BioPAX pathway converted from "ESPL1 (Separase) cleaves centromeric cohesin" in the Reactome database. LEFT-TO-RIGHT 3.4 ESPL1 (Separase) cleaves centromeric cohesin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules Reactome DB_ID: 9867683 chromosome, centromeric region GENE ONTOLOGY GO:0000775 p-RAD21-Ac-Cohesin Reactome DB_ID: 9867681 SMC1A Q9CU62 Reactome DB_ID: 9867636 UniProt:Q9CU62 Smc1a Smc1a Sb1.8 Smc1 Smc1l1 Smcb FUNCTION Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.SUBUNIT Forms a heterodimer with SMC3 in cohesin complexes. Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their SMC hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. In germ cell cohesin complexes, SMC1A is mutually exclusive with SMC1B (PubMed:10375619). Interacts with STAG3 (PubMed:11483963). Found in a complex with CDCA5, SMC3 and RAD21, PDS5A/SCC-112 and PDS5B/APRIN. Found in a complex containing POLE and SMC3. Interacts with BRCA1, SYCP2, NDC80, RPGR and BRAT1. Found in a cohesin complex with SMC3, STAG1 and RAD21. The SMC1A-SMC3 heterodimer interacts with the NIPBL-MAU2 heterodimer (By similarity).TISSUE SPECIFICITY Ubiquitous (at protein level).DOMAIN The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity).PTM Phosphorylated upon ionizing radiation or DNA methylation. Phosphorylation of Ser-957 and Ser-966 activates it and is required for S-phase checkpoint activation (By similarity).PTM Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation.SIMILARITY Belongs to the SMC family. SMC1 subfamily. Mus musculus NCBI Taxonomy 10090 UniProt Q9CU62 1 EQUAL 1233 EQUAL Reactome Database ID Release 82 9867636 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867636 Reactome R-MMU-2466015 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2466015.1 Reactome http://www.reactome.org 1 Q9CW03 2xAcK-SMC3 Reactome DB_ID: 9867641 UniProt:Q9CW03 Smc3 Smc3 Bam Bmh Cspg6 Mmip1 Smc3l1 Smcd FUNCTION Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.SUBUNIT Forms a heterodimer with SMC1A or SMC1B in cohesin complexes (PubMed:11564881). Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their SMC hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Also found in meiosis-specific cohesin complexes. Found in a complex with SMC1A, CDCA5 and RAD21, PDS5A/SCC-112 and PDS5B/APRIN. Interacts with PDS5A and WAPL; regulated by SMC3 acetylation. Interacts with NUMA1, and forms a ternary complex with KIF3B and KIFAP3, suggesting a function in tethering the chromosomes to the spindle pole and a function in chromosome movement. Interacts with SYCP2 and RPGR. Interacts (via SMC hinge domain) with KIAA1328 (via N- and C-terminal domains). Interacts with DDX11. Found in a cohesin complex with SMC1A, STAG1 and RAD21. The SMC1A-SMC3 heterodimer interacts with the NIPBL-MAU2 heterodimer (By similarity). Interacts with MXI1, MXD3 and MXD4 (PubMed:9528857). Interacts with STAG3 (PubMed:11483963). Interacts with the NuRD complex component HDAC2; the interaction is direct (By similarity).TISSUE SPECIFICITY Spermatocytes (at protein level). Widely expressed, with higher expression in testis and brain.DOMAIN The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC1A or SMC1B, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity).PTM Phosphorylated at Ser-1083 in a SPO11-dependent manner.PTM Acetylation at Lys-105 and Lys-106 by ESCO1 is important for genome stability and S phase sister chromatid cohesion. Regulated by DSCC1, it is required for processive DNA synthesis, coupling sister chromatid cohesion establishment during S phase to DNA replication (By similarity). Deacetylation by HDAC8, regulates release of the cohesin complex from chromatin (By similarity).PTM Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation.SIMILARITY Belongs to the SMC family. SMC3 subfamily.CAUTION Was originally isolated as a proteoglycan protein (explaining its name). Although not excluded, such secreted function is not clear. UniProt Q9CW03 105 EQUAL N6-acetyl-L-lysine MOD MOD:00064 106 EQUAL 1 EQUAL 1217 EQUAL Reactome Database ID Release 82 9867641 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867641 Reactome R-MMU-2468148 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2468148.1 1 Stag2 STAG2 O35638 Reactome DB_ID: 9867633 UniProt:O35638 Stag2 Stag2 Sa2 Sap2 FUNCTION Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity).SUBUNIT Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3 (By similarity).PTM Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).SIMILARITY Belongs to the SCC3 family. UniProt O35638 1 EQUAL 1231 EQUAL Reactome Database ID Release 82 9867633 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867633 Reactome R-MMU-2466018 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2466018.1 1 Stag1 STAG1 Q9D3E6 Reactome DB_ID: 9867630 UniProt:Q9D3E6 Stag1 Stag1 Sa1 FUNCTION Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity).SUBUNIT Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG1 is mutually exclusive with STAG2 and STAG3. Interacts directly with RAD21 in cohesin complex. Found in a cohesin complex with SMC1A, SMC3 and RAD21.PTM Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).SIMILARITY Belongs to the SCC3 family. UniProt Q9D3E6 