BioPAX pathway converted from "Transport of vitamins, nucleosides, and related molecules" in the Reactome database. Transport of vitamins, nucleosides, and related molecules This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT Na+-dependent multivitamin transporter SLC5A6 transports vitamins from extracellular region to cytosol This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Na+ sodium ion sodium(1+) Sodium Reactome DB_ID: 74113 extracellular region GENE ONTOLOGY GO:0005576 sodium(1+) [ChEBI:29101] sodium(1+) ChEBI CHEBI:29101 Reactome Database ID Release 78 74113 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74113 Reactome R-ALL-74113 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74113.3 Reactome http://www.reactome.org COMPOUND C01330 additional information MI MI:0361 2 Converted from EntitySet in Reactome vitamins transported by SMVT Reactome DB_ID: 429605 Btn D-Biotin biotin Vitamin H Coenzyme R Reactome DB_ID: 199238 biotin [ChEBI:15956] biotin ChEBI CHEBI:15956 Reactome Database ID Release 78 199238 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=199238 Reactome R-ALL-199238 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-199238.3 COMPOUND C00120 LIPA Lipoate lipoic acid Reactome DB_ID: 429590 lipoic acid [ChEBI:16494] lipoic acid ChEBI CHEBI:16494 Reactome Database ID Release 78 429590 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429590 Reactome R-ALL-429590 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-429590.3 PanK Pantothenate pantothenic acid Reactome DB_ID: 199192 pantothenic acid [ChEBI:7916] pantothenic acid ChEBI CHEBI:7916 Reactome Database ID Release 78 199192 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=199192 Reactome R-ALL-199192 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-199192.3 COMPOUND C00864 Reactome Database ID Release 78 429605 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429605 Reactome R-ALL-429605 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-429605.1 Converted from EntitySet in Reactome vitamins transported by SMVT Reactome DB_ID: 429627 Btn D-Biotin biotin Vitamin H Coenzyme R Reactome DB_ID: 199207 cytosol GENE ONTOLOGY GO:0005829 Reactome Database ID Release 78 199207 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=199207 Reactome R-ALL-199207 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-199207.3 COMPOUND C00120 LIPA Lipoate lipoic acid Reactome DB_ID: 429608 Reactome Database ID Release 78 429608 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429608 Reactome R-ALL-429608 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-429608.3 PanK Pantothenate pantothenic acid Vitamin B5 Reactome DB_ID: 196820 Reactome Database ID Release 78 196820 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196820 Reactome R-ALL-196820 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-196820.4 COMPOUND C00864 Reactome Database ID Release 78 429627 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429627 Reactome R-ALL-429627 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-429627.1 Na+ sodium ion sodium(1+) Sodium Reactome DB_ID: 83910 Reactome Database ID Release 78 83910 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83910 Reactome R-ALL-83910 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83910.3 COMPOUND C01330 2 ACTIVATION SLC5A6:PDZD11 Reactome DB_ID: 9769903 plasma membrane GENE ONTOLOGY GO:0005886 Pdzd11 PDZD11 Q9CZG9 Reactome DB_ID: 9769897 UniProt:Q9CZG9 Pdzd11 Mus musculus NCBI Taxonomy 10090 UniProt Q9CZG9 1 EQUAL 140 EQUAL Reactome Database ID Release 78 9769897 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9769897 Reactome R-MMU-5358989 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5358989.1 1 Slc5a6 SLC5A6 Q5U4D8 Reactome DB_ID: 9769901 UniProt:Q5U4D8 Slc5a6 UniProt Q5U4D8 1 EQUAL 635 EQUAL Reactome Database ID Release 78 9769901 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9769901 Reactome R-MMU-199221 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-199221.1 1 Reactome Database ID Release 78 9769903 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9769903 Reactome R-MMU-5359005 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5359005.1 GENE ONTOLOGY GO:0008523 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 78 9769904 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9769904 Reactome Database ID Release 78 9783005 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9783005 Reactome R-MMU-429581 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-429581.1 Biotin (vitamin H or B7) is a water-soluble B-complex vitamin. Biotin is a cofactor in the metabolism of fatty acids and leucine, and it plays a role in gluconeogenesis. D-Pantothoate (vitamin B5), is a water-soluble vitamin needed to form coenzyme-A (CoA), and is critical in the metabolism and synthesis of carbohydrates, proteins, and fats. Lipoic acid is an organosulfur compound, the R-enantiomer of which is an essential cofactor for many enzyme complexes.<br><br>The human SLC5A6 encodes the Na+-dependent multivitamin transporter SMVT (Prasad PD et al, 1999; Wang H et al, 1999). SMVT co-transports these vitamins/cofactors into cells with Na+ ions electrogenically. PDZ domain-containing protein 11 (PDZD11 aka AIPP1) is a cytosolic protein with a single PDZ domain which can bind to the C-terminal class 1 PDZ binding motif of SMVT, resulting in a significant induction of vitamin uptake over that with SMVT alone (Nabokina et al. 2011). 10329687 Pubmed 1999 Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. Wang, H Huang, Wei Fei, YJ Xia, H Yang-Feng, TL Leibach, FH Devoe, LD Ganapathy, V Prasad, PD J Biol Chem 274:14875-83 21183659 Pubmed 2011 Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter Nabokina, Svetlana M Subramanian, VS Said, HM Am. J. Physiol. Gastrointest. Liver Physiol. 300:G561-7 10334869 Pubmed 1999 Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter Prasad, PD Wang, H Huang, Wei Fei, YJ Leibach, FH Devoe, LD Ganapathy, V Arch Biochem Biophys 366:95-106 inferred from electronic annotation EVIDENCE CODE ECO:0000203 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome ligands of SLC28A1 Reactome DB_ID: 179738 dA deoxyadenosine 2'-deoxyadenosine Reactome DB_ID: 83919 2'-deoxyadenosine [ChEBI:17256] 2'-deoxyadenosine deoxyadenosine ChEBI CHEBI:17256 Reactome Database ID Release 78 83919 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83919 Reactome R-ALL-83919 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83919.3 COMPOUND C00559 Ade-Rib adenosine Reactome DB_ID: 83908 adenosine [ChEBI:16335] adenosine ChEBI CHEBI:16335 Reactome Database ID Release 78 83908 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83908 Reactome R-ALL-83908 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83908.3 COMPOUND C00212 Cyt-Rib cytidine Reactome DB_ID: 83948 cytidine [ChEBI:17562] cytidine ChEBI CHEBI:17562 Reactome Database ID Release 78 83948 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83948 Reactome R-ALL-83948 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83948.3 COMPOUND C00475 Thy-dRib 2'-deoxythymidine thymidine Reactome DB_ID: 83922 thymidine [ChEBI:17748] thymidine ChEBI CHEBI:17748 Reactome Database ID Release 78 83922 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83922 Reactome R-ALL-83922 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83922.3 COMPOUND C00214 Ura-Rib uridine Reactome DB_ID: 83923 uridine [ChEBI:16704] uridine ChEBI CHEBI:16704 Reactome Database ID Release 78 83923 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83923 Reactome R-ALL-83923 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83923.3 COMPOUND C00299 Reactome Database ID Release 78 179738 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179738 Reactome R-ALL-179738 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179738.1 Converted from EntitySet in Reactome ligands of SLC28A1 Reactome DB_ID: 179739 dA deoxyadenosine 2'-deoxyadenosine Reactome DB_ID: 83925 Reactome Database ID Release 78 83925 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83925 Reactome R-ALL-83925 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83925.3 COMPOUND C00559 Ade-Rib ADENOCARD (TN) adenosine Reactome DB_ID: 83909 Reactome Database ID Release 78 83909 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83909 Reactome R-ALL-83909 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83909.3 COMPOUND C00212 Cyt-Rib cytidine Reactome DB_ID: 83949 Reactome Database ID Release 78 83949 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83949 Reactome R-ALL-83949 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83949.3 COMPOUND C00475 Thy-dRib 2'-deoxythymidine thymidine Deoxythymidine Reactome DB_ID: 83928 Reactome Database ID Release 78 83928 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83928 Reactome R-ALL-83928 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83928.3 COMPOUND C00214 Ura-Rib uridine Reactome DB_ID: 83929 Reactome Database ID Release 78 83929 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83929 Reactome R-ALL-83929 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83929.3 COMPOUND C00299 Reactome Database ID Release 78 179739 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179739 Reactome R-ALL-179739 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179739.1 ACTIVATION E9PXX9 Slc28a1 SLC28A1 Reactome DB_ID: 9757873 UniProt:E9PXX9 Slc28a1 UniProt E9PXX9 1 EQUAL 649 EQUAL Reactome Database ID Release 78 9757873 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757873 Reactome R-MMU-64023 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-64023.1 GENE ONTOLOGY GO:0005415 Reactome Database ID Release 78 9757874 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757874 Reactome Database ID Release 78 9757876 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757876 Reactome R-MMU-109530 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-109530.1 The plasma membrane-associated protein SLC28A1 mediates the transport of one molecule of 2'-deoxyadenosine, adenosine, cytidine, thymidine, or uridine, and one sodium ion, from the extracellular space to the cytosol. 9124315 Pubmed 1997 Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1) Ritzel, MW Yao, SY Huang, MY Elliott, JF Cass, CE Young, JD Am J Physiol Cell Physiol 272:707-714 LEFT-TO-RIGHT Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome ligands of SLC28A3 & 29A1 Reactome DB_ID: 179737 Gua-Rib guanosine Reactome DB_ID: 83920 guanosine [ChEBI:16750] guanosine ChEBI CHEBI:16750 Reactome Database ID Release 78 83920 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83920 Reactome R-ALL-83920 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83920.3 COMPOUND C00387 Ino inosine Reactome DB_ID: 83921 inosine [ChEBI:17596] inosine ChEBI CHEBI:17596 Reactome Database ID Release 78 83921 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83921 Reactome R-ALL-83921 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83921.3 COMPOUND C00294 Reactome Database ID Release 78 179737 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179737 Reactome R-ALL-179737 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179737.2 2 Converted from EntitySet in Reactome ligands of SLC28A3 & 29A1 Reactome DB_ID: 179743 Gua-Rib guanosine Reactome DB_ID: 83926 Reactome Database ID Release 78 83926 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83926 Reactome R-ALL-83926 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83926.3 COMPOUND C00387 Ino inosine Reactome DB_ID: 83927 Reactome Database ID Release 78 83927 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83927 Reactome R-ALL-83927 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83927.3 COMPOUND C00294 Reactome Database ID Release 78 179743 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179743 Reactome R-ALL-179743 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179743.2 2 ACTIVATION Q9ERH8 Slc28a3 SLC28A3 Reactome DB_ID: 9757887 UniProt:Q9ERH8 Slc28a3 UniProt Q9ERH8 1 EQUAL 691 EQUAL Reactome Database ID Release 78 9757887 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757887 Reactome R-MMU-83915 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-83915.1 Reactome Database ID Release 78 9757888 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757888 Reactome Database ID Release 78 9757890 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757890 Reactome R-MMU-109538 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-109538.1 The plasma membrane-associated protein SLC28A3 mediates the transport of one molecule of adenosine, cytidine, guanosine, inosine, thymidine, or uridine, and two sodium ions, from the extracellular space to the cytosol. 11032837 Pubmed 2001 Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib) Ritzel, MW Ng, AM Yao, SY Graham, K Loewen, SK Smith, KM Ritzel, RG Mowles, DA Carpenter, P Chen, XZ Karpinski, E Hyde, RJ Baldwin, SA Cass, CE Young, JD J Biol Chem 276:2914-2927 LEFT-TO-RIGHT Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome ligands of SLC28A2 Reactome DB_ID: 179740 Reactome Database ID Release 78 179740 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179740 Reactome R-ALL-179740 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179740.1 Converted from EntitySet in Reactome ligands of SLC28A2 Reactome DB_ID: 179741 Reactome Database ID Release 78 179741 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179741 Reactome R-ALL-179741 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179741.1 ACTIVATION O88627 Slc28a2 SLC28A2 Reactome DB_ID: 9757894 UniProt:O88627 Slc28a2 UniProt O88627 1 EQUAL 658 EQUAL Reactome Database ID Release 78 9757894 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757894 Reactome R-MMU-64025 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-64025.1 Reactome Database ID Release 78 9757895 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757895 Reactome Database ID Release 78 9757897 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757897 Reactome R-MMU-109539 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-109539.1 The plasma membrane-associated protein SLC28A2 mediates the transport of one molecule of adenosine, guanosine, inosine, or uridine, and one sodium ion, from the extracellular space to the cytosol. 