several epitopes derived from HIV-1 gag-pol (EVIPMFSAL, ETKLGKAGY) and env (LVSDGGPNLY), carrying as anchor residues preferentially Glu at position 1, Val or Thr at position 2 and Tyr at the C-terminus.FUNCTION Allele A*29:02: Presents peptides having a common motif, namely a Glu residue at position 2 and Tyr or Leu anchor residues at the C-terminus.FUNCTION Allele A*32:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response.FUNCTION Allele A*68:01: Presents viral epitopes derived from IAV NP (KTGGPIYKR) and HIV-1 tat (ITKGLGISYGR), having a common signature motif namely, Val or Thr at position 2 and positively charged residues Arg or Lys at the C-terminal anchor.FUNCTION Allele A*74:01: Presents immunodominant HIV-1 epitopes derived from gag-pol (GQMVHQAISPR, QIYPGIKVR) and rev (RQIHSISER), carrying an aliphatic residue at position 2 and Arg anchor residue at the C-terminus. May contribute to viral load control in chronic HIV-1 infection.SUBUNIT Heterotrimer that consists of an alpha chain HLA-A, a beta chain B2M and a peptide (peptide-HLA-A-B2M) (PubMed:7504010, PubMed:7679507, PubMed:21943705, PubMed:19177349, PubMed:24395804, PubMed:26758806, PubMed:7504010, PubMed:7506728, PubMed:8805302, PubMed:7694806, PubMed:7935798, PubMed:9177355, PubMed:18275829, PubMed:22245737, PubMed:28250417, PubMed:11502003, PubMed:8906788, PubMed:19542454). Early in biogenesis, HLA-A-B2M dimer interacts with the components of the peptide-loading complex composed of TAPBP, TAP1-TAP2, TAPBPL, PDIA3/ERP57 and CALR (PubMed:21263072). Interacts with TAP1-TAP2 transporter via TAPBP; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:8805302, PubMed:8630735, PubMed:21263072). Interacts with TAPBPL; TAPBPL binds peptide-free HLA-A-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange for higher affinity peptides (PubMed:26869717). Only optimally assembled peptide-HLA-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells. HLA-A (via polymorphic alpha-1 and alpha-2 domains) interacts with antigen-specific TCR (via CDR3 domains) (PubMed:22245737, PubMed:12796775, PubMed:18275829). One HLA-A molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop); this interaction insures peptide-HLA-A-B2M recognition by CD8-positive T cells only (PubMed:9177355, PubMed:2784196). Alleles A*23:01; A*24:02 and A*32:01 interact (via Bw4 motif) with KIR3DL1 on NK cells; this interaction is direct.SUBUNIT (Microbial infection) Interacts with HHV-8 MIR1 protein.SUBUNIT (Microbial infection) Interacts with HTLV-1 accessory protein p12I.TISSUE SPECIFICITY Ubiquitous.INDUCTION Up-regulated by IFNG, and proinflammatory cytokines IL1B and TNF.DOMAIN The alpha-1 domain is a structural part of the peptide-binding cleft.DOMAIN The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:21543847, PubMed:21943705, PubMed:19177349, PubMed:26758806, PubMed:24395804, PubMed:7694806, PubMed:8906788, PubMed:2784196, PubMed:28250417, PubMed:22245737, PubMed:19542454, PubMed:20619457, PubMed:20844028). Mediates the interaction with TAP1-TAP2 complex (PubMed:8805302).DOMAIN The alpha-3 Ig-like domain mediates the interaction with CD8 coreceptor.PTM (Microbial infection) Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system.PTM N-linked glycosylation at Asn-110.POLYMORPHISM Highly polymorphic. Polymorphic residues encode for alpha-1 and alpha-2 domains of the peptide-binding cleft, where they contribute to variations in peptide binding and TCR recognition among different alleles. The human population is estimated to have millions of HLA-A alleles. But only 11 common HLA-A alleles are considered core alleles, representing all functionally significant variation (polymorphism) in alpha-1 and alpha-2 domains. These are: A*01:01; A*02:01; A*02:05; A*03:01; A*11:01; A*24:02; A*26:01; A*29:02; A*30:01; A*74:01 and A*80:01. Among these, A*02:01; A*11:01; A*24:02 and A*26:01, were likely passed by introgression from archaic to modern humans. Functional alleles of more recent origin (non-core) were derived by recombination (PubMed:28650991). The sequence shown is that of A*03:01. The sequences of core alleles and common representative alleles of serologically distinct allele groups are described as variants of A*03:01 (PubMed:28650991). Allele A*31:01 is associated with carbamazepine-induced hypersensitivity reactions among subjects of Northern European ancestry [MIM:608579] (PubMed:21428769).DISEASE Alleles A*02:01 and A*24:02 are associated with increased susceptibility to diabetes mellitus, insulin-dependent (IDDM) (PubMed:22245737, PubMed:18802479, PubMed:16731854, PubMed:22522618). In a glucose-dependent way, allele A*02:01 may aberrantly present the signal peptide of preproinsulin (ALWGPDPAAA) on the surface of pancreatic beta cells to autoreactive CD8-positive T cells, potentially driving T-cell mediated cytotoxicity in pancreatic islets (PubMed:22245737, PubMed:18802479). Allele A*24:02 may present the signal peptide of preproinsulin (LWMRLLPLL) and contribute to acute pancreatic beta-cell destruction and early onset of IDDM (PubMed:16731854, PubMed:22522618).DISEASE Allele A*03:01 is associated with increased susceptibility to multiple sclerosis (MS), an autoimmune disease of the central nervous system (PubMed:10746785). May contribute to the initiation phase of the disease by presenting myelin PLP1 self-peptide (KLIETYFSK) to autoreactive CD8-positive T cells capable of initiating the first autoimmune attacks (PubMed:18953350).DISEASE Allele A*26:01 is associated with increased susceptibility to Behcet disease (BD) in the Northeast Asian population. Especially in the HLA-B*51-negative BD populations, HLA-A*26 is significantly associated with the onset of BD.DISEASE Allele A*29:02 is associated with increased susceptibility to birdshot chorioretinopathy (BSCR). May aberrantly present retinal autoantigens and induce autoimmune uveitis.SIMILARITY Belongs to the MHC class I family.UniProtP0443925EQUAL365EQUALReactome Database ID Release 75983100Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983100ReactomeR-HSA-9831001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983100.1HLA-CHLA class I histocompatibility antigen, Cw-3 alpha chain precursor1C03_HUMANReactome DB_ID: 983086UniProt:P04222 HLA-CHLA-CHLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of Cw-3 are known: Cw*03:02 (Cw3.2), Cw*03:03, Cw*03:04 (Cw3.1), Cw*03:05, Cw*03:06, Cw*03:07, Cw*03:08, Cw*03:09 and Cw*03:13. The sequence shown is that of Cw*03:04.SIMILARITY Belongs to the MHC class I family.UniProtP0422225EQUAL366EQUALReactome Database ID Release 75983086Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983086ReactomeR-HSA-9830861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983086.1HLA-CHLA class I histocompatibility antigen, Cw-4 alpha chain precursor1C04_HUMANReactome DB_ID: 983064UniProt:P30504 HLA-CHLA-CHLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).SUBUNIT (Microbial infection) Interacts with HTLV-1 p12I accessory protein.PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of Cw-4 are known: Cw*04:01 Cw*04:03, Cw*04:04, Cw*04:05 and Cw*04:06. The sequence shown is that of Cw*04:01.SIMILARITY Belongs to the MHC class I family.UniProtP3050425EQUAL366EQUALReactome Database ID Release 75983064Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983064ReactomeR-HSA-9830641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983064.1HLA-CHLA class I histocompatibility antigen, Cw-5 alpha chain precursor1C05_HUMANReactome DB_ID: 983059UniProt:Q9TNN7 HLA-CHLA-CHLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of Cw-5 are known: Cw*05:01 Cw*0502, Cw*05:03 and Cw*05:04. The sequence shown is that of Cw*05:01.SIMILARITY Belongs to the MHC class I family.UniProtQ9TNN725EQUAL366EQUALReactome Database ID Release 75983059Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983059ReactomeR-HSA-9830591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983059.1HLA-CHLA class I histocompatibility antigen, Cw-6 alpha chain precursor1C06_HUMANReactome DB_ID: 983055UniProt:Q29963 HLA-CHLA-CHLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of Cw-6 are known: Cw*06:02 Cw*06:03 and Cw*06:04. Allele Cw*062 is a risk factor that confers susceptibility to psoriasis. The sequence shown is that of Cw*06:02.SIMILARITY Belongs to the MHC class I family.UniProtQ2996325EQUAL366EQUALReactome Database ID Release 75983055Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983055ReactomeR-HSA-9830551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983055.1HLA-CHLA class I histocompatibility antigen, Cw-7 alpha chain precursor1C07_HUMANReactome DB_ID: 983044UniProt:P10321 HLA-CHLA-CHLACFUNCTION Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity (PubMed:20972337, PubMed:24091323, PubMed:20439706, PubMed:11172028, PubMed:20104487, PubMed:28649982, PubMed:29312307). In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells (PubMed:16141329). In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary for placentation and overall fetal growth (PubMed:20972337, PubMed:24091323). During viral infection, may present viral peptides with low affinity for KIRs, impeding KIR-mediated inhibition through peptide antagonism and favoring lysis of infected cells (PubMed:20439706). Presents a restricted repertoire of viral peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-C-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected cells, particularly in chronic viral infection settings such as HIV-1 or CMV infection (PubMed:11172028, PubMed:20104487, PubMed:28649982). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (By similarity). Typically presents intracellular peptide antigens of 9 amino acids that arise from cytosolic proteolysis via proteasome. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9. Preferentially displays peptides having a restricted repertoire of hydrophobic or aromatic amino acids (Phe, Ile, Leu, Met, Val and Tyr) at the C-terminal anchor (PubMed:8265661, PubMed:25311805).FUNCTION ALLELE C*01:02: The peptide-bound form interacts with KIR2DL2 and KIR2DL3 inhibitory receptors on NK cells. The low affinity peptides compete with the high affinity peptides impeding KIR-mediated inhibition and favoring lysis of infected cells (PubMed:20439706). Presents to CD8-positive T cells a CMV epitope derived from UL83/pp65 (RCPEMISVL), an immediate-early antigen necessary for initiating viral replication (PubMed:12947002).FUNCTION ALLELE C*04:01: Presents a conserved HIV-1 epitope derived from env (SFNCGGEFF) to memory CD8-positive T cells, eliciting very strong IFNG responses (PubMed:20104487). Presents CMV epitope derived from UL83/pp65 (QYDPVAALF) to CD8-positive T cells, triggering T cell cytotoxic response (PubMed:12947002).FUNCTION ALLELE C*05:01: Presents HIV-1 epitope derived from rev (SAEPVPLQL) to CD8-positive T cells, triggering T cell cytotoxic response.FUNCTION ALLELE C*06:02: In trophoblasts, interacts with KIR2DS2 on uterine NK cells and triggers NK cell activation, including secretion of cytokines such as GMCSF that enhances trophoblast migration.FUNCTION ALLELE C*07:02: Plays an important role in the control of chronic CMV infection. Presents immunodominant CMV epitopes derived from IE1 (LSEFCRVL and CRVLCCYVL) and UL28 (FRCPRRFCF), both antigens synthesized during immediate-early period of viral replication. Elicits a strong anti-viral CD8-positive T cell immune response that increases markedly with age.FUNCTION ALLELE C*08:01: Presents viral epitopes derived from CMV UL83 (VVCAHELVC) and IAV M1 (GILGFVFTL), triggering CD8-positive T cell cytotoxic response.FUNCTION ALLELE C*12:02: Presents CMV epitope derived from UL83 (VAFTSHEHF) to CD8-positive T cells.FUNCTION ALLELE C*15:02: Presents CMV epitope derived from UL83 CC (VVCAHELVC) to CD8-positive T cells, triggering T cell cytotoxic response.SUBUNIT Heterotrimer that consists of an alpha chain HLA-C, a beta chain B2M and a peptide (peptide-HLA-C-B2M) (PubMed:28649982, PubMed:10850706, PubMed:24990997). Early in biogenesis, HLA-C-B2M dimer interacts with the components of the peptide-loading complex composed of TAPBP, TAP1-TAP2, TAPBPL, PDIA3/ERP57 and CALR (PubMed:18420581). Interacts with TAP1-TAP2 transporter via TAPBP; this interaction is obligatory for the loading of peptide epitopes delivered to the endoplasmic reticulum (ER) by TAP1-TAP2 transporter (By similarity). Being very selective in the peptide binding, forms a stable interaction with TAP1-TAP2, often leading to the accumulation of free heavy chains in the ER (PubMed:18420581). Only optimally assembled peptide-HLA-C-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells. HLA-C (via polymorphic alpha-1 and alpha-2 domains) interacts with antigen-specific TCR (via CDR3 domains) (By similarity). One HLA-C molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop); this interaction insures peptide-HLA-C-B2M recognition by CD8-positive T cells only (By similarity). The peptide-HLA-C-B2M complex also interacts with KIRs. HLA-C type 1 (C1, with Asn104), including HLA-C*02, C*04, C*05, C*06 and C*15, interact with KIR2DL1 and KIR2DS1, and HLA-C type 2 (C2, with Lys104), including HLA-C*01, C*03, C*07 and C*08, interact with KIR2DL2 and KIR2DL3 (PubMed:20972337, PubMed:24091323, PubMed:16141329, PubMed:20439706, PubMed:11323700, PubMed:10850706).SUBUNIT (Microbial infection) Interacts with HTLV-1 p12I accessory protein.TISSUE SPECIFICITY Ubiquitous. Highly expressed in fetal extravillous trophoblasts in the decidua basalis (at protein level).DOMAIN The alpha-1 domain is a structural part of the peptide-binding cleft.DOMAIN The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:28649982, PubMed:10850706, PubMed:24990997). Mediates the interaction with TAP1-TAP2 complex.DOMAIN The alpha-3 Ig-like domain mediates the interaction with CD8 coreceptor.PTM N-linked glycosylation at Asn-110 is required for efficient interaction with CANX and CALR chaperones and appropriate HLA-C-B2M folded conformers prior to peptide loading.POLYMORPHISM Displays lower polymorphism than HLA-A and HLA-B. Polymorphic residues encode for alpha-1 and alpha-2 domains of the peptide-binding cleft, where they contribute to variations in peptide binding and TCR recognition among different alleles. The human population is estimated to have millions of HLA-C alleles. But only 14 common HLA-C alleles are considered core alleles, representing all functionally significant variation (polymorphism) in alpha-1 and alpha-2 domains. These are: C*01:02; C*02:02; C*03:02; C*04:01; C*05:01; C*06:02; C*07:01; C*07:04; C*08:01; C*12:02; C*14:02; C*15:02; C*16:01 and C*17:01. Among these, C*01:02; C*02:02; C*03:02; C*08:01; C*12:02; C*14:02 and C*15:02, were likely passed by introgression from archaic to modern humans. Functional alleles of more recent origin (non-core) were derived by recombination (PubMed:28650991). The sequence shown is that of C*07:02. The sequences of core alleles and common representative alleles of serologically distinct allele groups are described as variants of C*07:02.UniProtP1032125EQUAL366EQUALReactome Database ID Release 75983044Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983044ReactomeR-HSA-9830441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983044.1HLA-EHLA class I histocompatibility antigen, E alpha chain precursorHLAE_HUMANReactome DB_ID: 983090UniProt:P13747 HLA-EHLA-EHLA-6.2HLAEFUNCTION Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8+ cytotoxic T cells, ultimately triggering antimicrobial immune response (PubMed:16474394, PubMed:30087334).FUNCTION (Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells.SUBUNIT Forms a heterotrimer with B2M and a self- or a pathogen-derived peptide (peptide-bound HLA-E-B2M) (PubMed:18339401, PubMed:30087334). Similarly to MHC class Ia assembly, HLA-E-B2M heterodimer interacts with components of the antigen processing machinery TAPBP and TAP1-TAP2 complex; this interaction is required for peptide loading and translocation to the cell surface (PubMed:9427624). Interacts with CALCR; this interaction is required for appropriate folding (PubMed:9427624). The optimum binding peptide is a nonamer (VL9) that is primarily derived from amino-acid residues 3-11 of the signal sequences of most HLA-A, -B, -C and -G molecules (PubMed:9754572, PubMed:18083576, PubMed:9660937, PubMed:18339401). The VL9 peptide anchors to five main sites in the peptide-binding groove of HLA-E (PubMed:18339401). Peptide-bound HLA-E-B2M complex interacts with KLRD1-KLRC1 receptor on NK cells (PubMed:9486650, PubMed:18083576). Binds with lower affinity to activating KLRD1-KLRC2 (PubMed:18083576, PubMed:23335510). The common subunit KLRC1 plays a prominent role in directly interacting with HLA-E (PubMed:18083576). Peptide-bound HLA-E-B2M interacts with the alpha-beta TCR on unconventional CD8+ T cells (PubMed:16474394). Peptide-free HLA-E interacts with HLA-F-B2M complex; this interaction may regulate the intracellular trafficking and the stability of peptide-free MHC class I OCs.TISSUE SPECIFICITY Expressed in secretory endometrial cells during pregnancy (at protein level). The expression in nonlymphoid tissues is restricted to endothelial cells from all types of vessels, including arteries, veins, capillaries, and lymphatics (at protein level). In lymphoid organs, it is mainly expressed in endothelial venules, B and T cells, monocytes, macrophages, NK cells and megakaryocytes (at protein level).DEVELOPMENTAL STAGE Expressed in extravillous trophoblast (at protein level).INDUCTION Proinflammatory cytokines including TNF, IL1B and IFNG up-regulate membrane bound HLA-E expression on endothelial and NK cells and induce the release of soluble HLA-E (sHLA-E) in the extracellular compartment.PTM N-glycosylated.PTM The soluble form (sHLA-E) can be partly produced by proteolytic cleavage at the cell surface (shedding) by a matrix metalloproteinase. Alternative splicing is also suggested as a mechanism for generation of sHLA-E, although it remains to be proved.POLYMORPHISM The following alleles are known: E*01:01 and E*01:03 (PubMed:3131426, PubMed:10064069, PubMed:16702430, PubMed:16570139, PubMed:28127896). The frequency of E*01:01 and E*01:03 alleles in the population is about equal suggesting balanced selection in diverse populations. Evolutionary studies suggest that E*01:03 is the original allele (PubMed:12445303). Two other alleles has been described E*01:02 and E*01:04 (PubMed:3260916, PubMed:1977695). Allele E*01:02 was found to be identical to HLA E*01:01 (PubMed:3260916, PubMed:22665232). The existence of allele E*01:04 is uncertain as it could not be confirmed in further studies (PubMed:1977695, PubMed:12445303). The sequence shown is that of E*01:03 (PubMed:10064069, PubMed:16702430, PubMed:16570139, PubMed:28127896).SIMILARITY Belongs to the MHC class I family.UniProtP1374722EQUAL358EQUALReactome Database ID Release 75983090Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983090ReactomeR-HSA-9830901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983090.1HLA-FHLA class I histocompatibility antigen, alpha chain F precursorHLAF_HUMANReactome DB_ID: 983093UniProt:P30511 HLA-FHLA-FHLA-5.4HLAFFUNCTION Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors (PubMed:28636952). Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production (PubMed:27455421). Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions (PubMed:24018270). May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses (PubMed:23851683). May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464).SUBUNIT Forms a heterotrimer with B2M and a self-peptide (PubMed:28636952). Binds a diverse number of peptides ranging from 7 to more than 30 amino acids (PubMed:28636952). Peptide-bound HLA-F-B2M interacts with LILRB1 and LILRB2 but not with KIR3DS1 or KIR3DL2; this interaction is direct (PubMed:28636952, PubMed:11169396). The OC form interacts with KIR3DS1, KIR2DS4 and KIR3DL2; this interaction is direct (PubMed:28636952, PubMed:27455421, PubMed:24018270). Interacts with TAP1-TAP2 complex and CALR; this interaction is required for appropriate folding and peptide loading (PubMed:10605026, PubMed:11169396). Interacts with the coat protein complex II and 14-3-3 proteins; these interactions likely control the anterograde ER-to-Golgi transport of HLA-F (PubMed:16709803). HLA-F-B2M complex interacts with the heavy chain of other MHC class I molecules including HLA-A and HLA-E; this interaction may regulate the intracellular trafficking and the stability of peptide-free MHC class I OCs (PubMed:20483783).TISSUE SPECIFICITY Expressed in resting B cells (at protein level). Expressed in secondary lymphoid organs rich in B and T cells such as the tonsils, spleen, and thymus (at protein level) (PubMed:10605026, PubMed:11169396). Expressed in the endothelial cells of the tonsils (PubMed:11169396). Expressed on activated lymphoid cells including B cells, NK cells, CD4+ T cells and memory T cells (at protein level) (PubMed:27455421, PubMed:20865824). Expressed in motor neurons of spinal cord (PubMed:26928464).DEVELOPMENTAL STAGE Expressed in fetal liver (at protein level) (PubMed:10605026). Expressed in placenta villous mesenchyme, cytotrophoblast, syncytiotrophoblast and invasive extravillous trophoblast (at protein level) (PubMed:28185362).INDUCTION Up-regulated in CD4+ T cells upon stimulation via TCR and upon HIV-1 infection.PTM N-glycosylated.SIMILARITY Belongs to the MHC class I family.UniProtP3051122EQUAL362EQUALReactome Database ID Release 75983093Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983093ReactomeR-HSA-9830931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983093.1HLA-GHLA class I histocompatibility antigen, alpha chain G precursorHLAG_HUMANReactome DB_ID: 983065UniProt:P17693 HLA-GHLA-GHLA-6.0HLAGSUBUNIT Forms a heterotrimer with B2M and a self-peptide (peptide-bound HLA-G-B2M) (PubMed:7584149, PubMed:8805247). HLA-G-B2M complex interacts with components of the antigen processing machinery TAPBP and TAP1-TAP2 complex; this interaction is required for loading of high affinity peptides and heterotrimer translocation to the cell surface (PubMed:7584149). Interacts with CALCR; this interaction is required for appropriate folding (PubMed:9640257). Interacts with COPB1; this interaction mediates the endoplasmic reticulum (ER) retrieval of HLA-G-B2M complexes that bind low affinity peptides (PubMed:11520457, PubMed:12582157). On the cell surface, peptide-bound HLA-G-B2M molecules (referred to as monomers) can form disulfide-linked homomultimers, homodimers and homotrimers (PubMed:12454284, PubMed:12874224, PubMed:16455647). Interacts with KIR2DL4; this interaction is direct (PubMed:10190900, PubMed:16366734). Interacts with LILRB1 and LILRB2 receptors; this interaction is direct (PubMed:16455647, PubMed:16366734, PubMed:17056715, PubMed:12853576). Interacts with CD160; this interactions is direct (PubMed:16809620). Interacts with CD8A homodimer; this interaction is direct and might down-regulate T cell receptor signaling (PubMed:12853576). Isoform 2: Forms a non-disulfide-linked homodimer and interacts with LILRB2 (PubMed:28348268).TISSUE SPECIFICITY Expressed in adult eye (PubMed:1570318). Expressed in immune cell subsets including monocytes, myeloid and plasmacytoid dendritic cells and regulatory T cells (Tr1)(at protein level) (PubMed:20448110). Secreted by follicular dendritic cell and follicular helper T cells (PubMed:24453251). Isoform 5: Detected in physiological fluids including amniotic fluid and serum (PubMed:11137219). Isoform 7: Expressed in placenta, amniotic membrane, skin cord blood and peripheral blood mononuclear cells (PubMed:11137219).DEVELOPMENTAL STAGE Expressed at the morula stage (at protein level) (PubMed:29262349). Expressed in extravillous trophoblast and cytotrophoblast (PubMed:26460007, PubMed:16210391, PubMed:7589701). Expressed in fetal eye and thymus (PubMed:2336406). Isoform 7: Expressed in fetal liver (PubMed:11137219).INDUCTION Up-regulated by immunosuppressive cytokine IL10 on dendritic cells and CD4+ T cells (PubMed:20448110). Up-regulated by progesterone in cytotrophoblasts (PubMed:16210391).PTM N-glycosylated.SIMILARITY Belongs to the MHC class I family.UniProtP1769325EQUAL338EQUALReactome Database ID Release 75983065Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983065ReactomeR-HSA-9830651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983065.1class I MHC B13Reactome DB_ID: 983066UniProt:P30461 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-13 are known: B*13:01 (B13.1), B*13:02 (B13.2), B*13:04 and B*13:08. The sequence shown is that of B*13:02.SIMILARITY Belongs to the MHC class I family.UniProtP3046125EQUAL362EQUALReactome Database ID Release 75983066Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983066ReactomeR-HSA-9830661Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983066.1class I MHC B14Reactome DB_ID: 983096UniProt:P30462 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-14 are known: B*14:01 (Bw-64; B-64), B*14:02 (Bw-65, B-65) and B*14:03. The sequence shown is that of B*14:01.SIMILARITY Belongs to the MHC class I family.UniProtP3046225EQUAL362EQUALReactome Database ID Release 75983096Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983096ReactomeR-HSA-9830961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983096.1class I MHC B15Reactome DB_ID: 983069UniProt:P30464 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-15 are known: B*15:01 (Bw-62; B-62), B*15:02 (Bw-75, B-75), B*15:03 (Bw-72; B-72; B-70) B*15:04, B*15:11, B*15:19 and B*15:66. The sequence shown is that of B*15:01.SIMILARITY Belongs to the MHC class I family.UniProtP3046425EQUAL362EQUALReactome Database ID Release 75983069Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983069ReactomeR-HSA-9830691Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983069.1class I MHC B18Reactome DB_ID: 983045UniProt:P30466 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-18 are known: B*18:01 B*18:02, B*18:03, B*18:07 (B*MF), B*18:10, B*18:11, B*18:12 and B*18:13. The sequence shown is that of B*18:01.SIMILARITY Belongs to the MHC class I family.UniProtP3046625EQUAL362EQUALReactome Database ID Release 75983045Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983045ReactomeR-HSA-9830451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983045.1class I MHC B27Reactome DB_ID: 983042UniProt:P03989 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-27 are known: B*27:01=B*27:05, B*27:02 (B27.2; B-27k; B27e), B*27:03 (B27d), B*27:04, B*27:06, B*27:07, B*27:08 (B7Qui) and B*27:09 (B27-ci). The sequence shown is that of B*27:01.SIMILARITY Belongs to the MHC class I family.UniProtP0398925EQUAL362EQUALReactome Database ID Release 75983042Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983042ReactomeR-HSA-9830421Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983042.1class I MHC B35Reactome DB_ID: 983104UniProt:P30685 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-35 are known: B*35:01, B*35:02, B*35:03, B*35:04, B*35:05 (B35-G), B*35:06 (B35-K), B*35:07, B*35:08, B*35:25, B*35:28, B*35:29 (B*KG), B*35:30, B*35:32 (B*TMUL) and B*35:36. The sequence shown is that of B*35:01.SIMILARITY Belongs to the MHC class I family.UniProtP3068525EQUAL362EQUALReactome Database ID Release 75983104Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983104ReactomeR-HSA-9831041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983104.1class I MHC B37Reactome DB_ID: 983052UniProt:P18463 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-37 are known: B*37:01, B*37:04 and B*37:05. The sequence shown is that of B*37:01.SIMILARITY Belongs to the MHC class I family.UniProtP1846325EQUAL362EQUALReactome Database ID Release 75983052Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983052ReactomeR-HSA-9830521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983052.1class I MHC B38Reactome DB_ID: 983057UniProt:Q95365 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-38 are known: B*38:01, B*38:02, B*38:03, B*38:04, B*38:05, B*38:06, B*38:07 and B*38:08. The sequence shown is that of B*38:01.SIMILARITY Belongs to the MHC class I family.UniProtQ9536525EQUAL362EQUALReactome Database ID Release 75983057Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983057ReactomeR-HSA-9830571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983057.1class I MHC B39Reactome DB_ID: 983072UniProt:P30475 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-39 are known: B*39:01 (B39.1), B*39:02 (B9.2), B*39:03, B*39:04 (B39N), B*39:05 (ST-16), B*39:06 (B39G), B*39:07 (B39uw3), B*39:09, B*39:10, B*39:12 (B3901v), B*39:23 (B39022v1) and B*39:24. The sequence shown is that of B*39:01.SIMILARITY Belongs to the MHC class I family.UniProtP3047525EQUAL362EQUALReactome Database ID Release 75983072Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983072ReactomeR-HSA-9830721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983072.1class I MHC B40Reactome DB_ID: 983077UniProt:Q04826 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-40 are known: B*40:01, B*40:02, B*40:03 (B40-G1), B*40:04 (B40-G2), B*40:05 (BN21), B*40:06, B*40:08, B*40:09, B*40:16 and B*40:27. The sequence shown is that of B*40:02.SIMILARITY Belongs to the MHC class I family.UniProtQ0482625EQUAL362EQUALReactome Database ID Release 75983077Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983077ReactomeR-HSA-9830771Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983077.1class I MHC B41Reactome DB_ID: 983080UniProt:P30479 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-41 are known: B*41:01, B*41:02 (B41.2), B*41:03, B*41:04 and B*41:05. The sequence shown is that of B*41:01.SIMILARITY Belongs to the MHC class I family.UniProtP3047925EQUAL362EQUALReactome Database ID Release 75983080Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983080ReactomeR-HSA-9830801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983080.1class I MHC B42Reactome DB_ID: 983087UniProt:P30480 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-42 are known: B*42:01 (Bw-42) and B*42:02. The sequence shown is that of B*42:01.SIMILARITY Belongs to the MHC class I family.UniProtP3048025EQUAL362EQUALReactome Database ID Release 75983087Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983087ReactomeR-HSA-9830871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983087.1class I MHC B44Reactome DB_ID: 983061UniProt:P30481 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-44 are known: B*44:02 (B-12; B44.2), B*44:04, B*44:05, B*44:07, B*44:08 (B44BO), B*44:09, B*44:12 and B*44:13. The sequence shown is that of B*44:02.SIMILARITY Belongs to the MHC class I family.UniProtP3048125EQUAL362EQUALReactome Database ID Release 75983061Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983061ReactomeR-HSA-9830611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983061.1class I MHC B45Reactome DB_ID: 983094UniProt:P30483 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-45 are known: B*45:01 (B-12), B*45:03 and B*45:04. The sequence shown is that of B*45:01.SIMILARITY Belongs to the MHC class I family.UniProtP3048325EQUAL362EQUALReactome Database ID Release 75983094Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983094ReactomeR-HSA-9830941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983094.1class I MHC B46Reactome DB_ID: 983049UniProt:P30484 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-46 are known: B*46:01 and B*46:02. The sequence shown is that of B*46:01.SIMILARITY Belongs to the MHC class I family.UniProtP3048425EQUAL362EQUALReactome Database ID Release 75983049Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983049ReactomeR-HSA-9830491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983049.1class I MHC B47Reactome DB_ID: 983041UniProt:P30485 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-47 are known: B*47:01, B*47:02 and B*47:03. The sequence shown is that of B*47:01.SIMILARITY Belongs to the MHC class I family.UniProtP3048525EQUAL362EQUALReactome Database ID Release 75983041Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983041ReactomeR-HSA-9830411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983041.1class I MHC B49Reactome DB_ID: 983067UniProt:P30487 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-49 are known: B*49:01, B*49:02 and B*49:03 (B*RA). The sequence shown is that of B*49:01.SIMILARITY Belongs to the MHC class I family.UniProtP3048725EQUAL362EQUALReactome Database ID Release 75983067Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983067ReactomeR-HSA-9830671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983067.1class I MHC B50Reactome DB_ID: 983092UniProt:P30488 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-50 are known: B*50:01, B*50:02 (B*45ZJ; B50IM) and B*50:04. The sequence shown is that of B*50:01.SIMILARITY Belongs to the MHC class I family.UniProtP3048825EQUAL362EQUALReactome Database ID Release 75983092Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983092ReactomeR-HSA-9830921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983092.1class I MHC B51Reactome DB_ID: 983106UniProt:P18464 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-51 are known: B*51:01, B*51:03, B*51:04, B*51:08 and B*51:24. The sequence shown is that of B*51:01.MISCELLANEOUS There is evidence that HLA-B51 is associated with susceptibility to Behcet disease. However, it is not certain whether HLA-B51 itself or a closely linked gene is responsible for susceptibility. The world distribution of HLA-B51 in healthy people corresponds to the global distribution of Behcet disease; in Southern hemisphere countries (Africa, South Pacific, etc.) and in some parts of Europe, the prevalence of HLA-B51 in healthy people is low or null, corresponding to a low prevalence of Behcet disease. The wide variation that exists in the relative risk of HLA-B51 would support other nongenetic risk factors.SIMILARITY Belongs to the MHC class I family.UniProtP1846425EQUAL362EQUALReactome Database ID Release 75983106Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983106ReactomeR-HSA-9831061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983106.1class I MHC B52Reactome DB_ID: 983108UniProt:P30490 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-52 are known: B*52:01, B*52:02 (B*52012V) and B*52:03. The sequence shown is that of B*52:01.SIMILARITY Belongs to the MHC class I family.UniProtP3049025EQUAL362EQUALReactome Database ID Release 75983108Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983108ReactomeR-HSA-9831081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983108.1class I MHC B53Reactome DB_ID: 983071UniProt:P30491 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-53 are known: B*53:01, B*53:02, B*53:03, B*53:04, B*53:05, B*53:06 and B*53:07. The sequence shown is that of B*53:01.SIMILARITY Belongs to the MHC class I family.UniProtP3049125EQUAL362EQUALReactome Database ID Release 75983071Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983071ReactomeR-HSA-9830711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983071.1class I MHC B54Reactome DB_ID: 983046UniProt:P30492 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-54 are known: B*54:01 and B*54:02 (B5401V). The sequence shown is that of B*54:01.SIMILARITY Belongs to the MHC class I family.UniProtP3049225EQUAL362EQUALReactome Database ID Release 75983046Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983046ReactomeR-HSA-9830461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983046.1class I MHC B55Reactome DB_ID: 983110UniProt:P30493 HLA-BHLA-BHLABCDABP0067FUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-55 are known: B*55:01, B*55:02, B*55:04 (B55.2), B*55:05, B*55:08 (B*ER), B*55:09 and B*55:12. The sequence shown is that of B*55:01.SIMILARITY Belongs to the MHC class I family.UniProtP3049325EQUAL362EQUALReactome Database ID Release 75983110Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983110ReactomeR-HSA-9831101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983110.1class I MHC B56Reactome DB_ID: 983109UniProt:P30495 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-56 are known: B*56:01, B*56:02, B*56:03 (B22N), B*56:04, B*56:05 (B56V1), B*56:06 and B*56:07. The sequence shown is that of B*56:01.SIMILARITY Belongs to the MHC class I family.UniProtP3049525EQUAL362EQUALReactome Database ID Release 75983109Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983109ReactomeR-HSA-9831091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983109.1class I MHC B57Reactome DB_ID: 983105UniProt:P18465 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-57 are known: B*57:01, B*57:02 (Bw57.2), B*57:03 (B-57SAU) and B*57:05. The sequence shown is that of B*57:01.SIMILARITY Belongs to the MHC class I family.UniProtP1846525EQUAL362EQUALReactome Database ID Release 75983105Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983105ReactomeR-HSA-9831051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983105.1class I MHC B58Reactome DB_ID: 983079UniProt:P10319 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-58 are known: B*58:01, B*58:02, B*58:04 and B*58:05. The sequence shown is that of B*58:01. Allele B*58:01 is an important genetic risk factor for severe cutaneous adverse reactions to allopurinol in the Han Chinese population [MIM:608579].SIMILARITY Belongs to the MHC class I family.UniProtP1031925EQUAL362EQUALReactome Database ID Release 75983079Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983079ReactomeR-HSA-9830791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983079.1class I MHC B59Reactome DB_ID: 983101UniProt:Q29940 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).SIMILARITY Belongs to the MHC class I family.UniProtQ2994025EQUAL362EQUALReactome Database ID Release 75983101Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983101ReactomeR-HSA-9831011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983101.1class I MHC B67Reactome DB_ID: 983038UniProt:Q29836 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-67 are known: B*67:01 (B-67LAV) and B*67:02. The sequence shown is that of B*67:01.SIMILARITY Belongs to the MHC class I family.UniProtQ2983625EQUAL362EQUALReactome Database ID Release 75983038Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983038ReactomeR-HSA-9830381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983038.1class I MHC B7Reactome DB_ID: 983073UniProt:P01889 HLA-BHLA-BHLABFUNCTION Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:25808313, PubMed:29531227, PubMed:9620674, PubMed:23209413). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7743181, PubMed:18991276). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:29531227, PubMed:9620674, PubMed:24600035). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227).FUNCTION Allele B*07:02: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and mainly a Leu anchor residue at the C-terminus (PubMed:7743181). Presents a long peptide (APRGPHGGAASGL) derived from the cancer-testis antigen CTAG1A/NY-ESO-1, eliciting a polyclonal CD8-positive T cell response against tumor cells (PubMed:29531227). Presents viral epitopes derived from HIV-1 gag-pol (TPQDLNTML) and Nef (RPQVPLRPM) (PubMed:25808313). Displays self-peptides including a peptide derived from the signal sequence of HLA-DPB1 (APRTVALTA) (PubMed:7743181).FUNCTION Allele B*08:01: Presents to CD8-positive T cells viral epitopes derived from EBV/HHV-4 EBNA3 (QAKWRLQTL), eliciting cytotoxic T cell response.FUNCTION Allele B*13:02: Presents multiple HIV-1 epitopes derived from gag (RQANFLGKI, GQMREPRGSDI), nef (RQDILDLWI), gag-pol (RQYDQILIE, GQGQWTYQI) and rev (LQLPPLERL), all having in common a Gln residue at position 2 and mainly hydrophobic amino acids Leu, Ile or Val at the C-terminus. Associated with succesful control of HIV-1 infection.FUNCTION Allele B*18:01: Preferentially presents octomeric and nonameric peptides sharing a common motif, namely a Glu at position 2 and Phe or Tyr anchor residues at the C-terminus (PubMed:14978097, PubMed:23749632, PubMed:18991276). Presents an EBV/HHV-4 epitope derived from BZLF1 (SELEIKRY) (PubMed:23749632). May present to CD8-positive T cells an antigenic peptide derived from MAGEA3 (MEVDPIGHLY), triggering an anti-tumor immune response (PubMed:12366779). May display a broad repertoire of self-peptides with a preference for peptides derived from RNA-binding proteins (PubMed:14978097).FUNCTION Allele B*27:05: Presents to CD8-positive T cells immunodominant viral epitopes derived from HCV POLG (ARMILMTHF), HIV-1 gag (KRWIILGLNK), IAV NP (SRYWAIRTR), EBV/HHV-4 EBNA4 (HRCQAIRKK) and EBV/HHV-4 EBNA6 (RRIYDLIEL), confering longterm protection against viral infection (PubMed:19139562, PubMed:18385228, PubMed:15113903, PubMed:9620674). Can present self-peptides derived from cytosolic and nuclear proteins. All peptides carry an Arg at position 2 (PubMed:1922338). The peptide-bound form interacts with NK cell inhibitory receptor KIR3DL1 and inhibits NK cell activation in a peptide-specific way, being particularly sensitive to the nature of the amino acid side chain at position 8 of the antigenic peptide (PubMed:8879234, PubMed:15657948). KIR3DL1 fails to recognize HLA-B*27:05 in complex with B2M and EBV/HHV-4 EBNA6 (RRIYDLIEL) peptide, which can lead to increased activation of NK cells during infection (PubMed:15657948). May present an altered repertoire of peptides in the absence of TAP1-TAP2 and TAPBPL (PubMed:9620674).FUNCTION Allele B*40:01: Presents an immunodominant viral epitope derived from EBV/HHV-4 LMP2 (IEDPPFNSL), triggering memory CD8-positive T cell response (PubMed:18991276). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and a Leu anchor residue at the C-terminus (PubMed:18991276).FUNCTION Allele B*41:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.FUNCTION Allele B*44:02: Presents immunodominant viral epitopes derived from EBV/HHV-4 EBNA4 (VEITPYKPTW) and EBNA6 (AEGGVGWRHW, EENLLDFVRF), triggering memory CD8-positive T cell response (PubMed:9620674, PubMed:18991276). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Phe, Tyr or Trp anchor residues at the C-terminus (PubMed:18991276).FUNCTION Allele B*45:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.FUNCTION Allele B*46:01: Preferentially presents nonameric peptides sharing a signature motif, namely Ala and Leu at position 2 and Tyr, Phe, Leu, or Met anchor residues at the C-terminus. The peptide-bound form interacts with KIR2DL3 and inhibits NK cell cytotoxic response in a peptide-specific way.FUNCTION Allele B*47:01: Displays self-peptides sharing a signature motif, namely an Asp at position 2 and Leu or Met anchor residues at the C-terminus.FUNCTION Allele B*49:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ile or Val anchor residues at the C-terminus.FUNCTION Allele B*50:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.FUNCTION Allele B*51:01: Presents an octomeric HIV-1 epitope derived from gag-pol (TAFTIPSI) to the public TRAV17/TRBV7-3 TCR clonotype, strongly suppressing HIV-1 replication.FUNCTION Allele B*54:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.FUNCTION Allele B*55:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.FUNCTION Allele B*56:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.FUNCTION Allele B*57:01: The peptide-bound form recognizes KIR3DL1 and inhibits NK cell cytotoxic response.FUNCTION Allele B*67:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Leu anchor residue at the C-terminus.SUBUNIT Heterotrimer that consists of an alpha chain HLA-B, a beta chain B2M and a peptide (peptide-HLA-B-B2M) (PubMed:25808313, PubMed:29531227, PubMed:15657948, PubMed:17057332, PubMed:22020283, PubMed:24600035). Early in biogenesis, HLA-B-B2M dimer interacts with the components of the peptide-loading complex composed of TAPBP, TAP1-TAP2, TAPBPL, PDIA3/ERP57 and CALR (PubMed:9036970, PubMed:9620674, PubMed:26439010, PubMed:26416272). Interacts with TAP1-TAP2 transporter via TAPBP; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:9036970, PubMed:9620674). Interacts with TAPBPL; TAPBPL binds peptide-free HLA-B-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange for higher affinity peptides (PubMed:26439010). Only optimally assembled peptide-HLA-B-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells. HLA-B (via polymorphic alpha-1 and alpha-2 domains) interacts with antigen-specific TCR (via CDR1, CDR2 and CDR3 domains) (PubMed:29531227, PubMed:24600035). One HLA-B molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop); this interaction insures peptide-HLA-B-B2M recognition by CD8-positive T cells only (PubMed:29531227). Allele B*57:01 interacts (via Bw4 motif) with KIR3DL1 (via Ig-like C2-type domain); this interaction may interfere with peptide binding (PubMed:22020283, PubMed:25480565). Allele B*46:01 interacts with KIR2DL3 (PubMed:28514659).SUBUNIT (Microbial infection) Interacts with HTLV-1 accessory protein p12I.DOMAIN The alpha-1 domain is a structural part of the peptide-binding cleft (PubMed:25808313). Residues 101-107 determine Bw4/Bw6 motifs, which serologically distinguish HLA-B alleles. Each HLA-B allele posseses either the Bw4 or Bw6 motif. Only HLA-B alleles bearing the Bw4 epitope are recognized by NK cell inhibitory receptor KIR3DL1 (PubMed:25480565, PubMed:22020283).DOMAIN The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:25808313). Mediates the interaction with TAP1-TAP2 complex (By similarity).DOMAIN The alpha-3 Ig-like domain mediates the interaction with CD8 coreceptor.POLYMORPHISM The most polymorphic of the mammalian genome. Polymorphic residues encode for alpha-1 and alpha-2 domains of the peptide-binding cleft, where they contribute to variations in peptide binding and TCR recognition among different alleles. The human population is estimated to have millions of HLA-B alleles. But only 17 common HLA-A alleles are considered core alleles, representing all functionally significant variation (polymorphism) in alpha-1 and alpha-2 domains. These are: B*07:02; B*08:01; B*13:02; B*15:01; B*18:01; B*27:05; B*35:01; B*37:01; B*38:01; B*40:01; B*44:02; B*45:01; B*51:01; B*54:01; B*57:01 and B*73:01. Among these, B*07:02; B*15:01; B*18:01; B*37:01; B*51:01; B*54:01; B*57:01 and B*73:01, were likely passed by introgression from archaic to modern humans. Functional alleles of more recent origin (non-core) were derived by recombination (PubMed:28650991). The sequence shown is that of B*07:02. The sequences of core alleles and common representative alleles of serologically distinct allele groups are described as variants of B*07:02.DISEASE There is evidence that HLA-B*51 is associated with susceptibility to Behcet disease (BD). However, it is not certain whether HLA-B*51 itself or a closely linked gene is responsible for susceptibility. The world distribution of HLA-B*51 in healthy people corresponds to the global distribution of BD; in Southern hemisphere countries (Africa, South Pacific, etc.) and in some parts of Europe, the prevalence of HLA-B*51 in healthy people is low or null, corresponding to a low prevalence of BD. The wide variation that exists in the relative risk of HLA-B*51 would support other nongenetic risk factors.DISEASE The presence of allele B*57:01 is associated with increased susceptibility to abacavir hypersensitivity [MIM:142830] in HIV-1 patients.DISEASE Allele group B*08 is associated with increased susceptibility to rheumatoid arthritis, where affected individuals have antibodies to cyclic citrullinated peptide (anti-CCP-positive rheumatoid arthritis).UniProtP0188925EQUAL362EQUALReactome Database ID Release 75983073Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983073ReactomeR-HSA-9830731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983073.1class I MHC B73Reactome DB_ID: 983062UniProt:Q31612 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).SIMILARITY Belongs to the MHC class I family.UniProtQ3161225EQUAL363EQUALReactome Database ID Release 75983062Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983062ReactomeR-HSA-9830621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983062.1class I MHC B78Reactome DB_ID: 983047UniProt:P30498 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-78 are known: B*78:01 (B SNA), B*78:02 and B*78:03. The sequence shown is that of B*78:01.SIMILARITY Belongs to the MHC class I family.UniProtP3049825EQUAL362EQUALReactome Database ID Release 75983047Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983047ReactomeR-HSA-9830471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983047.1class I MHC B8Reactome DB_ID: 983107UniProt:P30460 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-8 are known: B*08:01, B*08:04, B*08:06, B*08:07 (B*NV), B*08:09 (B*HM; B*08HO), B*08:10, B*08:12, B*08:13 and B*08:14. The sequence shown is B*08:01.SIMILARITY Belongs to the MHC class I family.UniProtP3046025EQUAL362EQUALReactome Database ID Release 75983107Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983107ReactomeR-HSA-9831071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983107.1class I MHC B81Reactome DB_ID: 983053UniProt:Q31610 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).SIMILARITY Belongs to the MHC class I family.UniProtQ3161025EQUAL362EQUALReactome Database ID Release 75983053Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983053ReactomeR-HSA-9830531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983053.1class I MHC B82Reactome DB_ID: 983048UniProt:Q29718 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-82 are known: B*82:01 and B*82:02. The sequence shown is that of B*82:01.SIMILARITY Belongs to the MHC class I family.UniProtQ2971825EQUAL362EQUALReactome Database ID Release 75983048Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983048ReactomeR-HSA-9830481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983048.1HLA-CHLA class I histocompatibility antigen, Cw-1 alpha chain1C01_HUMANReactome DB_ID: 2220884UniProt:P30499 HLA-CHLA-CHLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of Cw-1 are known: Cw*01:01 (Cw1.1), Cw*01:02 (Cw1.2), Cw*01:03 and Cw*01:04. The sequence shown is that of Cw*01:01.SIMILARITY Belongs to the MHC class I family.UniProtP3049925EQUAL366EQUALReactome Database ID Release 752220884Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220884ReactomeR-HSA-22208841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220884.1HLA-CHLA class I histocompatibility antigen, Cw-12 alpha chain1C12_HUMANReactome DB_ID: 2220885UniProt:P30508 HLA-CHLA-CHLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of Cw-12 are known: Cw*12:02, Cw*12:03, Cw*12:04, Cw*12:05, Cw*12:06, Cw*12:07, Cw*12:08 and Cw*12:09. The sequence shown is that of Cw*12:02.SIMILARITY Belongs to the MHC class I family.UniProtP3050825EQUAL366EQUALReactome Database ID Release 752220885Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220885ReactomeR-HSA-22208851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220885.1HLA-CHLA class I histocompatibility antigen, Cw-14 alpha chain1C14_HUMANReactome DB_ID: 2220883UniProt:P30510 HLA-CHLA-CHLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of Cw-14 are known: Cw*14:02 (CB-1), Cw*14:03 (CX44) and Cw*14:04. The sequence shown is that of Cw*14:02.SIMILARITY Belongs to the MHC class I family.UniProtP3051025EQUAL366EQUALReactome Database ID Release 752220883Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220883ReactomeR-HSA-22208831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220883.1HLA-CHLA class I histocompatibility antigen, Cw-15 alpha chain1C15_HUMANReactome DB_ID: 2220879UniProt:Q07000 HLA-CHLA-CHLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of Cw-15 are known: Cw*15:02, Cw*15:03, Cw*15:04, Cw*15:05, Cw*15:10 and Cw*15:11. The sequence shown is that of Cw*15:02.SIMILARITY Belongs to the MHC class I family.UniProtQ0700025EQUAL366EQUALReactome Database ID Release 752220879Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220879ReactomeR-HSA-22208791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220879.1HLA-CHLA class I histocompatibility antigen, Cw-16 alpha chain1C16_HUMANReactome DB_ID: 2220882UniProt:Q29960 HLA-CHLA-CHLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of Cw-16 are known: Cw*16:01, Cw*16:02 (CW*CL10V) and Cw*16:04. The sequence shown is that of Cw*16:01.SIMILARITY Belongs to the MHC class I family.UniProtQ2996025EQUAL366EQUALReactome Database ID Release 752220882Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220882ReactomeR-HSA-22208821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220882.1HLA-CHLA class I histocompatibility antigen, Cw-17 alpha chain1C17_HUMANReactome DB_ID: 2220876UniProt:Q95604 HLA-CHLA-CD6S204HLA-JY3HLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM Cw*17 appears at low frequencies in Caucasoid and Mongoloid populations (gene frequency 0.41 % in English Caucasoids, 0% in Japanese), but seems to be a common specificity in populations of African origin (PubMed:9098935). The following alleles of Cw-17 are known: Cw*17:01, Cw*17:02 and Cw*17:03. The sequence shown is that of Cw*17:01.SIMILARITY Belongs to the MHC class I family.UniProtQ9560425EQUAL372EQUALReactome Database ID Release 752220876Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220876ReactomeR-HSA-22208761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220876.1HLA-CHLA class I histocompatibility antigen, Cw-18 alpha chain1C18_HUMANReactome DB_ID: 2220878UniProt:Q29865 HLA-CHLA-CHLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of Cw-18 are known: Cw*18:01 (Cw*04GB) and Cw*18:02 (Cw*18GB). The sequence shown is that of Cw*18:01.SIMILARITY Belongs to the MHC class I family.UniProtQ2986525EQUAL366EQUALReactome Database ID Release 752220878Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220878ReactomeR-HSA-22208781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220878.1HLA-CHLA class I histocompatibility antigen, Cw-2 alpha chain1C02_HUMANReactome DB_ID: 2220877UniProt:P30501 HLA-CHLA-CHLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of Cw-2 are known: Cw*02:01 (Cw2.1) and Cw*02:02 (Cw2.2). The sequence shown is that of Cw*02:01.SIMILARITY Belongs to the MHC class I family.UniProtP3050125EQUAL366EQUALReactome Database ID Release 752220877Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220877ReactomeR-HSA-22208771Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220877.1HLA-CHLA class I histocompatibility antigen, Cw-8 alpha chain1C08_HUMANReactome DB_ID: 2220881UniProt:P30505 HLA-CHLA-CHLACFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of Cw-8 are known: Cw*08:01 (Cw8.1), Cw*08:02 (Cw8.2) and Cw*08:03. The sequence shown is that of Cw*08:01.SIMILARITY Belongs to the MHC class I family.UniProtP3050525EQUAL366EQUALReactome Database ID Release 752220881Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220881ReactomeR-HSA-22208811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220881.1HLA-AHLA class I histocompatibility antigen, A-11 alpha chain1A11_HUMANReactome DB_ID: 3318217UniProt:P13746 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-11 are known: A*11:01 (A-11E), A*11:02 (A-11K), A*11:03, A*11:04, A*11:05 and A*11:07. The sequence shown is that of A*11:01.SIMILARITY Belongs to the MHC class I family.UniProtP1374625EQUAL365EQUALReactome Database ID Release 753318217Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318217ReactomeR-HSA-33182171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318217.1HLA-AHLA class I histocompatibility antigen, A-23 alpha chain1A23_HUMANReactome DB_ID: 3318224UniProt:P30447 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-23 are known: A*23:01, A*23:02, A*23:03, A*23:04 and A*23:05. The sequence shown is that of A*23:01.SIMILARITY Belongs to the MHC class I family.UniProtP3044725EQUAL365EQUALReactome Database ID Release 753318224Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318224ReactomeR-HSA-33182241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318224.1HLA-AHLA class I histocompatibility antigen, A-24 alpha chain1A24_HUMANReactome DB_ID: 3318221UniProt:P05534 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-24 are known: A*24:01, A*24:02, A*24:03, A*24:06, A*24:08 (A9HH), A*24:10 (A*24JV), A*24:13 (A*24YM), A*24:14 (A*24SA) and A*24:29. Allele A*24:02 is represented in all major racial groups. Allele A*24:06 and allele A*24:13 are found in the Australian Aboriginal population. Allele A*24:14 is found in individuals of South American descent. The sequence shown is that of A*24:02.SIMILARITY Belongs to the MHC class I family.UniProtP0553425EQUAL365EQUALReactome Database ID Release 753318221Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318221ReactomeR-HSA-33182211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318221.1HLA-AHLA class I histocompatibility antigen, A-25 alpha chain1A25_HUMANReactome DB_ID: 3318215UniProt:P18462 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-25 are known: A*25:01 A*25:02 and A*25:03. The sequence shown is that of A*25:01.SIMILARITY Belongs to the MHC class I family.UniProtP1846225EQUAL365EQUALReactome Database ID Release 753318215Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318215ReactomeR-HSA-33182151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318215.1HLA-AHLA class I histocompatibility antigen, A-26 alpha chain1A26_HUMANReactome DB_ID: 3318210UniProt:P30450 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-26 are known: A*26:01, A*26:02, A*26:03, A*26:04 (A-10SA), A*26:05, A*26:07, A*26:08, A*26:12 and A*26:15. The sequence shown is that of A*26:01.SIMILARITY Belongs to the MHC class I family.UniProtP3045025EQUAL365EQUALReactome