BioPAX pathway converted from "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane" in the Reactome database.
LEFT-TO-RIGHT
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane
This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>
Arrb1
Reactome DB_ID: 5632461
cytosol
GENE ONTOLOGY
GO:0005829
UniProt:Q8BWG8 Arrb1
Arrb1
FUNCTION Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in IL8-mediated granule release in neutrophils. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates in the recruitment of the ubiquitin-protein ligase to the receptor (PubMed:23886940).SUBUNIT Monomer. Homodimer. Homooligomer; the self-association is mediated by InsP6-binding. Heterooligomer with ARRB2; the association is mediated by InsP6-binding. Interacts with ADRB2 (phosphorylated). Interacts with CHRM2 (phosphorylated). Interacts with LHCGR. Interacts with CYTH2 and CASR. Interacts with AP2B1 (dephosphorylated); phosphorylation of AP2B1 disrupts the interaction. Interacts (dephosphorylated at Ser-412) with CLTC. Interacts with CCR2 and GRK2. Interacts with CRR5. Interacts with PTAFR (phosphorylated on serine residues). Interacts with CLTC and MAP2K3. Interacts with CREB1. Interacts with TRAF6. Interacts with IGF1R and MDM2. Interacts with C5AR1. Interacts with PDE4D. Interacts with SRC (via the SH3 domain and the protein kinase domain); the interaction is independent of the phosphorylation state of SRC C-terminus. Interacts with TACR1. Interacts with RAF1. Interacts with DVL1; the interaction is enhanced by phosphorylation of DVL1. Interacts with DVL2; the interaction is enhanced by phosphorylation of DVL2. Interacts with IGF1R. Interacts with CHUK, IKBKB and MAP3K14. Associates with MAP kinase p38. Part of a MAPK signaling complex consisting of TACR1, ARRB1, SRC, MAPK1 (activated) and MAPK3 (activated). Part of a MAPK signaling complex consisting of F2RL1, ARRB1, RAF1, MAPK1 (activated) and MAPK3 (activated). Interacts with GPR143 (By similarity). Interacts with MAP2K4/MKK4. Interacts with HCK and CXCR1 (phosphorylated) (By similarity). Interacts with ACKR3 and ACKR4 (By similarity). Interacts with ARRDC1; the interaction is direct (PubMed:23886940). Interacts with GPR61, GPR62 and GPR135 (By similarity).DOMAIN The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1. Binding to phosphorylated GPCRs induces a conformationanl change that exposes the motif to the surface (By similarity).DOMAIN The N-terminus binds InsP6 with low affinity.DOMAIN The C-terminus binds InsP6 with high affinity.PTM Constitutively phosphorylated at in the cytoplasm. At the plasma membrane, is rapidly dephosphorylated, a process that is required for clathrin binding and ADRB2 endocytosis but not for ADRB2 binding and desensitization. Once internalized, is rephosphorylated (By similarity).PTM The ubiquitination status appears to regulate the formation and trafficking of beta-arrestin-GPCR complexes and signaling. Ubiquitination appears to occur GPCR-specific. Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2. Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex. Stimulation of a class A GPCR, such as ADRB2, induces transient ubiquitination and subsequently promotes association with USP33 (By similarity).SIMILARITY Belongs to the arrestin family.