9435697 Pubmed 1997 Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization Wang, J Su, SF Dresser, MJ Schaner, ME Washington, CB Giacomini, KM Am J Physiol Renal Physiol 273:1058-1065 10455109 Pubmed 1999 Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na+ nucleoside cotransporters hCNT1 and hCNT2 Loewen, SK Ng, AM Yao, SY Cass, CE Baldwin, SA Young, JD J Biol Chem 274:24475-24484 LEFT-TO-RIGHT Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ACTIVATION Converted from EntitySet in Reactome SLC29A1-like proteins Reactome DB_ID: 9757878 Q9JIM1 Slc29a1 SLC29A1 Reactome DB_ID: 9757862 UniProt:Q9JIM1 Slc29a1 UniProt Q9JIM1 2 EQUAL 456 EQUAL Reactome Database ID Release 78 9757862 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757862 Reactome R-MMU-54335 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-54335.1 Q61672 Slc29a2 SLC29A2 Reactome DB_ID: 9757858 UniProt:Q61672 Slc29a2 UniProt Q61672 1 EQUAL 456 EQUAL Reactome Database ID Release 78 9757858 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757858 Reactome R-MMU-54337 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-54337.1 Reactome Database ID Release 78 9757878 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757878 Reactome R-MMU-4127407 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4127407.1 GENE ONTOLOGY GO:0005337 Reactome Database ID Release 78 9757879 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757879 Reactome Database ID Release 78 9757881 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757881 Reactome R-MMU-109534 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-109534.1 The plasma membrane-associated protein SLC29A1 mediates the reversible transport of one molecule of adenosine, cytosine, guanosine, inosine, thymidine, or uridine from the extracellular space to the cytosol. 8986748 Pubmed 1997 Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs Griffiths, M Beaumont, N Yao, SY Sundaram, M Boumah, CE Davies, A Kwong, FY Coe, I Cass, CE Young, JD Baldwin, SA Nature Medicine89-93 LEFT-TO-RIGHT Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome ligands of SLC29A2 Reactome DB_ID: 179742 Ade 6-aminopurine adenine Reactome DB_ID: 83951 adenine [ChEBI:16708] adenine 6-aminopurine ChEBI CHEBI:16708 Reactome Database ID Release 78 83951 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83951 Reactome R-ALL-83951 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83951.3 COMPOUND C00147 Cyt cytosine Reactome DB_ID: 83924 cytosine [ChEBI:16040] cytosine ChEBI CHEBI:16040 Reactome Database ID Release 78 83924 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83924 Reactome R-ALL-83924 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83924.3 COMPOUND C00380 Gua 2-amino-6-hydroxypurine guanine Reactome DB_ID: 83956 guanine [ChEBI:16235] guanine 2-amino-6-hydroxypurine ChEBI CHEBI:16235 Reactome Database ID Release 78 83956 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83956 Reactome R-ALL-83956 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83956.3 COMPOUND C00242 Hyp hypoxanthine Purine-6-ol Reactome DB_ID: 113599 hypoxanthine [ChEBI:17368] hypoxanthine ChEBI CHEBI:17368 Reactome Database ID Release 78 113599 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113599 Reactome R-ALL-113599 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113599.4 COMPOUND C00262 Thy thymine Reactome DB_ID: 83960 thymine [ChEBI:17821] thymine ChEBI CHEBI:17821 Reactome Database ID Release 78 83960 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83960 Reactome R-ALL-83960 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83960.3 COMPOUND C00178 Ura uracil Reactome DB_ID: 83962 uracil [ChEBI:17568] uracil ChEBI CHEBI:17568 Reactome Database ID Release 78 83962 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83962 Reactome R-ALL-83962 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83962.3 COMPOUND C00106 Reactome Database ID Release 78 179742 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179742 Reactome R-ALL-179742 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179742.1 Converted from EntitySet in Reactome ligands of SLC29A2 Reactome DB_ID: 179747 Ade 6-aminopurine adenine Reactome DB_ID: 83947 Reactome Database ID Release 78 83947 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83947 Reactome R-ALL-83947 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83947.3 COMPOUND C00147 Cyt cytosine Reactome DB_ID: 83918 Reactome Database ID Release 78 83918 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83918 Reactome R-ALL-83918 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83918.3 COMPOUND C00380 Gua 2-amino-6-hydroxypurine guanine Reactome DB_ID: 83955 Reactome Database ID Release 78 83955 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83955 Reactome R-ALL-83955 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83955.3 COMPOUND C00242 Hyp hypoxanthine Reactome DB_ID: 83957 Reactome Database ID Release 78 83957 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83957 Reactome R-ALL-83957 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83957.3 COMPOUND C00262 Thy thymine Reactome DB_ID: 83959 Reactome Database ID Release 78 83959 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83959 Reactome R-ALL-83959 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83959.3 COMPOUND C00178 Ura uracil Reactome DB_ID: 83961 Reactome Database ID Release 78 83961 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83961 Reactome R-ALL-83961 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83961.3 COMPOUND C00106 Reactome Database ID Release 78 179747 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179747 Reactome R-ALL-179747 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179747.1 ACTIVATION Converted from EntitySet in Reactome SLC29A2-like proteins Reactome DB_ID: 9757864 Reactome Database ID Release 78 9757864 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757864 Reactome R-MMU-3907272 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3907272.1 Reactome Database ID Release 78 9757865 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757865 Reactome Database ID Release 78 9757869 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757869 Reactome R-MMU-109529 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-109529.1 The plasma membrane-associated protein SLC29A2 mediates the reversible transport of one molecule of adenine, adenosine, cytidine, cytosine, guanine, guanosine, hypoxanthine, inosine, thymidine, thymine, uracil, or uridine from the cytosol to the extracellular space. 9478986 Pubmed 1998 Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line Crawford, CR Patel, DH Naeve, C Belt, JA J Biol Chem 273:5288-5293 LEFT-TO-RIGHT Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ACTIVATION Reactome Database ID Release 78 9757883 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757883 Reactome R-MMU-109536 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-109536.1 The plasma membrane-associated protein SLC29A1 mediates the reversible transport of one molecule of adenosine, guanosine, inosine, or uridine from the cytosol to the extracellular space. LEFT-TO-RIGHT Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ACTIVATION Reactome Database ID Release 78 9757867 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757867 Reactome R-MMU-109527 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-109527.1 The plasma membrane-associated protein SLC29A2 mediates the reversible transport of one molecule of adenine, adenosine, cytidine, cytosine, guanine, guanosine, hypoxanthine, inosine, thymidine, thymine, uracil, or uridine from the extracellular space to the cytosol. LEFT-TO-RIGHT SLC29A3 transports nucleosides from lysosomal lumen to cytosol Equilibrative transport (export) of nucleosides and adenine by solute carrier family 29 (nucleoside transporters), member 3 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome nucleosides SLC29A3 substrates Reactome DB_ID: 727782 Ade-Rib adenosine Reactome DB_ID: 727755 lysosomal lumen GENE ONTOLOGY GO:0043202 Reactome Database ID Release 78 727755 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727755 Reactome R-ALL-727755 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727755.3 COMPOUND C00212 Cyt-Rib cytidine Reactome DB_ID: 727758 Reactome Database ID Release 78 727758 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727758 Reactome R-ALL-727758 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727758.3 COMPOUND C00475 Gua-Rib guanosine Reactome DB_ID: 727743 Reactome Database ID Release 78 727743 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727743 Reactome R-ALL-727743 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727743.3 COMPOUND C00387 Ino inosine Reactome DB_ID: 727739 Reactome Database ID Release 78 727739 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727739 Reactome R-ALL-727739 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727739.3 COMPOUND C00294 Thy-dRib 2'-deoxythymidine thymidine Deoxythymidine Reactome DB_ID: 727735 Reactome Database ID Release 78 727735 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727735 Reactome R-ALL-727735 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727735.3 COMPOUND C00214 Ura-Rib uridine Reactome DB_ID: 727787 Reactome Database ID Release 78 727787 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727787 Reactome R-ALL-727787 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727787.3 COMPOUND C00299 Ade 6-aminopurine adenine Reactome DB_ID: 727751 Reactome Database ID Release 78 727751 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727751 Reactome R-ALL-727751 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727751.3 COMPOUND C00147 Reactome Database ID Release 78 727782 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727782 Reactome R-ALL-727782 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727782.1 Converted from EntitySet in Reactome nucleosides SLC29A3 substrates Reactome DB_ID: 727746 Reactome Database ID Release 78 727746 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727746 Reactome R-ALL-727746 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727746.1 ACTIVATION Q99P65 Slc29a3 SLC29A3 Reactome DB_ID: 9787406 lysosomal membrane GENE ONTOLOGY GO:0005765 UniProt:Q99P65 Slc29a3 UniProt Q99P65 1 EQUAL 475 EQUAL Reactome Database ID Release 78 9787406 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787406 Reactome R-MMU-727733 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-727733.1 Reactome Database ID Release 78 9787407 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787407 Reactome Database ID Release 78 9787409 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787409 Reactome R-MMU-727749 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-727749.1 The human gene SLC29A3 encodes the equilibrative nucleoside transporter 3 (ENT3). It is abundant in many tissues, especially the placenta and is localized intracellularly on the lysosomal membrane. SLC29A3 mediates the reversible transport of nucleosides and the nucleobase adenine (Baldwin et al. 2005). Defects in SLC29A3 can cause histiocytosis-lymphadenopathy plus syndrome (HLAS; MIM:602782), an autosomal recessive disorder characterised by combined features from 2 or more of four histiocytic disorders (Molho-Pessach et al. 2008). 18940313 Pubmed 2008 The H syndrome is caused by mutations in the nucleoside transporter hENT3 Molho-Pessach, V Lerer, I Abeliovich, Dvorah Agha, Z Abu Libdeh, Abdulasalam Broshtilova, V Elpeleg, O Zlotogorski, A Am J Hum Genet 83:529-34 15701636 Pubmed 2005 Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes Baldwin, SA Yao, SY Hyde, RJ Ng, AM Foppolo, S Barnes, K Ritzel, MW Cass, CE Young, JD J Biol Chem 280:15880-7 LEFT-TO-RIGHT SLC29A3 transports nucleosides from cytosol to lysosomal lumen Equilibrative transport (import) of nucleosides and adenine by solute carrier family 29 (nucleoside transporters), member 3 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ACTIVATION Reactome Database ID Release 78 9787418 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787418 Reactome R-MMU-727767 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-727767.1 The human gene SLC29A3 encodes the equilibrative nucleoside transporter 3 (ENT3). It is abundant in many tissues, especially the placenta and is localized intracellularly on the lysosomal membrane. SLC29A3 mediates the reversible transport of nucleosides and the nucleobase adenine (Baldwin et al. 2005). Defects in SLC29A3 can cause histiocytosis-lymphadenopathy plus syndrome (HLAS; MIM:602782), an autosomal recessive disorder characterised by combined features from 2 or more of four histiocytic disorders (Molho-Pessach et al. 2008). LEFT-TO-RIGHT Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome ligands of SLC29A4 Reactome DB_ID: 727737 DA dopamine Reactome DB_ID: 159362 dopamine [ChEBI:18243] dopamine ChEBI CHEBI:18243 Reactome Database ID Release 78 159362 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159362 Reactome R-ALL-159362 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-159362.3 COMPOUND C03758 5HT 5-Hydroxytryptamine serotonin 3-(2-Aminoethyl)-1H-indol-5-ol Enteramine Reactome DB_ID: 209914 serotonin [ChEBI:28790] serotonin ChEBI CHEBI:28790 Reactome Database ID Release 78 209914 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=209914 Reactome R-ALL-209914 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-209914.3 COMPOUND C00780 ADR Adrenaline (R)-adrenaline Epinephrine Reactome DB_ID: 209794 (R)-adrenaline [ChEBI:28918] (R)-adrenaline ChEBI CHEBI:28918 Reactome Database ID Release 78 209794 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=209794 Reactome R-ALL-209794 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-209794.3 COMPOUND C00788 NAd Noradrenaline (R)-noradrenaline Norepinephrine Reactome DB_ID: 209789 (R)-noradrenaline [ChEBI:18357] (R)-noradrenaline ChEBI CHEBI:18357 Reactome Database ID Release 78 209789 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=209789 Reactome R-ALL-209789 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-209789.3 COMPOUND C00547 Reactome Database ID Release 78 727737 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727737 Reactome R-ALL-727737 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727737.1 Converted from EntitySet in Reactome ligands of SLC29A4 Reactome DB_ID: 727774 DA dopamine Reactome DB_ID: 380873 Reactome Database ID Release 78 380873 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=380873 Reactome R-ALL-380873 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-380873.3 COMPOUND C03758 ADR Adrenaline (R)-adrenaline Epinephrine Reactome DB_ID: 549254 Reactome Database ID Release 78 549254 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=549254 Reactome R-ALL-549254 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-549254.3 COMPOUND C00788 NAd Noradrenaline (R)-noradrenaline Norepinephrine Reactome DB_ID: 374935 Reactome Database ID Release 78 374935 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=374935 Reactome R-ALL-374935 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-374935.3 COMPOUND C00547 5HT 5-Hydroxytryptamine serotonin 3-(2-Aminoethyl)-1H-indol-5-ol Enteramine Reactome DB_ID: 114523 Reactome Database ID Release 78 114523 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114523 Reactome R-ALL-114523 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-114523.3 COMPOUND C00780 Reactome Database ID Release 78 727774 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727774 Reactome R-ALL-727774 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727774.1 ACTIVATION Q8R139 Slc29a4 SLC29A4 Reactome DB_ID: 9787399 UniProt:Q8R139 Slc29a4 UniProt Q8R139 1 EQUAL 530 EQUAL Reactome Database ID Release 78 9787399 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787399 Reactome R-MMU-727736 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-727736.1 Reactome Database ID Release 78 9787400 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787400 Reactome Database ID Release 78 9787420 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787420 Reactome R-MMU-727768 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-727768.1 The human gene SLC29A4 encodes the equilibrative nucleoside transporter 4 (ENT4). It is ubiquitously expressed and mediates the reversible transport of the nucleoside adenosine at acidic pH (this transport is absent at pH 7.4) (Barnes K et al, 2006). ENT4 has also been shown to mediate the transport of biogenic amines such as serotonin, dopamine, norepinephrine and epinephrine. For this reason, ENT4 is also known as the plasma membrane monoamine transporter (PMAT) (Engel K et al, 2004). 