Database ID Release 753318210Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318210ReactomeR-HSA-33182101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318210.1HLA-AHLA class I histocompatibility antigen, A-29 alpha chain1A29_HUMANReactome DB_ID: 3318211UniProt:P30512 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-29 are known: A*29:01 (A29.1), A*29:02 (A29.2), A*29:03 and A*29:04. The sequence shown is that of A*29:01.SIMILARITY Belongs to the MHC class I family.UniProtP3051225EQUAL365EQUALReactome Database ID Release 753318211Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318211ReactomeR-HSA-33182111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318211.1HLA-AHLA class I histocompatibility antigen, A-30 alpha chain1A30_HUMANReactome DB_ID: 3318223UniProt:P16188 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-30 are known: A*30:01 (A30.3), A*30:02, A*30:03, A*30:04 (A30W7), A*30:06, A*30:07 and A*30:08. The sequence shown is that of A*30:01.SIMILARITY Belongs to the MHC class I family.UniProtP1618825EQUAL365EQUALReactome Database ID Release 753318223Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318223ReactomeR-HSA-33182231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318223.1HLA-AHLA class I histocompatibility antigen, A-31 alpha chain1A31_HUMANReactome DB_ID: 3318209UniProt:P16189 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-31 are known: A*31:01, A*31:02, A*31:03, A*31:04, A*31:05 (A3101v1) and A*31:06. The sequence shown is that of A*31:01. Allele A*31:01 is associated with carbamazepine-induced hypersensitivity reactions among subjects of Northern European ancestry [MIM:608579].SIMILARITY Belongs to the MHC class I family.UniProtP1618925EQUAL365EQUALReactome Database ID Release 753318209Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318209ReactomeR-HSA-33182091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318209.1HLA-AHLA class I histocompatibility antigen, A-32 alpha chain1A32_HUMANReactome DB_ID: 3318222UniProt:P10314 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-32 are known: A*32:01, A*32:02, A*32:03, A*32:04, A*32:05 and A*32:06. The sequence shown is that of A*32:01.SIMILARITY Belongs to the MHC class I family.UniProtP1031425EQUAL365EQUALReactome Database ID Release 753318222Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318222ReactomeR-HSA-33182221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318222.1HLA-AHLA class I histocompatibility antigen, A-33 alpha chain1A33_HUMANReactome DB_ID: 3318208UniProt:P16190 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-33 are known: A*33:01 (Aw-33.1), A*33:02 and A*33:03. The sequence shown is that of A*33:01.SIMILARITY Belongs to the MHC class I family.UniProtP1619025EQUAL365EQUALReactome Database ID Release 753318208Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318208ReactomeR-HSA-33182081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318208.1HLA-AHLA class I histocompatibility antigen, A-34 alpha chain1A34_HUMANReactome DB_ID: 3318207UniProt:P30453 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-34 are known: A*34:01 (Aw-34.1) and A*34:02 (Aw-34.2). The sequence shown is that of A*34:01.SIMILARITY Belongs to the MHC class I family.UniProtP3045325EQUAL365EQUALReactome Database ID Release 753318207Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318207ReactomeR-HSA-33182071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318207.1HLA-AHLA class I histocompatibility antigen, A-36 alpha chain1A36_HUMANReactome DB_ID: 3318218UniProt:P30455 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-36 are known: A*36:01 and A*36:02. The sequence shown is that of A*36:01.SIMILARITY Belongs to the MHC class I family.UniProtP3045525EQUAL365EQUALReactome Database ID Release 753318218Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318218ReactomeR-HSA-33182181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318218.1HLA-AHLA class I histocompatibility antigen, A-43 alpha chain1A43_HUMANReactome DB_ID: 3318220UniProt:P30456 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The only allele of A-43 known is A*43:01 which is shown here.SIMILARITY Belongs to the MHC class I family.UniProtP3045625EQUAL365EQUALReactome Database ID Release 753318220Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318220ReactomeR-HSA-33182201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318220.1HLA-AHLA class I histocompatibility antigen, A-66 alpha chain1A66_HUMANReactome DB_ID: 3318206UniProt:P30457 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-66 are known: A*66:01 and A*66:02 (Aw67). The sequence shown is that of A*66:01.SIMILARITY Belongs to the MHC class I family.UniProtP3045725EQUAL365EQUALReactome Database ID Release 753318206Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318206ReactomeR-HSA-33182061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318206.1HLA-AHLA class I histocompatibility antigen, A-68 alpha chain1A68_HUMANReactome DB_ID: 3318212UniProt:P01891 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-68 are known: A*68:01 (Aw68.1), A*68:02, A*68:03. A*68:04, A*68:05, A*68:06, A*68:07, A*68:08, A*68:09, A*68:10, A*68:16 and A*68:17. The sequence shown is that of A*68:01.SIMILARITY Belongs to the MHC class I family.UniProtP0189125EQUAL365EQUALReactome Database ID Release 753318212Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318212ReactomeR-HSA-33182121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318212.1HLA-AHLA class I histocompatibility antigen, A-69 alpha chain1A69_HUMANReactome DB_ID: 3318219UniProt:P10316 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The only allele of A-69 known is A*69:01 which is shown here.SIMILARITY Belongs to the MHC class I family.UniProtP103161EQUAL365EQUALReactome Database ID Release 753318219Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318219ReactomeR-HSA-33182191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318219.1HLA-AHLA class I histocompatibility antigen, A-74 alpha chain1A74_HUMANReactome DB_ID: 3318216UniProt:P30459 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of A-74 are known: A*74:01 A*74:02, A*74:03, A*74:04 and A*74:05. The sequence shown is that of A*74:01.SIMILARITY Belongs to the MHC class I family.UniProtP3045925EQUAL365EQUALReactome Database ID Release 753318216Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318216ReactomeR-HSA-33182161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318216.1HLA-AHLA class I histocompatibility antigen, A-80 alpha chain1A80_HUMANReactome DB_ID: 3318214UniProt:Q09160 HLA-AHLA-AHLAAFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The only allele of A-80 known is A*80:01 which is shown here.SIMILARITY Belongs to the MHC class I family.UniProtQ0916025EQUAL365EQUALReactome Database ID Release 753318214Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318214ReactomeR-HSA-33182141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318214.1HLA-BHLA class I histocompatibility antigen, B-48 alpha chain1B48_HUMANReactome DB_ID: 8855905UniProt:P30486 HLA-BHLA-BHLABFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Dimer of alpha chain and a beta chain (beta-2-microglobulin).PTM Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).POLYMORPHISM The following alleles of B-48 are known: B*48:01 and B*48:03. The sequence shown is that of B*48:01.SIMILARITY Belongs to the MHC class I family.UniProtP3048625EQUAL362EQUALReactome Database ID Release 758855905Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8855905ReactomeR-HSA-88559051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8855905.1HLA-HPutative HLA class I histocompatibility antigen, alpha chain HHLAH_HUMANReactome DB_ID: 8855907UniProt:P01893 HLA-HHLA-HHLAHFUNCTION Involved in the presentation of foreign antigens to the immune system.SUBUNIT Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).SIMILARITY Belongs to the MHC class I family.CAUTION Could be the product of a pseudogene.UniProtP0189325EQUAL362EQUALReactome Database ID Release 758855907Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8855907ReactomeR-HSA-88559071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8855907.1Reactome Database ID Release 75983117Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983117ReactomeR-HSA-9831172Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983117.21(Glc)1 (GlcNAc)2 (Man)9N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residueReactome DB_ID: 532679endoplasmic reticulum lumenGENE ONTOLOGYGO:0005788N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue [ChEBI:59080]N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residueChEBICHEBI:59080Reactome Database ID Release 75532679Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=532679ReactomeR-ALL-5326793Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-532679.31Reactome Database ID Release 75983120Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983120ReactomeR-HSA-9831201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983120.1monoglucosylated MHC class I HC:Calnexin/BiPReactome DB_ID: 98311611Reactome Database ID Release 75983116Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983116ReactomeR-HSA-9831161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983116.1Reactome Database ID Release 75983145Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983145ReactomeR-HSA-9831451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983145.111470776Pubmed2001Distinct differences in association of MHC class I with endoplasmic reticulum proteins in wild-type, and beta 2-microglobulin- and TAP-deficient cell linesPaulsson, KMWang, PAnderson, POChen, SPettersson, RFLi, SInt Immunol 13:1063-7312495737Pubmed2003Assembly and export of MHC class I peptide ligandsAntoniou, ANPowis, SJElliott, TCurr Opin Immunol 15:75-8110777614Pubmed2000Functional relationship between calreticulin, calnexin, and the endoplasmic reticulum luminal domain of calnexinDanilczyk, UGCohen-Doyle, MFWilliams, DBJ Biol Chem 275:13089-9711514579Pubmed2001Relationship between calnexin and BiP in suppressing aggregation and promoting refolding of protein and glycoprotein substratesStronge, VSSaito, YIhara, YWilliams, DBJ Biol Chem 276:39779-877642652Pubmed1995Calnexin influences folding of human class I histocompatibility proteins but not their assembly with beta 2-microglobulinTector, MSalter, RDJ Biol Chem 270:19638-4211160214Pubmed2001A role for calnexin in the assembly of the MHC class I loading complex in the endoplasmic reticulumDiedrich, GBangia, NPan, MCresswell, PJ Immunol 166:1703-97876241Pubmed1995The molecular chaperone calnexin binds Glc1Man9GlcNAc2 oligosaccharide as an initial step in recognizing unfolded glycoproteinsWare, FEVassilakos, APeterson, PAJackson, MRLehrman, MAWilliams, DBJ Biol Chem 270:4697-7049605141Pubmed1998Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class IHarris, MRYu, YYKindle, CSHansen, THSolheim, JCJ Immunol 160:5404-9LEFT-TO-RIGHTInteraction of Erp57 with MHC class I HCEndoplasmic reticulum resident protein 57 (ERp57), is a member of the protein disulphide isomerase (PDI) family of thiol oxidoreducatases. It associates with Calnexin (CNX), and its soluble homolog calreticulin (CRT) and is recruited to MHC Class I Heavy Chain (HC). ERp57 is involved in the formation of HC disulphide bonds.Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29PDIA3ERp57Protein disulfide-isomerase A3PDIA3_HUMANReactome DB_ID: 901028UniProt:P30101 PDIA3PDIA3ERP57ERP60GRP58SUBUNIT Subunit of the TAP complex, also known as the peptide loading complex (PLC). Can form disulfide-linked heterodimers with TAPBP. Interacts with ERP27 and CANX. Interacts with SERPINA2 and with the S and Z variants of SERPINA1. Interacts with ATP2A2 (By similarity).TISSUE SPECIFICITY Detected in the flagellum and head region of spermatozoa (at protein level).SIMILARITY Belongs to the protein disulfide isomerase family.CAUTION Was originally thought to be a phosphatidylinositol 4,5-bisphosphate phosphodiesterase type I (phospholipase C-alpha).UniProtP3010125EQUAL505EQUALReactome Database ID Release 75901028Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=901028ReactomeR-HSA-9010281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-901028.1MHC class I HC:Calnexin/BiP:Erp57Reactome DB_ID: 98311911Reactome Database ID Release 75983119Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983119ReactomeR-HSA-9831191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983119.1Reactome Database ID Release 75983148Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983148ReactomeR-HSA-9831481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983148.1LEFT-TO-RIGHTInteraction of beta-2-microglobulin (B2M) chain with class I HCInteraction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX.Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29B2M(21-119)Beta-2-microglobulinReactome DB_ID: 983063UniProt:P61769 B2MB2MCDABP0092HDCMA22PFUNCTION Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).SUBUNIT Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M alone (not in complex with HLA-I) interacts with M.tuberculosis EsxA (ESAT-6) and an EsxA-EsxB (CFP-10) complex; the tripartite complex can be detected in the host endoplasmic reticulum (PubMed:25356553). The B2M-EsxA complex can be detected in patients with pleural tuberculosis and is stable from pH 4.0 to 8.0 and in the presence of 2M NaCl (PubMed:25356553). Forms a heterotrimer with HLA-E and a self- or a foreign peptide (PubMed:9427624). Forms a heterotrimer with HLA-G and a self-peptide (PubMed:17056715). Forms a heterotrimer with HLA-F and a self-peptide (PubMed:10605026). Forms a heterotrimer with MR1 and a metabolite antigen.SUBCELLULAR LOCATION (Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553).PTM Glycation of Ile-21 is observed in long-term hemodialysis patients.SIMILARITY Belongs to the beta-2-microglobulin family.UniProtP6176921EQUAL119EQUALReactome Database ID Release 75983063Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983063ReactomeR-HSA-9830631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983063.1MHC HC:B2M:Erp57Reactome DB_ID: 983136111Reactome Database ID Release 75983136Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983136ReactomeR-HSA-9831361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983136.1Reactome Database ID Release 75983146Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983146ReactomeR-HSA-9831461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983146.12450918Pubmed1988Specific associations of fluorescent beta-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for beta-2-microglobulinHochman, JHShimizu, YDeMars, REdidin, MJ Immunol 140:2322-910064069Pubmed1999Cell surface expression of HLA-E: interaction with human beta2-microglobulin and allelic differencesUlbrecht, MCouturier, AMartinozzi, SPla, MSrivastava, RPeterson, PAWeiss, EHEur J Immunol 29:537-4714681859Pubmed2003Beta-2 microglobulin in ESRD: an in-depth reviewWinchester, JFSalsberg, JALevin, NWAdv Ren Replace Ther 10:279-309LEFT-TO-RIGHTFormation of peptide loading complex (PLC)Upon interaction of Beta-2-microglobin (B2M) with MHC class I Heavy Chain (HC), calnexin is fully replaced by its soluble ortholog calreticulin (CRT) and this complex is incorporated into the peptide loading complex (PLC). PLC is a multiprotein complex that includes CRT, ERp57 and the additional components tapasin, transporter associated with antigen processing (TAP) and Bap31. The stoichometry of components in PLC remains unclear. The PLC loads antigenic peptides onto MHC class I molecules; components of the PLC cooperate to stabilize the MHC class I complex and optimally load peptides. Tapasin is a type I transmembrane protein that interacts directly with TAP and tethers the MHC complex to it. TAP facilitates the transport of peptides from the cytosol to the ER lumen. B cell receptor–associated protein (Bap31), a putative cargo receptor, associates with HC and acts as a retrograde transporter, carrying peptide-loaded class I MHC molecules.Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29TAPBPTapasinTPSN_HUMANReactome DB_ID: 983083UniProt:O15533 TAPBPTAPBPNGS17TAPAFUNCTION Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).SUBUNIT Heterodimer with PDIA3; disulfide-linked. Interacts with TAP1 and is thus a subunit of the TAP complex, also known as the peptide-loading complex (PLC). Interaction with TAP1 is TAP2-independent and is required for efficient peptide-TAP interaction. Obligatory mediator for the interaction between newly assembled MHC class I molecules, calreticulin, PDIA3 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP (PubMed:19119025, PubMed:21263072). Interacts with HLA-G-B2M complex; this interaction is required for loading of high affinity peptides.TISSUE SPECIFICITY Neutrophils, mostly in fully differentiated cells.DOMAIN The N-terminus is required for efficient association with MHC class I molecule and for a stable interaction between MHC I and calreticulin. Binding to TAP is mediated by the C-terminal region.POLYMORPHISM The 2 alleles of TAPBP; TAPBP*01 (Tapasin*01) (shown here) and TAPBP*02 (Tapasin*02); are in linkage disequilibria with the HLA-DRB1 locus in a Japanese population.UniProtO1553321EQUAL448EQUALReactome Database ID Release 75983083Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983083ReactomeR-HSA-9830831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983083.1CALRcalreticulinReactome DB_ID: 985502UniProt:P27797 CALRCALRCRTCFUNCTION Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).SUBUNIT Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and SPACA9 (By similarity). Interacts with TRIM21 (PubMed:8666824). Interacts with NR3C1 (PubMed:11149926). Interacts with PPIB (PubMed:20801878). Interacts (via P-domain) with PDIA5 (PubMed:23614004). Interacts with GABARAP (PubMed:19154346). Interacts with HLA-E-B2M and HLA-G-B2M complexes (PubMed:9427624, PubMed:9640257). Interacts with HLA-F (PubMed:10605026). Interacts with CLCC1 (PubMed:30157172).DOMAIN Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.DOMAIN The interaction with glycans occurs through a binding site in the globular lectin domain.DOMAIN The zinc binding sites are localized to the N-domain.DOMAIN Associates with PDIA3 through the tip of the extended arm formed by the P-domain.DISEASE CARL somatic mutations are frequently found in myeloproliferative neoplasms lacking JAK2 or MPL mutations. Myeloproliferative neoplasms are chronic myeloid cancers characterized by overproduction of mature blood cells, and may evolve into acute myeloid leukemia. In addition to chronic myeloid leukemia with the BCR-ABL fusion gene, the three most common myeloproliferative neoplasms are essential thrombocythemia, polycythemia vera, and myelofibrosis.SIMILARITY Belongs to the calreticulin family.CAUTION Was originally thought to be the 52 kDa Ro autoantigen.UniProtP2779718EQUAL417EQUALReactome Database ID Release 75985502Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=985502ReactomeR-HSA-9855021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-985502.1TAPTransporter associated with antigen processing (TAP)TAP1:TAP2 heterodimerReactome DB_ID: 