Mus musculus
NCBI Taxonomy
10090
UniProt
Q8BWG8
1
EQUAL
418
EQUAL
Reactome Database ID Release 83
5632461
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632461
Reactome
R-MMU-5632461
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5632461.1
Reactome
http://www.reactome.org
Converted from EntitySet in Reactome
Lysosome Destined Cargo
Reactome DB_ID: 9852757
M6pr
M6PR
P24668
Reactome DB_ID: 9852753
Golgi membrane
GENE ONTOLOGY
GO:0000139
UniProt:P24668
M6pr
UniProt
P24668
27
EQUAL
277
EQUAL
Reactome Database ID Release 83
9852753
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9852753
Reactome
R-MMU-429824
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-429824.1
O55102
Bloc1s1
BLOC1S1
Reactome DB_ID: 9852755
UniProt:O55102
Bloc1s1
UniProt
O55102
1
EQUAL
153
EQUAL
Reactome Database ID Release 83
9852755
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9852755
Reactome
R-MMU-434324
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-434324.1
Reactome Database ID Release 83
9852757
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9852757
Reactome
R-MMU-432690
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-432690.1
AP-1 Complex
Reactome DB_ID: 9851001
Converted from EntitySet in Reactome
AP-1 sigma
Reactome DB_ID: 9850997
Ap1s1
AP1S1
P61967
Reactome DB_ID: 9850991
UniProt:P61967
Ap1s1
UniProt
P61967
1
EQUAL
158
EQUAL
Reactome Database ID Release 83
9850991
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850991
Reactome
R-MMU-167696
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167696.1
Ap1s2
AP1S2
Q9DB50
Reactome DB_ID: 9850993
UniProt:Q9DB50
Ap1s2
UniProt
Q9DB50
1
EQUAL
157
EQUAL
Reactome Database ID Release 83
9850993
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850993
Reactome
R-MMU-167695
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167695.1
Ap1s3
AP1S3
Q7TN05
Reactome DB_ID: 9850995
UniProt:Q7TN05
Ap1s3
UniProt
Q7TN05
1
EQUAL
154
EQUAL
Reactome Database ID Release 83
9850995
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850995
Reactome
R-MMU-167692
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167692.1
Reactome Database ID Release 83
9850997
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850997
Reactome
R-MMU-167713
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167713.1
1
Converted from EntitySet in Reactome
AP-1 mu
Reactome DB_ID: 9850989
Ap1m1
AP1M1
P35585
Reactome DB_ID: 9850985
UniProt:P35585
Ap1m1
UniProt
P35585
2
EQUAL
423
EQUAL
Reactome Database ID Release 83
9850985
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850985
Reactome
R-MMU-167700
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167700.1
Ap1m2
AP1M2
Q9WVP1
Reactome DB_ID: 9850987
UniProt:Q9WVP1
Ap1m2
UniProt
Q9WVP1
1
EQUAL
423
EQUAL
Reactome Database ID Release 83
9850987
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850987
Reactome
R-MMU-167699
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167699.1
Reactome Database ID Release 83
9850989
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850989
Reactome
R-MMU-167716
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167716.1
1
Ap1g1
AP1G1
P22892
Reactome DB_ID: 9850983
UniProt:P22892
Ap1g1
UniProt
P22892
2
EQUAL
822
EQUAL
Reactome Database ID Release 83
9850983
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850983
Reactome
R-MMU-167703
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167703.1
1
Ap1b1
AP1B1
O35643
Reactome DB_ID: 9850999
UniProt:O35643
Ap1b1
UniProt
O35643
1
EQUAL
949
EQUAL
Reactome Database ID Release 83
9850999
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850999
Reactome
R-MMU-167705
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167705.1
1
Reactome Database ID Release 83
9851001
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9851001
Reactome
R-MMU-167717
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167717.1
Arf1-GTP
Reactome DB_ID: 9843946
ARF1
P84078
Reactome DB_ID: 9843944
UniProt:P84078
UniProt
P84078
2
EQUAL
181
EQUAL
Reactome Database ID Release 83
9843944
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9843944
Reactome
R-MMU-199971
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-199971.1
1
GTP
Guanosine 5'-triphosphate
GTP)(4-)
Reactome DB_ID: 29438
GTP(4-) [ChEBI:37565]
GTP(4-)
GTP
gtp
guanosine 5'-triphosphate(4-)
ChEBI
CHEBI:37565
Reactome Database ID Release 83
