BioPAX pathway converted from "Signaling by GPCR" in the Reactome database. Signaling by GPCR This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> GPCR ligand binding This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Class A/1 (Rhodopsin-like receptors) This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Peptide ligand-binding receptors This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT AGT(34-41) binds to AGTR1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> AGTR1 Agtr1a P29754 Reactome DB_ID: 9775715 plasma membrane GENE ONTOLOGY GO:0005886 UniProt:P29754 Agtr1a Mus musculus NCBI Taxonomy 10090 UniProt P29754 1 EQUAL 359 EQUAL Reactome Database ID Release 78 9775715 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775715 Reactome R-MMU-374247 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374247.1 Reactome http://www.reactome.org Agt AGT(34-41) P11859 Reactome DB_ID: 9775719 extracellular region GENE ONTOLOGY GO:0005576 UniProt:P11859 Agt UniProt P11859 34 EQUAL 41 EQUAL Reactome Database ID Release 78 9775719 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775719 Reactome R-MMU-374187 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374187.1 AGTR1:AGT(34-41) Reactome DB_ID: 9775721 1 1 Reactome Database ID Release 78 9775721 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775721 Reactome R-MMU-389876 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-389876.1 Reactome Database ID Release 78 9775725 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775725 Reactome R-MMU-374173 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374173.1 The cardiovascular and other actions of the vasoconstricting peptide angiotensin II are mediated by the type 1 and type 2 angiotensin II receptors (AT1 and AT2), which are seven transmembrane glycoproteins with 30% sequence similarity. AT1 receptors (Bergsma DJ et al, 1992) couple to G(q/11), and signal through phospholipases A, C, D, inositol phosphates, calcium channels, and a variety of serine/threonine and tyrosine kinases. The AT2 receptor (Tsuzuki S et al, 1994) is expressed mainly during fetal development. It is much less abundant in adult tissues and is up-regulated in pathological conditions. Its signaling pathways include serine and tyrosine phosphatases, phospholipase A2, nitric oxide, and cyclic guanosine monophosphate. The AT2 receptor counteracts several of the growth responses initiated by the AT1 and growth factor receptors. <br> 1567413 Pubmed 1992 Cloning and characterization of a human angiotensin II type 1 receptor Bergsma, DJ Ellis, C Kumar, C Nuthulaganti, P Kersten, H Elshourbagy, N Griffin, E Stadel, JM Aiyar, N Biochem Biophys Res Commun 183:989-95 inferred from electronic annotation EVIDENCE CODE ECO:0000203 INHIBITION Reactome Database ID Release 78 9775726 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775726 ARBs:AGTR1 Reactome DB_ID: 9775723 Converted from EntitySet in Reactome ARBs Angiotensin II receptor blockers Reactome DB_ID: 9615246 candesartan Reactome DB_ID: 9615297 candesartan [Guide to Pharmacology:587] candesartan CV-11974 TCV-116 (prodrug) Guide to Pharmacology 587 Reactome Database ID Release 78 9615297 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9615297 Reactome R-ALL-9615297 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9615297.2 ChEBI 3347 additional information MI MI:0361 eprosartan Reactome DB_ID: 9615301 eprosartan [Guide to Pharmacology:588] eprosartan Eprozar&reg; SK-108566 Teveten&reg; Guide to Pharmacology 588 Reactome Database ID Release 78 9615301 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9615301 Reactome R-ALL-9615301 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9615301.2 ChEBI 4814 irbesartan Reactome DB_ID: 9615287 irbesartan [Guide to Pharmacology:589] irbesartan Aprovel&reg; Avapro&reg; SR 47436 Guide to Pharmacology 589 Reactome Database ID Release 78 9615287 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9615287 Reactome R-ALL-9615287 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9615287.2 ChEBI 5959 losartan Reactome DB_ID: 9615293 losartan [Guide to Pharmacology:590] losartan Cozaar&reg; DuP 753 MK-954 Guide to Pharmacology 590 Reactome Database ID Release 78 9615293 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9615293 Reactome R-ALL-9615293 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9615293.2 ChEBI 6541 olmesartan Reactome DB_ID: 9615294 olmesartan [Guide to Pharmacology:591] olmesartan Benicar&reg; CS-866 Olmetec&reg; Guide to Pharmacology 591 Reactome Database ID Release 78 9615294 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9615294 Reactome R-ALL-9615294 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9615294.2 ChEBI 48416 telmisartan Reactome DB_ID: 9615288 telmisartan [Guide to Pharmacology:592] telmisartan BIBR-277SE Micardis&reg; Pritor&reg; Guide to Pharmacology 592 Reactome Database ID Release 78 9615288 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9615288 Reactome R-ALL-9615288 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9615288.2 ChEBI 9434 valsartan Reactome DB_ID: 9615299 valsartan [Guide to Pharmacology:3937] valsartan CGP-48933 Diovan&reg; Prexxartan&reg; (oral solution) Guide to Pharmacology 3937 Reactome Database ID Release 78 9615299 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9615299 Reactome R-ALL-9615299 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9615299.2 ChEBI 9927 forasartan Reactome DB_ID: 9615735 forasartan [Guide to Pharmacology:6896] forasartan SC-52458 Guide to Pharmacology 6896 Reactome Database ID Release 78 9615735 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9615735 Reactome R-ALL-9615735 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9615735.2 ChEBI 141552 Reactome Database ID Release 78 9615246 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9615246 Reactome R-ALL-9615246 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9615246.1 1 1 Reactome Database ID Release 78 9775723 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775723 Reactome R-MMU-9615251 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9615251.1 LEFT-TO-RIGHT AGT(34-41) binds to AGTR2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Agtr2 AGTR2 P35374 Reactome DB_ID: 9778056 UniProt:P35374 Agtr2 UniProt P35374 1 EQUAL 363 EQUAL Reactome Database ID Release 78 9778056 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778056 Reactome R-MMU-374130 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374130.1 AGTR2:AGT(34-41) Reactome DB_ID: 9778058 1 1 Reactome Database ID Release 78 9778058 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778058 Reactome R-MMU-389873 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-389873.1 Reactome Database ID Release 78 9856865 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9856865 Reactome R-MMU-9615348 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9615348.1 The cardiovascular and other actions of the vasoconstricting peptide angiotensin II are mediated by the type 1 and type 2 angiotensin II receptors (AT1 and AT2), which are seven transmembrane glycoproteins with 30% sequence similarity. AT1 receptors (Bergsma DJ et al, 1992) couple to G(q/11), and signal through phospholipases A, C, D, inositol phosphates, calcium channels, and a variety of serine/threonine and tyrosine kinases. The AT2 receptor (Tsuzuki S et al, 1994) is expressed mainly during fetal development. It is much less abundant in adult tissues and is up-regulated in pathological conditions. Its signaling pathways include serine and tyrosine phosphatases, phospholipase A2, nitric oxide, and cyclic guanosine monophosphate. The AT2 receptor counteracts several of the growth responses initiated by the AT1 and growth factor receptors. <br> 8185599 Pubmed 1994 Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor Tsuzuki, S Ichiki, T Nakakubo, H Kitami, Y Guo, DF Shirai, H Inagami, T Biochem Biophys Res Commun 200:1449-54 LEFT-TO-RIGHT ARBs bind AGRT1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome Database ID Release 78 9856863 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9856863 Reactome R-MMU-9615249 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9615249.1 The vasoconstricting actions of the peptide angiotensin II (AGT(34-41)) are mediated by type 1 angiotensin II receptors (AGTR1), which belongs to class A/1 G protein-coupled receptors (GPCRs). Angiotensin II receptor blockers (ARBs, also known as angiotensin II receptor antagonists, AT1 receptor antagonists or sartans) are a group of pharmaceuticals that modulate the renin–angiotensin system (RAS). ARBs block the activation of AGTR1 receptors, preventing the binding of angiotensin II. Blockage of AGTR1 receptors directly causes vasodilation, reduces secretion of vasopressin, and reduces production and secretion of aldosterone. These combined effects reduce blood pressure by reducing peripheral vascular resistance usually without a rise in heart rate (Israili 2000, Unger 2001). ARBs are primarily used for the treatment of hypertension where the patient is intolerant of ACE inhibitor therapy but also for diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure. ARBs do not inhibit the breakdown of bradykinin or other kinins, and are thus rarely associated with the persistent dry cough or angioedema that limit ACE inhibitor therapy.<br><br>Losartan (Cozaar) was the first successful ARB drug, approved in the United States in 1995. It is primarily used to treat hypertension (Goldberg et al. 1995, Mallion & Goldberg 1996) but can also be used to treat diabetic kidney disease (Ruilope & Segura 2003) and congestive heart failure (Konstam et al. 2009). Irbesartan (Avapro) is indicated for the treatment of hypertension, to delay progression of diabetic nephropathy and for the reduction of renal disease progression in patients with type 2 diabetes (Gialama & Maniadakis 2013). Olmesartan medoxomil (Benicar) is an ester prodrug which is completely and rapidly hydrolyzed to the active acid form, olmesartan (RNH-6270) (Brunner 2002). Olmesartan is indicated for the treatment of hypertension, alone or in combination with other antihypertensive agents. The prodrug candesartan cilexetil is hydrolysed to the active form candesartan (Ishizuka et al. 2013). It is indicated for hypertension and congestive heart failure (Zheng et al. 2011).<br><br>Valsartan (Diovan) is mainly used for the treatment of hypertension (Black et al. 1997), congestive heart failure, and to increase survivability after a heart attack (Cohn et al. 2001). Eprosartan (Teveten) is used for the treatment of hypertension (Sega 1999) and is generally better tolerated than enalapril (an ACE inhibitor), especially among the elderly (Ruilope et al. 2001). Telmisartan (Micardis) is indicated in the treatment of essential hypertension and possesses a long duration of action (Littlejohn et al. 2000). Forasartan (compound SC-52458) is sparingly used in the treatment of hypertension because of its short duration of action and being less potent than losartan (Hagmann et al. 1997). 14749145 Pubmed 2003 Losartan and other angiotensin II antagonists for nephropathy in type 2 diabetes mellitus: a review of the clinical trial evidence Ruilope, Luis M Segura, Julian Clin Ther 25:3044-64 10451039 Pubmed 1999 Efficacy and safety of eprosartan in severe hypertension. Eprosartan Multinational Study Group Sega, R Blood Press. 8:114-21 7717281 Pubmed 1995 Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension Goldberg, A I Dunlay, M C Sweet, C S Am. J. Cardiol. 75:793-5 11759645 Pubmed 2001 A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure Cohn, J N Tognoni, G N. Engl. J. Med. 345:1667-75 9156352 Pubmed 1997 SC-52458, an orally active angiotensin II-receptor antagonist: inhibition of blood pressure response to angiotensin II challenges and pharmacokinetics in normal volunteers Hagmann, M Nussberger, J Naudin, R B Burns, T S Karim, A Waeber, B Brunner, H R J. Cardiovasc. Pharmacol. 29:444-50 21421652 Pubmed 2011 A systematic review and meta-analysis of candesartan and losartan in the management of essential hypertension Zheng, Zhenfeng Shi, Huilan Jia, Junya Li, Dong Lin, Shan J Renin Angiotensin Aldosterone Syst 12:365-74 10854085 Pubmed 2000 Clinical pharmacokinetics of angiotensin II (AT1) receptor blockers in hypertension Israili, Z H J Hum Hypertens 14:S73-86 11021956 Pubmed 2000 A prospective, randomized, open-label trial comparing telmisartan 80 mg with valsartan 80 mg in patients with mild to moderate hypertension using ambulatory blood pressure monitoring Littlejohn, T Mroczek, W Marbury, T VanderMaelen, C P Dubiel, R F Can J Cardiol 16:1123-32 23946449 Pubmed 2013 Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1 Ishizuka, Tomoko Yoshigae, Yasushi Murayama, Nobuyuki Izumi, Takashi Drug Metab. Dispos. 41:1888-95 19922995 Pubmed 2009 Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial Konstam, Marvin A Neaton, James D Dickstein, Kenneth Drexler, Helmut Komajda, Michel Martinez, Felipe A Riegger, Gunter A J Malbecq, William Smith, Ronald D Guptha, Soneil Poole-Wilson, Philip A Lancet 374:1840-8 11800061 Pubmed 2001 Eprosartan versus enalapril in elderly patients with hypertension: a double-blind, randomized trial Ruilope, L Jäger, B Prichard, B Blood Press. 10:223-9 11683476 Pubmed 2001 Pharmacology of AT1-receptor blockers Unger, T Blood Press Suppl5-10 24124375 Pubmed 2013 Comprehensive overview: efficacy, tolerability, and cost-effectiveness of irbesartan Gialama, Fotini Maniadakis, Nikos Vasc Health Risk Manag 9:575-92 11967728 Pubmed 2002 The new oral angiotensin II antagonist olmesartan medoxomil: a concise overview Brunner, Hans R J Hum Hypertens 16:S13-6 8913546 Pubmed 1996 Global efficacy and tolerability of losartan, an angiotensin II subtype 1-receptor antagonist, in the treatment of hypertension Mallion, J M Goldberg, A I Blood Press Suppl 2:82-6 9322828 Pubmed 1997 Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: efficacy, tolerability and safety compared to an angiotensin-converting enzyme inhibitor, lisinopril Black, H R Graff, A Shute, D Stoltz, R Ruff, D Levine, J Shi, Y Mallows, S J Hum Hypertens 11:483-9 LEFT-TO-RIGHT Apelin receptor binds to apelin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Aplnr APLNR Q9WV08 Reactome DB_ID: 9775841 UniProt:Q9WV08 Aplnr UniProt Q9WV08 1 EQUAL 380 EQUAL Reactome Database ID Release 78 9775841 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775841 Reactome R-MMU-374259 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374259.1 Apln APLN(65-77) Q9R0R4 Reactome DB_ID: 9775831 UniProt:Q9R0R4 Apln UniProt Q9R0R4 65 EQUAL 77 EQUAL Reactome Database ID Release 78 9775831 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775831 Reactome R-MMU-374315 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374315.1 APLNR:Apelin peptides Reactome DB_ID: 9775843 1 1 Reactome Database ID Release 78 9775843 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775843 Reactome R-MMU-374316 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374316.1 Reactome Database ID Release 78 9775845 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775845 Reactome R-MMU-374337 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374337.1 Apelin (Tatemoto K et al, 1998) is an endogenous ligand for the apelin (APJ) receptor (O'Dowd BF et al, 1993) and is widely expressed in the human body including the heart and brain. Apelin is one of the most potent stimulators of cardiac contractility and mediates blood pressure and blood flow. Several active peptides can be produced by proteolytic processing of the peptide precursor (apelin-36, 31, 28 and 13). APJ is related to the angiotensin receptor (40-50% identity) and couples to G proteins that inhibit adenylate cyclase activity. It is an alternative coreceptor with CD4 for HIV-1 infection. Binding of apelin to its receptor inhibits HIV-1 entry in cells coexpressing CD4 and APJ. 8294032 Pubmed 1993 A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11 O'Dowd, BF Heiber, M Chan, A Heng, HH Tsui, LC Kennedy, JL Shi, X Petronis, A George, SR Nguyen, T Gene 136:355-60 9792798 Pubmed 1998 Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor Tatemoto, K Hosoya, M Habata, Y Fujii, R Kakegawa, T Zou, MX Kawamata, Y Fukusumi, S Hinuma, S Kitada, C Kurokawa, T Onda, H Fujino, M Biochem Biophys Res Commun 251:471-6 LEFT-TO-RIGHT Bombesin-like receptors bind bombesin homologues This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome Bombesin-like peptide Reactome DB_ID: 9776548 Grp GRP(24-50) Q8R1I2 Reactome DB_ID: 9776542 UniProt:Q8R1I2 Grp UniProt Q8R1I2 24 EQUAL 50 EQUAL Reactome Database ID Release 78 9776542 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776542 Reactome R-MMU-375358 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375358.1 Nmb NMB(47-56) Q9CR53 Reactome DB_ID: 9776546 UniProt:Q9CR53 Nmb UniProt Q9CR53 47 EQUAL 56 EQUAL Reactome Database ID Release 78 9776546 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776546 Reactome R-MMU-375361 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375361.1 Reactome Database ID Release 78 9776548 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776548 Reactome R-MMU-375360 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375360.1 Converted from EntitySet in Reactome Bombesin-like receptor Reactome DB_ID: 9776562 Grpr GRPR P21729 Reactome DB_ID: 9776552 UniProt:P21729 Grpr UniProt P21729 1 EQUAL 384 EQUAL Reactome Database ID Release 78 9776552 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776552 Reactome R-MMU-375363 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375363.1 Nmbr NMBR O54799 Reactome DB_ID: 9776556 UniProt:O54799 Nmbr UniProt O54799 1 EQUAL 390 EQUAL Reactome Database ID Release 78 9776556 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776556 Reactome R-MMU-375357 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375357.1 Brs3 BRS3 O54798 Reactome DB_ID: 9776560 UniProt:O54798 Brs3 UniProt O54798 1 EQUAL 399 EQUAL Reactome Database ID Release 78 9776560 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776560 Reactome R-MMU-947694 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-947694.1 Reactome Database ID Release 78 9776562 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776562 Reactome R-MMU-375362 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375362.1 Bombesin-like receptor:bombesin-like peptide Reactome DB_ID: 9776564 1 1 Reactome Database ID Release 78 9776564 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776564 Reactome R-MMU-375359 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375359.1 Reactome Database ID Release 78 9776566 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776566 Reactome R-MMU-375384 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375384.1 Bombesin-like receptors are widely distributed in the CNS as well as in the GI tract where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behaviour through the binding of bombesin-like peptides. They include gastrin-releasing peptide receptor (GRP-R), neuromedin B receptor (NMB-R) (Corjay MH et al, 1991) and bombesin-like receptor-3 (BRS-3) (Fathi Z et al, 1993). BRS-3 binds bombesin peptides with low affinity and is often classed as an orphan receptor. There are two homologues of bombesin-like peptides; Gastrin-releasing peptide (GRP) (Sausville EA et al, 1986) and Neuromedin-B (NMB) (Krane IM et al, 1988). GRP regulates gastric acid secretion and motor function and is a negative feedback operator regulating fear. NMB is involved in the regulation of many functions such as cell growth, body temperature and blood pressure and glucose levels. 