983113endoplasmic reticulum membraneGENE ONTOLOGYGO:0005789TAP2Antigen peptide transporter 2TAP2_HUMANReactome DB_ID: 947475UniProt:Q03519 TAP2TAP2ABCB3PSF2RING11Y1FUNCTION Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.SUBUNIT Heterodimer of TAP1 and TAP2. Interacts with HLA-A*02-B2M complex; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:8805302, PubMed:8630735). Similarly to classical MHC class I assembly, HLA-E-B2M complex binds TAP1-TAP2 heterodimer and CALR before the peptide loading (PubMed:9427624). Interacts with HLA-F (PubMed:10605026).SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus BLNF2a.SUBUNIT (Microbial infection) Interacts with herpes simplex virus ICP47.INDUCTION By IFNG/IFN-gamma.DOMAIN The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.POLYMORPHISM 4 common alleles are officially recognized: TAP2*01:01 (TAP2A or PSF2A or RING11A), TAP2*01:02 (TAP2E), TAP2*01:03 (TAP2F), and TAP2*02:01 (TAP2B or PSF2B or RING11B). Other relatively common alleles have been identified: TAP2*01D, TAP2*01E, TAP2*01F, TAP2*01G, TAP2*01H, TAP2*02B, TAP2*02C (TAP2*02:02), TAP2*02D, TAP2*02E, TAP2*02F, TAP2*03A and TAP2*04A. The sequence shown is that of TAP2*01:01.POLYMORPHISM The allele TAP2*Bky2 is commonly found only in the Japanese population. It may be associated with susceptibility to Sjoegren syndrome, an autoimmune disorder characterized by abnormal dryness of the conjunctiva, cornea and mouth due to exocrine glands dysfunction.SIMILARITY Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.UniProtQ035191EQUAL686EQUALReactome Database ID Release 75947475Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=947475ReactomeR-HSA-9474751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-947475.11TAP1Antigen peptide transporter 1TAP1_HUMANReactome DB_ID: 947474UniProt:Q03518 TAP1TAP1ABCB2PSF1RING4Y3FUNCTION Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.SUBUNIT Heterodimer of TAP1 and TAP2. Interacts with HLA-A*02-B2M complex; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:8805302, PubMed:8630735). Interacts with PSMB5 and PSMB8 (PubMed:15488952). Similarly to classical MHC class I assembly, HLA-E-B2M complex binds TAP1-TAP2 heterodimer and CALR before the peptide loading (PubMed:9427624). Interacts with HLA-F (PubMed:10605026). Interacts with PSMB5 and PSMB8 (PubMed:15488952).SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus BNLF2a.SUBUNIT (Microbial infection) Interacts with herpes simplex virus ICP47.INDUCTION By IFNG/IFN-gamma.DOMAIN The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.POLYMORPHISM There are five common alleles; TAP1*01:01 (PSF1A), TAP1*02:01 (PSF1B), TAP1*03:01 (PSF1C), TAP1*01:04 and TAP1*x. The sequence of TAP1*01:01 is shown here.SIMILARITY Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.CAUTION It is uncertain whether Met-1 or Met-61 is the initiator.UniProtQ035181EQUAL808EQUALReactome Database ID Release 75947474Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=947474ReactomeR-HSA-9474741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-947474.11Reactome Database ID Release 75983113Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983113ReactomeR-HSA-9831131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983113.1BAP31 oligomerReactome DB_ID: 983323Reactome Database ID Release 75983323Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983323ReactomeR-HSA-9833232Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983323.2ChEBI36080additional informationMIMI:0361MHC:B2M peptide loading complexReactome DB_ID: 98312111111Reactome Database ID Release 75983121Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983121ReactomeR-HSA-9831212Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983121.2Reactome Database ID Release 75983142Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983142ReactomeR-HSA-9831421Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983142.116465444Pubmed2006The macromolecular peptide-loading complex in MHC class I-dependent antigen presentationKoch, JTampé, RCell Mol Life Sci 63:653-6214718384Pubmed2004Quality control of MHC class I maturationPaulsson, KMWang, PFASEB J 18:31-819426129Pubmed2009The peptide-loading complex--antigen translocation and MHC class I loadingSchölz, CTampé, RBiol Chem 390:783-9419119025Pubmed2009Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimerDong, GWearsch, PAPeaper, DRCresswell, PReinisch, KMImmunity 30:21-3219361863Pubmed2009A transmembrane tail: interaction of tapasin with TAP and the MHC class I moleculeSimone, LCWang, XSolheim, JCMol Immunol 46:2147-5015286279Pubmed2004Tapasin enhances MHC class I peptide presentation according to peptide half-lifeHowarth, MWilliams, ATolstrup, ABElliott, TProc Natl Acad Sci U S A 101:11737-42LEFT-TO-RIGHTTransport of Antigen peptide in to ERTtransporter associated with antigen processing (TAP) is a heterodimeric complex, composed of TAP1 and TAP2 proteins, members of the ATP-binding cassette (ABC) superfamily. TAP consists of two transmembrane domains (TMDs) and two cytosolic nucleotide-binding domains. Peptide binding to the cytosolic-facing cavity formed by the TMDs causes it to undergo a conformational change that induces ATP hydrolysis, forcing the opening of a pore and translocation of the peptide into the ER lumen. TAP transports peptides in the range of 8-16 amino acids into the ER, which is the peptide length typically generated by the immunoproteasome.Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29oligopeptideoligopeptide fragment (8-16aa)Reactome DB_ID: 983032cytosolGENE ONTOLOGYGO:0005829oligopeptide [ChEBI:25676]oligopeptideOligopeptidoligopeptidoChEBICHEBI:25676Reactome Database ID Release 75983032Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983032ReactomeR-ALL-9830324Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-983032.4H2OwaterReactome DB_ID: 29356water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7529356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293565Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5COMPOUNDC00001ATPAdenosine 5'-triphosphateATP(4-)Reactome DB_ID: 113592ATP(4-) [ChEBI:30616]ATP(4-)ATPatpAdenosine 5'-triphosphateChEBICHEBI:30616Reactome Database ID Release 75113592Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592ReactomeR-ALL-1135924Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.4COMPOUNDC000022oligopeptideoligopeptide fragmentReactome DB_ID: 983034Reactome Database ID Release 75983034Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983034ReactomeR-ALL-9830344Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-983034.4ADPAdenosine 5'-diphosphateADP(3-)Reactome DB_ID: 29370ADP(3-) [ChEBI:456216]ADP(3-)ADP5&apos;-O-[(phosphonatooxy)phosphinato]adenosineADP trianionChEBICHEBI:456216Reactome Database ID Release 7529370Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370ReactomeR-ALL-293704Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.4COMPOUNDC000082PiOrthophosphatehydrogenphosphatePhosphateInorganic PhosphateReactome DB_ID: 29372hydrogenphosphate [ChEBI:43474]hydrogenphosphatehydrogen phosphatephosphate[PO3(OH)](2-)INORGANIC PHOSPHATE GROUPHYDROGENPHOSPHATE IONHPO4(2-)[P(OH)O3](2-)ChEBICHEBI:43474Reactome Database ID Release 7529372Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372ReactomeR-ALL-293724Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29372.4COMPOUNDC000092ACTIVATIONGENE ONTOLOGYGO:0015433gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 75983154Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983154Reactome Database ID Release 75983144Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983144ReactomeR-HSA-9831443Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983144.319261456Pubmed2009Antigen processing and presentation: TAPping into ABC transportersProcko, EGaudet, RCurr Opin Immunol 21:84-918342042Pubmed1993Selective and ATP-dependent translocation of peptides by the MHC-encoded transporterNeefjes, JJMomburg, FHämmerling, GJScience 261:769-7110600378Pubmed1999Kinetic analysis of peptide binding to the TAP transport complex: evidence for structural rearrangements induced by substrate bindingNeumann, LTampé, RJ Mol Biol 294:1203-1312645939Pubmed2003The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAPHewitt, EWLehner, Paul JEur J Immunol 33:422-7LEFT-TO-RIGHTTrimming of peptides in ERTransporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove.Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29L-amino acidL-alpha-amino acid zwitterionReactome DB_ID: 8943716L-alpha-amino acid zwitterion [ChEBI:59869]L-alpha-amino acid zwitterionC2H4NO2RL-alpha-amino acid zwitterions[NH3+][C@@H]([*])C([O-])=Oan L-amino acidChEBICHEBI:59869Reactome Database ID Release 758943716Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8943716ReactomeR-ALL-89437163Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8943716.3oligopeptideAntigen peptideReactome DB_ID: 983033Reactome Database ID Release 75983033Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983033ReactomeR-ALL-9830334Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-983033.4ACTIVATIONConverted from EntitySet in ReactomeERAP1/2Reactome DB_ID: 983125ERAP2Endoplasmic reticulum aminopeptidase 2ERAP2_HUMANReactome DB_ID: 983097UniProt:Q6P179 ERAP2ERAP2LRAPFUNCTION Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.SUBUNIT Heterodimer with ERAP1.TISSUE SPECIFICITY Ubiquitously expressed. Highly expressed in spleen and leukocytes.INDUCTION By IFNG/IFN-gamma.PTM N-glycosylated.MISCELLANEOUS Defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance.SIMILARITY Belongs to the peptidase M1 family.UniProtQ6P1791EQUAL960EQUALReactome Database ID Release 75983097Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983097ReactomeR-HSA-9830971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983097.1ERAP1Endoplasmic reticulum aminopeptidase 1ERAP1_HUMANReactome DB_ID: 947609UniProt:Q9NZ08 ERAP1ERAP1APPILSARTS1KIAA0525UNQ584/PRO1154FUNCTION Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.SUBUNIT Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX.TISSUE SPECIFICITY Ubiquitous.INDUCTION By IFNG/IFN-gamma.PTM N-glycosylated.SIMILARITY Belongs to the peptidase M1 family.CAUTION It is uncertain whether Met-1 or Met-13 is the initiator.UniProtQ9NZ081EQUAL941EQUALReactome Database ID Release 75947609Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=947609ReactomeR-HSA-9476091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-947609.1Reactome Database ID Release 75983125Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983125ReactomeR-HSA-9831251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983125.1GENE ONTOLOGYGO:0004175Reactome Database ID Release 75983143Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983143Reactome Database ID Release 75983158Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983158ReactomeR-HSA-9831583Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983158.312436110Pubmed2002The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residuesYork, IAChang, SCSaric, TKeys, JAFavreau, JMGoldberg, ALRock, KLNat Immunol 3:1177-8412436109Pubmed2002An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptidesSaric, TChang, SCHattori, AYork, IAMarkant, SRock, KLTsujimoto, MGoldberg, ALNat Immunol 3:1169-7617088086Pubmed2006ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulumKanaseki, TBlanchard, NHammer, GEGonzalez, FShastri, NImmunity 25:795-806LEFT-TO-RIGHTLoading of antigenic peptides on to class I MHCMHC class I heterodimers are only stable in peptide bound form and only as a trimer (with bound peptide) present on the cell surface. Class I MHC molecules prefer nonapeptides, and less frequently use octa- or deca-peptides. The peptide binding groove in MHC class I molecules is formed by the intimate association of the alpha1 and alpha2 domains of the heavy chain. Structural studies have revealed that the alpha1:alpha2 domains form a single peptide binding groove consisting of 2 parallel helices on a floor of 8 beta-strands. Hydrogen bonding networks are established in the binding groove with the antigenic peptide main chain and terminal atoms that enable largely sequence independent ligation. Upon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.<br>MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al, 2009; Garstka et al, 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al, 2009).Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Jupe, Steve, 2016-12-09Antigenic peptide:MHC:B2M peptide loading complexReactome DB_ID: 895149611Reactome Database ID Release 758951496Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8951496ReactomeR-HSA-89514961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8951496.1Reactome Database ID Release 758951499Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8951499ReactomeR-HSA-89514991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8951499.119851281Pubmed2009Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I moleculesHowe, CGarstka, MAl-Balushi, MGhanem, EAntoniou, ANFritzsche, SJankevicius, GKontouli, NSchneeweiss, CWilliams, AElliott, TSpringer, SEMBO J 28:3730-4417656363Pubmed2007Peptide-receptive major histocompatibility complex class I molecules cycle between endoplasmic reticulum and cis-Golgi in wild-type lymphocytesGarstka, MBorchert, BAl-Balushi, MPraveen, PVKühl, NMajoul, IDuden, RSpringer, SJ Biol Chem 282:30680-9016473882Pubmed2006Structural definition of the H-2Kd peptide-binding motifMitaksov, VFremont, DHJ Biol Chem 281:10618-252038058Pubmed1991Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolutionSaper, MABjorkman, PJWiley, DCJ Mol Biol 219:277-31921050182Pubmed2010The cell biology of major histocompatibility complex class I assembly: towards a molecular understandingVan Hateren, AJames, EBailey, APhillips, ADalchau, NElliott, TTissue Antigens 76:259-75LEFT-TO-RIGHTDissociation of the Antigenic peptide:MHC:B2M peptide loading complexUpon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.<br>MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al. 2009, Garstka et al. 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al. 2009).Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29Antigen peptide bound class I MHC:BAP31 oligomerReactome DB_ID: 983132Peptide bound class I MHCReactome DB_ID: 983127111Reactome Database ID Release 75983127Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983127ReactomeR-HSA-9831271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983127.111Reactome Database ID Release 75983132Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983132ReactomeR-HSA-9831321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983132.1Reactome Database ID Release 75983161Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983161ReactomeR-HSA-9831612Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983161.2LEFT-TO-RIGHTTransport of MHC heterotrimer to ER exit siteWhen the loaded peptide is of a sufficiently high-affinity the trimeric complex is transported to a special ER exit site by a putative cargo receptor, B cell receptor-associated protein (BAP31), where it translocates to the cell surface, possibly by transport in COPII-coated vesicles.Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29Antigen peptide bound class I MHCReactome DB_ID: 983114111Reactome Database ID Release 75983114Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983114ReactomeR-HSA-9831141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983114.1Reactome Database ID Release 75983138Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983138ReactomeR-HSA-9831381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983138.119342655Pubmed2009Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulumAbe, FVan Prooyen, NLadasky, JJEdidin, MJ Immunol 182:4776-8311163199Pubmed2000Selective export of MHC class I molecules from the ER after their dissociation from TAPSpiliotis, ETManley, HOsorio, MZúñiga, MCEdidin, MImmunity 13:841-5117056546Pubmed2006Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC moleculesLadasky, JJBoyle, SSeth, MLi, HPentcheva, TAbe, FSteinberg, SJEdidin, MJ Immunol 177:6172-81LEFT-TO-RIGHTCoat AssemblySar1p-GTP recruits the cytoplasmic Sec23p-Sec24p complex. (Though not represented in the subsequent steps, Sec23p-Sec24p would bind to members of the p24 protein family of possible cargo receptors, and together with Sar1p bind the appropiate v-SNARE, and Rab-GTP.)