16873718 Pubmed 2006 Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH Barnes, K Dobrzynski, H Foppolo, S Beal, PR Ismat, F Scullion, ER Sun, L Tellez, J Ritzel, MW Claycomb, WC Cass, CE Young, JD Billeter-Clark, R Boyett, MR Baldwin, SA Circ Res 99:510-9 15448143 Pubmed 2004 Identification and characterization of a novel monoamine transporter in the human brain Engel, K Zhou, Ming Wang, J J Biol Chem 279:50042-9 LEFT-TO-RIGHT Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ACTIVATION Reactome Database ID Release 78 9787402 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787402 Reactome R-MMU-727740 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-727740.1 The human gene SLC29A4 encodes the equilibrative nucleoside transporter 4 (ENT4). It is ubiquitously expressed and mediates the reversible transport of the nucleoside adenosine at acidic pH (this transport is absent at pH 7.4) (Barnes K et al, 2006). ENT4 has also been shown to mediate the transport of biogenic amines such as serotonin, dopamine, norepinephrine and epinephrine. For this reason, ENT4 is also known as the plasma membrane monoamine transporter (PMAT) (Engel K et al, 2004). LEFT-TO-RIGHT ARL2:GTP binds ARL2BP This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ARL2:GTP Reactome DB_ID: 9821878 Arl2 ARL2 Q9D0J4 Reactome DB_ID: 9821876 UniProt:Q9D0J4 Arl2 UniProt Q9D0J4 2 EQUAL 184 EQUAL Reactome Database ID Release 78 9821876 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821876 Reactome R-MMU-5216230 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5216230.1 1 GTP Guanosine 5'-triphosphate GTP)(4-) Reactome DB_ID: 29438 GTP(4-) [ChEBI:37565] GTP(4-) GTP gtp guanosine 5'-triphosphate(4-) ChEBI CHEBI:37565 Reactome Database ID Release 78 29438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438 Reactome R-ALL-29438 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.4 COMPOUND C00044 1 Reactome Database ID Release 78 9821878 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821878 Reactome R-MMU-5250197 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5250197.1 Arl2bp ARL2BP Q9D385 Reactome DB_ID: 9821880 UniProt:Q9D385 Arl2bp UniProt Q9D385 1 EQUAL 163 EQUAL Reactome Database ID Release 78 9821880 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821880 Reactome R-MMU-5215982 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5215982.1 ARL2:GTP:ARL2BP Reactome DB_ID: 9821882 1 1 Reactome Database ID Release 78 9821882 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821882 Reactome R-MMU-5250221 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5250221.1 Reactome Database ID Release 78 9821886 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821886 Reactome R-MMU-5250217 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5250217.1 ADP-ribosylation factor-like protein 2 (ARL2) is a small (21kDa) GTPase protein that is able to bind GDP or GTP. It is implicated in a range of processes from trafficking processes to regulation of microtuble dynamics. ADP-ribosylation factor-like protein 2-binding protein (ARL2BP aka BART) is an effector protein that binds ARL2 (Zhang et al. 2009, Bailey et al. 2009). This binding is dependent on ARL2 being in its GTP-bound form. 18981177 Pubmed 2009 The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function Bailey, Laura K Campbell, Louise J Evetts, Katrina A Littlefield, Keily Rajendra, Eeson Nietlispach, Daniel Owen, Darerca Mott, Helen R J. Biol. Chem. 284:992-9 19368893 Pubmed 2009 Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector Zhang, Tianlong Li, Sheng Zhang, Yichen Zhong, Chen Lai, Zheng Ding, Jianping Structure 17:602-10 LEFT-TO-RIGHT ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ARL2:GTP:ARL2BP Reactome DB_ID: 9821866 mitochondrial matrix GENE ONTOLOGY GO:0005759 ARL2:GTP Reactome DB_ID: 9821860 Arl2 ARL2 Q9D0J4 Reactome DB_ID: 9821858 2 EQUAL 184 EQUAL Reactome Database ID Release 78 9821858 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821858 Reactome R-MMU-5250216 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5250216.1 1 GTP Guanosine 5'-triphosphate GTP)(4-) Reactome DB_ID: 113573 Reactome Database ID Release 78 113573 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113573 Reactome R-ALL-113573 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113573.3 COMPOUND C00044 1 Reactome Database ID Release 78 9821860 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821860 Reactome R-MMU-5250198 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5250198.1 1 Arl2bp ARL2BP Q9D385 Reactome DB_ID: 9821864 1 EQUAL 163 EQUAL Reactome Database ID Release 78 9821864 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821864 Reactome R-MMU-5250220 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5250220.1 1 Reactome Database ID Release 78 9821866 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821866 Reactome R-MMU-5250201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5250201.1 Reactome Database ID Release 78 9821884 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821884 Reactome R-MMU-5250210 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5250210.1 When ADP-ribosylation factor-like protein 2-binding protein (ARL2BP aka BART) binds GTP-bound ADP-ribosylation factor-like protein 2 (ARL2:GTP), the resultant complex can enter the mitochondrion via an unknown mechanism (Zhang et al. 2009, Bailey et al. 2009). Although ARL2 is a member of the ARF family of G proteins, it lacks the myristoylation at glycine-2 characteristic of that family and thus can move across the mitochondrial membrane into the intermembrane space (Sharer et al. 2002). 11809823 Pubmed 2002 ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter Sharer, J Daniel Shern, Jack F Van Valkenburgh, Hillary Wallace, DC Kahn, Richard A Mol. Biol. Cell 13:71-83 LEFT-TO-RIGHT ARL2:GTP:ARL2BP binds SLC25A4 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> P48962 Slc25a4 SLC25A4 Reactome DB_ID: 9821870 mitochondrial inner membrane GENE ONTOLOGY GO:0005743 UniProt:P48962 Slc25a4 UniProt P48962 2 EQUAL 298 EQUAL Reactome Database ID Release 78 9821870 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821870 Reactome R-MMU-49741 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-49741.1 ARL2:GTP:ARL2BP:SLC25A4 Reactome DB_ID: 9821872 1 1 Reactome Database ID Release 78 9821872 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821872 Reactome R-MMU-5250205 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5250205.1 Reactome Database ID Release 78 9821874 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821874 Reactome R-MMU-5250209 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5250209.1 The complex between ADP-ribosylation factor-like protein 2-binding protein (ARL2BP aka BART) and GTP-bound ADP-ribosylation factor-like protein 2 (ARL2:GTP) is able to bind the ADP/ATP translocase 1 protein (SLC25A4 aka ANT1) at the mitochondrial inner membrane (Zhang et al. 2009, Bailey et al. 2009). ARL2 is essential for a number of mitochondrial functions, including mitochondrial morphology, motility and maintenance of ATP levels. LEFT-TO-RIGHT ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113593 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 78 113593 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113593 Reactome R-ALL-113593 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113593.4 COMPOUND C00002 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 78 29370 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 Reactome Database ID Release 78 113592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 COMPOUND C00002 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 113581 Reactome Database ID Release 78 113581 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113581 Reactome R-ALL-113581 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113581.4 COMPOUND C00008 ACTIVATION GENE ONTOLOGY GO:0015207 Reactome Database ID Release 78 9827937 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9827937 Reactome Database ID Release 78 9827939 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9827939 Reactome R-MMU-5672027 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5672027.1 A family of antiport, dimeric ATP-ADP translocases (SLC25A4,5,6), preferentially export ATP from the matrix while importing ADP from the cytosol, thereby maintaining a high ADP:ATP ratio in the matrix. When there are increased energy demands on the body, such as under heavy exercise, cytosolic ADP rises and is exchanged with mitochondrial matrix ATP via the transmembrane ADP:ATP translocase. Increased ADP causes the proton-motive force to be discharged and protons enter via ATPase, thereby regenerating the ATP pool. There are 3 isoforms of translocases in humans with isoform 1 (SLC25A4, NAT1) being the heart/skeletal muscle form. 24911211 Pubmed 2014 The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels Newman, Laura E Zhou, Cheng-jing Mudigonda, Samatha Mattheyses, Alexa L Paradies, Eleonora Marobbio, Carlo Marya Thomas Kahn, Richard A PLoS ONE 9:e99270 LEFT-TO-RIGHT ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ACTIVATION SLC25A5 dimer Reactome DB_ID: 9762122 P51881 Slc25a5 SLC25A5 Reactome DB_ID: 9762120 UniProt:P51881 Slc25a5 UniProt P51881 2 EQUAL 298 EQUAL Reactome Database ID Release 78 9762120 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9762120 Reactome R-MMU-49743 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-49743.1 2 Reactome Database ID Release 78 9762122 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9762122 Reactome R-MMU-77447 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-77447.1 Reactome Database ID Release 78 9762123 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9762123 Reactome Database ID Release 78 9762125 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9762125 Reactome R-MMU-163215 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-163215.1 A family of antiport, ATP-ADP translocases (SLC25A4,5,6), preferentially export ATP from the matrix while importing ADP from the cytosol, thereby maintaining a high ADP:ATP ratio in the matrix. When there are increased energy demands on the body, such as under heavy exercise, cytosolic ADP rises and is exchanged with mitochondrial matrix ATP via the transmembrane ADP:ATP translocase. Increased ADP causes the proton-motive force to be discharged and protons enter via ATPase, thereby regenerating the ATP pool.<br>There are 3 isoforms of translocases in humans; isoform 1 (SLC25A4) is the heart/skeletal muscle form, isoform 2 (SLC25A5) is the fibroblast form and isoform 3 (SLC25A6) is the liver form. All isoforms exist as homodimers. 9587671 Pubmed 1998 The mitochondrial ADP/ATP carrier: structural, physiological and Fiore, C Trezeguet, V Le Saux, A Roux, P Schwimmer, C Dianoux, AC Noel, F Lauquin, GJ Brandolin, G Vignais, PV Biochimie 80:137-50 2648994 Pubmed 1989 Molecular aspects of the adenine nucleotide carrier from mitochondria Klingenberg, M Arch Biochem Biophys 270:1-14 5857365 Pubmed 1965 [Exchange between extra- and intramitochondrial adenine nucleotides] Duee, ED Vignais, PV Biochim Biophys Acta 107:184-8 5840415 Pubmed 1965 Unspecific permeation and specific exchange of adenine nucleotides in Pfaff, E Klingenberg, M Heldt, HW Biochim Biophys Acta 104:312-5 Reactome Database ID Release 78 9860386 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9860386 Reactome R-MMU-83936 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-83936.1 Two families of transport proteins mediate the movement of nucleosides and free purine and pyrimidine bases across the plasma membrane. Equilibrative nucleoside transporters allow the movement of these molecules along concentration gradients into or out of cells (Baldwin et al. 2003); concentrative nucleoside transporters actively transport nucleosides into cells by coupling their transport to the inward movement of sodium ions (Gray et al. 2003).<P>Of the four human equilibrative nucleoside transporters, two are well characterized. SLC29A1 (solute carrier family 29 (nucleoside transporters), member 1) mediates the transport of nucleosides across the plasma membrane. SLC29A2 (solute carrier family 29 (nucleoside transporters), member 2) mediates the transport of both nucleosides and free bases. Transporter specificities were determined by expressing cloned human genes in Xenopus oocytes or in mammalian cultured cell lines whose own nucleotide transporters had been disrupted by mutation. These studies establish that the transport processes are specific and saturable, and that the multiple nucleotides and bases compete for a single binding site on each transporter. Some features of SLC29A2 specificity are complex. For example, in the Xenopus oocyte system, radiolabeled uracil and adenine are taken up, and an excess of either molecule inhibits uptake of radiolabeled hypoxanthine, while in the cultured mammalian cell system, neither adenine nor uracil can inhibit uptake of radiolabeled uridine. If these results reflect ENT2 function in vivo, they indicate that the net movement of a nucleoside or base across the cell membrane is determined not only by its own concentrations in the extracellular space and the cytosol, but also by the concentrations of the other nucleosides and bases competing for access to the transporter.