29438
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438
Reactome
R-ALL-29438
4
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.4
COMPOUND
C00044
additional information
MI
MI:0361
1
Reactome Database ID Release 83
9843946
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9843946
Reactome
R-MMU-199981
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-199981.1
Converted from EntitySet in Reactome
Vamp
Reactome DB_ID: 9850861
Vamp2
VAMP2
P63044
Reactome DB_ID: 9850857
UniProt:P63044 Vamp2
Vamp2
Syb2
FUNCTION Involved in the targeting and/or fusion of transport vesicles to their target membrane (PubMed:9430681). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (PubMed:15475946). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity).SUBUNIT Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A (PubMed:19196426). This complex binds to CPLX1. Interacts with VAPA and VAPB (By similarity). Interacts (via N-terminus) with KCNB1 (via N-terminus and C-terminus); stimulates the channel inactivation rate of KCNB1 (By similarity). Interacts with BVES and STX4. Interacts with WDFY2, PRKCZ and PRKCI (PubMed:17313651). Forms a complex with WDFY2 and PRKCZ (PubMed:17313651). Interacts with SEPT8; the interaction inhibits interaction of VAMP2 with SYP (PubMed:19196426). Interacts with SYP; the interaction is inhibited by interaction with SEPT8 (PubMed:19196426). Interacts with PICALM (By similarity). Interacts with alpha-synuclein/SNCA. Interacts with STX3 isoform 3B (PubMed:26406599).TISSUE SPECIFICITY Expressed in the outer plexiform layer of the retina (at protein level).PTM Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2.PTM (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB); 20 hours after treatment of spinal cord cells almost all the protein has been digested (PubMed:10413679). BoNT/B hydrolyzes the 76-Gln-|-Phe-77 bond and inhibits neurotransmitter release (Probable).PTM (Microbial infection) Targeted and hydrolyzed by C.tetani toxin (tetX); 20 hours after treatment of spinal cord cells almost all the protein has been digested (PubMed:10413679). Tetanus toxin hydrolyzes the 76-Gln-|-Phe-77 bond and inhibits neurotransmitter release (Probable).SIMILARITY Belongs to the synaptobrevin family.
UniProt
P63044
2
EQUAL
116
EQUAL
Reactome Database ID Release 83
9850857
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850857
Reactome
R-MMU-375425
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375425.1
Vamp8
VAMP8
O70404
Reactome DB_ID: 9850859
UniProt:O70404
Vamp8
UniProt
O70404
1
EQUAL
100
EQUAL
Reactome Database ID Release 83
9850859
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850859
Reactome
R-MMU-266201
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-266201.1
Reactome Database ID Release 83
9850861
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850861
Reactome
R-MMU-432668
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-432668.1
Converted from EntitySet in Reactome
Lysosome Destined Cargo
Reactome DB_ID: 9852767
Ctsz
CTSZ
Q9WUU7
Reactome DB_ID: 9852759
Golgi lumen
GENE ONTOLOGY
GO:0005796
UniProt:Q9WUU7
Ctsz
UniProt
Q9WUU7
62
EQUAL
303
EQUAL
Reactome Database ID Release 83
9852759
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9852759
Reactome
R-MMU-434321
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-434321.1
Dnase2
DNASE2
P56542
Reactome DB_ID: 9852761
UniProt:P56542
Dnase2
UniProt
P56542
19
EQUAL
360
EQUAL
Reactome Database ID Release 83
9852761
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9852761
Reactome
R-MMU-434322
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-434322.1
Txndc5
TXNDC5
Q91W90
Reactome DB_ID: 9852763
UniProt:Q91W90
Txndc5
UniProt
Q91W90
33
EQUAL
432
EQUAL
Reactome Database ID Release 83
9852763
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9852763
Reactome
R-MMU-434325
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-434325.1
GNS
Q8BFR4
Reactome DB_ID: 9852765
UniProt:Q8BFR4
UniProt
Q8BFR4
37
EQUAL
552
EQUAL
Reactome Database ID Release 83
9852765
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9852765
Reactome
R-MMU-434323
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-434323.1
Reactome Database ID Release 83
9852767
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9852767
Reactome
R-MMU-435031