1 EQUAL 1258 EQUAL Reactome Database ID Release 82 9867630 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867630 Reactome R-MMU-2466017 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2466017.1 1 Q61550 phospho-Rad21 p-S454-RAD21 Reactome DB_ID: 9867672 UniProt:Q61550 Rad21 Rad21 Hr21 Scc1 SUBUNIT Component of the cohesin complex, which consists of an SMC1A/B and SMC3 heterodimer core and 2 non-Smc subunits RAD21 and STAG1/SA1, STAG2/SA2 or STAG3/SA3 (PubMed:10375619, PubMed:18237772). Interacts (via N-terminus) with SMC1A; the interaction is direct (By similarity). The cohesin complex interacts with NUMA1. The cohesin complex also interacts with CDCA5, PDS5A and PDS5B; this interaction might regulate the ability of the cohesin complex to mediate sister chromatid cohesion. The interaction with PDS5B is direct and is stimulated by STAG1/SA1. The cohesin complex interacts with the cohesin loading complex subunits NIPBL/Scc2 (via HEAT repeats) and MAU2/Scc4. The cohesin complex interacts with DDX11/ChIR1. Directly interacts with WAPL; this interaction is stimulated by STAG1/SA1 (By similarity). Interacts with the ISWI chromatin remodeling complex component SMARCA5; the interaction is direct (By similarity). Interacts with the NuRD complex component CHD4; the interaction is direct (By similarity).TISSUE SPECIFICITY Widely expressed with highest levels in testis, brain, kidney, heart and thymus. Lowest levels in skeletal muscle.DEVELOPMENTAL STAGE Not regulated during the cell cycle (at protein level).DOMAIN The C-terminal part associates with the head of SMC1A, while the N-terminal part binds to the head of SMC3.PTM Cleaved by separase/ESPL1 at the onset of anaphase; this cleavage is required for sister chromatid separation and cytokinesis. Cleaved by caspase-3/CASP3 or caspase-7/CASP7 at the beginning of apoptosis.PTM Phosphorylated; becomes hyperphosphorylated in M phase of cell cycle. The large dissociation of cohesin from chromosome arms during prophase may be partly due to its phosphorylation by PLK1.MISCELLANEOUS Seems to bind calcium.SIMILARITY Belongs to the rad21 family. UniProt Q61550 454 EQUAL O-phospho-L-serine MOD MOD:00046 1 EQUAL 631 EQUAL Reactome Database ID Release 82 9867672 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867672 Reactome R-MMU-2485163 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2485163.1 1 Reactome Database ID Release 82 9867681 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867681 Reactome R-MMU-2500251 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2500251.1 1 Microtubule-bound kinetochore Reactome DB_ID: 9840752 cytosol GENE ONTOLOGY GO:0005829 Kinetochore Reactome DB_ID: 9825263 Ranbp2 RANBP2 Q9ERU9 Reactome DB_ID: 9820898 UniProt:Q9ERU9 Ranbp2 Ranbp2 FUNCTION E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1 (By similarity). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.PATHWAY Protein modification; protein sumoylation.SUBUNIT Part of the nuclear pore complex (By similarity). Forms a complex with NXT1, NXF1 and RANGAP1 (By similarity). Forms a tight complex with RANBP1 and UBE2I (By similarity). Interacts with SUMO1 but not SUMO2 (By similarity). Interacts with sumoylated RANGAP1 (By similarity). Interacts with CDCA8 (By similarity). Interacts with PML (By similarity). Interacts with BICD2 (By similarity). Interacts with PRKN (PubMed:16332688). Interacts with MCM3AP (By similarity). Interacts with COX11 (By similarity).DOMAIN Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.DOMAIN The PPIase cyclophilin-type domain has high structural similarity with PPIA, but has extremely low and barely detectable proline isomerase activity (in vitro) (By similarity). Only about half of the residues that surround the PPIA active site cleft are conserved.PTM Polyubiquitinated by PRKN, which leads to proteasomal degradation.PTM The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.SIMILARITY Belongs to the RanBP2 E3 ligase family.CAUTION Despite the presence of a PPIase cyclophilin-type domain, it has probably no peptidyl-prolyl cis-trans isomerase activity. UniProt Q9ERU9 1 EQUAL 3224 EQUAL Reactome Database ID Release 82 9820898 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9820898 Reactome R-MMU-157703 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-157703.1 1 Nudc NUDC O35685 Reactome DB_ID: 9825068 UniProt:O35685 Nudc UniProt O35685 1 EQUAL 331 EQUAL Reactome Database ID Release 82 9825068 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825068 Reactome R-MMU-377731 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377731.1 1 Ska1 SKA1 Q9CPV1 Reactome DB_ID: 9824988 UniProt:Q9CPV1 Ska1 UniProt Q9CPV1 2 EQUAL 255 EQUAL Reactome Database ID Release 82 9824988 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824988 Reactome R-MMU-376228 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376228.1 1 Ahctf1 AHCTF1 Q8CJF7 Reactome DB_ID: 9824948 UniProt:Q8CJF7 Ahctf1 UniProt Q8CJF7 1 EQUAL 2266 EQUAL Reactome Database ID Release 82 9824948 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824948 Reactome R-MMU-376244 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376244.1 1 Clasp2 CLASP2 Q8BRT1 Reactome DB_ID: 9824940 UniProt:Q8BRT1 