<P>The human genome encodes three concentrative transporters, SLC28A1, 2, and 3 (solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, 2, and 3). All three genes have been cloned, and expression of the human proteins in Xenopus oocytes has allowed their transport properties to be determined. SLC28A1 mediates the uptake of pyrimidine nucleosides and adenosine (Ritzel et al. 1997); SLC28A2 the uptake of purine nucleosides and uridine (Wang et al. 1997); and SLC28A3 the uptake of purine and pyrimidine nucleosides (Ritzel et al. 2001). Amino acid sequence motifs that determine the specificities of these transporters have been identified in studies of chimeric and mutant proteins (Loewen et al. 1999). SLC28A3 protein co-transports two sodium ions per nucleoside; SLC28A1 and 2 transport one sodium per nucleoside (Ritzel et al. 2001).<P>Physiological roles for nucleoside and base transport include provision of nucleosides to cells with little capacity to synthesize these molecules de novo, and regulation of extracellular levels of adenosine, which is released from muscle during intense exercise and has signaling properties. In kidney and intestinal epithelia, the combination of apically localized CNT transporters and basolaterally localized ENT transporters provides a mechanism for net transport of nucleosides (Mangravite et al. 2003). These transporters also mediate the uptake of nucleoside analogs used clinically as anti-viral and anti-tumor drugs.<P>Orthologs of human concentrative and equilibrative transporter proteins have been identified in many eukaryotes, but functional studies of transporters even from organisms closely related to humans (e.g. rat, Gerstin et al. 2002) have revealed differences in substrate specificities. Prediction of drug uptake and other functions of these molecules by human - model organism orthology is thus risky. 12110519 Pubmed 2002 Specificty of human and rat orthologs of the concentrative nucleoside transporter, SPNT Gerstin, KM Dresser, MJ Giacomini, KM Am J Physiol Renal Physiol 283:344-349 12527552 Pubmed 2003 Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells Mangravite, LM Xiao, G Giacomini, KM Am J Physiol Renal Physiol 284:902-910 12856181 Pubmed 2003 The concentrative nucleoside transporter family, SLC28 Gray, JH Owen, RP Giacomini, KM Pflugers Archpreprint 12838422 Pubmed 2003 The equilibrative nucleoside transporter family, SLC29 Baldwin, SA Beal, PR Yao, SY King, AE Cass, CE Young, JD Pflugers Archpreprint LEFT-TO-RIGHT SLC33A1 transports Ac-CoA from cytosol to Golgi lumen This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Ac-CoA Acetyl coenzyme A acetyl-CoA acetyl-CoA(4-) Reactome DB_ID: 76183 acetyl-CoA(4-) [ChEBI:57288] acetyl-CoA(4-) acetyl-CoA 3'-phosphonatoadenosine 5'-(3-{(3R)-4-[(3-{[2-(acetylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} diphosphate) acetyl-coenzyme A(4-) acetyl-CoA tetraanion AcCoA(4-) ChEBI CHEBI:57288 Reactome Database ID Release 78 76183 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76183 Reactome R-ALL-76183 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-76183.4 COMPOUND C00024 Ac-CoA Acetyl coenzyme A acetyl-CoA Reactome DB_ID: 727753 Golgi lumen GENE ONTOLOGY GO:0005796 Reactome Database ID Release 78 727753 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727753 Reactome R-ALL-727753 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727753.4 COMPOUND C00024 ACTIVATION Q99J27 Slc33a1 SLC33A1 Reactome DB_ID: 9787413 Golgi membrane GENE ONTOLOGY GO:0000139 UniProt:Q99J27 Slc33a1 UniProt Q99J27 1 EQUAL 549 EQUAL Reactome Database ID Release 78 9787413 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787413 Reactome R-MMU-727745 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-727745.1 GENE ONTOLOGY GO:0008521 Reactome Database ID Release 78 9787414 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787414 Reactome Database ID Release 78 9787416 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787416 Reactome R-MMU-727759 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-727759.1 The human gene SLC33A1 encodes acetyl-CoA transporter AT1 (Kanamori et al. 1997). Acetyl-CoA is transported to the lumen of the Golgi apparatus, where it serves as the substrate of acetyltransferases that O-acetylates sialyl residues of gangliosides and glycoproteins. Defects in SLC33A1 are the cause of spastic paraplegia autosomal dominant type 42 (SPG42) which is a neurodegenerative disorder (Lin et al. 2008). 9096318 Pubmed 1997 Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O-acetylated ganglioside: a putative acetyl-CoA transporter Kanamori, A Nakayama, J Fukuda, MN Stallcup, WB Sasaki, K Fukuda, M Hirabayashi, Y Proc Natl Acad Sci U S A 94:2897-902 19061983 Pubmed 2008 A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42) Lin, P Li, J Liu, Q Mao, F Li, J Qiu, R Hu, H Song, Y Yang, Y Gao, G Yan, C Yang, W Shao, C Gong, Y Am J Hum Genet 83:752-9 Transport of nucleotide sugars This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT SLC35A1 exchanges CMP-Neu5Ac for CMP SLC35A1 mediates the antiport of CMP-sialic acid in exchange for CMP This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> CMP-Neu5Ac CMP-N-acetylneuraminate CMP-N-acetyl-beta-neuraminic acid Reactome DB_ID: 4085435 CMP-N-acetyl-beta-neuraminic acid [ChEBI:16556] CMP-N-acetyl-beta-neuraminic acid ChEBI CHEBI:16556 Reactome Database ID Release 78 4085435 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4085435 Reactome R-ALL-4085435 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-4085435.3 CMP cytidine 5'-monophosphate cytidylic acid Cytidine-5'-monophosphate Reactome DB_ID: 727810 cytidine 5'-monophosphate(2-) [ChEBI:60377] cytidine 5'-monophosphate(2-) CMP Cytidine-5-monophosphate dianion CMP dianion 5'-O-phosphonatocytidine CMP(2-) ChEBI CHEBI:60377 Reactome Database ID Release 78 727810 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727810 Reactome R-ALL-727810 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727810.5 COMPOUND C00055 CMP cytidine 5'-monophosphate cytidylic acid Cytidine-5'-monophosphate CMP(2-) Reactome DB_ID: 109395 Reactome Database ID Release 78 109395 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109395 Reactome R-ALL-109395 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109395.5 COMPOUND C00055 CMP-Neu5Ac CMP-sialic acid CMP-N-acetyl-beta-neuraminic acid Reactome DB_ID: 727815 Reactome Database ID Release 78 727815 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727815 Reactome R-ALL-727815 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-727815.3 ACTIVATION Q61420 Slc35a1 SLC35A1 Reactome DB_ID: 9787424 UniProt:Q61420 Slc35a1 UniProt Q61420 1 EQUAL 337 EQUAL Reactome Database ID Release 78 9787424 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787424 Reactome R-MMU-727812 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-727812.1 GENE ONTOLOGY GO:0005456 Reactome Database ID Release 78 9787425 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787425 Reactome Database ID Release 78 9787427 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787427 Reactome R-MMU-727807 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-727807.1 The human gene SLC35A1 encodes the CMP-sialic acid transporter which mediates the antiport of CMP-sialic acid (CMP-Neu5Ac) into the Golgi lumen in exchange for CMP (Ishida et al. 1996). Defects in SLC35A1 are the cause of congenital disorder of glycosylation type 2F (CDG2F; MIM:603585). CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation (Martinez-Duncker et al. 2005). 9010752 Pubmed 1996 Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family Ishida, N Miura, N Yoshioka, S Kawakita, M J Biochem 120:1074-8 15576474 Pubmed 2005 Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter Martinez-Duncker, I Dupré, T Piller, V Piller, F Candelier, JJ Trichet, C Tchernia, G Oriol, R Mollicone, R Blood 105:2671-6 LEFT-TO-RIGHT SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> UMP uridine 5'-monophosphate uridylic acid Uridine monophosphate 5'Uridylic acid Reactome DB_ID: 735698 uridine 5'-monophosphate(2-) [ChEBI:57865] uridine 5'-monophosphate(2-) uridine 5'-phosphate 5'-O-phosphonatouridine UMP dianion UMP UMP(2-) 5'-uridylate ChEBI CHEBI:57865 Reactome Database ID Release 78 735698 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=735698 Reactome R-ALL-735698 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-735698.4 COMPOUND C00105 Converted from EntitySet in Reactome UDP-Gal, UDP-GalNAc UDP-Gal transporter substrates Reactome DB_ID: 735692 UDP-Gal UDPgalactose UDP-D-galactose UDP-D-galactopyranose Reactome DB_ID: 29452 UDP-D-galactose [ChEBI:18307] UDP-D-galactose UDPgalactose UDP-D-galactopyranose ChEBI CHEBI:18307 Reactome Database ID Release 78 29452 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29452 Reactome R-ALL-29452 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29452.3 COMPOUND C00052 UDP-GalNAc UDP--N-acetylgalactosamine UDP-N-acetyl-D-galactosamine Reactome DB_ID: 735683 UDP-N-acetyl-D-galactosamine [ChEBI:16650] UDP-N-acetyl-D-galactosamine ChEBI CHEBI:16650 Reactome Database ID Release 78 735683 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=735683 Reactome R-ALL-735683 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-735683.3 Reactome Database ID Release 78 735692 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=735692 Reactome R-ALL-735692 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-735692.1 UMP uridine 5'-monophosphate uridylic acid Uridine monophosphate 5'Uridylic acid uridine 5'-monophosphate(2-) Reactome DB_ID: 109402 Reactome Database ID Release 78 109402 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109402 Reactome R-ALL-109402 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109402.5 COMPOUND C00105 Converted from EntitySet in Reactome UDP-Gal, UDP-GalNAc UDP-Gal transporter substrates Reactome DB_ID: 735691 UDP-Gal UDPgalactose UDP-D-galactose UDP-D-galactopyranose Reactome DB_ID: 735682 Reactome Database ID Release 78 735682 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=735682 Reactome R-ALL-735682 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-735682.3 COMPOUND C00052 UDP-GalNAc UDP--N-acetylgalactosamine UDP-N-acetyl-D-galactosamine Reactome DB_ID: 735700 Reactome Database ID Release 78 735700 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=735700 Reactome R-ALL-735700 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-735700.3 Reactome Database ID Release 78 735691 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=735691 Reactome R-ALL-735691 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-735691.1 ACTIVATION Q9R0M8 Slc35a2 SLC35A2 Reactome DB_ID: 9787434 UniProt:Q9R0M8 Slc35a2 UniProt Q9R0M8 1 EQUAL 396 EQUAL Reactome Database ID Release 78 9787434 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787434 Reactome R-MMU-735686 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-735686.1 GENE ONTOLOGY GO:0005459 Reactome Database ID Release 78 9787435 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787435 Reactome Database ID Release 78 9787437 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787437 Reactome R-MMU-735702 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-735702.1 The human gene SLC35A2 encodes the UDP-galactose transporter (Miura et al. 1996). It is located on the Golgi membrane and mediates the antiport of UDP-Gal into the Golgi lumen in exchange for UMP. This transporter is also known to transport UDP-N-acetylgalactosamine (UDP-GalNAc) by the same antiport mechanism (Segawa et al. 2002). 11784306 Pubmed 2002 Human and Drosophila UDP-galactose transporters transport UDP-N-acetylgalactosamine in addition to UDP-galactose Segawa, H Kawakita, M Ishida, N Eur J Biochem 269:128-38 8889805 Pubmed 1996 Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator Miura, N Ishida, N Hoshino, M Yamauchi, M Hara, T Ayusawa, D Kawakita, M J Biochem 120:236-41 LEFT-TO-RIGHT SLC35A3 exchanges UDP-GlcNAc for UMP This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> UDP-GlcNAc UDP-N-acetyl-D-glucosamine UDP-N-acetyl-alpha-D-glucosamine UDP-N-acetylglucosamine Reactome DB_ID: 162756 UDP-N-acetyl-alpha-D-glucosamine [ChEBI:16264] UDP-N-acetyl-alpha-D-glucosamine ChEBI CHEBI:16264 Reactome Database ID Release 78 162756 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=162756 Reactome R-ALL-162756 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-162756.3 UDP-GlcNAc UDP-N-acetyl-D-glucosamine UDP-N-acetyl-alpha-D-glucosamine UDP-N-acetylglucosamine Reactome DB_ID: 914003 Reactome Database ID Release 78 914003 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=914003 Reactome R-ALL-914003 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-914003.3 ACTIVATION Q8R1T4 Slc35a3 SLC35A3 Reactome DB_ID: 9787467 UniProt:Q8R1T4 Slc35a3 UniProt Q8R1T4 1 EQUAL 325 EQUAL Reactome Database ID Release 78 9787467 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787467 Reactome R-MMU-741452 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-741452.1 GENE ONTOLOGY GO:0005462 Reactome Database ID Release 78 9787468 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787468 Reactome Database ID Release 78 9787470 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787470 Reactome R-MMU-741450 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-741450.1 The human gene SLC35A3 encodes a UDP-GlcNAc transporter (Ishida et al. 1999). It is ubiquitously expressed and resides on the Golgi membrane where it transports UDP- N-acetylglucosamine (GlcNAc) into the Golgi lumen in exchange for UMP. 10393322 Pubmed 1999 Molecular cloning and functional expression of the human Golgi UDP-N-acetylglucosamine transporter Ishida, N Yoshioka, S Chiba, Y Takeuchi, M Kawakita, M J Biochem 126:68-77 LEFT-TO-RIGHT SLC35B2,3 transport cytosolic PAPS to Golgi lumen This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PAPS 3'-phospho-5'-adenylyl sulfate Reactome DB_ID: 158471 3'-phospho-5'-adenylyl sulfate [ChEBI:17980] 3'-phospho-5'-adenylyl sulfate ChEBI CHEBI:17980 Reactome Database ID Release 78 158471 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158471 Reactome R-ALL-158471 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158471.3 COMPOUND C00053 PAPS 3'-phospho-5'-adenylyl sulfate Reactome DB_ID: 741440 Reactome Database ID Release 78 741440 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=741440 Reactome R-ALL-741440 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-741440.3 COMPOUND C00053 ACTIVATION Converted from EntitySet in Reactome PAPST1,2 SLC35B2,3 Reactome DB_ID: 9787460 Q91ZN5 Slc35b2 SLC35B2 Reactome DB_ID: 9787454 UniProt:Q91ZN5 Slc35b2 UniProt Q91ZN5 1 EQUAL 432 EQUAL Reactome Database ID Release 78 9787454 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787454 Reactome R-MMU-741454 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-741454.1 Q922Q5 Slc35b3 SLC35B3 Reactome DB_ID: 9787458 UniProt:Q922Q5 Slc35b3 UniProt Q922Q5 1 EQUAL 401 EQUAL Reactome Database ID Release 78 9787458 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787458 Reactome R-MMU-3465610 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3465610.1 Reactome Database ID Release 78 9787460 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787460 Reactome R-MMU-3465611 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3465611.1 GENE ONTOLOGY GO:0046964 Reactome Database ID Release 78 9787461 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787461 Reactome Database ID Release 78 9787463 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787463 Reactome R-MMU-741449 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-741449.1 The human gene SLC35B2 encodes the adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPST1) (Ozeran et al. 1996, Kamiyama et al. 2003). In human tissues, PAPST1 is highly expressed in the placenta and pancreas and present at lower levels in the colon and heart. The human gene SLC35B3 encodes a human PAPS transporter gene that is closely related to PAPST1. Called PAPST2, it is predominantly expressed in the colon (Kamiyama et al. 2006). Both proteins can transport PAPS from the cytosol to the Golgi lumen. 