2458345 Pubmed 1988 Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin Krane, IM Naylor, SL Helin-Davis, D Chin, WW Spindel, ER J Biol Chem 263:13317-23 1655761 Pubmed 1991 Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells Corjay, MH Dobrzanski, DJ Way, JM Viallet, J Shapira, H Worland, P Sausville, EA Battey, JF J Biol Chem 266:18771-9 3003116 Pubmed 1986 Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs Sausville, EA Lebacq-Verheyden, AM Spindel, ER Cuttitta, F Gazdar, AF Battey, JF J Biol Chem 261:2451-7 8383682 Pubmed 1993 BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells Fathi, Z Corjay, MH Shapira, H Wada, E Benya, R Jensen, R Viallet, J Sausville, EA Battey, JF J Biol Chem 268:5979-84 LEFT-TO-RIGHT Bradykinin receptors B1 and B2 bind to bradykinin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome BDKRB1,BDKRB2 Bradykinin receptor Reactome DB_ID: 9775823 Bdkrb1 BDKRB1 Q61125 Reactome DB_ID: 9775817 UniProt:Q61125 Bdkrb1 UniProt Q61125 1 EQUAL 353 EQUAL Reactome Database ID Release 78 9775817 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775817 Reactome R-MMU-374257 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374257.1 Bdkrb2 BDKRB2 P32299 Reactome DB_ID: 9775821 UniProt:P32299 Bdkrb2 UniProt P32299 1 EQUAL 391 EQUAL Reactome Database ID Release 78 9775821 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775821 Reactome R-MMU-374255 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374255.1 Reactome Database ID Release 78 9775823 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775823 Reactome R-MMU-374323 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374323.1 Kng2 Bradykinin Q6S9I3 Reactome DB_ID: 9761232 UniProt:Q6S9I3 Kng2 UniProt Q6S9I3 381 EQUAL 389 EQUAL Reactome Database ID Release 78 9761232 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9761232 Reactome R-MMU-158344 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-158344.1 Bradykinin receptor:Bradykinin Reactome DB_ID: 9775825 1 1 Reactome Database ID Release 78 9775825 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775825 Reactome R-MMU-374321 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374321.1 Reactome Database ID Release 78 9775827 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775827 Reactome R-MMU-374331 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374331.1 Bradykinin (Rocha e Silva M, et al, 1949) is a 9 amino-acid peptide belonging to the kinin group of proteins. It causes blood vessel dilation via the release of prostacyclin, nitric oxide and endothelial-derived hyperpolarizing factor, resulting in lower blood pressure. It is also involved in the pain mechanism. Bradykinin exerts its effects through two receptors, bradykinin receptor B1 and 2 (B1R and B2R respectively). B1R (Menke JG et al, 1994) is synthesized de novo following tissue injury and receptor binding leads to an increase in cytosolic calcium concentration, resulting in chronic and acute inflammatory responses. Unlike B1R, B2R (Hess JF et al, 1992) is ubiquitously and constitutively expressed in healthy tissues. It also increase cytosolic calcium concentration and stimulates the mitogen-activated protein kinase pathways. 18127230 Pubmed 1949 Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin ROCHA E SILVA, M Beraldo, WT ROSENFELD, G Am J Physiol 156:261-73 3366244 Pubmed 1988 Isolation and identification of hydroxyproline analogues of bradykinin in human urine Kato, H Matsumura, Y Maeda, H FEBS Lett 232:252-4 8063797 Pubmed 1994 Expression cloning of a human B1 bradykinin receptor Menke, JG Borkowski, JA Bierilo, KK MacNeil, T Derrick, AW Schneck, KA Ransom, RW Strader, CD Linemeyer, DL Hess, JF J Biol Chem 269:21583-6 1314587 Pubmed 1992 Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor Hess, JF Borkowski, JA Young, GS Strader, CD Ransom, RW Biochem Biophys Res Commun 184:260-8 LEFT-TO-RIGHT C5AR2 binds anaphylatoxins and thier desArginated derivatives This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> C5ar2 C5AR2 Q8BW93 Reactome DB_ID: 9789851 UniProt:Q8BW93 C5ar2 UniProt Q8BW93 1 EQUAL 337 EQUAL Reactome Database ID Release 78 9789851 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789851 Reactome R-MMU-964798 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-964798.1 Converted from EntitySet in Reactome C5AR2 ligands Reactome DB_ID: 9789847 C5 C5a P06684 Reactome DB_ID: 9764888 UniProt:P06684 C5 UniProt P06684 678 EQUAL 751 EQUAL Reactome Database ID Release 78 9764888 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9764888 Reactome R-MMU-173677 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-173677.1 C3 C3a P01027 Reactome DB_ID: 9763788 UniProt:P01027 C3 UniProt P01027 672 EQUAL 748 EQUAL Reactome Database ID Release 78 9763788 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9763788 Reactome R-MMU-166828 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-166828.1 Reactome Database ID Release 78 9789847 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789847 Reactome R-MMU-964782 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-964782.1 C5AR2:C5AR2 ligands Reactome DB_ID: 9789853 1 1 Reactome Database ID Release 78 9789853 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789853 Reactome R-MMU-964812 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-964812.1 Reactome Database ID Release 78 9789855 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789855 Reactome R-MMU-964811 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-964811.1 C5AR2 (GPR77, C5L2) has been described as a receptor for the chemotactic and inflammatory peptides anaphylatoxin C5a, C4a and C3a and even their des-arginated derivatives. Highest binding affinity was for C3a-desArg, also called Acylation Stimulating Protein (ASP), produced from C3a following arginine removal by carboxypeptidases. Binding of C3a and its derivatives has been disputed (Johswich et al. 2006) leading to suggestions that this receptor may be a C5a scavenger. It is weakly coupled to G(i)-mediated signaling pathways and believed to function primarily as a decoy receptor though it can interact with beta arrestin (Van Lith et al. 2009). 17068344 Pubmed 2006 Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines Johswich, K Martin, M Thalmann, J Rheinheimer, C Monk, PN Klos, A J Biol Chem 281:39088-95 11773063 Pubmed 2002 The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74) Cain, SA Monk, PN J Biol Chem 277:7165-9 12540846 Pubmed 2003 The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein Kalant, D Cain, SA Maslowska, M Sniderman, AD Cianflone, K Monk, PN J Biol Chem 278:11123-9 19641221 Pubmed 2009 C5a-stimulated recruitment of beta-arrestin2 to the nonsignaling 7-transmembrane decoy receptor C5L2 Van Lith, LH Oosterom, J Van Elsas, A Zaman, GJ J Biomol Screen 14:1067-75 LEFT-TO-RIGHT C5a receptor binds C5a anaphylatoxin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> C5ar1 C5AR1 P30993 Reactome DB_ID: 9776570 UniProt:P30993 C5ar1 UniProt P30993 1 EQUAL 350 EQUAL Reactome Database ID Release 78 9776570 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776570 Reactome R-MMU-375356 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375356.1 C5AR1:C5a Reactome DB_ID: 9776572 1 1 Reactome Database ID Release 78 9776572 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776572 Reactome R-MMU-375354 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375354.1 Reactome Database ID Release 78 9776574 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776574 Reactome R-MMU-375395 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375395.1 C5a (Fernandez HN and Hugli TE, 1978) is a protein fragment released from complement component C5. C5a is a potent anaphylatoxin, causing the release of histamine from mast cells and also being an effective leukocyte attractant. The C5a receptor (complement component 5a receptor 1, C5AR1; Cluster of Differentiation 88, CD88) (Gerard NP and Gerard C, 1991) mediates the pro-inflammatory and chemotactic actions of C5a. 1847994 Pubmed 1991 The chemotactic receptor for human C5a anaphylatoxin Gerard, NP Gerard, C Nature 349:614-7 690134 Pubmed 1978 Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a Fernandez, HN Hugli, TE J Biol Chem 253:6955-64 LEFT-TO-RIGHT C3a receptor binds anaphylatoxin C3a This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> C3ar1 C3AR1 O09047 Reactome DB_ID: 9778050 UniProt:O09047 C3ar1 UniProt O09047 1 EQUAL 482 EQUAL Reactome Database ID Release 78 9778050 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778050 Reactome R-MMU-444727 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-444727.1 C3AR1:C3a Reactome DB_ID: 9778052 1 1 Reactome Database ID Release 78 9778052 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778052 Reactome R-MMU-444688 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-444688.1 Reactome Database ID Release 78 9784393 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784393 Reactome R-MMU-444647 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-444647.1 The complement component 3a receptor (C3AR) binds C3a, a 77-amino acid anaphylatoxin generated after proteolytic cleavage of C3 and C5 in response to complement activation. C3a is involved in a variety of inflammatory responses including chemotaxis and activation of granulocytes, mast cells and macrophages (Peng et al. 200, Klos et al. 2009). 8702752 Pubmed 1996 Molecular cloning and characterization of the human anaphylatoxin C3a receptor Ames, RS Li, Y Sarau, HM Nuthulaganti, P Foley, JJ Ellis, C Zeng, Z Su, K Jurewicz, AJ Hertzberg, RP Bergsma, DJ Kumar, C J Biol Chem 271:20231-4 19477527 Pubmed 2009 The role of the anaphylatoxins in health and disease Klos, A Tenner, Andrea J Johswich, Kay-Ole Ager, Rahasson R Reis, Edimara S Köhl, J Mol. Immunol. 46:2753-66 19601884 Pubmed 2009 The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses Peng, Q Li, K Sacks, SH Zhou, W Inflamm Allergy Drug Targets 8:236-46 LEFT-TO-RIGHT G protein-coupled estrogen receptor 1 binds estrogen non-classically This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ESTG estrogen Reactome DB_ID: 374146 estrogen [ChEBI:50114] estrogen ChEBI CHEBI:50114 Reactome Database ID Release 78 374146 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=374146 Reactome R-ALL-374146 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-374146.3 Gper1 GPER1 Q8BMP4 Reactome DB_ID: 9775730 UniProt:Q8BMP4 Gper1 UniProt Q8BMP4 1 EQUAL 375 EQUAL Reactome Database ID Release 78 9775730 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775730 Reactome R-MMU-374191 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374191.1 GPER1:ESTG Reactome DB_ID: 9775732 1 1 Reactome Database ID Release 78 9775732 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775732 Reactome R-MMU-374150 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374150.1 Reactome Database ID Release 78 9775734 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775734 Reactome R-MMU-374207 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374207.1 G protein-coupled estrogen receptor 1 (GPER; CEPR; G-protein coupled receptor 30, GPR30) (Feng Y and Gregor P, 1997) has a ubiquitous tissue distribution. This orphan receptor is unrelated to nuclear estrogen receptors, but shows all the binding and signaling characteristics of a membrane estrogen receptor (mER). This suggests a role for GPCRs in nonclassical steroid hormone actions. 15539556 Pubmed 2005 Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells Thomas, P Pang, Y Filardo, Edward J Dong, J Endocrinology 146:624-32 9070864 Pubmed 1997 Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors Feng, Y Gregor, P Biochem Biophys Res Commun 231:651-4 LEFT-TO-RIGHT GPCR neuropeptide receptor binds neuropeptides B and W This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Npbwr1 NPBWR1 P49681 Reactome DB_ID: 9776000 UniProt:P49681 Npbwr1 UniProt P49681 1 EQUAL 328 EQUAL Reactome Database ID Release 78 9776000 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776000 Reactome R-MMU-374780 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374780.1 Converted from EntitySet in Reactome Neuropeptides B/W Reactome DB_ID: 9775996 Npb NPB(25-48) Q8K4P1 Reactome DB_ID: 9775986 UniProt:Q8K4P1 Npb UniProt Q8K4P1 25 EQUAL 48 EQUAL Reactome Database ID Release 78 9775986 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775986 Reactome R-MMU-374794 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374794.1 Npw NPW(33-55) F7B5D6 Reactome DB_ID: 9775992 UniProt:F7B5D6 Npw UniProt F7B5D6 33 EQUAL 55 EQUAL Reactome Database ID Release 78 9775992 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775992 Reactome R-MMU-374802 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374802.1 Reactome Database ID Release 78 9775996 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775996 Reactome R-MMU-374796 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374796.1 Neuropeptides B/W receptor:neuropeptides B/W Reactome DB_ID: 9776002 1 1 Reactome Database ID Release 78 9776002 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776002 Reactome R-MMU-374779 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374779.1 Reactome Database ID Release 78 9776004 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9776004 Reactome R-MMU-374787 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374787.1 The structurally related (70% identity) orphan G-protein-coupled receptors, neuropeptides B/W receptor 1 and 2 (GPR7 and GPR8 respectively) (O'Dowd BF et al, 1995), are wideley expressed in the central nervous system of humans. Natural ligands identified for these receptors are involved in the regulation of feeding. Neuropeptide B is cleaved into two chains; NPB23 (L7) and NPB29 (L7C). Neuropeptide W is also cleaved into two chains; NPW23 (L8) and NPW30 (L8C) (Tanaka H et al, 2003). Both these peptides can bind to either GPR7 or 8 to elicit their effects downstream. 