Clasp2 UniProt Q8BRT1 1 EQUAL 1294 EQUAL Reactome Database ID Release 82 9824940 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824940 Reactome R-MMU-376252 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376252.1 1 Nup107-160 complex Reactome DB_ID: 9820968 Nup85 NUP85 Q8R480 Reactome DB_ID: 9820950 UniProt:Q8R480 Nup85 UniProt Q8R480 1 EQUAL 656 EQUAL Reactome Database ID Release 82 9820950 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9820950 Reactome R-MMU-376238 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376238.1 1 Nup107 NUP107 Q8BH74 Reactome DB_ID: 9820938 UniProt:Q8BH74 Nup107 UniProt Q8BH74 1 EQUAL 925 EQUAL Reactome Database ID Release 82 9820938 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9820938 Reactome R-MMU-376241 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376241.1 1 Nup43 NUP43 P59235 Reactome DB_ID: 9820960 UniProt:P59235 Nup43 UniProt P59235 1 EQUAL 380 EQUAL Reactome Database ID Release 82 9820960 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9820960 Reactome R-MMU-376243 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376243.1 1 Nup133 NUP133 Q8R0G9 Reactome DB_ID: 9820942 UniProt:Q8R0G9 Nup133 UniProt Q8R0G9 1 EQUAL 1156 EQUAL Reactome Database ID Release 82 9820942 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9820942 Reactome R-MMU-376251 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376251.1 1 Nup160 NUP160 Q9Z0W3 Reactome DB_ID: 9820946 UniProt:Q9Z0W3 Nup160 UniProt Q9Z0W3 1 EQUAL 1436 EQUAL Reactome Database ID Release 82 9820946 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9820946 Reactome R-MMU-376253 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376253.1 1 Sec13 SEC13 Q9D1M0 Reactome DB_ID: 9820964 UniProt:Q9D1M0 Sec13 UniProt Q9D1M0 2 EQUAL 322 EQUAL Reactome Database ID Release 82 9820964 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9820964 Reactome R-MMU-203981 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-203981.1 1 Nup98 NUP98-5 Q6PFD9 Reactome DB_ID: 9820952 UniProt:Q6PFD9 Nup98 UniProt Q6PFD9 1 EQUAL 880 EQUAL Reactome Database ID Release 82 9820952 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9820952 Reactome R-MMU-376247 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376247.1 1 Nup37 NUP37 Q9CWU9 Reactome DB_ID: 9820956 UniProt:Q9CWU9 Nup37 UniProt Q9CWU9 1 EQUAL 326 EQUAL Reactome Database ID Release 82 9820956 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9820956 Reactome R-MMU-376237 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376237.1 1 Seh1l SEH1L-1 Q8R2U0 Reactome DB_ID: 9820966 UniProt:Q8R2U0 Seh1l UniProt Q8R2U0 1 EQUAL 360 EQUAL Reactome Database ID Release 82 9820966 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9820966 Reactome R-MMU-376246 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376246.1 1 Reactome Database ID Release 82 9820968 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9820968 Reactome R-MMU-377883 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377883.1 1 P63005 Pafah1b1 PAFAH1B1 Reactome DB_ID: 9824960 UniProt:P63005 Pafah1b1 UniProt P63005 1 EQUAL 410 EQUAL Reactome Database ID Release 82 9824960 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824960 Reactome R-MMU-376249 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376249.1 1 P46061 Rangap1 RANGAP1 Reactome DB_ID: 9824976 UniProt:P46061 Rangap1 UniProt P46061 2 EQUAL 587 EQUAL Reactome Database ID Release 82 9824976 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824976 Reactome R-MMU-376255 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376255.1 1 Cenpf CENPF E9Q3P4 Reactome DB_ID: 9824932 UniProt:E9Q3P4 Cenpf UniProt E9Q3P4 1 EQUAL 3207 EQUAL Reactome Database ID Release 82 9824932 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824932 Reactome R-MMU-376229 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376229.1 1 B9d2 B9D2 Q3UK10 Reactome DB_ID: 9825060 UniProt:Q3UK10 B9d2 UniProt Q3UK10 1 EQUAL 175 EQUAL Reactome Database ID Release 82 9825060 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825060 Reactome R-MMU-377736 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377736.1 1 RZZ complex Reactome DB_ID: 9825215 Zwilch ZWILCH Q8R060 Reactome DB_ID: 9825209 UniProt:Q8R060 Zwilch UniProt Q8R060 1 EQUAL 591 EQUAL Reactome Database ID Release 82 9825209 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825209 Reactome R-MMU-376234 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376234.1 1 Zw10 ZW10 O54692 Reactome DB_ID: 9825213 UniProt:O54692 Zw10 UniProt O54692 2 EQUAL 779 EQUAL Reactome Database ID Release 82 9825213 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825213 Reactome R-MMU-377880 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377880.1 1 Kntc1 KNTC1 Q8C3Y4 Reactome DB_ID: 9825205 UniProt:Q8C3Y4 Kntc1 UniProt Q8C3Y4 1 EQUAL 2209 EQUAL Reactome Database ID Release 82 9825205 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825205 Reactome R-MMU-376233 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376233.1 1 Reactome Database ID Release 82 9825215 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825215 Reactome R-MMU-377885 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377885.1 