<br><br><br>Authored: Gillespie, ME, 2007-07-13 20:42:29Reviewed: Gagneux, P, 2010-11-18SEC23:SEC24Reactome DB_ID: 203975SEC23AProtein transport protein Sec23AS23A_HUMANReactome DB_ID: 203972UniProt:Q15436 SEC23ASEC23AFUNCTION Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (By similarity).SUBUNIT COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:17499046). Interacts with SEC23IP. Interacts with HTR4 (By similarity). Interacts with SEC16A (PubMed:17192411). Interacts with SLC6A4 (By similarity). Interacts (as part of the Sec23/24 complex) with SEC22B; recruits SEC22B into COPII-coated vesicles and allows the transport of this cargo from the endoplasmic reticulum to the Golgi (PubMed:17499046). Interacts (via Gelsolin-like repeat) with MIA2 and MIA3; specifically involved in the transport of large cargos like the collagen COL7A1 (PubMed:27551091, PubMed:28442536). Interacts with DDHD1 (By similarity). Interacts with TMEM39A (PubMed:31806350). Interacts with SACM1L; this interaction is reduced in the absence of TMEM39A (PubMed:31806350).TISSUE SPECIFICITY Ubiquitously expressed.DOMAIN The Gelsolin-like repeat mediates interaction with proteins containing PPP motifs that include MIA2, MIA3 but also SEC31A. These interactions are probably competitive.SIMILARITY Belongs to the SEC23/SEC24 family. SEC23 subfamily.UniProtQ154361EQUAL765EQUALReactome Database ID Release 75203972Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203972ReactomeR-HSA-2039721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203972.11Converted from EntitySet in ReactomeSEC24Reactome DB_ID: 203991SEC24AProtein transport protein Sec24AS24A_HUMANReactome DB_ID: 203978UniProt:O95486 SEC24ASEC24AFUNCTION Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:20427317, PubMed:17499046, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296).SUBUNIT COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:17499046). Interacts with TMED2 (PubMed:20427317). Interacts (as part of the Sec23/24 complex) with SEC22B; recruits SEC22B into COPII-coated vesicles for its transport from the endoplasmic reticulum to the Golgi (PubMed:17499046). Interacts with TMEM39A (PubMed:31806350). Interacts with SACM1L; this interaction is reduced in the absence of TMEM39A (PubMed:31806350).SIMILARITY Belongs to the SEC23/SEC24 family. SEC24 subfamily.UniProtO954861EQUAL1093EQUALReactome Database ID Release 75203978Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203978ReactomeR-HSA-2039781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203978.1SEC24BProtein transport protein Sec24BS24B_HUMANReactome DB_ID: 204001UniProt:O95487 SEC24BSEC24BFUNCTION Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296).SUBUNIT COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and SAR1 (PubMed:10075675, PubMed:17499046). Interacts with RNF139 (PubMed:19706601). Interacts with TMED2 and TMED10 (PubMed:20427317). Interacts with CNIH4 (PubMed:24405750).SIMILARITY Belongs to the SEC23/SEC24 family. SEC24 subfamily.UniProtO954871EQUAL1268EQUALReactome Database ID Release 75204001Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204001ReactomeR-HSA-2040011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204001.1SEC24CProtein transport protein Sec24CS24C_HUMANReactome DB_ID: 203988UniProt:P53992 SEC24CSEC24CKIAA0079FUNCTION Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).SUBUNIT COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:10214955, PubMed:10075675, PubMed:17499046). Interacts with TMED2 and TMED10 (PubMed:20427317). Interacts with GOSR2 (via IxM motif) and STX5 (via IxM motif); recruits GOSR2 and STX5 into COPII-coated vesicles (PubMed:18843296). Interacts with DDHD1 (PubMed:17428803). Interacts with STING1; promoting STING1 translocation to the COPII vesicles (PubMed:30842662).TISSUE SPECIFICITY Ubiquitous.SIMILARITY Belongs to the SEC23/SEC24 family. SEC24 subfamily.UniProtP539921EQUAL1094EQUALReactome Database ID Release 75203988Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203988ReactomeR-HSA-2039881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203988.1SEC24DProtein transport protein Sec24DS24D_HUMANReactome DB_ID: 203990UniProt:O94855 SEC24DSEC24DKIAA0755FUNCTION Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).SUBUNIT COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:17499046, PubMed:27551091). Interacts with TMED2 and TMED10 (PubMed:20427317). Interacts with CNIH4 (PubMed:24405750). Interacts with GOSR2 (via IxM motif) and STX5 (via IxM motif); recruits GOSR2 and STX5 into COPII-coated vesicles (PubMed:18843296).TISSUE SPECIFICITY Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver.SIMILARITY Belongs to the SEC23/SEC24 family. SEC24 subfamily.UniProtO948551EQUAL1032EQUALReactome Database ID Release 75203990Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203990ReactomeR-HSA-2039901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203990.1Reactome Database ID Release 75203991Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203991ReactomeR-HSA-2039912Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203991.21Reactome Database ID Release 75203975Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203975ReactomeR-HSA-2039752Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203975.2SAR1B:GTPReactome DB_ID: 204003GTPGuanosine 5'-triphosphateReactome DB_ID: 29438GTP [ChEBI:15996]GTPGuanosine 5'-triphosphateChEBICHEBI:15996Reactome Database ID Release 7529438Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438ReactomeR-ALL-294383Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.3COMPOUNDC000441SAR1BSAR1B GTP-binding proteinSARA2Reactome DB_ID: 203995UniProt:Q9Y6B6 SAR1BSAR1BSARA2SARBFUNCTION Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.SUBUNIT Homodimer. Binds PREB. Part of the COPII coat complex. Binds to the cytoplasmic tails of target proteins in the endoplasmic reticulum (By similarity).TISSUE SPECIFICITY Expressed in many tissues including small intestine, liver, muscle and brain.SIMILARITY Belongs to the small GTPase superfamily. SAR1 family.UniProtQ9Y6B61EQUAL198EQUALReactome Database ID Release 75203995Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203995ReactomeR-HSA-2039951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203995.11Reactome Database ID Release 75204003Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204003ReactomeR-HSA-2040032Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204003.2SAR1B:GTP:SEC23:SEC24Reactome DB_ID: 203997SEC23:SEC24Reactome DB_ID: 204007SEC23AProtein transport protein Sec23AS23A_HUMANReactome DB_ID: 2039761EQUAL765EQUALReactome Database ID Release 75203976Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203976ReactomeR-HSA-2039761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203976.11Converted from EntitySet in ReactomeSEC24Reactome DB_ID: 203974SEC24AProtein transport protein Sec24AS24A_HUMANReactome DB_ID: 2039921EQUAL1093EQUALReactome Database ID Release 75203992Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203992ReactomeR-HSA-2039921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203992.1SEC24BProtein transport protein Sec24BS24B_HUMANReactome DB_ID: 2039821EQUAL1268EQUALReactome Database ID Release 75203982Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203982ReactomeR-HSA-2039821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203982.1SEC24CProtein transport protein Sec24CS24C_HUMANReactome DB_ID: 2039871EQUAL1094EQUALReactome Database ID Release 75203987Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203987ReactomeR-HSA-2039871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203987.1SEC24DProtein transport protein Sec24DS24D_HUMANReactome DB_ID: 2040041EQUAL1032EQUALReactome Database ID Release 75204004Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204004ReactomeR-HSA-2040041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204004.1Reactome Database ID Release 75203974Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203974ReactomeR-HSA-2039742Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203974.21Reactome Database ID Release 75204007Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204007ReactomeR-HSA-2040072Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204007.211Reactome Database ID Release 75203997Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203997ReactomeR-HSA-2039972Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203997.2Reactome Database ID Release 75203979Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203979ReactomeR-HSA-2039792Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203979.210982397Pubmed2000Dynamics of transitional endoplasmic reticulum sites in vertebrate cellsHammond, ATGlick, BSMol Biol Cell 11:3013-3010825291Pubmed2000COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sitesStephens, DJLin-Marq, NPagano, APepperkok, RPaccaud, JPJ Cell Sci 113:2177-85LEFT-TO-RIGHTCapturing cargo and formation of prebudding complexThe cytoplasmic tails of MHC class I molecules do not possess any of the known ER export sequences. BAP31 acts as a cargo receptor by exporting peptide-loaded class I MHC molecules to the ER exit sites or ER/Golgi intermediate compartment. Sec24 of the Sec23-Sec24/Sar1-GTP complex catches cargo by direct contact, forming the prebudding complex. Sar1/Sec23-Sec24 can bring about curvature of the membrane in the formation of vesicle. The cargo (antigen-bound MHC) accumulates within the COPII vesicle by binding to the Sec24 polypeptide of the COPII coat.Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IReactome DB_ID: 983413111Reactome Database ID Release 75983413Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983413ReactomeR-HSA-9834131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983413.1Reactome Database ID Release 75983426Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983426ReactomeR-HSA-9834263Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983426.317316621Pubmed2007Mechanisms of COPII vesicle formation and protein sortingSato, KNakano, AFEBS Lett 581:2076-82LEFT-TO-RIGHTRecruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicleSec13-Sec31 binds the prebudding complex and this Sec13-Sec31 heterotetramer forms the outer structural scaffold of the coat. Sec13-Sec31 is likely to crosslink the prebudding complexes generating COPII-coated vesicles.Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29SEC13SEC13-related proteinSC13_HUMANReactome DB_ID: 203981UniProt:P55735 SEC13SEC13D3S1231ESEC13ASEC13L1SEC13RFUNCTION Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity).FUNCTION As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).SUBUNIT At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13. At the COPII coat complex: interacts with SEC31A and SEC31B. Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers (PubMed:14517296, PubMed:16495487, PubMed:16957052, PubMed:18160040, PubMed:23723238). The GATOR2 complex interacts with CASTOR2 and CASTOR1; the interaction is negatively regulated by arginine (PubMed:26972053). The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids (PubMed:25263562, PubMed:25457612). Interacts with SEC16A (PubMed:17428803, PubMed:19638414, PubMed:25201882). Interacts with SEC16B (PubMed:22355596).SIMILARITY Belongs to the WD repeat SEC13 family.UniProtP557352EQUAL322EQUALReactome Database ID Release 75203981Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203981ReactomeR-HSA-2039811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203981.1SEC31AProtein transport protein Sec31ASC31A_HUMANReactome DB_ID: 203983UniProt:O94979 SEC31ASEC31AKIAA0905SEC31L1HSPC275HSPC334FUNCTION Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).SUBUNIT COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with PDCD6; interaction takes place in response to cytosolic calcium increase and leads to bridge together the BCR(KLHL12) complex and SEC31A, leading to monoubiquitination (PubMed:27716508) (PubMed:16957052, PubMed:17196169, PubMed:27716508, PubMed:25667979). Interacts with KLHL12.TISSUE SPECIFICITY Abundantly and ubiquitously expressed.DOMAIN The ALG-2-binding site motif-2 (ABS-2) contains a PXPGF sequence that binds hydrophobic pocket 3 of PDCD6.PTM Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.DISEASE A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.SIMILARITY Belongs to the WD repeat SEC31 family.UniProtO949791EQUAL1220EQUALReactome Database ID Release 75203983Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203983ReactomeR-HSA-2039831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203983.1COPII vesicle with MHC class IReactome DB_ID: 9834141Sec13p:Sec31p ComplexReactome DB_ID: 203993SEC31AProtein transport protein Sec31ASC31A_HUMANReactome DB_ID: 2040001EQUAL1220EQUALReactome Database ID Release 75204000Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204000ReactomeR-HSA-2040001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204000.11SEC13SEC13-related proteinSC13_HUMANSEC13L1Reactome DB_ID: 2039942EQUAL322EQUALReactome Database ID Release 75203994Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203994ReactomeR-HSA-2039941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203994.11Reactome Database ID Release 75203993Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203993ReactomeR-HSA-2039931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203993.11Reactome Database ID Release 75983414Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983414ReactomeR-HSA-9834141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983414.1Reactome Database ID Release 75983425Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983425ReactomeR-HSA-9834251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983425.1LEFT-TO-RIGHTBudding of COPII coated vesicleOnce the entire COPII coat has been assembled, the bud is separated from the ER membrane in the form of a COPII coated vesicle.Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29COPII vesicle with MHC class IReactome DB_ID: 983418ER to Golgi transport vesicle membraneGENE ONTOLOGYGO:0012507SEC23:SEC24Reactome DB_ID: 204023SEC23AProtein transport protein Sec23AS23A_HUMANReactome DB_ID: 2040241EQUAL765EQUALReactome Database ID Release 75204024Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204024ReactomeR-HSA-2040241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204024.11Converted from EntitySet in ReactomeSEC24Reactome DB_ID: 204017SEC24AProtein transport protein Sec24AS24A_HUMANReactome DB_ID: 2040221EQUAL1093EQUALReactome Database ID Release 75204022Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204022ReactomeR-HSA-2040221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204022.1SEC24BProtein transport protein Sec24BS24B_HUMANReactome DB_ID: 2040211EQUAL1268EQUALReactome Database ID Release 75204021Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204021ReactomeR-HSA-2040211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204021.1SEC24CProtein transport protein Sec24CS24C_HUMANReactome DB_ID: 2040261EQUAL1094EQUALReactome Database ID Release 75204026Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204026ReactomeR-HSA-2040261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204026.1SEC24DProtein transport protein Sec24DS24D_HUMANReactome DB_ID: 2040201EQUAL1032EQUALReactome Database ID Release 75204020Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204020ReactomeR-HSA-2040201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204020.1Reactome Database ID Release 75204017Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204017ReactomeR-HSA-2040172Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204017.21Reactome Database ID Release 75204023Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204023ReactomeR-HSA-2040232Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204023.21Antigen peptide bound class I MHCReactome DB_ID: 983412B2M(21-119)Beta-2-microglobulinReactome DB_ID: 98337821EQUAL119EQUALReactome Database ID Release 75983378Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983378ReactomeR-HSA-9833781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983378.11Antigen peptideReactome DB_ID: 983326Reactome Database ID Release 75983326Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983326ReactomeR-ALL-9833262Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-983326.2ChEBI158411monoglucosylated MHC class I HC(Glc)1(Man)9(GlcNAc)2-MHC class I heavy chainReactome DB_ID: 983419Converted from EntitySet in ReactomeClass I MHC heavy chain (MHC HC)Reactome DB_ID: 983408HLA-AHLA class I histocompatibility antigen, A-1 alpha chain precursor1A01_HUMANReactome DB_ID: 98339925EQUAL365EQUALReactome Database ID Release 75983399Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983399ReactomeR-HSA-9833991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983399.1HLA class I histocompatibility antigen, A-2 alpha chainReactome DB_ID: 98338925EQUAL365EQUALReactome Database ID Release 75983389Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983389ReactomeR-HSA-9833891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983389.1HLA-AHLA class I histocompatibility antigen, A-3 alpha chain precursor1A03_HUMANReactome DB_ID: 98334725EQUAL365EQUALReactome Database ID Release 75983347Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983347ReactomeR-HSA-9833471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983347.1HLA-CHLA class I histocompatibility antigen, Cw-3 alpha chain precursor1C03_HUMANReactome DB_ID: 98336525EQUAL366EQUALReactome Database ID Release 75983365Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983365ReactomeR-HSA-9833651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983365.1HLA-CHLA class I histocompatibility antigen, Cw-4 alpha chain precursor1C04_HUMANReactome DB_ID: 98336325EQUAL366EQUALReactome Database ID Release 75983363Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983363ReactomeR-HSA-9833631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983363.1HLA-CHLA class I histocompatibility antigen, Cw-5 alpha chain precursor1C05_HUMANReactome DB_ID: 98333125EQUAL366EQUALReactome Database ID Release 75983331Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983331ReactomeR-HSA-9833311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983331.1HLA-CHLA class I histocompatibility antigen, Cw-6 alpha chain precursor1C06_HUMANReactome DB_ID: 98337725EQUAL366EQUALReactome Database ID Release 75983377Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983377ReactomeR-HSA-9833771Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983377.1HLA-CHLA class I histocompatibility antigen, Cw-7 alpha chain precursor1C07_HUMANReactome DB_ID: 98335425EQUAL366EQUALReactome Database ID Release 75983354Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983354ReactomeR-HSA-9833541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983354.1HLA-EHLA class I histocompatibility antigen, E alpha chain precursorHLAE_HUMANReactome DB_ID: 98340722EQUAL358EQUALReactome Database ID Release 75983407Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983407ReactomeR-HSA-9834071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983407.1HLA-FHLA class I histocompatibility antigen, alpha chain F precursorHLAF_HUMANReactome DB_ID: 98337522EQUAL362EQUALReactome Database ID Release 75983375Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983375ReactomeR-HSA-9833751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983375.1HLA-GHLA class I histocompatibility antigen, alpha chain G precursorHLAG_HUMANReactome DB_ID: 98340625EQUAL338EQUALReactome Database ID Release 75983406Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983406ReactomeR-HSA-9834061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983406.1class I MHC B13Reactome DB_ID: 98337325EQUAL362EQUALReactome Database ID Release 75983373Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983373ReactomeR-HSA-9833731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983373.1class I MHC B14Reactome DB_ID: 98339025EQUAL362EQUALReactome Database ID Release 75983390Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983390ReactomeR-HSA-9833901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983390.1class I MHC B15Reactome DB_ID: 98339325EQUAL362EQUALReactome Database ID Release 75983393Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983393ReactomeR-HSA-9833931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983393.1class I MHC B18Reactome DB_ID: 98338425EQUAL362EQUALReactome Database ID Release 75983384Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983384ReactomeR-HSA-9833841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983384.1class I MHC B27Reactome DB_ID: 98334825EQUAL362EQUALReactome Database ID Release 75983348Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983348ReactomeR-HSA-9833481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983348.1class I MHC B35Reactome DB_ID: 98335125EQUAL362EQUALReactome Database ID Release 75983351Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983351ReactomeR-HSA-9833511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983351.1class I MHC B37Reactome DB_ID: 98338625EQUAL362EQUALReactome Database ID Release 75983386Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983386ReactomeR-HSA-9833861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983386.1class I MHC B38Reactome DB_ID: 98333525EQUAL362EQUALReactome Database ID Release 75983335Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983335ReactomeR-HSA-9833351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983335.1class I MHC B39Reactome DB_ID: 98338525EQUAL362EQUALReactome Database ID Release 75983385Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983385ReactomeR-HSA-9833851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983385.1class I MHC B40Reactome DB_ID: 98334325EQUAL362EQUALReactome Database ID Release 75983343Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983343ReactomeR-HSA-9833431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983343.1class