16492677 Pubmed 2006 Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2 Kamiyama, S Sasaki, N Goda, E Ui-Tei, K Saigo, K Narimatsu, H Jigami, Y Kannagi, R Irimura, T Nishihara, S J Biol Chem 281:10945-53 12716889 Pubmed 2003 Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter Kamiyama, S Suda, T Ueda, R Suzuki, M Okubo, R Kikuchi, N Chiba, Y Goto, S Toyoda, H Saigo, K Watanabe, M Narimatsu, H Jigami, Y Nishihara, S J Biol Chem 278:25958-63 8619989 Pubmed 1996 Identification and partial purification of PAPS translocase Ozeran, JD Westley, J Schwartz, NB Biochemistry 35:3695-703 LEFT-TO-RIGHT SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> UDP-Xyl UDP-xylose UDP-alpha-D-xylose Reactome DB_ID: 742353 UDP-alpha-D-xylose [ChEBI:16082] UDP-alpha-D-xylose ChEBI CHEBI:16082 Reactome Database ID Release 78 742353 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=742353 Reactome R-ALL-742353 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-742353.3 UDP-Xyl UDP-xylose UDP-alpha-D-xylose Reactome DB_ID: 742361 Reactome Database ID Release 78 742361 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=742361 Reactome R-ALL-742361 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-742361.4 ACTIVATION Q8CIA5 Slc35b4 SLC35B4 Reactome DB_ID: 9787481 UniProt:Q8CIA5 Slc35b4 UniProt Q8CIA5 1 EQUAL 331 EQUAL Reactome Database ID Release 78 9787481 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787481 Reactome R-MMU-742365 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-742365.1 GENE ONTOLOGY GO:0005464 Reactome Database ID Release 78 9787485 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787485 Reactome Database ID Release 78 9787487 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787487 Reactome R-MMU-742373 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-742373.1 The human gene SLC35B4 encodes the bifunctional UDP-xylose and UDP-N-acetylglucosamine transporter YEA4. YEA4 resides on the Golgi membrane and mediates the influx of UDP-xylose into the lumen (Ashikov A et al, 2005). 15911612 Pubmed 2005 The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine Ashikov, Angel Routier, F Fuhlrott, J Helmus, Y Wild, M Gerardy-Schahn, Rita Bakker, Hans J Biol Chem 280:27230-5 LEFT-TO-RIGHT SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ACTIVATION Reactome Database ID Release 78 9787482 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787482 Reactome Database ID Release 78 9787484 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787484 Reactome R-MMU-742354 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-742354.1 The human gene SLC35B4 encodes the bifunctional UDP-xylose and UDP-N-acetylglucosamine transporter YEA4. YEA4 resides on the Golgi membrane and mediates the influx of UDP-N-acetylglucosamine into the lumen (Ashikov A et al, 2005). LEFT-TO-RIGHT SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> GDP-Fuc GDP-L-fucose Reactome DB_ID: 742368 GDP-L-fucose [ChEBI:17009] GDP-L-fucose ChEBI CHEBI:17009 Reactome Database ID Release 78 742368 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=742368 Reactome R-ALL-742368 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-742368.3 GDP-Fuc GDP-L-fucose Reactome DB_ID: 205683 Reactome Database ID Release 78 205683 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=205683 Reactome R-ALL-205683 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-205683.3 ACTIVATION Q8BLX4 Slc35c1 SLC35C1 Reactome DB_ID: 9787474 UniProt:Q8BLX4 Slc35c1 UniProt Q8BLX4 1 EQUAL 364 EQUAL Reactome Database ID Release 78 9787474 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787474 Reactome R-MMU-742352 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-742352.1 GENE ONTOLOGY GO:0005457 Reactome Database ID Release 78 9787475 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787475 Reactome Database ID Release 78 9787477 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787477 Reactome R-MMU-742345 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-742345.1 The human gene SLC35C1 encodes the GDP-fucose transporter FUCT1. It resides on the Golgi membrane and mediates the transport of GDP-fucose (GDP-Fuc) formed from a de novo pathway and/or a salvage pathway into the Golgi lumen. Defects in SLC35C1 causes the congenital disorder of glycosylation type 2C, also known as leukocyte adhesion deficiency type II (LAD2) (Lubke et al. 2001). 11326280 Pubmed 2001 Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency Lübke, T Marquardt, T Etzioni, A Hartmann, E von Figura, K Körner, C Nat Genet 28:73-6 LEFT-TO-RIGHT SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> UDP-GlcA UDP-glucuronic acid UDP-alpha-D-glucuronic acid Reactome DB_ID: 158601 UDP-alpha-D-glucuronic acid [ChEBI:17200] UDP-alpha-D-glucuronic acid ChEBI CHEBI:17200 Reactome Database ID Release 78 158601 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158601 Reactome R-ALL-158601 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158601.3 COMPOUND C00167 UDP-GlcA UDP-glucuronic acid UDP-alpha-D-glucuronic acid Reactome DB_ID: 174384 endoplasmic reticulum lumen GENE ONTOLOGY GO:0005788 Reactome Database ID Release 78 174384 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174384 Reactome R-ALL-174384 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-174384.3 COMPOUND C00167 UDP-GlcNAc UDP-N-acetyl-D-glucosamine UDP-N-acetyl-alpha-D-glucosamine UDP-N-acetylglucosamine Reactome DB_ID: 3499326 Reactome Database ID Release 78 3499326 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3499326 Reactome R-ALL-3499326 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-3499326.3 ACTIVATION SLC35D1 hexamer Reactome DB_ID: 9765280 endoplasmic reticulum membrane GENE ONTOLOGY GO:0005789 A2AKQ0 Slc35d1 SLC35D1 Reactome DB_ID: 9765278 UniProt:A2AKQ0 Slc35d1 UniProt A2AKQ0 1 EQUAL 355 EQUAL Reactome Database ID Release 78 9765278 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9765278 Reactome R-MMU-174361 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-174361.1 6 Reactome Database ID Release 78 9765280 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9765280 Reactome R-MMU-174388 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-174388.1 GENE ONTOLOGY GO:0005461 Reactome Database ID Release 78 9765281 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9765281 Reactome Database ID Release 78 9765283 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9765283 Reactome R-MMU-174368 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-174368.1 The UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter (SLC35D1) in hexameric form transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytosol into the ER lumen across the ER membrane (Muraoka et al. 2001). These substrates participate in glucuronidation and/or chondroitin sulfate biosynthesis. 11322953 Pubmed 2001 Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity Muraoka, M Kawakita, M Ishida, N FEBS Lett 495:87-93 LEFT-TO-RIGHT SLC35D2 exchanges UDP-sugars for UMP This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome UDP-sugars UDP-GlcNAc, UDP-Glc UDP-sugar substrates of SLC35D2 Reactome DB_ID: 744229 UDP-Glc UDP-glucose UDP-D-glucose UDPglucose Reactome DB_ID: 29410 UDP-D-glucose [ChEBI:18066] UDP-D-glucose ChEBI CHEBI:18066 Reactome Database ID Release 78 29410 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29410 Reactome R-ALL-29410 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29410.3 COMPOUND C00029 Reactome Database ID Release 78 744229 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=744229 Reactome R-ALL-744229 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-744229.2 Converted from EntitySet in Reactome UDP-sugars UDP-GlcNAc, UDP-Glc UDP-sugar substrates of SLC35D2 Reactome DB_ID: 744234 UDP-Glc UDP-glucose UDP-D-glucose UDPglucose Reactome DB_ID: 744227 Reactome Database ID Release 78 744227 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=744227 Reactome R-ALL-744227 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-744227.3 COMPOUND C00029 Reactome Database ID Release 78 744234 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=744234 Reactome R-ALL-744234 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-744234.2 ACTIVATION Q762D5 Slc35d2 SLC35D2 Reactome DB_ID: 9787491 UniProt:Q762D5 Slc35d2 UniProt Q762D5 1 EQUAL 337 EQUAL Reactome Database ID Release 78 9787491 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787491 Reactome R-MMU-744235 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-744235.1 GENE ONTOLOGY GO:0005338 Reactome Database ID Release 78 9787492 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787492 Reactome Database ID Release 78 9787496 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787496 Reactome R-MMU-744231 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-744231.1 The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the transport of nucleotide sugars such as UDP-GlcNAc and UDP-glucose into the Golgi lumen in exchange for UMP (Suda et al. 2004, Ishida et al. 2005). 15082721 Pubmed 2004 Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection Suda, T Kamiyama, S Suzuki, M Kikuchi, N Nakayama, K Narimatsu, H Jigami, Y Aoki, T Nishihara, S J Biol Chem 279:26469-74 15607426 Pubmed 2005 Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family Ishida, N Kuba, T Aoki, K Miyatake, S Kawakita, M Sanai, Y Genomics 85:106-16 LEFT-TO-RIGHT SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> GDP-Man guanosine 5'-(3-(alpha-D-mannopyranosyl) dihydrogen diphosphate) GDP-alpha-D-mannose Reactome DB_ID: 162860 GDP-alpha-D-mannose [ChEBI:15820] GDP-alpha-D-mannose ChEBI CHEBI:15820 Reactome Database ID Release 78 162860 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=162860 Reactome R-ALL-162860 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-162860.3 GMP guanosine 5'-monophosphate Guanosine 5'-phosphate Guanosine monophosphate Guanylic acid guanosine 5'-monophosphate(2-) Reactome DB_ID: 744239 guanosine 5'-monophosphate(2-) [ChEBI:58115] guanosine 5'-monophosphate(2-) guanosine 5'-phosphate(2-) GMP dianion 5'-O-phosphonatoguanosine GMP(2-) guanosine 5'-phosphate dianion GMP guanosine 5'-phosphate ChEBI CHEBI:58115 Reactome Database ID Release 78 744239 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=744239 Reactome R-ALL-744239 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-744239.4 COMPOUND C00144 GMP guanosine 5'-monophosphate Guanosine 5'-phosphate Guanosine monophosphate Guanylic acid guanosine 5'-monophosphate(2-) Reactome DB_ID: 113578 Reactome Database ID Release 78 113578 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113578 Reactome R-ALL-113578 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113578.5 COMPOUND C00144 GDP-Man guanosine 5'-(3-(alpha-D-mannopyranosyl) dihydrogen diphosphate) GDP-alpha-D-mannose Reactome DB_ID: 744233 Reactome Database ID Release 78 744233 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=744233 Reactome R-ALL-744233 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-744233.3 ACTIVATION Reactome Database ID Release 78 9787494 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787494 Reactome R-MMU-744230 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-744230.1 The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the antiport of GDP-mannose into the Golgi lumen in exchange for GMP (Suda T et al, 2004; Ishida N et al, 2005). Reactome Database ID Release 78 9860974 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9860974 Reactome R-MMU-727802 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-727802.1 Nucleotide sugars are used as sugar donors by glycosyltransferases to create the sugar chains for glycoconjugates such as glycoproteins, polysaccharides and glycolipids. Glycosyltransferases reside mainly in the lumen of the Golgi apparatus and endoplasmic reticulum (ER) whereas nucleotide sugars are synthesized in the cytosol. The human solute carrier family SLC35 encode nucleotide sugar transporters (NSTs) which can mediate the antiport of nucleotide sugars in exchange for the corresponding nucleoside monophosphates (eg. UMP for UDP-sugars). Owing to their function, NSTs are primarily located on Golgi and ER membranes (He L et al, 2009; Handford M et al, 2006; Ishida N and Kawakita M, 2004). 