1 CENPE Q6RT24 Reactome DB_ID: 9824928 UniProt:Q6RT24 UniProt Q6RT24 1 EQUAL 2698 EQUAL Reactome Database ID Release 82 9824928 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824928 Reactome R-MMU-376245 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376245.1 1 Mapre1 MAPRE1 Q61166 Reactome DB_ID: 9824944 UniProt:Q61166 Mapre1 UniProt Q61166 2 EQUAL 268 EQUAL Reactome Database ID Release 82 9824944 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824944 Reactome R-MMU-376240 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376240.1 1 PPP1CC P63087 Reactome DB_ID: 9825044 UniProt:P63087 UniProt P63087 2 EQUAL 323 EQUAL Reactome Database ID Release 82 9825044 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825044 Reactome R-MMU-163443 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-163443.1 1 Cdc20 CDC20 Q9JJ66 Reactome DB_ID: 9825199 UniProt:Q9JJ66 Cdc20 UniProt Q9JJ66 1 EQUAL 499 EQUAL Reactome Database ID Release 82 9825199 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825199 Reactome R-MMU-141412 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-141412.1 1 KIF18A Q91WD7 Reactome DB_ID: 9824952 UniProt:Q91WD7 UniProt Q91WD7 1 EQUAL 898 EQUAL Reactome Database ID Release 82 9824952 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824952 Reactome R-MMU-376239 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376239.1 1 BUB1 O08901 Reactome DB_ID: 9825219 UniProt:O08901 UniProt O08901 1 EQUAL 1085 EQUAL Reactome Database ID Release 82 9825219 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825219 Reactome R-MMU-377888 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377888.1 1 Mitotic checkpoint complex Reactome DB_ID: 9825201 Bub3 BUB3 Q9WVA3 Reactome DB_ID: 9825195 UniProt:Q9WVA3 Bub3 UniProt Q9WVA3 1 EQUAL 328 EQUAL Reactome Database ID Release 82 9825195 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825195 Reactome R-MMU-141416 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-141416.1 1 Mad2l1 MAD2L1 Q9Z1B5 Reactome DB_ID: 9825187 UniProt:Q9Z1B5 Mad2l1 UniProt Q9Z1B5 2 EQUAL 205 EQUAL Reactome Database ID Release 82 9825187 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825187 Reactome R-MMU-141400 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-141400.1 1 BUB1B Q9Z1S0 Reactome DB_ID: 9825191 UniProt:Q9Z1S0 UniProt Q9Z1S0 1 EQUAL 1050 EQUAL Reactome Database ID Release 82 9825191 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825191 Reactome R-MMU-141436 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-141436.1 1 1 Reactome Database ID Release 82 9825201 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825201 Reactome R-MMU-377882 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377882.1 1 TAOK1 Q5F2E8 Reactome DB_ID: 9825227 UniProt:Q5F2E8 UniProt Q5F2E8 1 EQUAL 1001 EQUAL Reactome Database ID Release 82 9825227 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825227 Reactome R-MMU-376248 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376248.1 1 Sgo1 SGOL1 Q9CXH7 Reactome DB_ID: 9824980 UniProt:Q9CXH7 Sgo1 UniProt Q9CXH7 1 EQUAL 561 EQUAL Reactome Database ID Release 82 9824980 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824980 Reactome R-MMU-376227 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376227.1 1 KIF2C Q922S8 Reactome DB_ID: 9824964 UniProt:Q922S8 UniProt Q922S8 1 EQUAL 725 EQUAL Reactome Database ID Release 82 9824964 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824964 Reactome R-MMU-376256 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376256.1 1 Rcc2 RCC2 Q8BK67 Reactome DB_ID: 9824996 UniProt:Q8BK67 Rcc2 UniProt Q8BK67 1 EQUAL 522 EQUAL Reactome Database ID Release 82 9824996 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824996 Reactome R-MMU-376235 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376235.1 1 Nde1 NDE1 Q9CZA6 Reactome DB_ID: 9824968 UniProt:Q9CZA6 Nde1 UniProt Q9CZA6 1 EQUAL 346 EQUAL Reactome Database ID Release 82 9824968 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824968 Reactome R-MMU-376257 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376257.1 1 Clasp1 CLASP1 Q80TV8 Reactome DB_ID: 9824936 UniProt:Q80TV8 Clasp1 UniProt Q80TV8 1 EQUAL 1538 EQUAL Reactome Database ID Release 82 9824936 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824936 Reactome R-MMU-376230 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376230.1 1 KIF2A P28740 Reactome DB_ID: 9824956 UniProt:P28740 UniProt P28740 1 EQUAL 706 EQUAL Reactome Database ID Release 82 9824956 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824956 Reactome R-MMU-376232 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376232.1 1 Rps27 RPS27 Q6ZWU9 Reactome DB_ID: 9819120 UniProt:Q6ZWU9 Rps27 Rps27 FUNCTION Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity).SUBUNIT Component of the small ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eS27 family. UniProt Q6ZWU9 2 EQUAL 84 EQUAL Reactome Database ID Release 82 9819120 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9819120 Reactome R-MMU-72361 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-72361.1 1 CCAN network Reactome DB_ID: 9825130 Cenps APITD1 Q9D084 Reactome DB_ID: 9825088 UniProt:Q9D084 Cenps