7590751 Pubmed 1995 The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain O'Dowd, BF Scheideler, MA Nguyen, T Cheng, R Rasmussen, JS Marchese, A Zastawny, R Heng, HH Tsui, LC Shi, X Genomics 28:84-91 12719537 Pubmed 2003 Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8 Tanaka, Hiroshi Yoshida, T Miyamoto, N Motoike, T Kurosu, H Shibata, K Yamanaka, A Williams, SC Richardson, JA Tsujino, N Garry, MG Lerner, MR King, DS O'Dowd, BF Sakurai, T Yanagisawa, M Proc Natl Acad Sci U S A 100:6251-6 LEFT-TO-RIGHT Nociceptin receptor binds to nociceptin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Pnoc PNOC(130-146) Q64387 Reactome DB_ID: 9775941 UniProt:Q64387 Pnoc UniProt Q64387 130 EQUAL 146 EQUAL Reactome Database ID Release 78 9775941 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775941 Reactome R-MMU-374749 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374749.1 Oprl1 OPRL1 P35377 Reactome DB_ID: 9775945 UniProt:P35377 Oprl1 UniProt P35377 1 EQUAL 370 EQUAL Reactome Database ID Release 78 9775945 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775945 Reactome R-MMU-374731 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374731.1 Nociceptin receptor:Nociceptin Reactome DB_ID: 9775947 1 1 Reactome Database ID Release 78 9775947 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775947 Reactome R-MMU-374725 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374725.1 Reactome Database ID Release 78 9775949 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775949 Reactome R-MMU-374723 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374723.1 The orphan nociceptin (ORL1) receptor (Mollereau C et al, 1994) is most closely related to opioid receptors on structural (sequence) and functional grounds but is not a typical opioid receptor. It may play a role in instinctive behaviours and emotions. Its natural ligand is nociceptin (orphanin FQ) (Mollereau C et al, 1996), a 17 amino acid neuropeptide which acts as a potent anti-analgesic. Both receptor and ligand are widely expressed in the CNS. 8137918 Pubmed 1994 ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization Mollereau, C Parmentier, M Mailleux, P Butour, JL Moisand, C Chalon, P Caput, D Vassart, G Meunier, JC FEBS Lett 341:33-8 9521323 Pubmed 1998 Nocistatin, a peptide that blocks nociceptin action in pain transmission Okuda-Ashitaka, E Minami, T Tachibana, S Yoshihara, Y Nishiuchi, Y Kimura, T Ito, S Nature 392:286-9 8710928 Pubmed 1996 Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene Mollereau, C Simons, MJ Soularue, P Liners, F Vassart, G Meunier, JC Parmentier, M Proc Natl Acad Sci U S A 93:8666-70 LEFT-TO-RIGHT Opioid receptors bind opioid peptides This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome Opioid receptors Reactome DB_ID: 9775785 Oprd1 OPRD1 P32300 Reactome DB_ID: 9775782 UniProt:P32300 Oprd1 UniProt P32300 1 EQUAL 372 EQUAL Reactome Database ID Release 78 9775782 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775782 Reactome R-MMU-374265 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374265.1 Oprm1 OPRM1 P42866 Reactome DB_ID: 9759062 UniProt:P42866 Oprm1 Oprm1 Mor Oprm FUNCTION Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 9 is involved in morphine-induced scratching and seems to cross-activate GRPR in response to morphine.SUBUNIT Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms) (PubMed:10842167, PubMed:12270145, PubMed:18836069, PubMed:21422164). Interacts with heterotrimeric G proteins; interaction with a heterotrimeric complex containing GNAI1, GNB1 and GNG2 stabilizes the active conformation of the receptor and increases its affinity for endomorphin-2, the synthetic opioid peptide DAMGO and for morphinan agonists (PubMed:26245379). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS and GPM6A (By similarity). Interacts with RTP4 (PubMed:18836069). Interacts with SYP and GNAS (By similarity). Interacts with RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1 (PubMed:15827571, PubMed:17725581, PubMed:18439408, PubMed:21153910). Isoform 9 interacts with GRPR (PubMed:22000021).PTM Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated phosphorylation modulates receptor internalization. Phosphorylated by GRK2 in a agonist-dependent manner. Phosphorylation at Tyr-166 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on tyrosine residues; the phosphorylation is involved in agonist-induced G-protein-independent receptor down-regulation. Phosphorylation at Ser-375 is involved in G-protein-dependent but not beta-arrestin-dependent activation of the ERK pathway.PTM Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.DISRUPTION PHENOTYPE During adult neurogenesis in hippocampus, increased numbers of granule cells maturing into neurons, larger granule cell layers and increased numbers of granule cells.SIMILARITY Belongs to the G-protein coupled receptor 1 family. UniProt P42866 1 EQUAL 400 EQUAL Reactome Database ID Release 78 9759062 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9759062 Reactome R-MMU-60951 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-60951.1 Oprk1 Kappa-type opioid receptor OPRK_MOUSE Reactome DB_ID: 9022001 UniProt:P33534 Oprk1 Oprk1 FUNCTION G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.SUBUNIT Interacts with SLC9A3R1. Interacts with GABARAPL1 (By similarity).TISSUE SPECIFICITY Detected in brain (at protein level). Brain (neocortex, hippocampus, amygdala, medial habenula, hypothalamus, locus ceruleus, and parabrachial nucleus).DISRUPTION PHENOTYPE Mice are born at the expected Mendelian rate and show no obvious phenotype. Mutant mice do not display analgesia after treatment with the synthetic agonist U-50,488H. Unlike wild-type mice, they do not show reduced locomotion and increased salivation in response to the synthetic agonist U-50,488H.SIMILARITY Belongs to the G-protein coupled receptor 1 family. UniProt P33534 1 EQUAL 380 EQUAL Reactome Database ID Release 78 9022001 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9022001 Reactome R-MMU-9022001 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9022001.1 Reactome Database ID Release 78 9775785 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775785 Reactome R-MMU-374277 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374277.1 Converted from EntitySet in Reactome Opioid ligands Reactome DB_ID: 9775809 Pomc POMC(237-267) P01193 Reactome DB_ID: 9759065 UniProt:P01193 Pomc Pomc Pomc1 TISSUE SPECIFICITY ACTH and MSH are produced by the pituitary gland.PTM Specific enzymatic cleavages at paired basic residues yield the different active peptides.SIMILARITY Belongs to the POMC family. UniProt P01193 237 EQUAL 267 EQUAL Reactome Database ID Release 78 9759065 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9759065 Reactome R-MMU-167405 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167405.1 Pdyn PDYN(207-238) O35417 Reactome DB_ID: 9775787 UniProt:O35417 Pdyn UniProt O35417 207 EQUAL 238 EQUAL Reactome Database ID Release 78 9775787 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775787 Reactome R-MMU-374380 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374380.1 Penk PENK(230-234) P22005 Reactome DB_ID: 9775799 UniProt:P22005 Penk UniProt P22005 230 EQUAL 234 EQUAL Reactome Database ID Release 78 9775799 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775799 Reactome R-MMU-374376 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374376.1 Reactome Database ID Release 78 9775809 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775809 Reactome R-MMU-374370 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374370.1 Opioid receptor:opioid ligand Reactome DB_ID: 9775811 1 1 Reactome Database ID Release 78 9775811 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775811 Reactome R-MMU-374302 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374302.1 Reactome Database ID Release 78 9775813 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775813 Reactome R-MMU-374298 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374298.1 There are three well-characterized families of opioid peptides produced by the body: endorphins, enkephalins and dynorphins. Endorphins are processed from the precursor proopiomelanocortin (POMC) (Takahashi H et al, 1981), which can also be processed to yield adrenocorticotropic hormone (ACTH) and alpha- and gamma-melanocyte stimulating hormone (MSH). Beta-endorphin (Dragon N et al, 1977) is a 31 amino acid peptide found in neurons of the hypothalamus and pituitary gland. It is released into the blood (from the pituitary gland) and into the spinal cord and brain from hypothalamic neurons during vigourous exercise, excitement and orgasm. Beta-endorphin binds with the highest affinity to the mu-opioid receptor but it also possesses some affinity towards the delta- and kappa-opioid receptors. Once bound, it acts as an analgesic in the body by dulling pain. It does this by breaking down bradykinins which are peptides which accumulate in response to injury. The mu-opioid receptor (MOR) (Wang JB et al, 1994) possesses high affinity for enkephalins and beta-endorphin but low affinity for dynorphins.<br>The enkephalins are endogenous ligands, or specifically endorphins, as they are internally derived and bind to the body's opioid receptors. There are two forms of enkephalin, one containing leucine ("leu"), while the other contains methionine ("met"). The met-enkephalin peptide sequence is coded by the POMC gene whereas leu-enkephalin is coded by both POMC and dynorphin genes. Enkephalins are pentapeptides involved in regulating pain and nociception in the body. Their action is mediated through the delta-opioid receptor (DOR) (Knapp RJ et al, 1994).<br>Dynorphins constitute a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released, amongst which are dynorphin A, dynorphin B, big-dyn and alpha/beta-neoendorphin (Day R et al, 1998). Dynorphins primarily exert their effects through the kappa-opioid receptor (KOR), a G-protein coupled receptor (Simonin F et al, 1995). Two subtypes of KORs have been identified: K1 and K2. Although KOR is the primary receptor for all dynorphins (James IF et al, 1982), the peptides do have some affinity for MOR and DOR. 6128656 Pubmed 1982 Selectivity of dynorphin for kappa opioid receptors James, IF Chavkin, C Goldstein, A Life Sci 31:1331-4 6281660 Pubmed 1982 Isolation and structural organization of the human preproenkephalin gene Noda, M Teranishi, Y Takahashi, H Toyosato, M Notake, M Nakanishi, S Numa, S Nature 297:431-4 7624359 Pubmed 1995 kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system Simonin, F Gaveriaux-Ruff, Claire Befort, K Matthes, H Lannes, B Micheletti, G Mattéi, MG Charron, G Bloch, B Kieffer, B Proc Natl Acad Sci U S A 92:7006-10 8201839 Pubmed 1994 Identification of a human delta opioid receptor: cloning and expression Knapp, RJ Malatynska, E Fang, L Li, X Babin, E Nguyen, M Santoro, G Varga, EV Hruby, VJ Roeske, WR Life Sci 54:PL463-9 7057924 Pubmed 1982 Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA Comb, M Seeburg, PH Adelman, J Eiden, L Herbert, E Nature 295:663-6 6274691 Pubmed 1981 Isolation and structural organization of the human corticotropin--beta-lipotropin precursor gene Takahashi, H Teranishi, Y Nakanishi, S Numa, S FEBS Lett 135:97-102 7905839 Pubmed 1994 Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment Wang, JB Johnson, PS Persico, AM Hawkins, AL Griffin, CA Uhl, GR FEBS Lett 338:217-22 9422738 Pubmed 1998 Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity Day, R Lazure, C Basak, A Boudreault, A Limperis, P Dong, W Lindberg, I J Biol Chem 273:829-36 195688 Pubmed 1977 Primary structure and morphine-like activity of human beta-endorphin Dragon, N Seidah, NG Lis, M Routhier, R Chretien, M Can J Biochem 55:666-70 Chemokine receptors bind chemokines This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT Receptor CCR10 binds CCL27 and 28 ligands This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Ccr10 CCR10 Q9JL21 Reactome DB_ID: 9775433 UniProt:Q9JL21 Ccr10 UniProt Q9JL21 1 EQUAL 362 EQUAL Reactome Database ID Release 78 9775433 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775433 Reactome R-MMU-373126 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373126.1 Converted from EntitySet in Reactome CCL27,28 Reactome DB_ID: 9775443 Ccl27 CCL27 Q9Z1X0 Reactome DB_ID: 9775437 UniProt:Q9Z1X0 Ccl27 UniProt Q9Z1X0 25 EQUAL 112 EQUAL Reactome Database ID Release 78 9775437 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775437 Reactome R-MMU-373098 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373098.1 Ccl28 CCL28 Q9JIL2 Reactome DB_ID: 9775441 UniProt:Q9JIL2 Ccl28 UniProt Q9JIL2 20 EQUAL 127 EQUAL Reactome Database ID Release 78 9775441 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775441 Reactome R-MMU-373300 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373300.1 Reactome Database ID Release 78 9775443 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775443 Reactome R-MMU-373322 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373322.1 CCR10:CCL27,28 Reactome DB_ID: 9775445 1 1 Reactome Database ID Release 78 9775445 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775445 Reactome R-MMU-373236 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373236.1 Reactome Database ID Release 78 9775447 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775447 Reactome R-MMU-373086 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373086.1 CCR10 (previously known as GPR2) (Jarmin DI et al, 2000) is implicated in skin inflammation and recruits regulatory T cells to mucosal layers. CCR10 binds both CCL27 (ESkine, CTACK) (Homey B et al, 2000) and CCL28 (Mucosae-associated epithelial chemokine, MEC) (Wang W et al, 2000) and signal transduction is via increase of intracellular calcium levels. 10781587 Pubmed 2000 Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2) Wang, Wei Soto, H Oldham, ER Buchanan, ME Homey, B Catron, D Jenkins, N Copeland, NG Gilbert, DJ Nguyen, N Abrams, J Kershenovich, D Smith, K McClanahan, T Vicari, AP Zlotnik, A J Biol Chem 275:22313-23 10725697 Pubmed 2000 Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC) Homey, B Wang, Wei Soto, H Buchanan, ME Wiesenborn, A Catron, D Müller, A McClanahan, TK Dieu-Nosjean, MC Orozco, R Ruzicka, T Lehmann, P Oldham, E Zlotnik, A J Immunol 164:3465-70 10725696 Pubmed 2000 Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine Jarmin, DI Rits, M Bota, D Gerard, NP Graham, GJ Clark-Lewis, I Gerard, C J Immunol 164:3460-4 LEFT-TO-RIGHT Receptor CCR6 binds CCL20 ligand This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Ccr6 CCR6 O54689 Reactome DB_ID: 9775451 UniProt:O54689 Ccr6 UniProt O54689 1 EQUAL 374 EQUAL Reactome Database ID Release 78 9775451 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775451 Reactome R-MMU-373089 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373089.1 Ccl20 CCL20(27-96) O89093 Reactome DB_ID: 9775455 UniProt:O89093 Ccl20 UniProt O89093 27 EQUAL 96 EQUAL Reactome Database ID Release 78 9775455 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775455 Reactome R-MMU-373097 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373097.1 CCR6:CCL20 Reactome DB_ID: 9775457 1 1 Reactome Database ID Release 78 9775457 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775457 Reactome R-MMU-373235 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373235.1 Reactome Database ID Release 78 9775459 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775459 Reactome R-MMU-373087 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373087.1 CCR6 (Baba M et al, 1997) is expressed on inactive memory T-cells and on Th17 cells. CCR6 is down-regulated in activated T-cells. CCL20 (macrophage inflammatory protein 3-alpha, MIP 3-alpha) binds and activates CCR6 and it does not share the binding site of CCR6 with any other chemokine. 9169459 Pubmed 1997 Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC Baba, M Imai, T Nishimura, M Kakizaki, M Takagi, S Hieshima, K Nomiyama, H Yoshie, O J Biol Chem 272:14893-8 12149255 Pubmed 2002 The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins Hoover, DM Boulegue, C Yang, D Oppenheim, JJ Tucker, K Lu, W Lubkowski, J J Biol Chem 277:37647-54 LEFT-TO-RIGHT Receptor CCR7 binds CCL19 and 21 ligands This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome CCL19,21 Reactome DB_ID: 9775361 Ccl19 CCL19 O70460 Reactome DB_ID: 9775349 UniProt:O70460 Ccl19 UniProt O70460 22 EQUAL 98 EQUAL Reactome Database ID Release 78 9775349 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775349 Reactome R-MMU-373094 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373094.1 Converted from EntitySet in Reactome Homologues of CCL21 Reactome DB_ID: 9775359 CCL21 Ccl21a P84444 Reactome DB_ID: 9775353 UniProt:P84444 Ccl21a UniProt P84444 24 EQUAL 134 EQUAL Reactome Database ID Release 78 9775353 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775353 Reactome R-MMU-373116 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373116.1 CCL21 Ccl21b P86792 Reactome DB_ID: 9775357 UniProt:P86792 Ccl21b UniProt P86792 24 EQUAL 134 EQUAL Reactome Database ID Release 78 9775357 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775357 Reactome R-MMU-373116-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373116-2.1 Reactome Database ID Release 78 9775359 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775359 Reactome R-MMU-373116-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373116-3.1 Reactome Database ID Release 78 9775361 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775361 Reactome R-MMU-373283 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373283.1 Ccr7 CCR7 P47774 Reactome DB_ID: 9775345 UniProt:P47774 Ccr7 UniProt P47774 25 EQUAL 378 EQUAL Reactome Database ID Release 78 9775345 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775345 Reactome R-MMU-373125 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373125.1 CCR7:CCL19,21 Reactome DB_ID: 9775363 1 1 Reactome Database ID Release 78 9775363 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775363 Reactome R-MMU-373319 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373319.1 Reactome Database ID Release 78 9775365 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775365 Reactome R-MMU-373071 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373071.1 CCR7 (Epstein-Barr virus-induced gene 1, EBI1) (Birkenbach M, 1993; Schweickart VL et al, 1994) plays an important role in the trafficking of B and T lymphocytes and dendritic cells across high endothelial venules. Both CCL19 (Macrophage inflammatory protein 3 beta, MIP-3-beta; EBI1-ligand chemokine, ELC) (Yoshida R et al, 1997) and CCL21 (Secondary lymphoid-tissue chemokine, SLC; Beta chemokine exodus-2) (Yoshida R et al, 1998) bind specifically to CCR7. 