16981043 Pubmed 2006 Nucleotide-sugar transporters: structure, function and roles in vivo Handford, M Rodriguez-Furlán, C Orellana, A Braz J Med Biol Res 39:1149-58 12759756 Pubmed 2004 Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35) Ishida, N Kawakita, M Pflugers Arch 447:768-75 19164095 Pubmed 2009 Analysis and update of the human solute carrier (SLC) gene superfamily He, Lei Vasiliou, K Nebert, DW Hum Genomics 3:195-206 Transport of fatty acids This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT SLC27A1,4,6 transport LCFAs from extracellular region to cytosol This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome LCFAs Long chain fatty acids Reactome DB_ID: 879559 OLEA (9Z)-octadec-9-enoic acid oleic acid Reactome DB_ID: 400431 oleic acid [ChEBI:16196] oleic acid ChEBI CHEBI:16196 Reactome Database ID Release 78 400431 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=400431 Reactome R-ALL-400431 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-400431.3 DDCX lauric acid dodecanoic acid Dodecylcarboxylate Dodecanoate Reactome DB_ID: 449678 dodecanoic acid [ChEBI:30805] dodecanoic acid ChEBI CHEBI:30805 Reactome Database ID Release 78 449678 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=449678 Reactome R-ALL-449678 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-449678.3 COMPOUND C02679 MYSA myristic acid tetradecanoic acid Reactome DB_ID: 400514 tetradecanoic acid [ChEBI:28875] tetradecanoic acid ChEBI CHEBI:28875 Reactome Database ID Release 78 400514 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=400514 Reactome R-ALL-400514 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-400514.3 PALM palmitic acid hexadecanoic acid Palmitate Reactome DB_ID: 400452 hexadecanoic acid [ChEBI:15756] hexadecanoic acid ChEBI CHEBI:15756 Reactome Database ID Release 78 400452 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=400452 Reactome R-ALL-400452 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-400452.3 COMPOUND C00249 AA arachidic acid icosanoic acid Reactome DB_ID: 879615 icosanoic acid [ChEBI:28822] icosanoic acid ChEBI CHEBI:28822 Reactome Database ID Release 78 879615 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879615 Reactome R-ALL-879615 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879615.4 DECA capric acid decanoic acid Reactome DB_ID: 879581 decanoic acid [ChEBI:30813] decanoic acid ChEBI CHEBI:30813 Reactome Database ID Release 78 879581 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879581 Reactome R-ALL-879581 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879581.3 LGCA lignoceric acid tetracosanoic acid Reactome DB_ID: 879605 tetracosanoic acid [ChEBI:28866] tetracosanoic acid ChEBI CHEBI:28866 Reactome Database ID Release 78 879605 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879605 Reactome R-ALL-879605 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879605.3 LINA linoleic acid Reactome DB_ID: 879520 linoleic acid [ChEBI:17351] linoleic acid ChEBI CHEBI:17351 Reactome Database ID Release 78 879520 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879520 Reactome R-ALL-879520 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879520.4 STEA stearic acid magnesium distearate Reactome DB_ID: 879644 magnesium distearate [ChEBI:9254] magnesium distearate ChEBI CHEBI:9254 Reactome Database ID Release 78 879644 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879644 Reactome R-ALL-879644 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879644.3 Reactome Database ID Release 78 879559 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879559 Reactome R-ALL-879559 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879559.1 Converted from EntitySet in Reactome LCFAs Long chain fatty acids Reactome DB_ID: 879544 OLEA (9Z)-octadec-9-enoic acid oleic acid Reactome DB_ID: 3632879 Reactome Database ID Release 78 3632879 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3632879 Reactome R-ALL-3632879 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-3632879.3 DDCX lauric acid dodecanoic acid Dodecylcarboxylate Dodecanoate Reactome DB_ID: 879557 Reactome Database ID Release 78 879557 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879557 Reactome R-ALL-879557 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879557.3 COMPOUND C02679 MYSA myristic acid tetradecanoic acid Reactome DB_ID: 879604 Reactome Database ID Release 78 879604 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879604 Reactome R-ALL-879604 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879604.3 PALM palmitic acid hexadecanoic acid Palmitate Reactome DB_ID: 3632881 Reactome Database ID Release 78 3632881 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3632881 Reactome R-ALL-3632881 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-3632881.3 COMPOUND C00249 AA arachidic acid icosanoic acid Reactome DB_ID: 879558 Reactome Database ID Release 78 879558 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879558 Reactome R-ALL-879558 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879558.4 DECA capric acid decanoic acid Reactome DB_ID: 879620 Reactome Database ID Release 78 879620 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879620 Reactome R-ALL-879620 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879620.3 LGCA lignoceric acid tetracosanoic acid Reactome DB_ID: 879505 Reactome Database ID Release 78 879505 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879505 Reactome R-ALL-879505 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879505.3 LA LINA linoleic acid linoleate phys-ent-participant87640 phys-ent-participant85043 phys-ent-participant87411 Reactome DB_ID: 1132021 Reactome Database ID Release 78 1132021 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1132021 Reactome R-ALL-1132021 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1132021.3 STEA stearic acid magnesium distearate Reactome DB_ID: 3632878 Reactome Database ID Release 78 3632878 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3632878 Reactome R-ALL-3632878 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-3632878.3 Reactome Database ID Release 78 879544 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879544 Reactome R-ALL-879544 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879544.2 ACTIVATION Converted from EntitySet in Reactome SLC27A1,4,6 Reactome DB_ID: 9787851 Q60714 Slc27a1 SLC27A1 Reactome DB_ID: 9787841 UniProt:Q60714 Slc27a1 UniProt Q60714 1 EQUAL 646 EQUAL Reactome Database ID Release 78 9787841 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787841 Reactome R-MMU-400190 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-400190.1 Q91VE0 Slc27a4 SLC27A4 Reactome DB_ID: 9787845 UniProt:Q91VE0 Slc27a4 UniProt Q91VE0 1 EQUAL 643 EQUAL Reactome Database ID Release 78 9787845 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787845 Reactome R-MMU-879638 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879638.1 E9Q9W4 Slc27a6 SLC27A6 Reactome DB_ID: 9787849 UniProt:E9Q9W4 Slc27a6 UniProt E9Q9W4 1 EQUAL 619 EQUAL Reactome Database ID Release 78 9787849 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787849 Reactome R-MMU-879656 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879656.1 Reactome Database ID Release 78 9787851 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787851 Reactome R-MMU-879582 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879582.1 GENE ONTOLOGY GO:0015245 Reactome Database ID Release 78 9787852 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787852 Reactome Database ID Release 78 9787854 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787854 Reactome R-MMU-879585 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879585.1 The SLC27 gene family code for fatty acid transporter proteins (FATPs). Of the six FATPs characterized, only three have been shown to mediate the influx of long chain fatty acids (LCFAs) into cells; FATP1, 4 and 6. They have been shown to transport the prototypical LCFA oleic acid (OLEA) but are believed to be able to transport LCFAs with chain lengths longer than 10 carbons. FATP1 is highly expressed in adipose tissue and muscle (Hatch GM et al, 2002). FATP4 is the major intestinal LCFA transporter (Fitscher BA et al, 1998; Stahl A et al, 1999). FATP6 is localized to cardiac myocytes (Gimeno RE et al, 2003). 9878842 Pubmed 1998 Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4) Fitscher, BA Riedel, HD Young, KC Stremmel, W Biochim Biophys Acta 1443:381-5 10518211 Pubmed 1999 Identification of the major intestinal fatty acid transport protein Stahl, A Hirsch, DJ Gimeno, RE Punreddy, S Ge, P Watson, N Patel, S Kotler, M Raimondi, A Tartaglia, LA Lodish, HF Mol Cell 4:299-308 12556534 Pubmed 2003 Characterization of a heart-specific fatty acid transport protein Gimeno, RE Ortegon, AM Patel, S Punreddy, S Ge, P Sun, Y Lodish, HF Stahl, A J Biol Chem 278:16039-44 12235169 Pubmed 2002 FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells Hatch, GM Smith, AJ Xu, FY Hall, AM Bernlohr, DA J Lipid Res 43:1380-9 LEFT-TO-RIGHT LCNs bind lipids This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> lipid lipids Reactome DB_ID: 5229279 lipid [ChEBI:18059] lipid ChEBI CHEBI:18059 Reactome Database ID Release 78 5229279 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5229279 Reactome R-ALL-5229279 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5229279.3 Converted from EntitySet in Reactome LCNs Reactome DB_ID: 9821806 Lcn3 LCN1 Q62471 Reactome DB_ID: 9821790 UniProt:Q62471 Lcn3 UniProt Q62471 19 EQUAL 176 EQUAL Reactome Database ID Release 78 9821790 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821790 Reactome R-MMU-5229284 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5229284.1 Lcn12 LCN12 Q6JVL5 Reactome DB_ID: 9821794 UniProt:Q6JVL5 Lcn12 UniProt Q6JVL5 20 EQUAL 192 EQUAL Reactome Database ID Release 78 9821794 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821794 Reactome R-MMU-5216213 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5216213.1 APOD dimer Reactome DB_ID: 9821800 Apod APOD P51910 Reactome DB_ID: 9821798 UniProt:P51910 Apod UniProt P51910 21 EQUAL 189 EQUAL Reactome Database ID Release 78 9821798 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821798 Reactome R-MMU-5216199 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5216199.1 2 Reactome Database ID Release 78 9821800 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821800 Reactome R-MMU-5229263 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5229263.1 Lcn9 LCN9 Q9D267 Reactome DB_ID: 9821804 UniProt:Q9D267 Lcn9 UniProt Q9D267 16 EQUAL 176 EQUAL Reactome Database ID Release 78 9821804 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821804 Reactome R-MMU-5215953 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5215953.1 Reactome Database ID Release 78 9821806 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821806 Reactome R-MMU-5229240 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5229240.1 LCNs:lipids Reactome DB_ID: 9821808 1 1 Reactome Database ID Release 78 9821808 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821808 Reactome R-MMU-5229291 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5229291.1 Reactome Database ID Release 78 9821810 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821810 Reactome R-MMU-5229283 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5229283.1 Lipocalins (LCNs) are a family of extracellular proteins that are implicated in the transport of small hydrophobic molecules such as lipids, retinoids, steroids and bilins (Grzyb et al. 2006). The family members differ in amino acid sequence but they share a highly conserved beta-barrel structure comprised of an eight-stranded anti-parallel beta-sheet. This structure forms a ligand-binding pocket that is responsible for binding and transporting lipids and other small hydrophobic molecules (Flower et al. 1993). LCNs have been associated with many biological processes such as immune response, prostaglandin synthesis, retinoid binding and cancer cell interactions. Lipocalins 1, 9, 12, and 15 (LCN1, 9, 12 and 15) are all able to transport different types of hydrophobic molecules.<br><br>Apolipoprotein D (APOD) is a 29-kDa glycoprotein that is primarily associated with high density lipoproteins (HDLs) in human plasma (Drayna et al. 1986, Yang et al. 1994). It is an atypical apolipoprotein and, based on its primary structure, it is predicted to be a member of the lipocalin family. Lipocalins adopt a tertiary beta-barrel structure and transport small hydrophobic ligands. Although APOD can bind cholesterol, progesterone, pregnenolone, bilirubin and arachidonic acid, it is unclear if any, or all of these, represent its physiological ligands (Perdomo et al. 2010). APOD's role in lipid metabolism could have implication in atherosclerosis and ageing (Perdomo & Dong 2009). 16504339 Pubmed 2006 Lipocalins - a family portrait Grzyb, Joanna Latowski, Dariusz Strza?ka, Kazimierz J. Plant Physiol. 163:895-915 7918467 Pubmed 1994 Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links Yang, C Y Gu, Z W Blanco-Vaca, F Gaskell, S J Yang, M Massey, J B Gotto, A M Pownall, H J Biochemistry 33:12451-5 7684291 Pubmed 1993 Structure and sequence relationships in the lipocalins and related proteins Flower, D R North, A C Attwood, T K Protein Sci. 2:753-61 20124557 Pubmed 2010 A role of apolipoprotein D in triglyceride metabolism Perdomo, German Kim, Dae Hyun Zhang, Ting Qu, Shen Thomas, Elizabeth A Toledo, Frederico G S Slusher, Sandra Fan, Yong Kelley, David E Dong, H Henry J. Lipid Res. 51:1298-311 19946382 Pubmed 2009 Apolipoprotein D in lipid metabolism and its functional implication in atherosclerosis and aging Perdomo, German Henry Dong, H Aging (Albany NY) 1:17-27 3453108 Pubmed 1986 Cloning and expression of human apolipoprotein D cDNA Drayna, D Fielding, C McLean, J Baer, B Castro, G Chen, E Comstock, L Henzel, W Kohr, W Rhee, L J. Biol. Chem. 261:16535-9 Reactome Database ID Release 78 9861974 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9861974 Reactome R-MMU-804914 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-804914.1 GENE ONTOLOGY GO:0015909 gene ontology term for cellular process MI MI:0359 Long chain fatty acids (LCFAs) are involved in many cellular functions. They can be used as an important source of energy by skeletal muscle and heart tissues. Also, they are used in the production of hormones which can regulate inflammation, blood pressure, the clotting process, blood lipid levels and the immune response. Fatty acid transporter proteins (FATPs) are a family of proteins which mediate fatty acid uptake into cells when overexpressed. FATPs also possess enzymatic activity, the details of which are captured elsewhere. There are 6 human genes of the SLC27A family which encode for FATP1-6 (Stahl A, 2004; Gimeno RE, 2007). To date, only FATP1, 4 and 6 have demonstrable transporter function. Fatty acids with carbon chain lengths of more than 10 are the most likely substrates for these transporters. 