BioPAX pathway converted from "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane" in the Reactome database.LEFT-TO-RIGHT3.1.4.11PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membraneThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PIP2PI(4,5)P21-phosphatidyl-1D-myo-inositol 4,5-bisphosphatePhosphatidylinositol-4,5-bisphosphate1-phosphatidyl-1D-myo-inositol 4,5- bisphosphateReactome DB_ID: 2023856endoplasmic reticulum membraneGENE ONTOLOGYGO:00057891-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]1-phosphatidyl-1D-myo-inositol 4,5-bisphosphatePIP2ChEBICHEBI:18348Reactome Database ID Release 752023856Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023856ReactomeR-ALL-20238563Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2023856.3Reactomehttp://www.reactome.orgCOMPOUNDC04637additional informationMIMI:0361H2OwaterReactome DB_ID: 29356cytosolGENE ONTOLOGYGO:0005829water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7529356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293565Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5COMPOUNDC00001DAG1,2-diacylglycerol1,2-diacyl-sn-glycerolReactome DB_ID: 15005961,2-diacyl-sn-glycerol [ChEBI:17815]1,2-diacyl-sn-glycerolChEBICHEBI:17815Reactome Database ID Release 751500596Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500596ReactomeR-ALL-15005963Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1500596.3COMPOUNDC00165IP3I(1,4,5)P31D-myo-inositol 1,4,5-trisphosphateD-myo-Inositol 1,4,5-trisphosphateInositol 1,4,5-trisphosphatephosphatidylinositol 1,4,5-trisphosphateReactome DB_ID: 1145201D-myo-inositol 1,4,5-trisphosphate [ChEBI:16595]1D-myo-inositol 1,4,5-trisphosphateChEBICHEBI:16595Reactome Database ID Release 75114520Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114520ReactomeR-ALL-1145203Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-114520.3COMPOUNDC01245ACTIVATIONConverted from EntitySet in ReactomePL(C)D4:3xCa2+Reactome DB_ID: 9875579PLCD4:3xCa2+Reactome DB_ID: 9875571Ca2+Calciumcalcium(2+)Reactome DB_ID: 1500625calcium(2+) [ChEBI:29108]calcium(2+)ChEBICHEBI:29108Reactome Database ID Release 751500625Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500625ReactomeR-ALL-15006253Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1500625.3COMPOUNDC000763Plcd4PLCD4Q62711Reactome DB_ID: 9875569UniProt:Q62711Plcd4Rattus norvegicusNCBI Taxonomy10116UniProtQ627111EQUAL762EQUALReactome Database ID Release 759875569Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9875569ReactomeR-RNO-88703141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-8870314.11Reactome Database ID Release 759875571Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9875571ReactomeR-RNO-88703161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-8870316.1PLD4:Ca2+Reactome DB_ID: 9875577Pld4PLD4(1-762)G3V904Reactome DB_ID: 9875575UniProt:G3V904Pld4UniProtG3V9041EQUAL762EQUALReactome Database ID Release 759875575Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9875575ReactomeR-RNO-20238761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-2023876.113Reactome Database ID Release 759875577Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9875577ReactomeR-RNO-20238691Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-2023869.1Reactome Database ID Release 759875579Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9875579ReactomeR-RNO-88703131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-8870313.1GENE ONTOLOGYGO:0004435gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 759875580Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9875580Reactome Database ID Release 759875582Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9875582ReactomeR-RNO-18552141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-1855214.1At the endoplasmic reticulum (ER) membrane, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (PLCD4) and phospholipase D4 (PLD4) hydrolyse phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to inositol 1,4,5-trisphosphate (I(1,4,5)P3) and diacylglycerol (DAG). Both lipases are thought to require three Ca2+ ions per subunit for activity. PLD4 is attached to the ER membrane via its PH domain while its C2 domain binds to the PI(4,5)P2 in the membrane (Lee et al. 2004). Overexpression or dysregulated expression of PLCD4 may initiate oncogenesis in certain tissues through upregulation of ErbB expression and activation of ERK pathway. PLCD4 can therefore be a useful tumor marker for breast or testicular cancer tissues (Leung et al. 2004).15037625Pubmed2004The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzymeLee, SBVárnai, PBalla, AJalink, KRhee, SGBalla, TJ Biol Chem 279:24362-7115140260Pubmed2004Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cellsLeung, DWTompkins, CBrewer, JBall, ACoon, MMorris, VWaggoner, DSinger, JWMol Cancer 3:15inferred from electronic annotationEVIDENCE CODEECO:0000203