7851893 Pubmed 1994 Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2 Schweickart, VL Raport, CJ Godiska, R Byers, MG Shows, Thomas B Gray, PW Genomics 23:643-50 9507024 Pubmed 1998 Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7 Yoshida, R Nagira, M Kitaura, M Imagawa, N Imai, T Yoshie, O J Biol Chem 273:7118-22 8383238 Pubmed 1993 Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors Birkenbach, M Josefsen, K Yalamanchili, R Lenoir, G Kieff, E J Virol 67:2209-20 9153236 Pubmed 1997 Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7 Yoshida, R Imai, T Hieshima, K Kusuda, J Baba, M Kitaura, M Nishimura, M Kakizaki, M Nomiyama, H Yoshie, O J Biol Chem 272:13803-9 LEFT-TO-RIGHT Receptor CCR9 binds CCL25 ligand This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Ccl25 CCL25 O35903 Reactome DB_ID: 9775379 UniProt:O35903 Ccl25 UniProt O35903 24 EQUAL 150 EQUAL Reactome Database ID Release 78 9775379 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775379 Reactome R-MMU-373096 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373096.1 Ccr9 CCR9 Q9WUT7 Reactome DB_ID: 9775383 UniProt:Q9WUT7 Ccr9 UniProt Q9WUT7 1 EQUAL 369 EQUAL Reactome Database ID Release 78 9775383 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775383 Reactome R-MMU-2976763 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2976763.1 CCR9:CCL25 Reactome DB_ID: 9775385 1 1 Reactome Database ID Release 78 9775385 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775385 Reactome R-MMU-373329 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373329.1 Reactome Database ID Release 78 9775387 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775387 Reactome R-MMU-373074 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373074.1 CCR9 (previously called orphan receptor GPR 9-6) is highly expressed in the thymus on both mature and immature T-cells. It is also abundant in T-cells of the intestine but is lowly expressed in lymph nodes and the spleen. Alternative splicing produces two receptors, called CCR9A and CCR9B, CCR9A containing 12 additional amino acids at its N terminus as compared with CCR9B (Yu CR et al, 2000). The A and B forms of the receptor were expressed at a ratio of approximately 10:1. CCR9 has a specific ligand in CCL25 (Thymus-expressed chemokine, TECK) (Zaballos A et al, 1999) and transduces the signal by intracellular calcium mobilization. 10640743 Pubmed 2000 CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand Yu, CR Peden, KW Zaitseva, MB Golding, H Farber, JM J Immunol 164:1293-305 10229797 Pubmed 1999 Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK Zaballos, A Gutiérrez, J Varona, R Ardavin, C Márquez, G J Immunol 162:5671-5 LEFT-TO-RIGHT CX3CR1 binds CX3CL1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Cx3cl1 O35188 Reactome DB_ID: 9775475 UniProt:O35188 Cx3cl1 UniProt O35188 Reactome Database ID Release 78 9775475 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775475 Reactome R-MMU-373368 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373368.1 Cx3cr1 CX3CR1 Q9Z0D9 Reactome DB_ID: 9775479 UniProt:Q9Z0D9 Cx3cr1 UniProt Q9Z0D9 1 EQUAL 355 EQUAL Reactome Database ID Release 78 9775479 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775479 Reactome R-MMU-2980688 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2980688.1 CX3CR1:CX3CL1 Reactome DB_ID: 9775481 1 1 Reactome Database ID Release 78 9775481 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775481 Reactome R-MMU-373352 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373352.1 Reactome Database ID Release 78 9775483 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775483 Reactome R-MMU-373342 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373342.1 CX3CL1 (fractalkine) is a member of the chemokine superfamily and functions as a human leukocyte chemoattractant protein (Bazan JF et al, 1997). Unlike other human chemokines, the chemokine domain of fractalkine has three amino acids between two conserved cysteines, referred to as the CX3C motif. This molecule can exist in two forms: either membrane-anchored or as a shed 95K glycoprotein. The soluble form has potent chemoattractant activity for T-cells and monocytes, and the membrane-bound protein, which is induced on activated primary endothelial cells, promotes strong adhesion of those leukocytes. The seven-transmembrane high-affinity receptor for fractalkine, termed CX3C1, mediates both the adhesive and migratory functions of fractalkine (Imai T et al, 1997). CX3CL1 is reported to signal via Gi (Brandt et al. 2002). 9024663 Pubmed 1997 A new class of membrane-bound chemokine with a CX3C motif Bazan, JF Bacon, KB Hardiman, G Wang, Wei Soo, K Rossi, D Greaves, DR Zlotnik, A Schall, TJ Nature 385:640-4 11781291 Pubmed 2002 Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells Brand, Stephan Sakaguchi, Takanori Gu, Xiubin Colgan, Sean P Reinecker, Hans-Christian Gastroenterology 122:166-77 9390561 Pubmed 1997 Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion Imai, T Hieshima, K Haskell, C Baba, M Nagira, M Nishimura, M Kakizaki, M Takagi, S Nomiyama, H Schall, TJ Yoshie, O Cell 91:521-30 LEFT-TO-RIGHT Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Xcl1 XCL2 P47993 Reactome DB_ID: 9775463 UniProt:P47993 Xcl1 UniProt P47993 22 EQUAL 114 EQUAL Reactome Database ID Release 78 9775463 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775463 Reactome R-MMU-373349 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373349.1 Xcr1 XCR1 Q9R0M1 Reactome DB_ID: 9775467 UniProt:Q9R0M1 Xcr1 UniProt Q9R0M1 1 EQUAL 333 EQUAL Reactome Database ID Release 78 9775467 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775467 Reactome R-MMU-373109 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373109.1 XCR1:XCL1,XCL2 Reactome DB_ID: 9775469 1 1 Reactome Database ID Release 78 9775469 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775469 Reactome R-MMU-373357 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373357.1 Reactome Database ID Release 78 9775471 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775471 Reactome R-MMU-373339 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373339.1 Single C motif-1 (SCM-1; lymphotactin, CXC1) is a member of the chemokine receptor family (Yoshida T et al, 1995). CXC differs from the CC chemokines by one amino acid separating two of the four conserved cysteine residues (to give the motif CXC) whereas two adjacent cysteines denote CC. In humans, there are two highly conserved SCM-1 genes, SCYC1 and 2, which encode two SCM-1 proteins, SCM1-alpha and beta (Yoshida T et al, 1996). These proteins act as specific ligands for the CXC1 receptor. This receptor is highly expressed in placenta but lowly in spleen and thymus. 7602097 Pubmed 1995 Molecular cloning and functional characterization of human lymphotactin Kennedy, J Kelner, GS Kleyensteuber, S Schall, TJ Weiss, MC Yssel, H Schneider, PV Cocks, BG Bacon, KB Zlotnik, A J Immunol 155:203-9 7875320 Pubmed 1995 Molecular cloning of a novel C or gamma type chemokine, SCM-1 Yoshida, T Imai, T Kakizaki, M Nishimura, M Yoshie, O FEBS Lett 360:155-9 8849694 Pubmed 1996 Structure and expression of two highly related genes encoding SCM-1/human lymphotactin Yoshida, T Imai, T Takagi, S Nishimura, M Ishikawa, I Yaoi, T Yoshie, O FEBS Lett 395:82-8 LEFT-TO-RIGHT Receptor CXCR1 binds CXCL6 and CXCL8 ligands This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Cxcl5 CXCL6(38-114) P50228 Reactome DB_ID: 9775668 UniProt:P50228 Cxcl5 UniProt P50228 38 EQUAL 114 EQUAL Reactome Database ID Release 78 9775668 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775668 Reactome R-MMU-373784 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373784.1 Cxcr1 CXCR1 Q810W6 Reactome DB_ID: 9775664 UniProt:Q810W6 Cxcr1 UniProt Q810W6 1 EQUAL 350 EQUAL Reactome Database ID Release 78 9775664 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775664 Reactome R-MMU-373805 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373805.1 CXCR1:CXCR1 ligands Reactome DB_ID: 9775670 1 1 Reactome Database ID Release 78 9775670 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775670 Reactome R-MMU-373801 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373801.1 Reactome Database ID Release 78 9775672 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775672 Reactome R-MMU-373791 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373791.1 CXCR1 (high affinity interleukin-8 receptor A) (Holmes WE et al, 1991) is closely related to CXCR2. They recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. CXCL8 (interleukin-8, IL-8) (Matsushima K et al, 1988) and CXCL6 (Rovai LE et al, 1997) can both bind CXCR1 in humans and elicit various effects. CXCL8 attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. CXCL6 is a chemotactic factor for neutrophil granulocytes. 1840701 Pubmed 1991 Structure and functional expression of a human interleukin-8 receptor Holmes, WE Lee, J Kuang, WJ Rice, GC Wood, WI Science 253:1278-80 9164944 Pubmed 1997 Cloning and characterization of the human granulocyte chemotactic protein-2 gene Rovai, LE Herschman, HR Smith, JB J Immunol 158:5257-66 3260265 Pubmed 1988 Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor Matsushima, K Morishita, K Yoshimura, T Lavu, S Kobayashi, Y Lew, W Appella, E Kung, HF Leonard, EJ Oppenheim, JJ J Exp Med 167:1883-93 LEFT-TO-RIGHT Receptor CXCR2 binds ligands CXCL1 to 7 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome CXCR2 ligands Reactome DB_ID: 9775702 Converted from EntitySet in Reactome Homologues of CXCL1(35-107) Reactome DB_ID: 9775690 Cxcl2 CXCL1(35-107) P10889 Reactome DB_ID: 9775680 UniProt:P10889 Cxcl2 UniProt P10889 35 EQUAL 107 EQUAL Reactome Database ID Release 78 9775680 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775680 Reactome R-MMU-373778 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373778.1 Cxcl1 CXCL1(35-107) P12850 Reactome DB_ID: 9775684 UniProt:P12850 Cxcl1 UniProt P12850 35 EQUAL 107 EQUAL Reactome Database ID Release 78 9775684 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775684 Reactome R-MMU-373778-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373778-2.1 Cxcl3 CXCL1(35-107) Q6W5C0 Reactome DB_ID: 9775688 UniProt:Q6W5C0 Cxcl3 UniProt Q6W5C0 35 EQUAL 107 EQUAL Reactome Database ID Release 78 9775688 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775688 Reactome R-MMU-373778-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373778-3.1 Reactome Database ID Release 78 9775690 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775690 Reactome R-MMU-373778-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373778-4.1 CXCL4 homotetramer Reactome DB_ID: 9775694 Pf4 PF4(48-101) Q9Z126 Reactome DB_ID: 9775692 UniProt:Q9Z126 Pf4 UniProt Q9Z126 48 EQUAL 101 EQUAL Reactome Database ID Release 78 9775692 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775692 Reactome R-MMU-114629 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-114629.1 4 Reactome Database ID Release 78 9775694 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775694 Reactome R-MMU-373835 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373835.1 Ppbp PPBP(35-128) Q9EQI5 Reactome DB_ID: 9775700 UniProt:Q9EQI5 Ppbp UniProt Q9EQI5 35 EQUAL 128 EQUAL Reactome Database ID Release 78 9775700 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775700 Reactome R-MMU-114573 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-114573.1 Reactome Database ID Release 78 9775702 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775702 Reactome R-MMU-373814 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373814.1 Cxcr2 CXCR2 P35343 Reactome DB_ID: 9775676 UniProt:P35343 Cxcr2 UniProt P35343 1 EQUAL 360 EQUAL Reactome Database ID Release 78 9775676 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775676 Reactome R-MMU-373796 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373796.1 CXCR2:CXCR2 ligands Reactome DB_ID: 9775704 1 1 Reactome Database ID Release 78 9775704 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775704 Reactome R-MMU-373773 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373773.1 Reactome Database ID Release 78 9775706 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775706 Reactome R-MMU-373813 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373813.1 CXCR2 (High affinity interleukin-8 receptor B) (Murphy PM and Tiffany HL, 1991) is closely related to CXCR1 and binding of IL-8 to the receptor causes activation of neutrophils. Other ELR-positive chemokines (CXCL1 to CXCL7) can also bind with CXCR2 to cause various effects as described below.<br>CXCL1 (previously known as GRO1 oncogene; NAP-3; MSGA-alpha) (Richmond A et al, 1988) is expressed by neutrophils, macrophages and epithelial cells and possesses neutrophil chemoattractant activity. It is secreted by melanoma cells and is implicated in melanoma pathogenesis. CXCL2 (MIP2-alpha;Gro-beta;Gro-2) (Iida N and Grotendorst GR, 1990; Haskill S et al, 1990) is closely related to CXCL1 (90% amino acid sequence). It is secreted by monocytes and macrophages and attracts polymorphonuclear leukocytes and hematopoietic stem cells. CXCL3 (GRO3; GROg; MIP2-beta) (Haskill S et al, 1990) controls the migration and adhesion of monocytes.<br>CXCL4 (platelet factor 4, PF4) (Poncz M et al, 1987) is released from platelets during aggregation and promotes blood coagulation by neutralization of heparin-like molecules. It is chemotactic for neutrophils, fibroblasts and monocytes. Due to all these roles, CXCL4 is implicated in wound repair and inflammation. CXCL5 (ENA-78) (Walz A et al, 1991) is produced by cells which have been stimulated by interleulin-1 or tumor necrosis factor-alpha. CXCL7 (pro-platelet basic protein, PPBP) (Holt JC et al, 1986) is released from platelets once they are activated. It can stimulate various processes including glucose metabolism, mitogenesis and syntheses of plasminogen activator and extracellular matrix. 1891716 Pubmed 1991 Cloning of complementary DNA encoding a functional human interleukin-8 receptor Murphy, PM Tiffany, HL Science 253:1280-3 2423119 Pubmed 1986 Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin Holt, JC Harris, ME Holt, AM Lange, E Henschen, Agnes Niewiarowski, S Biochemistry 25:1988-96 3098319 Pubmed 1987 Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line Poncz, M Surrey, S LaRocco, P Weiss, MJ Rappaport, EF Conway, TM Schwartz, E Blood 69:219-23 2078213 Pubmed 1990 Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue Iida, N Grotendorst, GR Mol Cell Biol 10:5596-9 2970963 Pubmed 1988 Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin Richmond, A Balentien, E Thomas, HG Flaggs, G Barton, DE Spiess, J Bordoni, R Francke, U Derynck, R EMBO J 7:2025-33 2217207 Pubmed 1990 Identification of three related human GRO genes encoding cytokine functions Haskill, S Peace, A Morris, J Sporn, SA Anisowicz, A Lee, SW Smith, T Martin, G Ralph, P Sager, R Proc Natl Acad Sci U S A 87:7732-6 1744577 Pubmed 1991 Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8 Walz, A Burgener, R Car, B Baggiolini, M Kunkel, SL Strieter, RM J Exp Med 174:1355-62 LEFT-TO-RIGHT Receptor CXCR3 binds ligands CXCL9 to 11 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome CXCR3 ligands Reactome DB_ID: 9775766 Cxcl9 CXCL9 P18340 Reactome DB_ID: 9775756 UniProt:P18340 Cxcl9 UniProt P18340 23 EQUAL 125 EQUAL Reactome Database ID Release 78 9775756 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775756 Reactome R-MMU-373856 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373856.1 Cxcl10 CXCL10(22-98) P17515 Reactome DB_ID: 9775760 UniProt:P17515 Cxcl10 UniProt P17515 22 EQUAL 98 EQUAL Reactome Database ID Release 78 9775760 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775760 Reactome R-MMU-373853 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373853.1 Cxcl11 CXCL11 Q9JHH5 Reactome DB_ID: 9775764 UniProt:Q9JHH5 Cxcl11 UniProt Q9JHH5 22 EQUAL 94 EQUAL Reactome Database ID Release 78 9775764 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775764 Reactome R-MMU-373852 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373852.1 Reactome Database ID Release 78 9775766 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775766 Reactome R-MMU-374233 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374233.1 Cxcr3 CXCR3 O88410 Reactome DB_ID: 9775770 UniProt:O88410 Cxcr3 UniProt O88410 1 EQUAL 368 EQUAL Reactome Database ID Release 78 9775770 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775770 Reactome R-MMU-2980699 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2980699.1 CXCR3:CXCR3 ligands Reactome DB_ID: 9775772 1 1 Reactome Database ID Release 78 9775772 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775772 Reactome R-MMU-374141 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374141.1 Reactome Database ID Release 78 9775774 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775774 Reactome R-MMU-374248 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374248.1 CXCR3 (Loetscher M et al, 1996) is predominantly expressed on T lymphocytes, and on other lymphocytes (some B cells and NK cells). It is highly induced following cell activation. There are three isoforms, CXCR3-A, CXCR3-B and CXCR3-alt. CXCR3 binds to three highly related ligands in mammals, CXCL9, CXCL10 and CXCL11 (Xanthou G et al, 2003). The ligands then elicit their chemoattractant functions. CXCL9 (CMK; monokine induced by gamma-interferon, MIG; SCYB9) is a T cell chemoattractant (Farber JM, 1993). CXCL10 (IP-10) (Booth V et al, 2002) is secreted by monocytes, endothelial cells and fibroblasts in response to gamma-interferon. It can act as a chemoattractant for monocytes, macrophages, T cells, NK cells and dendritic cells, promote T cell adhesion to endothelial cells and inhibit angiogenesis and bone marrow colony formation. CXCL11 (I-TAC,; iIP-9) (Cole KE et al, 1998) is highly expressed in peripheral blood leukocytes, pancreas and liver. It is regulated by interferon and has potent chemoattractant activity for interleukin-2-activated T cells. 