12856180 Pubmed 2004 A current review of fatty acid transport proteins (SLC27) Stahl, A Pflugers Arch 447:722-7 17495600 Pubmed 2007 Fatty acid transport proteins Gimeno, RE Curr Opin Lipidol 18:271-6 Transport of organic anions This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT SLCO1A2 transports Transport (influx) of bile salts and acids by OATP-A This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome bile salts and acids Reactome DB_ID: 192483 CCA cholate cholic acid Reactome DB_ID: 192431 cholic acid [ChEBI:16359] cholic acid ChEBI CHEBI:16359 Reactome Database ID Release 78 192431 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192431 Reactome R-ALL-192431 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-192431.3 GCCA glycocholate glycocholic acid Reactome DB_ID: 192464 glycocholic acid [ChEBI:17687] glycocholic acid ChEBI CHEBI:17687 Reactome Database ID Release 78 192464 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192464 Reactome R-ALL-192464 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-192464.3 TCCA taurocholate taurocholic acid Reactome DB_ID: 192421 taurocholic acid [ChEBI:28865] taurocholic acid ChEBI CHEBI:28865 Reactome Database ID Release 78 192421 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192421 Reactome R-ALL-192421 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-192421.3 CDCA chenodeoxycholate chenodeoxycholic acid Reactome DB_ID: 192442 chenodeoxycholic acid [ChEBI:16755] chenodeoxycholic acid ChEBI CHEBI:16755 Reactome Database ID Release 78 192442 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192442 Reactome R-ALL-192442 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-192442.3 GCDCA glycochenodeoxycholate glycochenodeoxycholic acid Reactome DB_ID: 192473 glycochenodeoxycholic acid [ChEBI:36274] glycochenodeoxycholic acid ChEBI CHEBI:36274 Reactome Database ID Release 78 192473 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192473 Reactome R-ALL-192473 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-192473.3 TCDCA taurochenodeoxycholate Reactome DB_ID: 192415 taurochenodeoxycholate [ChEBI:9407] taurochenodeoxycholate ChEBI CHEBI:9407 Reactome Database ID Release 78 192415 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192415 Reactome R-ALL-192415 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-192415.3 Reactome Database ID Release 78 192483 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192483 Reactome R-ALL-192483 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-192483.1 Converted from EntitySet in Reactome bile salts and acids Reactome DB_ID: 194131 CCA cholate cholic acid Reactome DB_ID: 193473 Reactome Database ID Release 78 193473 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193473 Reactome R-ALL-193473 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-193473.3 GCCA glycocholate glycocholic acid Reactome DB_ID: 159435 Reactome Database ID Release 78 159435 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159435 Reactome R-ALL-159435 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-159435.3 COMPOUND C01921 TCCA taurocholate taurocholic acid Reactome DB_ID: 192332 Reactome Database ID Release 78 192332 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192332 Reactome R-ALL-192332 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-192332.3 COMPOUND C05122 TCDCA taurochenodeoxycholate taurochenodeoxycholic acid Chenodeoxycholoyltaurine Reactome DB_ID: 159422 taurochenodeoxycholic acid [ChEBI:16525] taurochenodeoxycholic acid ChEBI CHEBI:16525 Reactome Database ID Release 78 159422 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159422 Reactome R-ALL-159422 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-159422.3 COMPOUND C03487 GCDCA glycochenodeoxycholate glycochenodeoxycholic acid Reactome DB_ID: 159432 Reactome Database ID Release 78 159432 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159432 Reactome R-ALL-159432 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-159432.3 COMPOUND C05466 CDCA chenodeoxycholate chenodeoxycholic acid Reactome DB_ID: 194127 Reactome Database ID Release 78 194127 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194127 Reactome R-ALL-194127 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-194127.3 Reactome Database ID Release 78 194131 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194131 Reactome R-ALL-194131 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-194131.2 ACTIVATION Q9EP96 Slco1a4 SLCO1A2 Reactome DB_ID: 9768430 UniProt:Q9EP96 Slco1a4 UniProt Q9EP96 1 EQUAL 670 EQUAL Reactome Database ID Release 78 9768430 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9768430 Reactome R-MMU-194062 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-194062.1 GENE ONTOLOGY GO:0015125 Reactome Database ID Release 78 9768431 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9768431 Reactome Database ID Release 78 9768433 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9768433 Reactome R-MMU-194130 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-194130.1 A molecule of extracellular bile salt (glyco- or taurocholate or taurochenodeoxycholate) or bile acid (cholate or chenodeoxycholate) is transported into the cytosol, mediated by OATP-A (SLCO1A2) in the plasma membrane. Bile salts and acids exist in the blood as complexes with serum albumin, and their uptake by OATP-A must involve disruption of this complex, but the molecular mechanism coupling release of a bile salt or acid from albumin to its uptake by OATP-A is unknown. In the body, OATP-A is expressed only at low levels on the basolateral surfaces of hepatocytes and may play only a minor role in the uptake of bile salts and acids by the liver (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). 14699511 Pubmed 2004 Enterohepatic bile salt transporters in normal physiology and liver disease Kullak-Ublick, GA Stieger, B Meier, PJ Gastroenterology 126:322-42 12663868 Pubmed 2003 Bile salt transporters: molecular characterization, function, and regulation Boyer, JL Trauner, M Physiol Rev 83:633-671 7557095 Pubmed 1995 Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver Kullak-Ublick, GA Hagenbuch, B Stieger, B Schteingart, CD Hofmann, AF Wolkoff, AW Meier, PJ Gastroenterology 109:1274-82 LEFT-TO-RIGHT SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome GCCA, TCCA cholate bile salts glycocholate; taurocholate Reactome DB_ID: 194117 Reactome Database ID Release 78 194117 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194117 Reactome R-ALL-194117 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-194117.1 Converted from EntitySet in Reactome GCCA, TCCA cholate bile salts glycocholate; taurocholate Reactome DB_ID: 194097 Reactome Database ID Release 78 194097 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194097 Reactome R-ALL-194097 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-194097.1 ACTIVATION Q9JJL3 Slco1b2 SLCO1B3 Reactome DB_ID: 9768411 UniProt:Q9JJL3 Slco1b2 UniProt Q9JJL3 1 EQUAL 702 EQUAL Reactome Database ID Release 78 9768411 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9768411 Reactome R-MMU-194075 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-194075.1 Reactome Database ID Release 78 9768412 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9768412 Reactome Database ID Release 78 9768414 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9768414 Reactome R-MMU-194079 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-194079.1 A molecule of extracellular glycocholate or taurocholate is transported into the cytosol, mediated by OATP-8 (SLCO1B3) in the plasma membrane. Glycocholate and taurocholate exist in the blood as complexes with serum albumin, and their uptake by OATP-8 must involve disruption of these complexes, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-8 is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of glycocholate and taurocholate by the liver under physiological conditions (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). 11159893 Pubmed 2001 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver Kullak-Ublick, GA Ismair, MG Stieger, B Landmann, L Huber, R Pizzagalli, F Fattinger, K Meier, PJ Hagenbuch, B Gastroenterology 120:525-33 LEFT-TO-RIGHT Transport (influx) of glycocholate and taurocholate by OATP-C SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ACTIVATION Q9JJL3 Slco1b2 SLCO1B1 Reactome DB_ID: 9768416 1 EQUAL 691 EQUAL Reactome Database ID Release 78 9768416 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9768416 Reactome R-MMU-194133 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-194133.1 Reactome Database ID Release 78 9768417 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9768417 Reactome Database ID Release 78 9768419 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9768419 Reactome R-MMU-194083 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-194083.1 A molecule of extracellular glycocholate (GCCA) or taurocholate (TCCA) is transported into the cytosol, mediated by OATP-C (SLCO1B1) in the plasma membrane. GCCA and TCCA exist in the blood as complexes with serum albumin (ALB), and its uptake by OATP-C must involve disruption of this complex, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-C is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of GCCA and TCCA by the liver under physiological conditions (Kullak-Ublick et al. 2004, Trauner & Boyer 2002). 10358072 Pubmed 1999 Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 Abe, T Kakyo, M Tokui, T Nakagomi, R Nishio, T Nakai, D Nomura, H Unno, M Suzuki, M Naitoh, T Matsuno, S Yawo, H J Biol Chem 274:17159-63 10601278 Pubmed 1999 A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters Hsiang, B Zhu, Y Wang, Z Wu, Y Sasseville, V Yang, WP Kirchgessner, TG J Biol Chem 274:37161-8 LEFT-TO-RIGHT SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome T3,T4 Reactome DB_ID: 879603 T3 3,5,3'-triiodothyronine 3,3',5'-triiodothyronine Reactome DB_ID: 352331 3,3',5'-triiodothyronine [ChEBI:28774] 3,3',5'-triiodothyronine ChEBI CHEBI:28774 Reactome Database ID Release 78 352331 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352331 Reactome R-ALL-352331 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-352331.4 T4 Thyroxine L-thyroxine 3,5,3'5'-tetraiodothyronine Reactome DB_ID: 352326 L-thyroxine [ChEBI:18332] L-thyroxine ChEBI CHEBI:18332 Reactome Database ID Release 78 352326 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352326 Reactome R-ALL-352326 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-352326.3 COMPOUND C01829 Reactome Database ID Release 78 879603 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879603 Reactome R-ALL-879603 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879603.1 Converted from EntitySet in Reactome T3,T4 Reactome DB_ID: 879628 T3 3,5,3'-triiodothyronine 3,3',5'-triiodothyronine Reactome DB_ID: 176667 Reactome Database ID Release 78 176667 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176667 Reactome R-ALL-176667 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176667.4 T4 Thyroxine L-thyroxine 3,5,3'5'-tetraiodothyronine Reactome DB_ID: 209937 Reactome Database ID Release 78 209937 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=209937 Reactome R-ALL-209937 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-209937.3 COMPOUND C01829 Reactome Database ID Release 78 879628 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879628 Reactome R-ALL-879628 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879628.1 ACTIVATION Converted from EntitySet in Reactome SLCOs, SLC16A2 dimer Reactome DB_ID: 9787821 Q9ERB5 Slco1c1 SLCO1C1 Reactome DB_ID: 9787809 UniProt:Q9ERB5 Slco1c1 UniProt Q9ERB5 1 EQUAL 712 EQUAL Reactome Database ID Release 78 9787809 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787809 Reactome R-MMU-879618 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879618.1 Q8K078 Slco4a1 SLCO4A1 Reactome DB_ID: 9787813 UniProt:Q8K078 Slco4a1 UniProt Q8K078 1 EQUAL 722 EQUAL Reactome Database ID Release 78 9787813 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787813 Reactome R-MMU-879523 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879523.1 SLC16A2 dimer Reactome DB_ID: 9787819 O70324 Slc16a2 SLC16A2 Reactome DB_ID: 9787817 UniProt:O70324 Slc16a2 UniProt O70324 2 EQUAL 539 EQUAL Reactome Database ID Release 78 9787817 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787817 Reactome R-MMU-5216020 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5216020.1 2 Reactome Database ID Release 78 9787819 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787819 Reactome R-MMU-8875468 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8875468.1 Reactome Database ID Release 78 9787821 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787821 Reactome R-MMU-879625 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879625.1 GENE ONTOLOGY GO:0015349 Reactome Database ID Release 78 9787822 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787822 Reactome Database ID Release 78 9787824 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787824 Reactome R-MMU-879575 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879575.1 Three organic anion transporting polypeptides (OATPs; now called solute carrier organic anion transporters, SLCOs) are able to mediate the transport of thyroid hormones, predominantly thyroxine (T4) and triiodothyronine (T3) (Fujiwara et al. 2001). SLCO1B1 (formerly OATP-C), which can also transport bile salts, is mainly expressed in the liver (Abe et al. 1999; Hsiang et al. 1999). SLCO4A1 (formerly OATP-E) is mainly expressed in peripheral tissue and has a broad substrate specificty (Tamai et al. 2000). SLCO1C1 (formerly OATP-F) is highly expressed in brain and is also a high affinity thyroid hormone transporter (Pizzagalli et al. 2002).<br><br>The monocarboxylate transporter 8 (MCT8, SLC16A2 is also a very active and specific thyroid hormone transporter in its dimeric form (Visser et al. 2009). Defects in SLC16A2 can cause severe X-linked psychomotor retardation. SLC16A2 mutations that inhibited SLC16A2 dimerisation resulted in defective transport function of SLC16A2 (Fischer et al. 2015). 10873595 Pubmed 2000 Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family Tamai, I Nezu, J Uchino, H Sai, Y Oku, A Shimane, M Tsuji, A Biochem Biophys Res Commun 273:251-60 25527620 Pubmed 2015 Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations Fischer, Jana Kleinau, Gunnar Müller, Anne Kühnen, Peter Zwanziger, Denise Kinne, Anita Rehders, Maren Moeller, Lars C Führer, Dagmar Gruters, Annette Krude, Heiko Brix, Klaudia Biebermann, Heike J. Mol. Endocrinol. 