UniProt Q9D084 1 EQUAL 138 EQUAL Reactome Database ID Release 82 9825088 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825088 Reactome R-MMU-375310 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375310.1 1 Cenpn CENPN Q9CZW2 Reactome DB_ID: 9825084 UniProt:Q9CZW2 Cenpn UniProt Q9CZW2 1 EQUAL 339 EQUAL Reactome Database ID Release 82 9825084 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825084 Reactome R-MMU-375306 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375306.1 1 CENP-(H,I, K) complex Reactome DB_ID: 9825128 Cenph CENPH Q9QYM8 Reactome DB_ID: 9825118 UniProt:Q9QYM8 Cenph UniProt Q9QYM8 1 EQUAL 247 EQUAL Reactome Database ID Release 82 9825118 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825118 Reactome R-MMU-375294 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375294.1 1 Cenpk CENPK Q9ESN5 Reactome DB_ID: 9825126 UniProt:Q9ESN5 Cenpk UniProt Q9ESN5 1 EQUAL 269 EQUAL Reactome Database ID Release 82 9825126 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825126 Reactome R-MMU-375296 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375296.1 1 Cenpi CENPI Q8K1K4 Reactome DB_ID: 9825122 UniProt:Q8K1K4 Cenpi UniProt Q8K1K4 1 EQUAL 756 EQUAL Reactome Database ID Release 82 9825122 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825122 Reactome R-MMU-375293 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375293.1 1 Reactome Database ID Release 82 9825128 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825128 Reactome R-MMU-377884 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377884.1 1 CENP-O complex Reactome DB_ID: 9825114 Q9CQ82 Itgb3bp ITGB3BP Reactome DB_ID: 9825112 UniProt:Q9CQ82 Itgb3bp UniProt Q9CQ82 1 EQUAL 177 EQUAL Reactome Database ID Release 82 9825112 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825112 Reactome R-MMU-3006405 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3006405.1 1 Cenpq CENPQ Q9CPQ5 Reactome DB_ID: 9825104 UniProt:Q9CPQ5 Cenpq UniProt Q9CPQ5 1 EQUAL 268 EQUAL Reactome Database ID Release 82 9825104 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825104 Reactome R-MMU-375298 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375298.1 1 Cenpp CENPP Q9CZ92 Reactome DB_ID: 9825100 UniProt:Q9CZ92 Cenpp UniProt Q9CZ92 1 EQUAL 288 EQUAL Reactome Database ID Release 82 9825100 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825100 Reactome R-MMU-375299 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375299.1 1 Cenpo CENPO Q8K015 Reactome DB_ID: 9825096 UniProt:Q8K015 Cenpo UniProt Q8K015 1 EQUAL 300 EQUAL Reactome Database ID Release 82 9825096 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825096 Reactome R-MMU-375301 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375301.1 1 Cenpu MLF1IP Q8C4M7 Reactome DB_ID: 9825108 UniProt:Q8C4M7 Cenpu UniProt Q8C4M7 1 EQUAL 418 EQUAL Reactome Database ID Release 82 9825108 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825108 Reactome R-MMU-375315 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375315.1 1 Reactome Database ID Release 82 9825114 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825114 Reactome R-MMU-377886 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377886.1 1 Cenpt CENPT Q3TJM4 Reactome DB_ID: 9825092 UniProt:Q3TJM4 Cenpt UniProt Q3TJM4 1 EQUAL 561 EQUAL Reactome Database ID Release 82 9825092 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825092 Reactome R-MMU-375316 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375316.1 1 Cenpm CENPM Q9CQA0 Reactome DB_ID: 9825080 UniProt:Q9CQA0 Cenpm UniProt Q9CQA0 1 EQUAL 180 EQUAL Reactome Database ID Release 82 9825080 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825080 Reactome R-MMU-375290 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375290.1 1 Cenpl CENPL Q3U3S3 Reactome DB_ID: 9825076 UniProt:Q3U3S3 Cenpl UniProt Q3U3S3 1 EQUAL 344 EQUAL Reactome Database ID Release 82 9825076 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825076 Reactome R-MMU-375295 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375295.1 1 Cenpc CENPC1 P49452 Reactome DB_ID: 9825072 UniProt:P49452 Cenpc UniProt P49452 1 EQUAL 943 EQUAL Reactome Database ID Release 82 9825072 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825072 Reactome R-MMU-375292 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375292.1 1 Reactome Database ID Release 82 9825130 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825130 Reactome R-MMU-377738 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377738.1 1 Zwint ZWINT Q9CQU5 Reactome DB_ID: 9825000 UniProt:Q9CQU5 Zwint UniProt Q9CQU5 1 EQUAL 277 EQUAL Reactome Database ID Release 82 9825000 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825000 Reactome R-MMU-376254 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376254.1 1 Ndel1 NDEL1 Q9ERR1 Reactome DB_ID: 9824972 UniProt:Q9ERR1 Ndel1 UniProt Q9ERR1 1 EQUAL 345 EQUAL Reactome Database ID Release 82 9824972 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824972 Reactome R-MMU-376258 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376258.1 1 Spdl1 SPDL1 Q923A2 Reactome DB_ID: 9825052 UniProt:Q923A2 Spdl1 UniProt Q923A2 1 EQUAL 605 EQUAL Reactome Database ID Release 82 