I MHC B41Reactome DB_ID: 98336025EQUAL362EQUALReactome Database ID Release 75983360Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983360ReactomeR-HSA-9833601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983360.1class I MHC B42Reactome DB_ID: 98333225EQUAL362EQUALReactome Database ID Release 75983332Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983332ReactomeR-HSA-9833321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983332.1class I MHC B44Reactome DB_ID: 98335925EQUAL362EQUALReactome Database ID Release 75983359Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983359ReactomeR-HSA-9833591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983359.1class I MHC B45Reactome DB_ID: 98337025EQUAL362EQUALReactome Database ID Release 75983370Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983370ReactomeR-HSA-9833701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983370.1class I MHC B46Reactome DB_ID: 98337425EQUAL362EQUALReactome Database ID Release 75983374Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983374ReactomeR-HSA-9833741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983374.1class I MHC B47Reactome DB_ID: 98337125EQUAL362EQUALReactome Database ID Release 75983371Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983371ReactomeR-HSA-9833711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983371.1class I MHC B49Reactome DB_ID: 98336625EQUAL362EQUALReactome Database ID Release 75983366Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983366ReactomeR-HSA-9833661Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983366.1class I MHC B50Reactome DB_ID: 98333425EQUAL362EQUALReactome Database ID Release 75983334Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983334ReactomeR-HSA-9833341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983334.1class I MHC B51Reactome DB_ID: 98335225EQUAL362EQUALReactome Database ID Release 75983352Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983352ReactomeR-HSA-9833521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983352.1class I MHC B52Reactome DB_ID: 98340025EQUAL362EQUALReactome Database ID Release 75983400Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983400ReactomeR-HSA-9834001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983400.1class I MHC B53Reactome DB_ID: 98339125EQUAL362EQUALReactome Database ID Release 75983391Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983391ReactomeR-HSA-9833911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983391.1class I MHC B54Reactome DB_ID: 98333725EQUAL362EQUALReactome Database ID Release 75983337Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983337ReactomeR-HSA-9833371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983337.1class I MHC B55Reactome DB_ID: 98336925EQUAL362EQUALReactome Database ID Release 75983369Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983369ReactomeR-HSA-9833691Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983369.1class I MHC B56Reactome DB_ID: 98336825EQUAL362EQUALReactome Database ID Release 75983368Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983368ReactomeR-HSA-9833681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983368.1class I MHC B57Reactome DB_ID: 98335825EQUAL362EQUALReactome Database ID Release 75983358Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983358ReactomeR-HSA-9833581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983358.1class I MHC B58Reactome DB_ID: 98335025EQUAL362EQUALReactome Database ID Release 75983350Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983350ReactomeR-HSA-9833501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983350.1class I MHC B59Reactome DB_ID: 98338125EQUAL362EQUALReactome Database ID Release 75983381Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983381ReactomeR-HSA-9833811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983381.1class I MHC B67Reactome DB_ID: 98334025EQUAL362EQUALReactome Database ID Release 75983340Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983340ReactomeR-HSA-9833401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983340.1class I MHC B7Reactome DB_ID: 98336225EQUAL362EQUALReactome Database ID Release 75983362Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983362ReactomeR-HSA-9833621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983362.1class I MHC B73Reactome DB_ID: 98333325EQUAL363EQUALReactome Database ID Release 75983333Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983333ReactomeR-HSA-9833331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983333.1class I MHC B78Reactome DB_ID: 98335525EQUAL362EQUALReactome Database ID Release 75983355Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983355ReactomeR-HSA-9833551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983355.1class I MHC B8Reactome DB_ID: 98339725EQUAL362EQUALReactome Database ID Release 75983397Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983397ReactomeR-HSA-9833971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983397.1class I MHC B81Reactome DB_ID: 98335625EQUAL362EQUALReactome Database ID Release 75983356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983356ReactomeR-HSA-9833561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983356.1class I MHC B82Reactome DB_ID: 98336125EQUAL362EQUALReactome Database ID Release 75983361Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983361ReactomeR-HSA-9833611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983361.1HLA-CHLA class I histocompatibility antigen, Cw-1 alpha chain1C01_HUMANReactome DB_ID: 222089525EQUAL366EQUALReactome Database ID Release 752220895Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220895ReactomeR-HSA-22208951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220895.1HLA-CHLA class I histocompatibility antigen, Cw-12 alpha chain1C12_HUMANReactome DB_ID: 222088825EQUAL366EQUALReactome Database ID Release 752220888Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220888ReactomeR-HSA-22208881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220888.1HLA-CHLA class I histocompatibility antigen, Cw-14 alpha chain1C14_HUMANReactome DB_ID: 222089125EQUAL366EQUALReactome Database ID Release 752220891Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220891ReactomeR-HSA-22208911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220891.1HLA-CHLA class I histocompatibility antigen, Cw-15 alpha chain1C15_HUMANReactome DB_ID: 222088725EQUAL366EQUALReactome Database ID Release 752220887Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220887ReactomeR-HSA-22208871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220887.1HLA-CHLA class I histocompatibility antigen, Cw-16 alpha chain1C16_HUMANReactome DB_ID: 222089025EQUAL366EQUALReactome Database ID Release 752220890Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220890ReactomeR-HSA-22208901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220890.1HLA-CHLA class I histocompatibility antigen, Cw-17 alpha chain1C17_HUMANReactome DB_ID: 222089425EQUAL372EQUALReactome Database ID Release 752220894Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220894ReactomeR-HSA-22208941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220894.1HLA-CHLA class I histocompatibility antigen, Cw-18 alpha chain1C18_HUMANReactome DB_ID: 222088925EQUAL366EQUALReactome Database ID Release 752220889Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220889ReactomeR-HSA-22208891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220889.1HLA-CHLA class I histocompatibility antigen, Cw-2 alpha chain1C02_HUMANReactome DB_ID: 222088625EQUAL366EQUALReactome Database ID Release 752220886Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220886ReactomeR-HSA-22208861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220886.1HLA-CHLA class I histocompatibility antigen, Cw-8 alpha chain1C08_HUMANReactome DB_ID: 222089325EQUAL366EQUALReactome Database ID Release 752220893Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220893ReactomeR-HSA-22208931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220893.1HLA-AHLA class I histocompatibility antigen, A-11 alpha chain1A11_HUMANReactome DB_ID: 331823425EQUAL365EQUALReactome Database ID Release 753318234Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318234ReactomeR-HSA-33182341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318234.1HLA-AHLA class I histocompatibility antigen, A-23 alpha chain1A23_HUMANReactome DB_ID: 331822925EQUAL365EQUALReactome Database ID Release 753318229Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318229ReactomeR-HSA-33182291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318229.1HLA-AHLA class I histocompatibility antigen, A-24 alpha chain1A24_HUMANReactome DB_ID: 331822725EQUAL365EQUALReactome Database ID Release 753318227Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318227ReactomeR-HSA-33182271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318227.1HLA-AHLA class I histocompatibility antigen, A-25 alpha chain1A25_HUMANReactome DB_ID: 331822825EQUAL365EQUALReactome Database ID Release 753318228Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318228ReactomeR-HSA-33182281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318228.1HLA-AHLA class I histocompatibility antigen, A-26 alpha chain1A26_HUMANReactome DB_ID: 331824325EQUAL365EQUALReactome Database ID Release 753318243Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318243ReactomeR-HSA-33182431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318243.1HLA-AHLA class I histocompatibility antigen, A-29 alpha chain1A29_HUMANReactome DB_ID: 331824125EQUAL365EQUALReactome Database ID Release 753318241Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318241ReactomeR-HSA-33182411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318241.1HLA-AHLA class I histocompatibility antigen, A-30 alpha chain1A30_HUMANReactome DB_ID: 331823825EQUAL365EQUALReactome Database ID Release 753318238Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318238ReactomeR-HSA-33182381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318238.1HLA-AHLA class I histocompatibility antigen, A-31 alpha chain1A31_HUMANReactome DB_ID: 331822525EQUAL365EQUALReactome Database ID Release 753318225Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318225ReactomeR-HSA-33182251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318225.1HLA-AHLA class I histocompatibility antigen, A-32 alpha chain1A32_HUMANReactome DB_ID: 331824025EQUAL365EQUALReactome Database ID Release 753318240Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318240ReactomeR-HSA-33182401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318240.1HLA-AHLA class I histocompatibility antigen, A-33 alpha chain1A33_HUMANReactome DB_ID: 331824225EQUAL365EQUALReactome Database ID Release 753318242Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318242ReactomeR-HSA-33182421Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318242.1HLA-AHLA class I histocompatibility antigen, A-34 alpha chain1A34_HUMANReactome DB_ID: 331823725EQUAL365EQUALReactome Database ID Release 753318237Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318237ReactomeR-HSA-33182371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318237.1HLA-AHLA class I histocompatibility antigen, A-36 alpha chain1A36_HUMANReactome DB_ID: 331823125EQUAL365EQUALReactome Database ID Release 753318231Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318231ReactomeR-HSA-33182311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318231.1HLA-AHLA class I histocompatibility antigen, A-43 alpha chain1A43_HUMANReactome DB_ID: 331823525EQUAL365EQUALReactome Database ID Release 753318235Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318235ReactomeR-HSA-33182351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318235.1HLA-AHLA class I histocompatibility antigen, A-66 alpha chain1A66_HUMANReactome DB_ID: 331823025EQUAL365EQUALReactome Database ID Release 753318230Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318230ReactomeR-HSA-33182301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318230.1HLA-AHLA class I histocompatibility antigen, A-68 alpha chain1A68_HUMANReactome DB_ID: 331823325EQUAL365EQUALReactome Database ID Release 753318233Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318233ReactomeR-HSA-33182331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318233.1HLA-AHLA class I histocompatibility antigen, A-69 alpha chain1A69_HUMANReactome DB_ID: 33182361EQUAL365EQUALReactome Database ID Release 753318236Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318236ReactomeR-HSA-33182361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318236.1HLA-AHLA class I histocompatibility antigen, A-74 alpha chain1A74_HUMANReactome DB_ID: 331823225EQUAL365EQUALReactome Database ID Release 753318232Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318232ReactomeR-HSA-33182321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318232.1HLA-AHLA class I histocompatibility antigen, A-80 alpha chain1A80_HUMANReactome DB_ID: 331823925EQUAL365EQUALReactome Database ID Release 753318239Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318239ReactomeR-HSA-33182391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318239.1HLA-BHLA class I histocompatibility antigen, B-48 alpha chain1B48_HUMANReactome DB_ID: 885589325EQUAL362EQUALReactome Database ID Release 758855893Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8855893ReactomeR-HSA-88558931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8855893.1HLA-HPutative HLA class I histocompatibility antigen, alpha chain HHLAH_HUMANReactome DB_ID: 885589225EQUAL362EQUALReactome Database ID Release 758855892Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8855892ReactomeR-HSA-88558921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8855892.1Reactome Database ID Release 75983408Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983408ReactomeR-HSA-9834082Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983408.21(Glc)1 (GlcNAc)2 (Man)9N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residueReactome DB_ID: 983317Reactome Database ID Release 75983317Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983317ReactomeR-ALL-9833173Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-983317.31Reactome Database ID Release 75983419Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983419ReactomeR-HSA-9834191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983419.11Reactome Database ID Release 75983412Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983412ReactomeR-HSA-9834121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983412.11Sar1p-GTPReactome DB_ID: 983415GTPGuanosine 5'-triphosphateReactome DB_ID: 983318Reactome Database ID Release 75983318Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983318ReactomeR-ALL-9833182Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-983318.2COMPOUNDC000441SAR1BSAR1B GTP-binding proteinSARA2Reactome DB_ID: 2114981EQUAL198EQUALReactome Database ID Release 75211498Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211498ReactomeR-HSA-2114981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-211498.11Reactome Database ID Release 75983415Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983415ReactomeR-HSA-9834151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983415.11Sec13p:Sec31p ComplexReactome DB_ID: 204015SEC31AProtein transport protein Sec31ASC31A_HUMANReactome DB_ID: 2040101EQUAL1220EQUALReactome Database ID Release 75204010Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204010ReactomeR-HSA-2040101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204010.11SEC13SEC13-related proteinSC13_HUMANSEC13L1Reactome DB_ID: 2040122EQUAL322EQUALReactome Database ID Release 75204012Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204012ReactomeR-HSA-2040121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204012.11Reactome Database ID Release 75204015Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204015ReactomeR-HSA-2040151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204015.11Reactome Database ID Release 75983418Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983418ReactomeR-HSA-9834181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983418.1Reactome Database ID Release 75983424Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983424ReactomeR-HSA-9834241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983424.1LEFT-TO-RIGHT3.6.5.43.6.5.33.6.5.23.6.5.1Disassembly of COPII coated vesicleBefore the cargo vesicle can fuse with target membrane, the COPII protein coat must be disassembled and its components released into cytosol. This uncoating is triggered by hydrolysis of the bound GTP to produce Sar1p-GDP, which has decreased affinity for the vesicle membrane. Disassociation of Sar1p-GDP from the membrane is followed by the release of the other COPII subunits.Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29GDPGuanosine 5'-diphosphateGuanosine diphosphateReactome DB_ID: 29420GDP [ChEBI:17552]GDPGuanosine 5'-diphosphateGuanosine diphosphateChEBICHEBI:17552Reactome Database ID Release 7529420Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29420ReactomeR-ALL-294202Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29420.2COMPOUNDC00035SAR1B:GDPReactome DB_ID: 2039891SAR1BSAR1B GTP-binding proteinSARA2Reactome DB_ID: 1746781EQUAL198EQUALReactome Database ID Release 75174678Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174678ReactomeR-HSA-1746781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-174678.11Reactome Database ID Release 75203989Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203989ReactomeR-HSA-2039892Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203989.2ACTIVATIONactiveUnit: #Protein187COPIISar1b:Sec23p:Sec24p:Sec13p:Sec31p ComplexReactome DB_ID: 204019111Reactome Database ID Release 75204019Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204019ReactomeR-HSA-2040192Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-204019.2GENE ONTOLOGYGO:0003924Reactome Database ID Release 75211500Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211500Reactome Database ID Release 75983422Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983422ReactomeR-HSA-9834221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983422.1LEFT-TO-RIGHTJourney of cargo through Golgi complexCargo must pass through the various compartments of the Golgi complex to reach the plasma membrane. This may occur through either of the two well known models, cisternal maturation or vesicular transport (Refer to review articles Glick et al. 2009, Jackson 2009, Nakano et al. 2010).Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29Antigen peptide bound class I MHCReactome DB_ID: 983416Golgi membraneGENE ONTOLOGYGO:0000139B2MB2M(21-119)Beta-2-microglobulinClass I MHC beta chainReactome DB_ID: 98340321EQUAL119EQUALReactome Database ID Release 75983403Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983403ReactomeR-HSA-9834031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983403.11monoglucosylated MHC class I HC(Glc)1(Man)9(GlcNAc)2-MHC class I heavy chainReactome DB_ID: 983420(Glc)1 (GlcNAc)2 (Man)9N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residueReactome DB_ID: 983321Reactome Database ID Release 75983321Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983321ReactomeR-ALL-9833213Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-983321.31Converted from EntitySet in ReactomeClass I MHC heavy chain (MHC HC)Reactome DB_ID: 983410HLA-AHLA class I histocompatibility antigen, A-1 alpha chain precursor1A01_HUMANReactome DB_ID: 98335325EQUAL365EQUALReactome Database ID Release 75983353Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983353ReactomeR-HSA-9833531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983353.1HLA class I histocompatibility antigen, A-2 alpha chainReactome DB_ID: 18225225EQUAL365EQUALReactome Database ID Release 75182252Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=182252ReactomeR-HSA-1822521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-182252.1HLA-AHLA class I histocompatibility antigen, A-3 alpha chain precursor1A03_HUMANReactome DB_ID: 98337625EQUAL365EQUALReactome Database ID Release 75983376Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983376ReactomeR-HSA-9833761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983376.1HLA-CHLA class I histocompatibility antigen, Cw-3 alpha chain precursor1C03_HUMANReactome DB_ID: 98333825EQUAL366EQUALReactome Database ID Release 75983338Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983338ReactomeR-HSA-9833381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983338.1HLA-CHLA class I histocompatibility antigen, Cw-4 alpha chain precursor1C04_HUMANReactome DB_ID: 98339825EQUAL366EQUALReactome Database ID Release 75983398Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983398ReactomeR-HSA-9833981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983398.1HLA-CHLA class I histocompatibility antigen, Cw-5 alpha chain precursor1C05_HUMANReactome DB_ID: 98340225EQUAL366EQUALReactome Database ID Release 75983402Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983402ReactomeR-HSA-9834021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983402.1HLA-CHLA class I histocompatibility antigen, Cw-6 alpha chain precursor1C06_HUMANReactome DB_ID: 98338825EQUAL366EQUALReactome Database ID Release 75983388Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983388ReactomeR-HSA-9833881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983388.1HLA-CHLA class I histocompatibility antigen, Cw-7 alpha chain precursor1C07_HUMANReactome DB_ID: 98338725EQUAL366EQUALReactome Database ID Release 75983387Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983387ReactomeR-HSA-9833871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983387.1HLA-EHLA class I histocompatibility antigen, E alpha chain precursorHLAE_HUMANReactome DB_ID: 98333922EQUAL358EQUALReactome Database ID Release 75983339Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983339ReactomeR-HSA-9833391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983339.1HLA-FHLA class I histocompatibility antigen, alpha chain F precursorHLAF_HUMANReactome DB_ID: 98339422EQUAL362EQUALReactome Database ID Release 75983394Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983394ReactomeR-HSA-9833941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983394.1HLA-GHLA class I histocompatibility antigen, alpha chain G precursorHLAG_HUMANReactome DB_ID: 98338225EQUAL338EQUALReactome Database ID Release 75983382Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983382ReactomeR-HSA-9833821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983382.1class I MHC B13Reactome DB_ID: 16774925EQUAL362EQUALReactome Database ID Release 75167749Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167749ReactomeR-HSA-1677491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167749.1class I MHC B14Reactome DB_ID: 16776125EQUAL362EQUALReactome Database ID Release 75167761Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167761ReactomeR-HSA-1677611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167761.1class I MHC B15Reactome DB_ID: 16774825EQUAL362EQUALReactome Database ID Release 75167748Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167748ReactomeR-HSA-1677481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167748.1class I MHC B18Reactome DB_ID: 16774125EQUAL362EQUALReactome Database ID Release 75167741Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167741ReactomeR-HSA-1677411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167741.1class I MHC B27Reactome DB_ID: 16777025EQUAL362EQUALReactome Database ID Release 75167770Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167770ReactomeR-HSA-1677701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167770.1class I MHC B35Reactome DB_ID: 16775125EQUAL362EQUALReactome Database ID Release 75167751Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167751ReactomeR-HSA-1677511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167751.1class I MHC B37Reactome DB_ID: 16775725EQUAL362EQUALReactome Database ID Release 75167757Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167757ReactomeR-HSA-1677571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167757.1class I MHC B38Reactome DB_ID: 16775425EQUAL362EQUALReactome Database ID Release 75167754Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167754ReactomeR-HSA-1677541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167754.1class I MHC B39Reactome DB_ID: 16775325EQUAL362EQUALReactome Database ID Release 75167753Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167753ReactomeR-HSA-1677531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167753.1class I MHC B40Reactome DB_ID: 16773625EQUAL362EQUALReactome Database ID Release 75167736Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167736ReactomeR-HSA-1677361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167736.1class I MHC B41Reactome DB_ID: 16774225EQUAL362EQUALReactome Database ID Release 75167742Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167742ReactomeR-HSA-1677421Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167742.1class I MHC B42Reactome DB_ID: 16777225EQUAL362EQUALReactome Database ID Release 75167772Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167772ReactomeR-HSA-1677721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167772.1class I MHC B44Reactome DB_ID: 98333025EQUAL362EQUALReactome Database ID Release 75983330Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983330ReactomeR-HSA-9833301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983330.1class I MHC B45Reactome DB_ID: 98340525EQUAL362EQUALReactome Database ID Release 75983405Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983405ReactomeR-HSA-9834051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983405.1class I MHC B46Reactome DB_ID: 98332825EQUAL362EQUALReactome Database ID Release 75983328Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983328ReactomeR-HSA-9833281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983328.1class I MHC B47Reactome DB_ID: 98334225EQUAL362EQUALReactome Database ID Release 75983342Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983342ReactomeR-HSA-9833421Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983342.1class I MHC B49Reactome DB_ID: 98340125EQUAL362EQUALReactome Database ID Release 75983401Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983401ReactomeR-HSA-9834011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983401.1class I MHC B50Reactome DB_ID: 98340425EQUAL362EQUALReactome Database ID Release 75983404Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983404ReactomeR-HSA-9834041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983404.1class I MHC B51Reactome DB_ID: 98339225EQUAL362EQUALReactome Database ID Release 75983392Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983392ReactomeR-HSA-9833921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983392.1class I MHC B52Reactome DB_ID: 98337225EQUAL362EQUALReactome Database ID Release 75983372Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983372ReactomeR-HSA-9833721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983372.1class I MHC B53Reactome DB_ID: 98339525EQUAL362EQUALReactome Database ID Release 75983395Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983395ReactomeR-HSA-9833951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983395.1class I MHC B54Reactome DB_ID: 98339625EQUAL362EQUALReactome Database ID Release 75983396Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983396ReactomeR-HSA-9833961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983396.1class I MHC B55Reactome DB_ID: 98336425EQUAL362EQUALReactome Database ID Release 75983364Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983364ReactomeR-HSA-9833641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983364.1class I MHC B56Reactome DB_ID: 98338025EQUAL362EQUALReactome Database ID Release 75983380Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983380ReactomeR-HSA-9833801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983380.1class I MHC B57Reactome DB_ID: 98334625EQUAL362EQUALReactome Database ID Release 75983346Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983346ReactomeR-HSA-9833461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983346.1class I MHC B58Reactome DB_ID: 98334525EQUAL362EQUALReactome Database ID Release 75983345Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983345ReactomeR-HSA-9833451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983345.1class I MHC B59Reactome DB_ID: 98338325EQUAL362EQUALReactome Database ID Release 75983383Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983383ReactomeR-HSA-9833831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983383.1class I MHC B67Reactome DB_ID: 98334425EQUAL362EQUALReactome Database ID Release 75983344Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983344ReactomeR-HSA-9833441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983344.1class I MHC B7Reactome DB_ID: 98337925EQUAL362EQUALReactome Database ID Release 75983379Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983379ReactomeR-HSA-9833791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983379.1class I MHC B73Reactome DB_ID: 98334925EQUAL363EQUALReactome Database ID Release 75983349Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983349ReactomeR-HSA-9833491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983349.1class I MHC B78Reactome DB_ID: 98334125EQUAL362EQUALReactome Database ID Release 75983341Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983341ReactomeR-HSA-9833411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983341.1class I MHC B8Reactome DB_ID: 98333625EQUAL362EQUALReactome Database ID Release 75983336Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983336ReactomeR-HSA-9833361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983336.1class I MHC B81Reactome DB_ID: 98336725EQUAL362EQUALReactome Database ID Release 75983367Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983367ReactomeR-HSA-9833671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983367.1class I MHC B82Reactome DB_ID: 98332925EQUAL362EQUALReactome Database ID Release 75983329Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983329ReactomeR-HSA-9833291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983329.1HLA-CHLA class I histocompatibility antigen, Cw-1 alpha chain1C01_HUMANReactome DB_ID: 222089925EQUAL366EQUALReactome Database ID Release 752220899Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220899ReactomeR-HSA-22208991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220899.1HLA-CHLA class I histocompatibility antigen, Cw-12 alpha chain1C12_HUMANReactome DB_ID: 222089825EQUAL366EQUALReactome Database ID Release 752220898Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220898ReactomeR-HSA-22208981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220898.1HLA-CHLA class I histocompatibility antigen, Cw-14 alpha chain1C14_HUMANReactome DB_ID: 222090025EQUAL366EQUALReactome Database ID Release 752220900Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220900ReactomeR-HSA-22209001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220900.1HLA-CHLA class I histocompatibility antigen, Cw-15 alpha chain1C15_HUMANReactome DB_ID: 222090525EQUAL366EQUALReactome Database ID Release 752220905Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220905ReactomeR-HSA-22209051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220905.1HLA-CHLA class I histocompatibility antigen, Cw-16 alpha chain1C16_HUMANReactome DB_ID: 222089625EQUAL366EQUALReactome Database ID Release 752220896Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220896ReactomeR-HSA-22208961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220896.1HLA-CHLA class I histocompatibility antigen, Cw-17 alpha chain1C17_HUMANReactome DB_ID: 222090225EQUAL372EQUALReactome Database ID Release 752220902Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220902ReactomeR-HSA-22209021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220902.1HLA-CHLA class I histocompatibility antigen, Cw-18 alpha chain1C18_HUMANReactome DB_ID: 222089725EQUAL366EQUALReactome Database ID Release 752220897Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220897ReactomeR-HSA-22208971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220897.1HLA-CHLA class I histocompatibility antigen, Cw-2 alpha chain1C02_HUMANReactome DB_ID: 222090325EQUAL366EQUALReactome Database ID Release 752220903Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220903ReactomeR-HSA-22209031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220903.1HLA-CHLA class I histocompatibility antigen, Cw-8 alpha chain1C08_HUMANReactome DB_ID: 222090125EQUAL366EQUALReactome Database ID Release 752220901Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2220901ReactomeR-HSA-22209011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2220901.1HLA-AHLA class I histocompatibility antigen, A-11 alpha chain1A11_HUMANReactome DB_ID: 331826125EQUAL365EQUALReactome Database ID Release 753318261Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318261ReactomeR-HSA-33182611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318261.1HLA-AHLA class I histocompatibility antigen, A-23 alpha chain1A23_HUMANReactome DB_ID: 331826025EQUAL365EQUALReactome Database ID Release 753318260Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318260ReactomeR-HSA-33182601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318260.1HLA-AHLA class I histocompatibility antigen, A-24 alpha chain1A24_HUMANReactome DB_ID: 331825125EQUAL365EQUALReactome Database ID Release 753318251Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318251ReactomeR-HSA-33182511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318251.1HLA-AHLA class I histocompatibility antigen, A-25 alpha chain1A25_HUMANReactome DB_ID: 331824525EQUAL365EQUALReactome Database ID Release 753318245Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318245ReactomeR-HSA-33182451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318245.1HLA-AHLA class I histocompatibility antigen, A-26 alpha chain1A26_HUMANReactome DB_ID: 331825025EQUAL365EQUALReactome Database ID Release 753318250Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318250ReactomeR-HSA-33182501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318250.1HLA-AHLA class I histocompatibility antigen, A-29 alpha chain1A29_HUMANReactome DB_ID: 331824625EQUAL365EQUALReactome Database ID Release 753318246Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318246ReactomeR-HSA-33182461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318246.1HLA-AHLA class I histocompatibility antigen, A-30 alpha chain1A30_HUMANReactome DB_ID: 331824925EQUAL365EQUALReactome Database ID Release 753318249Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318249ReactomeR-HSA-33182491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318249.1HLA-AHLA class I histocompatibility antigen, A-31 alpha chain1A31_HUMANReactome DB_ID: 331825425EQUAL365EQUALReactome Database ID Release 753318254Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318254ReactomeR-HSA-33182541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318254.1HLA-AHLA class I histocompatibility antigen, A-32 alpha chain1A32_HUMANReactome DB_ID: 331824725EQUAL365EQUALReactome Database ID Release 753318247Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318247ReactomeR-HSA-33182471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318247.1HLA-AHLA class I histocompatibility antigen, A-33 alpha chain1A33_HUMANReactome DB_ID: 331825225EQUAL365EQUALReactome Database ID Release 753318252Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318252ReactomeR-HSA-33182521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318252.1HLA-AHLA class I histocompatibility antigen, A-34 alpha chain1A34_HUMANReactome DB_ID: 331824425EQUAL365EQUALReactome Database ID Release 753318244Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318244ReactomeR-HSA-33182441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318244.1HLA-AHLA class I histocompatibility antigen, A-36 alpha chain1A36_HUMANReactome DB_ID: 331825325EQUAL365EQUALReactome Database ID Release 753318253Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318253ReactomeR-HSA-33182531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318253.1HLA-AHLA class I histocompatibility antigen, A-43 alpha chain1A43_HUMANReactome DB_ID: 331825525EQUAL365EQUALReactome Database ID Release 753318255Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318255ReactomeR-HSA-33182551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318255.1HLA-AHLA class I histocompatibility antigen, A-66 alpha chain1A66_HUMANReactome DB_ID: 331825925EQUAL365EQUALReactome Database ID Release 753318259Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318259ReactomeR-HSA-33182591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318259.1HLA-AHLA class I histocompatibility antigen, A-68 alpha chain1A68_HUMANReactome DB_ID: 331826225EQUAL365EQUALReactome Database ID Release 753318262Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318262ReactomeR-HSA-33182621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318262.1HLA-AHLA class I histocompatibility antigen, A-69 alpha chain1A69_HUMANReactome DB_ID: 33182481EQUAL365EQUALReactome Database ID Release 753318248Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318248ReactomeR-HSA-33182481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318248.1HLA-AHLA class I histocompatibility antigen, A-74 alpha chain1A74_HUMANReactome DB_ID: 331825725EQUAL365EQUALReactome Database ID Release 753318257Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318257ReactomeR-HSA-33182571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318257.1HLA-AHLA class I histocompatibility antigen, A-80 alpha chain1A80_HUMANReactome DB_ID: 331825625EQUAL365EQUALReactome Database ID Release 753318256Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3318256ReactomeR-HSA-33182561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3318256.1HLA-BHLA class I histocompatibility antigen, B-48 alpha chain1B48_HUMANReactome DB_ID: 8855897