54:39-50 12351693 Pubmed 2002 Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter Pizzagalli, F Hagenbuch, B Stieger, B Klenk, U Folkers, G Meier, PJ Mol Endocrinol 16:2283-96 19797118 Pubmed 2009 Evidence for a homodimeric structure of human monocarboxylate transporter 8 Visser, W Edward Philp, Nancy J van Dijk, Thamar B Klootwijk, Wim Friesema, Edith C H Jansen, Jurgen Beesley, Philip W Ianculescu, Alexandra G Visser, TJ Endocrinology 150:5163-70 11316767 Pubmed 2001 Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner Fujiwara, K Adachi, Hideki Nishio, T Unno, M Tokui, T Okabe, M Onogawa, T Suzuki, T Asano, N Tanemoto, M Seki, M Shiiba, K Suzuki, M Kondo, Y Nunoki, K Shimosegawa, T Iinuma, K Ito, S Matsuno, S Abe, T Endocrinology 142:2005-12 LEFT-TO-RIGHT SLCO1B1 transports T3,T4 from extracellular region to cytosol This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ACTIVATION Reactome Database ID Release 78 9857191 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9857191 Reactome Database ID Release 78 9857193 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9857193 Reactome R-MMU-9631987 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9631987.1 Three organic anion transporting polypeptides (OATPs; now called solute carrier organic anion transporters, SLCOs) are able to mediate the transport of thyroid hormones, predominantly thyroxine (T4) and triiodothyronine (T3) (Fujiwara et al. 2001). SLCO1B1 (formerly OATP-C), which can also transport bile salts, is mainly expressed in the liver (Abe et al. 1999, Hsiang et al. 1999). LEFT-TO-RIGHT PGT transports prostaglandins SLCO2A1 transports PGT substrates from extracellular region to cytosol This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome PGT substrates Reactome DB_ID: 879566 PGD2 prostaglandin D2 Reactome DB_ID: 416911 prostaglandin D2 [ChEBI:15555] prostaglandin D2 ChEBI CHEBI:15555 Reactome Database ID Release 78 416911 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=416911 Reactome R-ALL-416911 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-416911.3 COMPOUND C00696 PGE1 prostaglandin E1 Reactome DB_ID: 879611 prostaglandin E1 [ChEBI:15544] prostaglandin E1 ChEBI CHEBI:15544 Reactome Database ID Release 78 879611 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879611 Reactome R-ALL-879611 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879611.3 PGE2 prostaglandin E2 Reactome DB_ID: 391930 prostaglandin E2 [ChEBI:15551] prostaglandin E2 ChEBI CHEBI:15551 Reactome Database ID Release 78 391930 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=391930 Reactome R-ALL-391930 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-391930.3 PGF2a prostaglandin F2alpha Reactome DB_ID: 879657 prostaglandin F2alpha [ChEBI:15553] prostaglandin F2alpha ChEBI CHEBI:15553 Reactome Database ID Release 78 879657 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879657 Reactome R-ALL-879657 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879657.3 Reactome Database ID Release 78 879566 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879566 Reactome R-ALL-879566 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879566.1 Converted from EntitySet in Reactome PGT substrates Reactome DB_ID: 879614 PGD2 prostaglandin D2 Reactome DB_ID: 879629 Reactome Database ID Release 78 879629 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879629 Reactome R-ALL-879629 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879629.3 COMPOUND C00696 PGE1 prostaglandin E1 Reactome DB_ID: 879519 Reactome Database ID Release 78 879519 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879519 Reactome R-ALL-879519 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879519.3 PGE2 prostaglandin E2 Reactome DB_ID: 265287 Reactome Database ID Release 78 265287 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265287 Reactome R-ALL-265287 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-265287.3 PGF2a prostaglandin F2alpha Reactome DB_ID: 879535 Reactome Database ID Release 78 879535 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879535 Reactome R-ALL-879535 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879535.3 Reactome Database ID Release 78 879614 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879614 Reactome R-ALL-879614 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879614.1 ACTIVATION Q9EPT5 Slco2a1 SLCO2A1 Reactome DB_ID: 9787795 UniProt:Q9EPT5 Slco2a1 UniProt Q9EPT5 1 EQUAL 643 EQUAL Reactome Database ID Release 78 9787795 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787795 Reactome R-MMU-879624 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879624.1 GENE ONTOLOGY GO:0015132 Reactome Database ID Release 78 9787796 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787796 Reactome Database ID Release 78 9787798 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787798 Reactome R-MMU-879528 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879528.1 The human gene SLCO2A1 encodes prostaglandin transporter PGT. It is ubiquitously expressed and can transport the protaglandins PGD2, PGE1, PGE2 and PGF2A (Lu et al. 1996). 8787677 Pubmed 1996 Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT) Lu, R Kanai, N Bao, Y Schuster, VL J Clin Invest 98:1142-9 LEFT-TO-RIGHT SLCO2B1 has a narrow substrate specificity This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome SLCO2B1 substrates Reactome DB_ID: 879553 E1S estrone 3-sulfate Reactome DB_ID: 561076 estrone 3-sulfate [ChEBI:17474] estrone 3-sulfate ChEBI CHEBI:17474 Reactome Database ID Release 78 561076 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=561076 Reactome R-ALL-561076 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-561076.3 BSP bromosulphophthalein bromosulfophthalein Reactome DB_ID: 879541 bromosulfophthalein [ChEBI:63836] bromosulfophthalein 4,5,6,7-tetrabromo-3&apos;,3&apos;&apos;-disulfophenolphthalein Sulphobromophthalein ChEBI CHEBI:63836 Reactome Database ID Release 78 879541 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879541 Reactome R-ALL-879541 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879541.3 DHEA-SO4 Dehydroepiandro-sterone sulfate dehydroepiandrosterone sulfate Dehydroepiandro- sterone sulfate Dehydroepiandro_minus__br_sterone_space_sulfate Reactome DB_ID: 561069 dehydroepiandrosterone sulfate [ChEBI:16814] dehydroepiandrosterone sulfate ChEBI CHEBI:16814 Reactome Database ID Release 78 561069 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=561069 Reactome R-ALL-561069 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-561069.3 Reactome Database ID Release 78 879553 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879553 Reactome R-ALL-879553 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879553.1 Converted from EntitySet in Reactome SLCO2B1 substrates Reactome DB_ID: 879654 E1S estrone 3-sulfate Reactome DB_ID: 176501 Reactome Database ID Release 78 176501 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176501 Reactome R-ALL-176501 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176501.3 BSP bromosulphophthalein bromosulfophthalein Reactome DB_ID: 879576 Reactome Database ID Release 78 879576 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879576 Reactome R-ALL-879576 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879576.3 DHEA-SO4 Dehydroepiandro-sterone sulfate dehydroepiandrosterone sulfate Dehydroepiandro- sterone sulfate Dehydroepiandro_minus__br_sterone_space_sulfate Reactome DB_ID: 191976 Reactome Database ID Release 78 191976 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191976 Reactome R-ALL-191976 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-191976.3 Reactome Database ID Release 78 879654 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879654 Reactome R-ALL-879654 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879654.1 ACTIVATION Q8BXB6 Slco2b1 SLCO2B1 Reactome DB_ID: 9787802 UniProt:Q8BXB6 Slco2b1 UniProt Q8BXB6 1 EQUAL 709 EQUAL Reactome Database ID Release 78 9787802 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787802 Reactome R-MMU-879578 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879578.1 GENE ONTOLOGY GO:0015347 Reactome Database ID Release 78 9787803 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787803 Reactome Database ID Release 78 9787805 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787805 Reactome R-MMU-879562 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879562.1 SLCO2B1 (formerly OATP-B) is abundantly expressed in human liver, where it is localized at the basolateral membrane of hepatocytes. It has a narrow substrate range, able to transport bromosulphophthalein (BSP), estrone-3-sulphate and dehydroepiandrosterone-sulphate (DHEAS) (Kullak-Ublick GA et al, 2001). LEFT-TO-RIGHT SLCO3A1 isoform 1 has abroad substrate specificity This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome SLCO3A1 substrates Reactome DB_ID: 9787826 Avp AVP(20-28) P35455 Reactome DB_ID: 9777068 UniProt:P35455 Avp Avp FUNCTION Neurophysin 2 specifically binds vasopressin.FUNCTION Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (By similarity).SUBUNIT Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (By similarity). Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (By similarity).SIMILARITY Belongs to the vasopressin/oxytocin family. UniProt P35455 20 EQUAL 28 EQUAL Reactome Database ID Release 78 9777068 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777068 Reactome R-MMU-388474 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388474.1 Reactome Database ID Release 78 9787826 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787826 Reactome R-MMU-879529 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879529.1 Converted from EntitySet in Reactome SLCO3A1 substrates Reactome DB_ID: 9787830 Avp AVP(20-28) P35455 Reactome DB_ID: 9787828 20 EQUAL 28 EQUAL Reactome Database ID Release 78 9787828 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787828 Reactome R-MMU-879509 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879509.1 Reactome Database ID Release 78 9787830 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787830 Reactome R-MMU-879563 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879563.1 ACTIVATION Q8R3L5 Slco3a1 SLCO3A1-1 Reactome DB_ID: 9787834 UniProt:Q8R3L5 Slco3a1 UniProt Q8R3L5 1 EQUAL 710 EQUAL Reactome Database ID Release 78 9787834 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787834 Reactome R-MMU-879536 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879536.1 Reactome Database ID Release 78 9787835 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787835 Reactome Database ID Release 78 9787837 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787837 Reactome R-MMU-879584 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879584.1 The human gene SLCO3A1 encodes the organic anion transporting polypeptide D. Several variants are expressed but isoform 1 is ubiquitous and can transport a range of substrates including the prostaglandins E1 and E2, thyroxine and vasopressin (AVP) (Huber RD et al, 2007). 16971491 Pubmed 2007 Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain Huber, RD Gao, B Sidler Pfändler, MA Zhang-Fu, W Leuthold, S Hagenbuch, B Folkers, G Meier, PJ Stieger, B Am J Physiol Cell Physiol 292:C795-806 LEFT-TO-RIGHT SLCO4C1 mediates the transport of digoxin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> DIGX digoxin Reactome DB_ID: 879521 digoxin [ChEBI:4551] digoxin ChEBI CHEBI:4551 Reactome Database ID Release 78 879521 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879521 Reactome R-ALL-879521 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879521.3 DIGX digoxin Reactome DB_ID: 879517 Reactome Database ID Release 78 879517 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879517 Reactome R-ALL-879517 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-879517.3 ACTIVATION Q8BGD4 Slco4c1 SLCO4C1 Reactome DB_ID: 9787858 UniProt:Q8BGD4 Slco4c1 UniProt Q8BGD4 1 EQUAL 724 EQUAL Reactome Database ID Release 78 9787858 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787858 Reactome R-MMU-879598 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879598.1 Reactome Database ID Release 78 9787859 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787859 Reactome Database ID Release 78 9787861 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9787861 Reactome R-MMU-879594 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879594.1 Digoxin is a commonly prescribed drug for the treatment of heart failure. It is mainly eliminated from the body by the kidneys. Human SLCO4C1 (formerly OATP-H) is the first member of the organic anion transporting polypeptide (OATP) family expressed in human kidney. It is found on the baolateral membrane of the nephron and is thought to be the first step of the transport of digoxin into urine (Mikkaichi T et al, 2004). 14993604 Pubmed 2004 Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney Mikkaichi, T Suzuki, T Onogawa, T Tanemoto, M Mizutamari, H Okada, M Chaki, T Masuda, S Tokui, T Eto, N Abe, M Satoh, F Unno, M Hishinuma, T Inui, K Ito, S Goto, J Abe, T Proc Natl Acad Sci U S A 101:3569-74 Reactome Database ID Release 78 9861186 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9861186 Reactome R-MMU-879518 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-879518.1 GENE ONTOLOGY GO:0043252 Organic anion transporting polypeptides (OATPs) are membrane transport proteins that mediate the sodium-independent transport of a wide range of amphipathic organic compounds including bile salts, steroid conjugates, thyroid hormones, anionic oligopeptides and numerous drugs (Hagenbuch B and Meier PJ, 2004). 14579113 Pubmed 2004 Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties Hagenbuch, B Meier, PJ Pflugers Arch 447:653-65 Reactome Database ID Release 78 9860388 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9860388 Reactome R-MMU-425397 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-425397.1 This section groups the processes mediated by SLC transporters, by which vitamins and cofactors, as well as nucleosides, nucleotides, nucleobases, and related molecules cross lipid bilayer membranes (He et al. 2009).<br>The human SLC5A6 encodes the Na+-dependent multivitamin transporter SMVT (Prasad et al. 1999). SMVT co-transports biotin (vitamin B7), D-Pantothoate (vitamin B5) and lipoic acid into cells with Na+ ions electrogenically.<br>Four SLC gene families encode transporters that mediate the movement of nucleosides and free purine and pyrimidine bases across the plasma membrane. These transporters play key roles in nucleoside and nucleobase uptake for salvage pathways of nucleotide synthesis, and in the cellular uptake of nucleoside analogues used in the treatment of cancers and viral diseases (He et al. 2009).<br>The human gene SLC33A1 encodes acetyl-CoA transporter AT1 (Kanamori et al. 1997). Acetyl-CoA is transported to the lumen of the Golgi apparatus, where it serves as the substrate of acetyltransferases that O-acetylates sialyl residues of gangliosides and glycoproteins.<br>Nucleotide sugars are used as sugar donors by glycosyltransferases to create the sugar chains for glycoconjugates such as glycoproteins, polysaccharides and glycolipids. Glycosyltransferases reside mainly in the lumen of the Golgi apparatus and endoplasmic reticulum (ER) whereas nucleotide sugars are synthesized in the cytosol. The human solute carrier family SLC35 encode nucleotide sugar transporters (NSTs), localised on Golgi and ER membranes, which can mediate the antiport of nucleotide sugars in exchange for the corresponding nucleoside monophosphates (eg. UMP for UDP-sugars) (Handford et al. 2006).<br>Long chain fatty acids (LCFAs) can be used for energy sources and steroid hormone synthesis and regulate many cellular processes such as inflammation, blood pressure, the clotting process, blood lipid levels and the immune response. The SLC27A family encode fatty acid transporter proteins (FATPs) (Stahl 2004).<br>The SLC gene family members SLCO1 SLCO2 and SLCO3 encode organic anion transporting polypeptides (OATPs). OATPs are membrane transport proteins that mediate the sodium-independent transport of a wide range of amphipathic organic compounds including bile salts, steroid conjugates, thyroid hormones, anionic oligopeptides and numerous drugs (Hagenbuch & Meier 2004). 23506886 Pubmed 2013 SLC27 fatty acid transport proteins Anderson, Courtney M Stahl, Andreas Mol. Aspects Med. 34:516-28