12173928 Pubmed 2002 The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions Booth, V Keizer, DW Kamphuis, MB Clark-Lewis, I Sykes, BD Biochemistry 41:10418-25 9064356 Pubmed 1996 Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes Loetscher, M Gerber, B Loetscher, P Jones, SA Piali, L Clark-Lewis, I Baggiolini, M Moser, B J Exp Med 184:963-9 9625760 Pubmed 1998 Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3 Cole, KE Strick, CA Paradis, TJ Ogborne, KT Loetscher, M Gladue, RP Lin, W Boyd, JG Moser, B Wood, DE Sahagan, BG Neote, K J Exp Med 187:2009-21 12884299 Pubmed 2003 CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 Xanthou, G Duchesnes, CE Williams, TJ Pease, JE Eur J Immunol 33:2241-50 8476424 Pubmed 1993 HuMig: a new human member of the chemokine family of cytokines Farber, JM Biochem Biophys Res Commun 192:223-30 LEFT-TO-RIGHT Receptors CXCR4 and 7 bind CXCL12 ligand This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome CXCR4,7 Reactome DB_ID: 9775744 Ackr3 CXCR7 P56485 Reactome DB_ID: 9775738 UniProt:P56485 Ackr3 UniProt P56485 1 EQUAL 362 EQUAL Reactome Database ID Release 78 9775738 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775738 Reactome R-MMU-373859 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373859.1 Cxcr4 CXCR4 P70658 Reactome DB_ID: 9775742 UniProt:P70658 Cxcr4 UniProt P70658 1 EQUAL 352 EQUAL Reactome Database ID Release 78 9775742 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775742 Reactome R-MMU-2980772 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2980772.1 Reactome Database ID Release 78 9775744 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775744 Reactome R-MMU-374120 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374120.1 Cxcl12 CXCL12(22-93) P40224 Reactome DB_ID: 9775748 UniProt:P40224 Cxcl12 UniProt P40224 22 EQUAL 93 EQUAL Reactome Database ID Release 78 9775748 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775748 Reactome R-MMU-2980693 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2980693.1 CXCR4,7:CXCL12 Reactome DB_ID: 9775750 1 1 Reactome Database ID Release 78 9775750 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775750 Reactome R-MMU-374203 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374203.1 Reactome Database ID Release 78 9775752 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775752 Reactome R-MMU-374214 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374214.1 CXCL12 (stromal cell-derived factor-1, SDF-1) (Shirozu M et al, 1995) is produced in two forms, CXCL12alpha and CXCL12beta, by alternate splicing of the same gene (De La Luz Sierra M et al, 2004). It is a chemoattractant for T-lymphocytes and monocytes, but not neutrophils. In adult humans it plays an important role in angiogenesis by recruiting endothelial progenitor cells from the bone morrow through a CXCR4-dependent mechanism. CXCR4 (fusin) (Herzog H et al, 1993) is the receptor for CXCL12 and, like CCR5, is utilized by HIV-1 to gain entry into target cells. This receptor has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types and also on vascular endothelial cells and neuronal/nerve cells. CXCR7 (RDC-1) (Infantino S et al, 2006) is expressed in monocytes, basophils and B cells and was originally an orphan receptor. 16455976 Pubmed 2006 Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells Infantino, S Moepps, B Thelen, M J Immunol 176:2197-207 7490086 Pubmed 1995 Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene Shirozu, M Nakano, T Inazawa, J Tashiro, K Tada, H Shinohara, T Honjo, Tasuku Genomics 28:495-500 14525775 Pubmed 2004 Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity De La Luz Sierra, M Yang, F Narazaki, M Salvucci, O Davis, D Yarchoan, R Zhang, HH Fales, H Tosato, G Blood 103:2452-9 9618518 Pubmed 1998 Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor Dealwis, C Fernandez, EJ Thompson, DA Simon, RJ Siani, MA Lolis, E Proc Natl Acad Sci U S A 95:6941-6 16107333 Pubmed 2005 The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes Balabanian, K Lagane, B Infantino, S Chow, KY Harriague, J Moepps, B Arenzana-Seisdedos, F Thelen, M Bachelerie, F J Biol Chem 280:35760-6 8329116 Pubmed 1993 Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation Herzog, H Hort, YJ Shine, J Selbie, LA DNA Cell Biol 12:465-71 LEFT-TO-RIGHT CXCR5 binds CXCL13 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Cxcl13 CXCL13 O55038 Reactome DB_ID: 9778066 UniProt:O55038 Cxcl13 UniProt O55038 23 EQUAL 109 EQUAL Reactome Database ID Release 78 9778066 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778066 Reactome R-MMU-444506 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-444506.1 Cxcr5 CXCR5 Q04683 Reactome DB_ID: 9778062 UniProt:Q04683 Cxcr5 UniProt Q04683 1 EQUAL 372 EQUAL Reactome Database ID Release 78 9778062 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778062 Reactome R-MMU-444505 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-444505.1 CXCR5:CXCL13 Reactome DB_ID: 9778068 1 1 Reactome Database ID Release 78 9778068 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778068 Reactome R-MMU-444551 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-444551.1 Reactome Database ID Release 78 9784383 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784383 Reactome R-MMU-444523 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-444523.1 CXC-Chemokine receptor 5 (CXCR5) was originally called Burkitts Lymphoma receptor 1 after the source tissue. The primary ligand for this receptor is CXCL13 (B-cell attracting chemokine 1 also known as B-lymphocyte chemoattractant). 9463416 Pubmed 1998 B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5 Legler, DF Loetscher, M Roos, RS Clark-Lewis, I Baggiolini, M Moser, B J Exp Med 187:655-60 LEFT-TO-RIGHT Receptor CXCR6 binds CXCL16 ligand This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Cxcr6 CXCR6 Q9EQ16 Reactome DB_ID: 9775487 UniProt:Q9EQ16 Cxcr6 UniProt Q9EQ16 1 EQUAL 342 EQUAL Reactome Database ID Release 78 9775487 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775487 Reactome R-MMU-373825 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373825.1 Cxcl16 CXCL16 Q8BSU2 Reactome DB_ID: 9775491 UniProt:Q8BSU2 Cxcl16 UniProt Q8BSU2 30 EQUAL 254 EQUAL Reactome Database ID Release 78 9775491 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775491 Reactome R-MMU-373826 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373826.1 CXCR6:CXCL16 Reactome DB_ID: 9775493 1 1 Reactome Database ID Release 78 9775493 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775493 Reactome R-MMU-373797 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373797.1 Reactome Database ID Release 78 9775495 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775495 Reactome R-MMU-373358 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373358.1 CXCR6 (formerly called STRL33, BONZO, and TYMSTR) was assigned this name based on its chromosomal location (within the chemokine receptor cluster on human chromosome 3p21) and its similarity to other chemokine receptors in its gene sequence (Liao F et al, 1997). CXCR6 is structurally more closely related to CC chemokine receptors than to other CXC chemokine receptors. It is expressed in lymphoid tissues and activated T cells and is induced in activated peripheral blood lymphocytes. CXCR6 binds the ligand CXCL16 (Shimaoka T et al, 2000) which acts as a scavenger receptor on macrophages. It specifically binds to oxidized low density lipoprotein, suggesting that it may be involved in pathophysiology such as atherogenesis. 9166430 Pubmed 1997 STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1 Liao, F Alkhatib, G Peden, KW Sharma, G Berger, EA Farber, JM J Exp Med 185:2015-23 11060282 Pubmed 2000 Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages Shimaoka, T Kume, N Minami, M Hayashida, K Kataoka, H Kita, T Yonehara, S J Biol Chem 275:40663-6 LEFT-TO-RIGHT Receptors CCR3, 4 and 5 bind CCL5 ligand This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome CCR3,4,5 Reactome DB_ID: 9775337 Ccr3 CCR3 P51678 Reactome DB_ID: 9775327 UniProt:P51678 Ccr3 UniProt P51678 1 EQUAL 355 EQUAL Reactome Database ID Release 78 9775327 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775327 Reactome R-MMU-373106 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373106.1 Ccr4 CCR4 P51680 Reactome DB_ID: 9775331 UniProt:P51680 Ccr4 UniProt P51680 1 EQUAL 360 EQUAL Reactome Database ID Release 78 9775331 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775331 Reactome R-MMU-373090 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373090.1 Ccr5 CCR5 P51682 Reactome DB_ID: 9775335 UniProt:P51682 Ccr5 UniProt P51682 1 EQUAL 352 EQUAL Reactome Database ID Release 78 9775335 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775335 Reactome R-MMU-171279 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-171279.1 Reactome Database ID Release 78 9775337 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775337 Reactome R-MMU-373259 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373259.1 Ccl5 CCL5(24-91) P30882 Reactome DB_ID: 9775323 UniProt:P30882 Ccl5 UniProt P30882 24 EQUAL 91 EQUAL Reactome Database ID Release 78 9775323 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775323 Reactome R-MMU-373108 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373108.1 CCR3,4,5:CCL5(24-91) Reactome DB_ID: 9775339 1 1 Reactome Database ID Release 78 9775339 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775339 Reactome R-MMU-373299 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373299.1 Reactome Database ID Release 78 9775341 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775341 Reactome R-MMU-373061 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373061.1 Three receptors have a common CC chemokine CCL5 that can signal through them. CCR3 (Combadiere C et al, 1995) is highly expressed in eosinophils and basophils and also found in airway epithelial cells, thus implicating this receptor in allergic reactions. CCR4 (Power CA et al, 1995) is expressed in Th2 T lymphocytes and upregulated by T-cell receptor activation. CCR5 (Samson M et al, 1996) mediates the recruitment of cells involved in immune and inflammatory processes. 7622448 Pubmed 1995 Cloning and functional expression of a human eosinophil CC chemokine receptor Combadiere, C Ahuja, SK Murphy, PM J Biol Chem 270:16491-4 7642634 Pubmed 1995 Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line Power, CA Meyer, A Nemeth, K Bacon, KB Hoogewerf, AJ Proudfoot, AE Wells, TN J Biol Chem 270:19495-500 8639485 Pubmed 1996 Molecular cloning and functional expression of a new human CC-chemokine receptor gene Samson, M Labbe, O Mollereau, C Vassart, G Parmentier, M Biochemistry 35:3362-7 LEFT-TO-RIGHT Receptor ACKR2 binds most inflammatory CC chemokines This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Ackr2 ACKR2 O08707 Reactome DB_ID: 9784232 UniProt:O08707 Ackr2 UniProt O08707 1 EQUAL 384 EQUAL Reactome Database ID Release 78 9784232 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784232 Reactome R-MMU-443955 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443955.1 Converted from EntitySet in Reactome CCBP2 ligands Reactome DB_ID: 9784256 CCL2 Ccl12 Q62401 Reactome DB_ID: 9784236 UniProt:Q62401 Ccl12 UniProt Q62401 24 EQUAL 99 EQUAL Reactome Database ID Release 78 9784236 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784236 Reactome R-MMU-443967 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443967.1 Ccl3 CCL3(24-92) P10855 Reactome DB_ID: 9784240 UniProt:P10855 Ccl3 UniProt P10855 24 EQUAL 92 EQUAL Reactome Database ID Release 78 9784240 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784240 Reactome R-MMU-443989 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443989.1 Ccl4 CCL4(24-92) P14097 Reactome DB_ID: 9778476 UniProt:P14097 Ccl4 UniProt P14097 24 EQUAL 92 EQUAL Reactome Database ID Release 78 9778476 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778476 Reactome R-MMU-443976 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443976.1 Ccl7 CCL7 Q03366 Reactome DB_ID: 9784244 UniProt:Q03366 Ccl7 UniProt Q03366 24 EQUAL 99 EQUAL Reactome Database ID Release 78 9784244 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784244 Reactome R-MMU-443975 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443975.1 Ccl17 CCL17 F6R5P4 Reactome DB_ID: 9784248 UniProt:F6R5P4 Ccl17 UniProt F6R5P4 24 EQUAL 94 EQUAL Reactome Database ID Release 78 9784248 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784248 Reactome R-MMU-443987 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443987.1 Ccl22 CCL22(25-93) O88430 Reactome DB_ID: 9784252 UniProt:O88430 Ccl22 UniProt O88430 25 EQUAL 93 EQUAL Reactome Database ID Release 78 9784252 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784252 Reactome R-MMU-443980 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443980.1 Reactome Database ID Release 78 9784256 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784256 Reactome R-MMU-443962 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443962.1 ACKR2:CCBP2 ligands Reactome DB_ID: 9784258 1 1 Reactome Database ID Release 78 9784258 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784258 Reactome R-MMU-443988 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443988.1 Reactome Database ID Release 78 9784260 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784260 Reactome R-MMU-443986 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443986.1 Atypical chemokine receptor 2 (ACKR2, CCBP2, D6) is a promiscuous chemokine receptor which has no known signalling function and is therefore considered to be a 'silent' or 'scavenger' receptor. ACKR2 negatively regulates inflammatory responses by binding CC chemokines, targeting them for degradation following receptor internalization (Fra et al. 2003, Bonecchi et al. 2004, Graham & Locati 2013). 12594248 Pubmed 2003 Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6 Fra, AM Locati, M Otero, K Sironi, M Signorelli, P Massardi, ML Gobbi, M Vecchi, A Sozzani, S Mantovani, A J Immunol 170:2279-82 23125030 Pubmed 2013 Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6 Graham, Gerard J Locati, Massimo J. Pathol. 229:168-75 15067078 Pubmed 2004 Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor Bonecchi, R Locati, M Galliera, E Vulcano, M Sironi, M Fra, AM Gobbi, M Vecchi, A Sozzani, S Haribabu, B van Damme, J Mantovani, A J Immunol 172:4972-6 LEFT-TO-RIGHT Receptor CCR11 binds CCL19, CCL21 & CCL25 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome CCL19, CCL21, CCL25 Reactome DB_ID: 9784224 Reactome Database ID Release 78 9784224 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784224 Reactome R-MMU-443985 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443985.1 Ackr4 CCRL1 Q924I3 Reactome DB_ID: 9784222 UniProt:Q924I3 Ackr4 UniProt Q924I3 1 EQUAL 350 EQUAL Reactome Database ID Release 78 9784222 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784222 Reactome R-MMU-373331 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373331.1 CCR11:CCL19,21,25 Reactome DB_ID: 9784226 1 1 Reactome Database ID Release 78 9784226 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784226 Reactome R-MMU-443970 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443970.1 Reactome Database ID Release 78 9784228 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9784228 Reactome R-MMU-443978 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-443978.1 CCR11 binds CCL19, CCL21, and CCL25 but calcium signalling is low level, consequently it is regarded by some as a scavenger receptor (Comerford et al. 2006). 