9825052 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825052 Reactome R-MMU-377733 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377733.1 1 Mad1l1 MAD1L1 Q9WTX8 Reactome DB_ID: 9824916 UniProt:Q9WTX8 Mad1l1 UniProt Q9WTX8 1 EQUAL 718 EQUAL Reactome Database ID Release 82 9824916 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824916 Reactome R-MMU-141433 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-141433.1 1 ERCC6L Q8BHK9 Reactome DB_ID: 9825223 UniProt:Q8BHK9 UniProt Q8BHK9 1 EQUAL 1250 EQUAL Reactome Database ID Release 82 9825223 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825223 Reactome R-MMU-376250 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376250.1 1 Incenp INCENP Q9WU62 Reactome DB_ID: 9824920 UniProt:Q9WU62 Incenp UniProt Q9WU62 1 EQUAL 918 EQUAL Reactome Database ID Release 82 9824920 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824920 Reactome R-MMU-375311 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375311.1 1 KMN network Reactome DB_ID: 9825172 Mis12 complex Reactome DB_ID: 9825152 Mis12 MIS12 Q9CY25 Reactome DB_ID: 9825142 UniProt:Q9CY25 Mis12 UniProt Q9CY25 1 EQUAL 205 EQUAL Reactome Database ID Release 82 9825142 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825142 Reactome R-MMU-375313 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375313.1 1 Pmf1 PMF1 Q9CPV5 Reactome DB_ID: 9825150 UniProt:Q9CPV5 Pmf1 UniProt Q9CPV5 2 EQUAL 205 EQUAL Reactome Database ID Release 82 9825150 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825150 Reactome R-MMU-375320 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375320.1 1 Nsl1 NSL1 Q8K305 Reactome DB_ID: 9825146 UniProt:Q8K305 Nsl1 UniProt Q8K305 1 EQUAL 281 EQUAL Reactome Database ID Release 82 9825146 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825146 Reactome R-MMU-375309 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375309.1 1 Dsn1 DSN1 Q9CYC5 Reactome DB_ID: 9825138 UniProt:Q9CYC5 Dsn1 UniProt Q9CYC5 1 EQUAL 356 EQUAL Reactome Database ID Release 82 9825138 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825138 Reactome R-MMU-375308 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375308.1 1 Reactome Database ID Release 82 9825152 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825152 Reactome R-MMU-375441 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375441.1 1 Knl1 CASC5 Q66JQ7 Reactome DB_ID: 9825134 UniProt:Q66JQ7 Knl1 UniProt Q66JQ7 1 EQUAL 2342 EQUAL Reactome Database ID Release 82 9825134 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825134 Reactome R-MMU-375322 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375322.1 1 NDC80 complex Reactome DB_ID: 9825170 Nuf2 NUF2 Q99P69 Reactome DB_ID: 9825160 UniProt:Q99P69 Nuf2 UniProt Q99P69 1 EQUAL 464 EQUAL Reactome Database ID Release 82 9825160 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825160 Reactome R-MMU-375300 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375300.1 1 Spc25 SPC25 Q3UA16 Reactome DB_ID: 9825168 UniProt:Q3UA16 Spc25 UniProt Q3UA16 1 EQUAL 224 EQUAL Reactome Database ID Release 82 9825168 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825168 Reactome R-MMU-375307 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375307.1 1 Spc24 SPC24 Q9D083 Reactome DB_ID: 9825164 UniProt:Q9D083 Spc24 UniProt Q9D083 1 EQUAL 197 EQUAL Reactome Database ID Release 82 9825164 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825164 Reactome R-MMU-375297 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375297.1 1 Ndc80 NDC80 Q9D0F1 Reactome DB_ID: 9825156 UniProt:Q9D0F1 Ndc80 UniProt Q9D0F1 1 EQUAL 642 EQUAL Reactome Database ID Release 82 9825156 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825156 Reactome R-MMU-375314 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375314.1 1 Reactome Database ID Release 82 9825170 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825170 Reactome R-MMU-375444 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375444.1 1 Reactome Database ID Release 82 9825172 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825172 Reactome R-MMU-377745 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377745.1 1 Sgo2 SGOL2 Q7TSY8 Reactome DB_ID: 9824984 UniProt:Q7TSY8 Sgo2 UniProt Q7TSY8 1 EQUAL 1265 EQUAL Reactome Database ID Release 82 9824984 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824984 Reactome R-MMU-376242 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376242.1 1 Xpo1 XPO1 Q6P5F9 Reactome DB_ID: 9825036 UniProt:Q6P5F9 Xpo1 Xpo1 Crm1 FUNCTION Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity).SUBUNIT Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA (PubMed:10786834). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUP42, NUP88, NUP214, RANBP3 and TERT. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'. Interacts with SERTAD2; the interaction translocates SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8 (By similarity). Interacts with DTNBP1 and the interaction translocates DTNBP1 out of the nucleus (PubMed:20921223). Interacts with CPEB3 (By similarity). Interacts with HAX1 (By similarity). Interacts with BOK; translocates to the cytoplasm (By similarity). Interacts with HSP90AB1 (By similarity).SIMILARITY Belongs to the exportin family. UniProt Q6P5F9 1 EQUAL 1071 EQUAL Reactome Database ID Release 82 9825036 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825036 Reactome R-MMU-165539 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-165539.1 1 PP2A Reactome DB_ID: 9825033 Converted from EntitySet in Reactome PP2A-catalytic subunit C Reactome DB_ID: 9825031 PPP2CA P63330 Reactome DB_ID: 9825027 UniProt:P63330 UniProt P63330 1 EQUAL 309 EQUAL Reactome Database ID Release 82 9825027 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825027 Reactome R-MMU-165971 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-165971.1 PPP2CB P62715 Reactome DB_ID: 9825029 UniProt:P62715 Ppp2cb Ppp2cb FUNCTION Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.SUBUNIT PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGO1, most probably through regulatory B56 subunits. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD. Interacts with CTTNBP2NL. Interacts with PTPA.PTM Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (Lcmt1) and protein phosphatase methylesterase 1 (Ppme1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity).PTM Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation (By similarity).PTM May be monoubiquitinated by NOSIP.SIMILARITY Belongs to the PPP phosphatase family. PP-1 subfamily. UniProt P62715 1 EQUAL 309 EQUAL Reactome Database ID Release 82 9825029 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825029 Reactome R-MMU-165987 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-165987.1 Reactome Database ID Release 82 9825031 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825031 Reactome R-MMU-165977 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-165977.1 1 Converted from EntitySet in Reactome PP2A-subunit A Reactome DB_ID: 9825025 PP2A A subunit Reactome DB_ID: 206067 UniProt:Q76MZ3 Ppp2r1a Ppp2r1a FUNCTION The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:10100624). Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity).SUBUNIT PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with FOXO1; the interaction dephosphorylates FOXO1 on AKT-mediated phosphorylation sites (PubMed:22417654). Interacts with IPO9 (By similarity). Interacts with TP53 and SGO1 (By similarity). Interacts with PLA2G16; this interaction might decrease PP2A activity (By similarity). Interacts with CTTNBP2NL (By similarity). Interacts with GNA12; the interaction promotes protein phosphatase 2A activation causing dephosphorylation of MAPT (By similarity).Interacts with CIP2A; this interaction stabilizes CIP2A (By similarity). Interacts with PABIR1/FAM122A (By similarity). Interacts with ADCY8; antagonizes interaction between ADCY8 and calmodulin (PubMed:16258073). Interacts with CRTC3 (when phosphorylated at 'Ser-391') (PubMed:30611118). Interacts with SPRY2 (By similarity).DOMAIN Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.SIMILARITY Belongs to the phosphatase 2A regulatory subunit A family. UniProt Q76MZ3 2 EQUAL 589 EQUAL Reactome Database ID Release 82 206067 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=206067 Reactome R-MMU-206067 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-206067.1 Q7TNP2 Ppp2r1b PPP2R1B Reactome DB_ID: 9825023 UniProt:Q7TNP2 Ppp2r1b UniProt Q7TNP2 1 EQUAL 601 EQUAL Reactome Database ID Release 82 9825023 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825023 Reactome R-MMU-165980 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-165980.1 Reactome Database ID Release 82 9825025 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825025 Reactome R-MMU-165990 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-165990.1 1 Converted from EntitySet in Reactome PP2A regulatory subunit B56 Reactome DB_ID: 9825021 Q6PD03 Ppp2r5a PPP2R5A Reactome DB_ID: 9825003 UniProt:Q6PD03 Ppp2r5a Ppp2r5a FUNCTION The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.SUBUNIT PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1 (By similarity).TISSUE SPECIFICITY Widely expressed with highest levels in thymus and ovary.SIMILARITY Belongs to the phosphatase 2A regulatory subunit B56 family. UniProt Q6PD03 1 EQUAL 486 EQUAL Reactome Database ID Release 82 9825003 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825003 Reactome R-MMU-196235 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-196235.1 Q6PD28 Ppp2r5b PPP2R5B Reactome DB_ID: 9825007 UniProt:Q6PD28 Ppp2r5b UniProt Q6PD28 1 EQUAL 497 EQUAL Reactome Database ID Release 82 9825007 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825007 Reactome R-MMU-535469 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-535469.1 Q7TNL5 Ppp2r5d PPP2R5D Reactome DB_ID: 9825011 UniProt:Q7TNL5 Ppp2r5d UniProt Q7TNL5 1 EQUAL 602 EQUAL Reactome Database ID Release 82 9825011 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825011 Reactome R-MMU-3008950 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3008950.1 Q60996 Ppp2r5c PPP2R5C Reactome DB_ID: 9825015 UniProt:Q60996 Ppp2r5c UniProt Q60996 1 EQUAL 524 EQUAL Reactome Database ID Release 82 9825015 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825015 Reactome R-MMU-3008954 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3008954.1 