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-435031.1
Lysosome Destined Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex
Reactome DB_ID: 9852769
1
AP-1 Complex
Reactome DB_ID: 9850853
Converted from EntitySet in Reactome
AP-1 mu
Reactome DB_ID: 9850833
Ap1m1
AP1M1
P35585
Reactome DB_ID: 9850827
2
EQUAL
423
EQUAL
Reactome Database ID Release 83
9850827
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850827
Reactome
R-MMU-350805
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350805.1
Ap1m2
AP1M2
Q9WVP1
Reactome DB_ID: 9850831
1
EQUAL
423
EQUAL
Reactome Database ID Release 83
9850831
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850831
Reactome
R-MMU-350813
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350813.1
Reactome Database ID Release 83
9850833
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850833
Reactome
R-MMU-350815
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350815.1
1
Ap1b1
AP1B1
O35643
Reactome DB_ID: 9850851
1
EQUAL
949
EQUAL
Reactome Database ID Release 83
9850851
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850851
Reactome
R-MMU-350809
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350809.1
1
Converted from EntitySet in Reactome
AP-1 sigma
Reactome DB_ID: 9850847
Ap1s1
AP1S1
P61967
Reactome DB_ID: 9850837
1
EQUAL
158
EQUAL
Reactome Database ID Release 83
9850837
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850837
Reactome
R-MMU-350804
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350804.1
Ap1s2
AP1S2
Q9DB50
Reactome DB_ID: 9850841
1
EQUAL
157
EQUAL
Reactome Database ID Release 83
9850841
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850841
Reactome
R-MMU-350812
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350812.1
Ap1s3
AP1S3
Q7TN05
Reactome DB_ID: 9850845
1
EQUAL
154
EQUAL
Reactome Database ID Release 83
9850845
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850845
Reactome
R-MMU-350806
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350806.1
Reactome Database ID Release 83
9850847
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850847
Reactome
R-MMU-350807
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350807.1
1
Ap1g1
AP1G1
P22892
Reactome DB_ID: 9850823
2
EQUAL
822
EQUAL
Reactome Database ID Release 83
9850823
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850823
Reactome
R-MMU-350808
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350808.1
1
Reactome Database ID Release 83
9850853
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850853
Reactome
R-MMU-350811
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350811.1
1
1
1
ARRB1
Q8BWG8
Reactome DB_ID: 9850855
1
EQUAL
418
EQUAL
Reactome Database ID Release 83
9850855
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9850855
Reactome
R-MMU-350831
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350831.1
1
1
Reactome Database ID Release 83
9852769
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9852769
Reactome
R-MMU-432700
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-432700.1
Reactome Database ID Release 83
9852780
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9852780
Reactome
R-MMU-432712
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-432712.1
Once AP-1 is recruited to the trans-Golgi Network membrane the complex of functional vesicle building proteins is joined by the cargo that will be within that vesicle. As with other types of vesicles the cargo itself is part of the vesicle development. Here the cargo is destined for the lysosome membrane. It is at this stage that a specific Synaptobrevin (Vamp) molecule also joins the complex. It should be noted that only certain Vamp molecules will be found with specific cargo molecules on the newly forming vesicles. However here we represent this reaction in bulk, without specific Vamp and cargo molecule pairings.
11994746
Pubmed
2002
Regulated transport of the glucose transporter GLUT4.
Bryant, NJ
Govers, R
James, DE
Nat Rev Mol Cell Biol 3:267-77
17116749
Pubmed
2006
Comparative proteomics of clathrin-coated vesicles
Borner, GH
Harbour, M
Hester, S
Lilley, KS
Robinson, MS
J Cell Biol 175:571-8
11694590
Pubmed
2001
GGAs: roles of the different domains and comparison with AP-1 and clathrin
Hirst, J
Lindsay, MR
Robinson, MS
Mol Biol Cell 12:3573-88
inferred from electronic annotation
EVIDENCE CODE
ECO:0000203