10706668 Pubmed 2000 Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK Gosling, J Dairaghi, DJ Wang, Y Hanley, M Talbot, D Miao, Z Schall, TJ J Immunol 164:2851-6 16791897 Pubmed 2006 The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro Comerford, I Milasta, S Morrow, V Milligan, G Nibbs, R Eur J Immunol 36:1904-16 LEFT-TO-RIGHT CCRL2 binds CCL19 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Ccrl2 CCRL2 O35457 Reactome DB_ID: 9816092 UniProt:O35457 Ccrl2 UniProt O35457 1 EQUAL 344 EQUAL Reactome Database ID Release 78 9816092 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9816092 Reactome R-MMU-3296247 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3296247.1 CCRL2:CCL19 Reactome DB_ID: 9816094 1 1 Reactome Database ID Release 78 9816094 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9816094 Reactome R-MMU-3296272 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3296272.1 Reactome Database ID Release 78 9816096 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9816096 Reactome R-MMU-3296301 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3296301.1 CCRL2 binds the chemokine CCL19 with an affinity similar to the binding of CCL19 to its other receptor CCR7. In contrast to the known CCL19:CCR7 ligand:receptor interaction, binding to CCRL2 does not result in cellular activation. Instead CCRL2 is constitutively recycled via clathrin-coated pits. Thus CCRL2 may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19. 20002784 Pubmed 2010 CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B Leick, Marion Catusse, Julie Follo, Marie Nibbs, Robert J Hartmann, Tanja N Veelken, Hendrik Burger, Meike Immunology 129:536-46 LEFT-TO-RIGHT CCR8 binds CCL1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Ccr8 CCR8 P56484 Reactome DB_ID: 9775373 UniProt:P56484 Ccr8 UniProt P56484 1 EQUAL 355 EQUAL Reactome Database ID Release 78 9775373 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775373 Reactome R-MMU-373237 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-373237.1 Ccl1 CCL1 P10146 Reactome DB_ID: 9778470 UniProt:P10146 Ccl1 UniProt P10146 24 EQUAL 96 EQUAL Reactome Database ID Release 78 9778470 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778470 Reactome R-MMU-8851331 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8851331.1 CCR8:CCL1 Reactome DB_ID: 9778472 1 1 Reactome Database ID Release 78 9778472 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778472 Reactome R-MMU-8851339 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8851339.1 Reactome Database ID Release 78 9844161 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9844161 Reactome R-MMU-8851352 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8851352.1 CCR8 is the receptor for CCL1 (Roos et al. 1997, Tiffany et al. 1997)Goya et al. 1998, Dairaghi et al. 1999). CCL1-induced mobilization of intracellular calcium was inhibited by pertussis toxin, suggesting that CCR8 is coupled to the Gi class of Galpha subunits (Tiffany et al. 1997, Goya et al. 1998) 10419462 Pubmed 1999 HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines Dairaghi, D J Fan, R A McMaster, B E Hanley, M R Schall, T J J. Biol. Chem. 274:21569-74 9211859 Pubmed 1997 Identification of CCR8, the receptor for the human CC chemokine I-309 Roos, R S Loetscher, M Legler, D F Clark-Lewis, I Baggiolini, M Moser, B J. Biol. Chem. 272:17251-4 9207005 Pubmed 1997 Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309 Tiffany, HL Lautens, LL Gao, JL Pease, J Locati, M Combadiere, C Modi, W Bonner, TI Murphy, PM J Exp Med 186:165-70 9469461 Pubmed 1998 Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3 Goya, I Gutiérrez, J Varona, R Kremer, L Zaballos, A Márquez, G J. Immunol. 160:1975-81 Reactome Database ID Release 78 9861488 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9861488 Reactome R-MMU-380108 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-380108.1 Chemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of intracellular calcium which leads to chemotaxis. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. 11544102 Pubmed 2001 Chemokine receptors Horuk, R Cytokine Growth Factor Rev 12:313-35 15578986 Pubmed 2004 Chemokine-chemokine receptor network in immune cell trafficking Kim, CH Curr Drug Targets Immune Endocr Metabol Disord 4:343-61 10807766 Pubmed 2000 Chemokine receptors and their role in inflammation and infectious diseases Murdoch, C Finn, A Blood 95:3032-43 LEFT-TO-RIGHT Somatostatin receptors bind somatostatin and cortistatin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome Somatostatin, cortistatin Reactome DB_ID: 9775956 Converted from EntitySet in Reactome Somatostatin Reactome DB_ID: 9021910 Sst(103-116) Reactome DB_ID: 9021911 UniProt:P60041 Sst Sst Smst TISSUE SPECIFICITY In the pancreas, somatostatin is expressed in delta cells of the islets of Langerhans. In the stomach, it is expressed in parietal cells of oxyntic mucosa and in the small intestine, it is found in the villus (at protein level) (PubMed:18753129). Neuronostatin is expressed in the pancreas in delta cells of the islets of Langerhans, as well as in the stomach, in parietal cells of oxyntic mucosa and in the small intestine, in the villus (at protein level) (PubMed:18753129).PTM C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure.SIMILARITY Belongs to the somatostatin family. UniProt P60041 103 EQUAL 116 EQUAL Reactome Database ID Release 78 9021911 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9021911 Reactome R-MMU-9021911 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9021911.1 Sst(89-116) Reactome DB_ID: 9021913 89 EQUAL 116 EQUAL Reactome Database ID Release 78 9021913 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9021913 Reactome R-MMU-9021913 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9021913.1 Reactome Database ID Release 78 9021910 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9021910 Reactome R-MMU-9021910 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9021910.1 Cort CORT(89-105) P56469 Reactome DB_ID: 9775954 UniProt:P56469 Cort UniProt P56469 89 EQUAL 105 EQUAL Reactome Database ID Release 78 9775954 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775954 Reactome R-MMU-8849392 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8849392.1 Reactome Database ID Release 78 9775956 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775956 Reactome R-MMU-8849391 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8849391.1 Converted from EntitySet in Reactome Somatostatin receptors Reactome DB_ID: 9775978 Sstr1 SSTR1 P30873 Reactome DB_ID: 9775960 UniProt:P30873 Sstr1 UniProt P30873 1 EQUAL 391 EQUAL Reactome Database ID Release 78 9775960 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775960 Reactome R-MMU-374741 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374741.1 Sstr2 SSTR2 P30875 Reactome DB_ID: 9775964 UniProt:P30875 Sstr2 UniProt P30875 1 EQUAL 369 EQUAL Reactome Database ID Release 78 9775964 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775964 Reactome R-MMU-374757 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374757.1 Sstr3 SSTR3 P30935 Reactome DB_ID: 9775968 UniProt:P30935 Sstr3 UniProt P30935 1 EQUAL 418 EQUAL Reactome Database ID Release 78 9775968 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775968 Reactome R-MMU-374732 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374732.1 Sstr4 SSTR4 P49660 Reactome DB_ID: 9775972 UniProt:P49660 Sstr4 UniProt P49660 1 EQUAL 388 EQUAL Reactome Database ID Release 78 9775972 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775972 Reactome R-MMU-374745 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374745.1 Sstr5 SSTR5 O08858 Reactome DB_ID: 9775976 UniProt:O08858 Sstr5 UniProt O08858 1 EQUAL 364 EQUAL Reactome Database ID Release 78 9775976 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775976 Reactome R-MMU-374753 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374753.1 Reactome Database ID Release 78 9775978 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775978 Reactome R-MMU-374746 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374746.1 Somatostatin receptor:somatostatin Reactome DB_ID: 9775980 1 1 Reactome Database ID Release 78 9775980 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775980 Reactome R-MMU-374763 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374763.1 Reactome Database ID Release 78 9775982 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775982 Reactome R-MMU-374758 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-374758.1 Somatostatin (growth hormone inhibiting hormone, GHIH; somatotropin release-inhibiting factor, SRIF) (Shen LP et al, 1992) is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with somatostatin receptors 1-5 (Hoyer D et al, 1995). Somatostatin has two active forms produced by alternative cleavage of the single preproprotein and named according to the number of amino acids in the chain; Somatostatin-28 and somatostatin-14. The 5 receptors known to date all couple with pertussis toxin-sensitive G proteins to inhibit adenylate cyclase after ligand binding. They were classified according to the dates they were discovered; SSTR1 and 2 (Yamada Y et al, Jan. 1992), SSTR3 (Yamada Y et al, Dec. 1992) and SSTR4 and SSTR5 (Yamada Y et al, Sep. 1993). 1346068 Pubmed 1992 Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney Yamada, Y Post, SR Wang, K Tager, HS Bell, Graeme I Seino, S Proc Natl Acad Sci U S A 89:251-5 7792934 Pubmed 1995 Classification and nomenclature of somatostatin receptors Hoyer, D Bell, Graeme I Berelowitz, M Epelbaum, J Feniuk, W Humphrey, PP O'Carroll, AM Patel, YC Schonbrunn, A Taylor, JE Trends Pharmacol Sci 16:86-8 6126875 Pubmed 1982 Human somatostatin I: sequence of the cDNA Shen, LP Pictet, RL Rutter, WJ Proc Natl Acad Sci U S A 79:4575-9 1337145 Pubmed 1992 Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase Yamada, Y Reisine, T Law, SF Ihara, Y Kubota, A Kagimoto, S Seino, M Seino, Y Bell, Graeme I Seino, S Mol Endocrinol 6:2136-42 8373420 Pubmed 1993 Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype Yamada, Y Kagimoto, S Kubota, A Yasuda, K Masuda, K Someya, Y Ihara, Y Li, Q Imura, H Seino, S Biochem Biophys Res Commun 195:844-52 Tachykinin receptors bind tachykinins This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT Tachykinin receptor 1 (NK1) binds to substance P This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Tacr1 TACR1 P30548 Reactome DB_ID: 9777713 UniProt:P30548 Tacr1 UniProt P30548 1 EQUAL 407 EQUAL Reactome Database ID Release 78 9777713 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777713 Reactome R-MMU-380103 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-380103.1 Tac1 TAC1(58-68) P41539 Reactome DB_ID: 9777709 UniProt:P41539 Tac1 UniProt P41539 58 EQUAL 68 EQUAL Reactome Database ID Release 78 9777709 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777709 Reactome R-MMU-380066 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-380066.1 TACR1:TAC1(58-68) Reactome DB_ID: 9777715 1 1 Reactome Database ID Release 78 9777715 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777715 Reactome R-MMU-380119 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-380119.1 Reactome Database ID Release 78 9778574 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778574 Reactome R-MMU-380076 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-380076.1 Substance P (Harmar AJ et al, 1986) is an neuropeptide, 11 amino-acids in length, that acts as a neurotransmitter for pain response neurons. It does this by binding to its endogenous receptor neurokinin 1 (NK1R, substance P receptor) which belongs to the tachykinin receptor sub-family of GPCRs (Takeda Y et al, 1991). 3770210 Pubmed 1986 cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A Harmar, AJ Armstrong, A Pascall, JC Chapman, K Rosie, R Curtis, A Going, J Edwards, CR Fink, G FEBS Lett 208:67-72 1718267 Pubmed 1991 Molecular cloning, structural characterization and functional expression of the human substance P receptor Takeda, Y Chou, KB Takeda, J Sachais, BS Krause, JE Biochem Biophys Res Commun 179:1232-40 LEFT-TO-RIGHT Tachykinin receptor 2 (NK2) binds to nuerokinin A This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Tac1 TAC1(98-107) P41539 Reactome DB_ID: 9777717 98 EQUAL 107 EQUAL Reactome Database ID Release 78 9777717 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777717 Reactome R-MMU-380131 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-380131.1 Tacr2 TACR2 P30549 Reactome DB_ID: 9777721 UniProt:P30549 Tacr2 UniProt P30549 1 EQUAL 398 EQUAL Reactome Database ID Release 78 9777721 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777721 Reactome R-MMU-380135 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-380135.1 TACR2:TAC1(98-107) Reactome DB_ID: 9777723 1 1 Reactome Database ID Release 78 9777723 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777723 Reactome R-MMU-383351 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-383351.1 Reactome Database ID Release 78 9779403 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9779403 Reactome R-MMU-383363 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-383363.1 Neurokinin A (substance K) (Gerard NP et al, 1990) is a peptide neurotransmitter of the tachykinin family which can act as a mediator in human airway and gastrointestinal tissues. Neurokinin A acts via the substance K receptor (NK-2 receptor) (Harmar AJ et al, 1986), believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein. 2173708 Pubmed 1990 The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues Gerard, NP Eddy, Roger L Shows, Thomas B Gerard, C J Biol Chem 265:20455-62 LEFT-TO-RIGHT Tachykinin receptor 3 (NK3) binds to neurokinin B This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Tac3 TAC3 P55099 Reactome DB_ID: 9777727 UniProt:P55099 Tac3 UniProt P55099 81 EQUAL 90 EQUAL Reactome Database ID Release 78 9777727 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777727 Reactome R-MMU-380133 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-380133.1 Tacr3 TACR3 P47937 Reactome DB_ID: 9777731 UniProt:P47937 Tacr3 UniProt P47937 1 EQUAL 465 EQUAL Reactome Database ID Release 78 9777731 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777731 Reactome R-MMU-380132 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-380132.1 TACR3:TAC3 Reactome DB_ID: 9777733 1 1 Reactome Database ID Release 78 9777733 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777733 Reactome R-MMU-383372 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-383372.1 Reactome Database ID Release 78 9779405 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9779405 Reactome R-MMU-383373 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-383373.1 Neurokinin B peptide (NKB) (Torricelli M et al, 2007) is a tachykinin-related neuropeptide that is highly expressed in the placenta.It can bind to its receptor, NK3 (Huang RR et al, 1992), which is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Elevated levels of NKB in early pregnancy may be an indicator of hypertension and pre-eclampsia (Page NM et al, 2000), and treatment with certain neurokinin receptor antagonists may be useful in alleviating the symptoms. 17561251 Pubmed 2007 Placental neurokinin B mRNA expression increases at preterm labor Torricelli, M Giovannelli, A Leucci, E Florio, P De Falco, G Torres, PB Reis, FM Leoncini, L Petraglia, F Placenta 28:1020-3 1374246 Pubmed 1992 cDNA sequence and heterologous expression of the human neurokinin-3 receptor Huang, RR Cheung, AH Mazina, KE Strader, CD Fong, TM Biochem Biophys Res Commun 184:966-72 10866201 Pubmed 2000 Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia Page, NM Woods, RJ Gardiner, SM Lomthaisong, K Gladwell, RT Butlin, DJ Manyonda, IT Lowry, PJ Nature 405:797-800 Reactome Database ID Release 78 9861556 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9861556 Reactome R-MMU-380095 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-380095.1 Tachykinin peptides are one of the largest family of neuropeptides, so named due to their ability to rapidly induce contraction of gut tissue. Tachykinins excite neurons, elicit behavioural responses, are potent vasodilators and contract many smooth muscles. The tachykinin family is characterized by a common C-terminal sequence, Phe-X-Gly-Leu-Met-NH2 (where X can be either an aromatic or an aliphatic amino acid) and are ten to twelve residues long.<br><br>These peptides elicit their effects via the tachykinin receptors, of which there are three types in humans (NK1,2 and 3). There are two human tachykinin peptide genes in humans, TAC1 and TAC3. TAC1 encodes substance P and substance K while TAC3 encodes neurokinin B.<br><br>Antagonists of these receptors are promising candidates for classes of antidepressants, anxiolytics and antipsychotics. 16918325 Pubmed 2006 Overview of the primary structure, tissue-distribution, and functions of tachykinins and their receptors Satake, H Kawada, T Curr Drug Targets 7:963-74 15224188 Pubmed 2004 Hemokinins and endokinins Page, NM Cell Mol Life Sci 61:1652-63 Vasopressin-like receptors This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT AVP(20-28) binds AVPR1A,B This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome AVPR1A,B Vasopressin receptor type 1 Reactome DB_ID: 9777524 Avpr1a AVPR1A Q62463 Reactome DB_ID: 9777518 UniProt:Q62463 Avpr1a UniProt Q62463 1 EQUAL 418 EQUAL Reactome Database ID Release 78 9777518 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777518 Reactome R-MMU-388484 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388484.1 Avpr1b AVPR1B Q9WU02 Reactome DB_ID: 9777522 UniProt:Q9WU02 Avpr1b UniProt Q9WU02 1 EQUAL 424 EQUAL Reactome Database ID Release 78 9777522 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777522 Reactome R-MMU-388471 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388471.1 Reactome Database ID Release 78 9777524 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777524 Reactome R-MMU-388458 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388458.1 Avp AVP(20-28) P35455 Reactome DB_ID: 9777068 UniProt:P35455 Avp Avp FUNCTION Neurophysin 2 specifically binds vasopressin.FUNCTION Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (By similarity).SUBUNIT Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (By similarity). Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (By similarity).SIMILARITY Belongs to the vasopressin/oxytocin family. UniProt P35455 20 EQUAL 28 EQUAL Reactome Database ID Release 78 9777068 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777068 Reactome R-MMU-388474 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388474.1 AVPR1A,B:AVP(20-28) Reactome DB_ID: 9777526 1 1 Reactome Database ID Release 78 9777526 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777526 Reactome R-MMU-388502 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388502.1 Reactome Database ID Release 78 9779407 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9779407 Reactome R-MMU-388468 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388468.1 In humans there are three main arginine vasopressin receptors; AVPR1A, 1B and 2. AVPR1A (Thibonnier et al. 1994) and AVPR1B (Sugimoto et al. 1994) act as receptors for the signal peptide Arg-vasopressin (AVP(20-28)), a cleaved peptide from the precursor AVP protein (Mohr et al. 1985, Sausville et al. 1985) and are expressed mainly in the brain. The 1A and 1B forms use G protein alpha q/11 subunits as their second messenger system. 2991279 Pubmed 1985 The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line Sausville, E Carney, D Battey, J J Biol Chem 260:10236-41 7929452 Pubmed 1994 Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor Sugimoto, T Saito, M Mochizuki, S Watanabe, Y Hashimoto, S Kawashima, H J Biol Chem 269:27088-92 8106369 Pubmed 1994 Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor Thibonnier, M Auzan, C Madhun, Z Wilkins, P Berti-Mattera, L Clauser, E J Biol Chem 269:3304-10 4065330 Pubmed 1985 Expression of the vasopressin and oxytocin genes in human hypothalami Mohr, E Hillers, M Ivell, R Haulica, ID Richter, D FEBS Lett 193:12-6 LEFT-TO-RIGHT AVP(20-28) binds AVPR2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Avpr2 AVPR2 O88721 Reactome DB_ID: 9777072 UniProt:O88721 Avpr2 UniProt O88721 1 EQUAL 371 EQUAL Reactome Database ID Release 78 9777072 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777072 Reactome R-MMU-388431 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388431.1 AVPR2:AVP(20-28) Reactome DB_ID: 9777074 1 1 Reactome Database ID Release 78 9777074 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777074 Reactome R-MMU-392261 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-392261.1 Reactome Database ID Release 78 9780377 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9780377 Reactome R-MMU-392263 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-392263.1 Arginine vasopressin receptor 2 (AVPR2) (Birnbaumer et al. 1992) is expressed in the kidneys and can bind the signal peptide Arg-vasopressin (AVP(20-28)), a cleaved peptide from the precursor AVP protein (Mohr et al. 1985, Sausville et al. 1985). This receptor uses the G protein alpha s subunit as its second messenger system. 1534149 Pubmed 1992 Molecular cloning of the receptor for human antidiuretic hormone Birnbaumer, M Seibold, A Gilbert, S Ishido, M Barberis, C Antaramian, A Brabet, P Rosenthal, W Nature 357:333-5 LEFT-TO-RIGHT Oxytocin receptor bind oxytocin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Oxtr OXTR P97926 Reactome DB_ID: 9777791 UniProt:P97926 Oxtr UniProt P97926 1 EQUAL 389 EQUAL Reactome Database ID Release 78 9777791 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777791 Reactome R-MMU-388428 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388428.1 Oxt OXT(20-28) P35454 Reactome DB_ID: 9777787 UniProt:P35454 Oxt UniProt P35454 20 EQUAL 28 EQUAL Reactome Database ID Release 78 9777787 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777787 Reactome R-MMU-388430 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388430.1 OXTR:OXT(20-28) Reactome DB_ID: 9777793 1 1 Reactome Database ID Release 78 9777793 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777793 Reactome R-MMU-388495 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388495.1 Reactome Database ID Release 78 9779409 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9779409 Reactome R-MMU-388503 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388503.1 Oxytocin is a nonapetide closely related to vasopressin (Mohr E et al, 1985; Sausville E et al, 1985). It is best known for its roles in female reproduction: it is released in large amounts during labour facilitating birth and afterwards, breastfeeding. It also acts as a neurotransmitter in the brain. The actions of oxytocin via the oxytocin receptor (Kimura T et al, 1992) are mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. 1313946 Pubmed 1992 Structure and expression of a human oxytocin receptor Kimura, T Tanizawa, O Mori, K Brownstein, MJ Okayama, H Nature 356:526-9 Reactome Database ID Release 78 9861592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9861592 Reactome R-MMU-388479 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388479.1 The vasopressins are peptide hormones consisting of nine amino acids (nonapeptides). They include arginine vasopressin (AVP; anti-diuretic hormone, ADH) and oxytocin. They are synthesized in the hypothalamus from a precursor and released from stores in the posterior pituitary into the blood stream. One of the most important roles of vasopressins is the regulation of water retention in the body. Oxytocin is important in uterine contraction during birth. The vasopressins act via AVP and oxytocin receptors. These are connected to G proteins which act as second messengers and convey the signal inside the cell. 11274341 Pubmed 2001 The oxytocin receptor system: structure, function, and regulation Gimpl, G Fahrenholz, F Physiol Rev 81:629-83 8734452 Pubmed 1996 Vasopressin and oxytocin receptors Zingg, HH Baillieres Clin Endocrinol Metab 10:75-96 8719042 Pubmed 1995 Molecular neurobiology and pharmacology of the vasopressin/oxytocin receptor family Peter, J Burbach, H Adan, RA Lolait, SJ van Leeuwen, FW Mezey, E Palkovits, M Barberis, C Cell Mol Neurobiol 15:573-95 LEFT-TO-RIGHT Cholecystokinin receptors bind cholecystokinin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Cck CCK P09240 Reactome DB_ID: 9777592 UniProt:P09240 Cck UniProt P09240 21 EQUAL 115 EQUAL Reactome Database ID Release 78 9777592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777592 Reactome R-MMU-388539 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388539.1 Converted from EntitySet in Reactome CCKAR,CCKBR Cholecystokinin receptors Reactome DB_ID: 9777602 Cckar CCKAR O08786 Reactome DB_ID: 9777596 UniProt:O08786 Cckar UniProt O08786 1 EQUAL 428 EQUAL Reactome Database ID Release 78 9777596 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777596 Reactome R-MMU-388517 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388517.1 Cckbr CCKBR P56481 Reactome DB_ID: 9777600 UniProt:P56481 Cckbr UniProt P56481 1 EQUAL 447 EQUAL Reactome Database ID Release 78 9777600 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777600 Reactome R-MMU-388515 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388515.1 Reactome Database ID Release 78 9777602 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777602 Reactome R-MMU-388518 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388518.1 CCKAR,CCKBR:CCK Reactome DB_ID: 9777604 1 1 Reactome Database ID Release 78 9777604 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777604 Reactome R-MMU-388532 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388532.1 Reactome Database ID Release 78 9779411 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9779411 Reactome R-MMU-388529 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388529.1 Cholecystokinin (CCK, previously called pancreozymin) (Takahashi Y et al,1985) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. CCK is synthesized by I-cells in the small intestine and secreted in the duodenum, causing the release of digestive enzymes and bile from the pancreas and gall-bladder respectively. It also acts as a hunger suppressant. CCK receptors bind CCK. In humans, there are two receptor types, A (Ulrich CD et al, 1993) and B (Pisegna JR et al, 1992). The A type are primarily distributed in the GI tract whereas the B type are primarily in the CNS. In the CNS, type B receptors modulate anxiety, analgesia, arousal, and neuroleptic activity.These receptors mediates the action of CCK by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. 8503909 Pubmed 1993 Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor Ulrich, CD Ferber, I Holicky, E Hadac, E Buell, G Miller, LJ Biochem Biophys Res Commun 193:204-11 3856870 Pubmed 1985 Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine Takahashi, Y Kato, K Hayashizaki, Y Wakabayashi, T Ohtsuka, E Matsuki, S Ikehara, M Matsubara, K Proc Natl Acad Sci U S A 82:1931-5 1280419 Pubmed 1992 Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization Pisegna, JR de Weerth, A Huppi, K Wank, SA Biochem Biophys Res Commun 189:296-303 LEFT-TO-RIGHT 3.4.24.64 3.4.24.21 3.4.24.11 3.4.24.22 3.4.24.55 3.4.24.70 3.4.24.71 3.4.24.61 3.4.24.72 3.4.24.17 3.4.24.18 3.4.24.19 3.4.24.23 3.4.24.56 3.4.24.24 3.4.24.35 3.4.24.57 3.4.24.14 3.4.24.69 3.4.24.37 3.4.24.59 ECE1 cleaves EDN1(53-90) This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Edn1 EDN1(53-90) P22387 Reactome DB_ID: 9848702 UniProt:P22387 Edn1 UniProt P22387 53 EQUAL 90 EQUAL Reactome Database ID Release 78 9848702 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9848702 Reactome R-MMU-8876870 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8876870.1 Edn1 EDN1 P22387 Reactome DB_ID: 9777614 53 EQUAL 73 EQUAL Reactome Database ID Release 78 9777614 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777614 Reactome R-MMU-388545 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388545.1 ACTIVATION Ece1 ECE1 Q4PZA2 Reactome DB_ID: 9848706 UniProt:Q4PZA2 Ece1 UniProt Q4PZA2 1 EQUAL 770 EQUAL Reactome Database ID Release 78 9848706 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9848706 Reactome R-MMU-8876866 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8876866.1 GENE ONTOLOGY GO:0004222 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 78 9848707 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9848707 Reactome Database ID Release 78 9848709 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9848709 Reactome R-MMU-8876868 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8876868.1 Endothelin-converting enzyme 1 (ECE1) is a type II membrane-bound zinc metalloprotease. It cleaves the longer form of endothelin (EDN1(53-90), also known as Big ET-1, by an unusual selective hydrolysis of Trp21-Val22, producing EDN1. ECE1 exhibits maximal activity at pH 7.0. It comprises a short cytoplasmic N-terminal tail, a membrane-spanning region, and a large extracellular domain containing a zinc-binding motif essential for enzymatic activity (Schweizer et al. 1997, Valdenaire et al.1999, Jeng et al. 2002). 26956245 Pubmed 2016 Endothelin Davenport, Anthony P Hyndman, Kelly A Dhaun, Neeraj Southan, Christopher Kohan, Donald E Pollock, Jennifer S Pollock, David M Webb, David J Maguire, Janet J Pharmacol. Rev. 68:357-418 10462527 Pubmed 1999 Two di-leucine-based motifs account for the different subcellular localizations of the human endothelin-converting enzyme (ECE-1) isoforms Valdenaire, O Barret, A Schweizer, A Rohrbacher, E Mongiat, F Pinet, F Corvol, P Tougard, C J. Cell. Sci. 112:3115-25 8062389 Pubmed 1994 ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1 Xu, D Emoto, N Giaid, A Slaughter, C Kaw, S deWit, D Yanagisawa, M Cell 78:473-85 12056551 Pubmed 2002 Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications Jeng, Arco Y Mulder, Paul Kwan, Aij-Lie Battistini, Bruno Can. J. Physiol. Pharmacol. 80:440-9 9396733 Pubmed 1997 Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations Schweizer, A Valdenaire, O Nelböck, P Deuschle, U Dumas Milne Edwards, J B Stumpf, J G Löffler, B M Biochem. J. 328:871-7 LEFT-TO-RIGHT 3.4.24.64 3.4.24.21 3.4.24.11 3.4.24.22 3.4.24.55 3.4.24.70 3.4.24.71 3.4.24.61 3.4.24.72 3.4.24.17 3.4.24.18 3.4.24.19 3.4.24.23 3.4.24.56 3.4.24.24 3.4.24.35 3.4.24.57 3.4.24.14 3.4.24.69 3.4.24.37 3.4.24.59 ECE2 cleaves EDN1(53-90) This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Edn1 EDN1(53-90) P22387 Reactome DB_ID: 9848870 transport vesicle GENE ONTOLOGY GO:0030133 53 EQUAL 90 EQUAL Reactome Database ID Release 78 9848870 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9848870 Reactome R-MMU-8878413 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8878413.1 Edn1 EDN1 P22387 Reactome DB_ID: 9848872 53 EQUAL 73 EQUAL Reactome Database ID Release 78 9848872 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9848872 Reactome R-MMU-8878414 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8878414.1 ACTIVATION ECE2 Eef1akmt4-Ece2 P0DPD9 Reactome DB_ID: 9848876 transport vesicle membrane GENE ONTOLOGY GO:0030658 UniProt:P0DPD9 Eef1akmt4-Ece2 UniProt P0DPD9 1 EQUAL 811 EQUAL Reactome Database ID Release 78 9848876 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9848876 Reactome R-MMU-9608272 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9608272.1 Reactome Database ID Release 78 9848877 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9848877 Reactome Database ID Release 78 9848879 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9848879 Reactome R-MMU-8877620 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8877620.1 Endothelin-converting enzyme 2 (ECE2) belongs to the type II membrane-bound zinc metalloprotease family and shares 59% sequence similarity to ECE1 (Emoto & Yanagisawa1995, Yanagisawa et al. 2000, Lorenzo et al. 2001). In contrast to ECE1, the optimum pH for ECE2 activity is acidic (pH 5.5), which would favor an intracellular localization and a potential role under low pH conditions, for example in ischemia. This difference provides an experimental method for distinguishing between the activities of the two enzymes. ECE2 was found to be localized to the acidified environment of vesicles of the secretory pathway in human endothelial cells but was not detected in Weibel-Palade storage granules (Russell & Davenport 1999). 7797512 Pubmed 1995 Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum Emoto, N Yanagisawa, M J. Biol. Chem. 270:15262-8 12560336 Pubmed 2003 Characterization of endothelin-converting enzyme-2. Implication for a role in the nonclassical processing of regulatory peptides Mzhavia, Nino Pan, Hui Che, Fa-Yun Fricker, Lloyd D Devi, Lakshmi A J. Biol. Chem. 278:14704-11 11718899 Pubmed 2001 Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization Lorenzo, M N Khan, R Y Wang, Y Tai, S C Chan, G C Cheung, A H Marsden, P A Biochim. Biophys. Acta 1522:46-52 10222335 Pubmed 1999 Evidence for intracellular endothelin-converting enzyme-2 expression in cultured human vascular endothelial cells Russell, F D Davenport, A P Circ. Res. 84:891-6 10811845 Pubmed 2000 Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development Yanagisawa, H Hammer, R E Richardson, J A Emoto, N Williams, S C Takeda, S i Clouthier, D E Yanagisawa, M J. Clin. Invest. 105:1373-82 LEFT-TO-RIGHT 3.4.24.64 3.4.24.21 3.4.24.11 3.4.24.22 3.4.24.55 3.4.24.70 3.4.24.71 3.4.24.61 3.4.24.72 3.4.24.17 3.4.24.18 3.4.24.19 3.4.24.23 3.4.24.56 3.4.24.24 3.4.24.35 3.4.24.57 3.4.24.14 3.4.24.69 3.4.24.37 3.4.24.59 XK:KEL:Zn2+ cleaves EDN3 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Edn3 EDN3(97-238) P48299 Reactome DB_ID: 9832051 UniProt:P48299 Edn3 UniProt P48299 97 EQUAL 238 EQUAL Reactome Database ID Release 78 9832051 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9832051 Reactome R-MMU-5694133 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5694133.1 Edn3 EDN3(118-238) P48299 Reactome DB_ID: 9832053 118 EQUAL 238 EQUAL Reactome Database ID Release 78 9832053 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9832053 Reactome R-MMU-5694067 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5694067.1 Edn3 EDN3(97-117) P48299 Reactome DB_ID: 9777622 97 EQUAL 117 EQUAL Reactome Database ID Release 78 9777622 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777622 Reactome R-MMU-388543 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388543.1 ACTIVATION XK:KEL:Zn2+ Reactome DB_ID: 9832063 Xk XK Q9QXY7 Reactome DB_ID: 9832061 UniProt:Q9QXY7 Xk UniProt Q9QXY7 1 EQUAL 444 EQUAL Reactome Database ID Release 78 9832061 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9832061 Reactome R-MMU-5215986 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5215986.1 1 Zn2+ Zn++ zinc(2+) zinc Zn(II) Reactome DB_ID: 109265 zinc(2+) [ChEBI:29105] zinc(2+) ChEBI CHEBI:29105 Reactome Database ID Release 78 109265 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109265 Reactome R-ALL-109265 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109265.3 COMPOUND C00038 1 Kel KEL Q9EQF2 Reactome DB_ID: 9832057 UniProt:Q9EQF2 Kel UniProt Q9EQF2 1 EQUAL 732 EQUAL Reactome Database ID Release 78 9832057 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9832057 Reactome R-MMU-5694121 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5694121.1 1 Reactome Database ID Release 78 9832063 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9832063 Reactome R-MMU-5694128 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5694128.1 Reactome Database ID Release 78 9832064 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9832064 Reactome Database ID Release 78 9832066 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9832066 Reactome R-MMU-5694082 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5694082.1 The Kell blood group glycoprotein (KEL) is a zinc endopeptidase with endothelin-3-converting enzyme activity which can preferentially cleave endothelin-3 (EDN3), an endothelium-derived vasoconstrictor peptide. EDN3 is cleaved at Trp21-Ile22 to form the bioactive peptide EDN3(97-117) (Lee et al. 1999). KEL forms a heterodimer with membrane transport protein XK (Russo et al. 1998). 9593744 Pubmed 1998 Association of XK and Kell blood group proteins Russo, D Redman, C Lee, S J. Biol. Chem. 273:13950-6 10438732 Pubmed 1999 Proteolytic processing of big endothelin-3 by the kell blood group protein Lee, S Lin, M Mele, A Cao, Y Farmar, J Russo, D Redman, C Blood 94:1440-50 LEFT-TO-RIGHT EDNRA,EDNRB bind EDNs Endothelin receptors bind endothelin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome EDNs Endothelins EDN1, EDN2, EDN3 Reactome DB_ID: 9777624 Edn2 EDN2 P22389 Reactome DB_ID: 9777618 UniProt:P22389 Edn2 UniProt P22389 49 EQUAL 69 EQUAL Reactome Database ID Release 78 9777618 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777618 Reactome R-MMU-388542 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388542.1 Reactome Database ID Release 78 9777624 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777624 Reactome R-MMU-388544 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388544.1 Converted from EntitySet in Reactome EDNRA,EDNRB Endothelin receptors Reactome DB_ID: 9777634 Ednra EDNRA Q61614 Reactome DB_ID: 9777628 UniProt:Q61614 Ednra UniProt Q61614 21 EQUAL 427 EQUAL Reactome Database ID Release 78 9777628 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777628 Reactome R-MMU-388549 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388549.1 Ednrb EDNRB P48302 Reactome DB_ID: 9777632 UniProt:P48302 Ednrb UniProt P48302 27 EQUAL 442 EQUAL Reactome Database ID Release 78 9777632 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777632 Reactome R-MMU-388550 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388550.1 Reactome Database ID Release 78 9777634 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777634 Reactome R-MMU-388547 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388547.1 EDNRA,EDNRB:EDNs Reactome DB_ID: 9777636 1 1 Reactome Database ID Release 78 9777636 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777636 Reactome R-MMU-388546 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388546.1 Reactome Database ID Release 78 9779413 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9779413 Reactome R-MMU-388560 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388560.1 Endothelins (EDNs) are 21-amino acid vasoconstricting peptides produced primarily in the endothelium that play a key role in vascular homeostasis. An imbalance and over-expression of EDNs can contribute to hypertension (high blood pressure). EDNs are implicated in vascular diseases of several organ systems, including the heart, general circulation and brain. There are 3 isoforms derived from the genes EDN1, EDN2 and EDN3 (Inoue et al. 1989).<br><br>EDNs bind to two receptors (Elshourbagy et al. 1993), EDNRA (Adachi et al. 1991) and EDNRB (Nakamuta et al. 1991). EDNRA is primarily located in the smooth muscle of blood vessels. EDN binding to EDNRA results in vasoconstriction and sodium retention, leading to increased blood pressure. EDNRB is primarily located on endothelial cells lining the internal walls of vasculature. EDN binding to EDNRB leads to the release of NO (nitric oxide), a powerful vasodilator. 2649896 Pubmed 1989 The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes Inoue, A Yanagisawa, M Kimura, S Kasuya, Y Miyauchi, T Goto, K Masaki, T Proc Natl Acad Sci U S A 86:2863-7 8440682 Pubmed 1993 Molecular characterization and regulation of the human endothelin receptors Elshourbagy, NA Korman, DR Wu, HL Sylvester, DR Lee, JA Nuthalaganti, P Bergsma, DJ Kumar, CS Nambi, P J Biol Chem 268:3873-9 1710450 Pubmed 1991 Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor Nakamuta, M Takayanagi, R Sakai, Y Sakamoto, S Hagiwara, H Mizuno, T Saito, Y Hirose, S Yamamoto, M Nawata, H Biochem Biophys Res Commun 177:34-9 1719979 Pubmed 1991 Cloning and characterization of cDNA encoding human A-type endothelin receptor Adachi, M Yang, YY Furuichi, Y Miyamoto, C Biochem Biophys Res Commun 180:1265-72 LEFT-TO-RIGHT EDNRA binds EDNs Endothelin receptor A bind endothelins This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> EDNRA:EDNs Reactome DB_ID: 9859825 1 1 Reactome Database ID Release 78 9859825 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9859825 Reactome R-MMU-9731930 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9731930.1 Reactome Database ID Release 78 9859827 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9859827 Reactome R-MMU-9731924 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9731924.1 Endothelins (EDNs) are 21-amino acid vasoconstricting peptides produced primarily in the endothelium that play a key role in vascular homeostasis. An imbalance and over-expression of EDNs can contribute to hypertension (high blood pressure). EDNs are implicated in vascular diseases of several organ systems, including the heart, general circulation and brain. There are 3 isoforms derived from the genes EDN1, EDN2 and EDN3 (Inoue et al. 1989).<br><br>EDNs bind to two receptors (Elshourbagy et al. 1993), EDNRA (Adachi et al. 1991) and EDNRB. EDNRA is primarily located in the smooth muscle of blood vessels. EDNs binding to EDNRA result in vasoconstriction and sodium retention, leading to increased blood pressure. EDNRB is primarily located on endothelial cells lining the internal walls of vasculature. Conversely, EDNs binding to EDNRB leads to vasodilation due to the release of NO (nitric oxide), a powerful vasodilator. LEFT-TO-RIGHT Melanocortin receptors bind melanocortins This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome Melanocortin receptors Reactome DB_ID: 9777308 Mc1r MC1R Q01727 Reactome DB_ID: 9777294 UniProt:Q01727 Mc1r UniProt Q01727 1 EQUAL 317 EQUAL Reactome Database ID Release 78 9777294 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777294 Reactome R-MMU-388614 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388614.1 Mc3r MC3R(1-360) P33033 Reactome DB_ID: 9777298 UniProt:P33033 Mc3r UniProt P33033 1 EQUAL 360 EQUAL Reactome Database ID Release 78 9777298 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777298 Reactome R-MMU-388592 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388592.1 Mc4r MC4R P56450 Reactome DB_ID: 9777302 UniProt:P56450 Mc4r UniProt P56450 1 EQUAL 332 EQUAL Reactome Database ID Release 78 9777302 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777302 Reactome R-MMU-388606 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388606.1 Mc5r MC5R P41149 Reactome DB_ID: 9777306 UniProt:P41149 Mc5r UniProt P41149 1 EQUAL 325 EQUAL Reactome Database ID Release 78 9777306 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777306 Reactome R-MMU-388604 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388604.1 Reactome Database ID Release 78 9777308 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777308 Reactome R-MMU-388601 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388601.1 Pomc POMC(138-150) P01193 Reactome DB_ID: 9777286 138 EQUAL 150 EQUAL Reactome Database ID Release 78 9777286 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777286 Reactome R-MMU-388593 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388593.1 MSH:Melanocortin receptors Reactome DB_ID: 9777310 1 1 Reactome Database ID Release 78 9777310 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777310 Reactome R-MMU-388602 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388602.1 Reactome Database ID Release 78 9779415 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9779415 Reactome R-MMU-388596 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388596.1 Melanocortins are a group of pituitary peptide hormones that include corticotropin (ACTH) and the alpha, beta and gamma melanocyte-stimulating hormones (MSH) derived from the prohormone proopiomelanocortin (Takahashi H et al, 1981). Melanocortins can act through multiple melanocortin receptors (MC1R-MC5R) (Mountjoy KG et al, 1992). The majority of melanocortin receptors (MC1R, MC3R, MC4R and MC5R) are semi-selective in their ability to bind multiple melanocortins (MSH and ACTH). MSH regulates pigmentation. 1325670 Pubmed 1992 The cloning of a family of genes that encode the melanocortin receptors Mountjoy, KG Robbins, LS Mortrud, MT Cone, RD Science 257:1248-51 LEFT-TO-RIGHT ACTH binds MC2R POMC(138-176) binds MC2R This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Mc2r MC2R Q64326 Reactome DB_ID: 9777282 UniProt:Q64326 Mc2r UniProt Q64326 1 EQUAL 297 EQUAL Reactome Database ID Release 78 9777282 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777282 Reactome R-MMU-388600 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388600.1 Pomc POMC(138-176) P01193 Reactome DB_ID: 9777278 138 EQUAL 176 EQUAL Reactome Database ID Release 78 9777278 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777278 Reactome R-MMU-388607 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388607.1 POMC(138-176):MC2R Reactome DB_ID: 9777284 1 1 Reactome Database ID Release 78 9777284 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9777284 Reactome R-MMU-388603 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388603.1 Reactome Database ID Release 78 9779417 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9779417 Reactome R-MMU-388605 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388605.1 MC2R (aka ACTH receptor) selectively binds POMC(138-176) (ACTH, corticotropin) (Gantz et al. 1993, Lee et al. 1961, Mountjoy et al. 1992). ACTH regulates adrenal cortical function via the G protein alpha-s subunit. 8463333 Pubmed 1993 Molecular cloning of a novel melanocortin receptor Gantz, I Konda, Y Tashiro, T Shimoto, Y Miwa, H Munzert, G Watson, SJ DelValle, J Yamada, T J Biol Chem 268:8246-50 14463577 Pubmed 1961 On the structure of human corticotropin (adrenocorticotropic hormone) Lee, TH Lerner, AB Buettner-Janusch, V J Biol Chem 236:2970-4 LEFT-TO-RIGHT Prolactin-releasing hormone receptor binds PRH This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Prlhr PRLHR Q6VMN6 Reactome DB_ID: 9779565 UniProt:Q6VMN6 Prlhr UniProt Q6VMN6 1 EQUAL 370 EQUAL Reactome Database ID Release 78 9779565 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9779565 Reactome R-MMU-388865 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388865.1 Prlh PRLH(34-53) G3UWC3 Reactome DB_ID: 9779569 UniProt:G3UWC3 Prlh UniProt G3UWC3 34 EQUAL 53 EQUAL Reactome Database ID Release 78 9779569 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9779569 Reactome R-MMU-388856 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388856.1 PRLHR:PRLH peptides Reactome DB_ID: 9779573 1 1 Reactome Database ID Release 78 9779573 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9779573 Reactome R-MMU-388889 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388889.1 Reactome Database ID Release 78 9779575 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9779575 Reactome R-MMU-388855 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388855.1 The prolactin-releasing peptide receptor (PrRP; GRP10) (Marchese A et al, 1995) is expressed in the pituitary gland (Fujii R et al, 1999) and binds prolactin-releasing peptide (PrRP) (Hinuma S et al, 1998). PrRP is implicated in lactation, regulation of food intake and pain-signal processing. Human PrRP-20 failed to alter basal or forskolin-stimulated levels of intracellular cyclic AMP in HEK293-GPR10 cells, suggesting that GPR10 does not couple via either Gs or Gi (Langmead et al. 2000). 11030716 Pubmed 2000 Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor Langmead, CJ Szekeres, PG Chambers, JK Ratcliffe, SJ Jones, DN Hirst, WD Price, GW Herdon, HJ Br J Pharmacol 131:683-8 8666380 Pubmed 1995 Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors Marchese, A Heiber, M Nguyen, T Heng, HH Saldivia, VR Cheng, R Murphy, PM Tsui, LC Shi, X Gregor, P Genomics 29:335-44 9607765 Pubmed 1998 A prolactin-releasing peptide in the brain Hinuma, S Habata, Y Fujii, R Kawamata, Y Hosoya, M Fukusumi, S Kitada, C Masuo, Y Asano, T Matsumoto, H Sekiguchi, M Kurokawa, T Nishimura, O Onda, H Fujino, M Nature 393:272-6 10498338 Pubmed 1999 Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor Fujii, R Fukusumi, S Hosoya, M Kawamata, Y Habata, Y Hinuma, S Sekiguchi, M Kitada, C Kurokawa, T Nishimura, O Onda, H Sumino, Y Fujino, M Regul Pept 83:1-10 LEFT-TO-RIGHT Neuropeptide Y receptors can bind neuropeptide Y-related peptides This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome Neuropeptide Y receptors Reactome DB_ID: 9778258 Npy1r NPY1R Q04573 Reactome DB_ID: 9778244 UniProt:Q04573 Npy1r UniProt Q04573 1 EQUAL 384 EQUAL Reactome Database ID Release 78 9778244 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778244 Reactome R-MMU-388896 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388896.1 Npy2r NPY2R P97295 Reactome DB_ID: 9778248 UniProt:P97295 Npy2r UniProt P97295 1 EQUAL 381 EQUAL Reactome Database ID Release 78 9778248 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778248 Reactome R-MMU-388905 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388905.1 Npy4r PPYR1 Q61041 Reactome DB_ID: 9778252 UniProt:Q61041 Npy4r UniProt Q61041 1 EQUAL 375 EQUAL Reactome Database ID Release 78 9778252 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778252 Reactome R-MMU-388868 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388868.1 Npy5r NPY5R O70342 Reactome DB_ID: 9778256 UniProt:O70342 Npy5r UniProt O70342 1 EQUAL 445 EQUAL Reactome Database ID Release 78 9778256 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778256 Reactome R-MMU-388854 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388854.1 Reactome Database ID Release 78 9778258 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778258 Reactome R-MMU-388858 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388858.1 Converted from EntitySet in Reactome NPY receptor ligands Reactome DB_ID: 9778240 Npy NPY P57774 Reactome DB_ID: 9778230 UniProt:P57774 Npy UniProt P57774 29 EQUAL 64 EQUAL Reactome Database ID Release 78 9778230 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778230 Reactome R-MMU-388906 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388906.1 Ppy PPY(30-65) P10601 Reactome DB_ID: 9778234 UniProt:P10601 Ppy UniProt P10601 30 EQUAL 65 EQUAL Reactome Database ID Release 78 9778234 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778234 Reactome R-MMU-388882 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388882.1 Pyy PYY(29-64) Q9EPS2 Reactome DB_ID: 9778238 UniProt:Q9EPS2 Pyy UniProt Q9EPS2 29 EQUAL 64 EQUAL Reactome Database ID Release 78 9778238 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778238 Reactome R-MMU-388878 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-388878.1 Reactome Database ID Release 78 9778240 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778240 Reactome R-MMU-388902 1