Q61151 Ppp2r5e PPP2R5E Reactome DB_ID: 9825019 UniProt:Q61151 Ppp2r5e UniProt Q61151 1 EQUAL 467 EQUAL Reactome Database ID Release 82 9825019 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825019 Reactome R-MMU-1638770 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1638770.1 Reactome Database ID Release 82 9825021 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825021 Reactome R-MMU-196216 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-196216.1 1 Reactome Database ID Release 82 9825033 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825033 Reactome R-MMU-196206 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-196206.1 1 Chromosome passenger complex Reactome DB_ID: 9825183 Cdca8 CDCA8 Q8BHX3 Reactome DB_ID: 9825181 UniProt:Q8BHX3 Cdca8 UniProt Q8BHX3 1 EQUAL 280 EQUAL Reactome Database ID Release 82 9825181 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825181 Reactome R-MMU-375288 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375288.1 1 Ghost homologue of BIRC5 Reactome DB_ID: 9825177 Reactome Database ID Release 82 9825177 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825177 Reactome R-MMU-50851 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-50851.1 1 AURKB O70126 Reactome DB_ID: 9825175 UniProt:O70126 Aurkb Aurkb Aik2 Aim1 Airk2 Ark2 Stk1 Stk12 Stk5 FUNCTION Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (By similarity). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (By similarity). Required for central/midzone spindle assembly and cleavage furrow formation (By similarity). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (By similarity). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (By similarity). Phosphorylation of INCENP leads to increased AURKB activity (By similarity). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (By similarity). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (By similarity). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863). A positive feedback between HASPIN and AURKB contributes to CPC localization (By similarity). AURKB is also required for kinetochore localization of BUB1 and SGO1 (By similarity). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (By similarity). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (PubMed:24034696). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (By similarity). Phosphorylates KRT5 during anaphase and telophase (PubMed:29518391).ACTIVITY REGULATION Activity is greatly increased when AURKB is within the CPC complex. In particular, AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between HASPIN and AURKB contributes to CPC localization.SUBUNIT Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist. Associates with RACGAP1 during M phase. Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPTIN1, SIRT2 and TACC1. Interacts with SPDYC; this interaction may be required for proper localization of active, Thr-237-phosphorylated AURKB form during prometaphase and metaphase. Interacts with p53/TP53. Interacts (via the middle kinase domain) with NOC2L (via the N- and C-terminus domains). Interacts with TTC28 (By similarity). Interacts with RNF2/RING1B (PubMed:24034696).TISSUE SPECIFICITY Expressed in testis, intestine and spleen. All of them are tissues that contain a large number of proliferating cells. Expressed during S phase, in a cell-cycle-dependent fashion.DEVELOPMENTAL STAGE Strongly expressed in 8.5 and 12.5 dpc.PTM The phosphorylation of Thr-237 requires the binding to INCENP and occurs by means of an autophosphorylation mechanism. Thr-237 phosphorylation is indispensable for the AURKB kinase activity.PTM Acetylated at Lys-220 by KAT5 at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis.PTM Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.SIMILARITY Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. UniProt O70126 1 EQUAL 344 EQUAL Reactome Database ID Release 82 9825175 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825175 Reactome R-MMU-174231 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-174231.1 1 1 Reactome Database ID Release 82 9825183 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825183 Reactome R-MMU-377879 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377879.1 1 PLK1 Q07832 Reactome DB_ID: 9825040 UniProt:Q07832 UniProt Q07832 1 EQUAL 603 EQUAL Reactome Database ID Release 82 9825040 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825040 Reactome R-MMU-164603 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-164603.1 1 Clip1 CLIP1 Q922J3 Reactome DB_ID: 9825064 UniProt:Q922J3 Clip1 UniProt Q922J3 1 EQUAL 1438 EQUAL Reactome Database ID Release 82 9825064 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825064 Reactome R-MMU-377732 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377732.1 1 Dynein complex Reactome DB_ID: 9825261 Converted from EntitySet in Reactome DLCs Dynein light chain Reactome DB_ID: 9825249 Dynll1 DYNLL1 P63168 Reactome DB_ID: 9825245 UniProt:P63168 Dynll1 UniProt P63168 1 EQUAL 89 EQUAL Reactome Database ID Release 82 9825245 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825245 Reactome R-MMU-387105 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-387105.1 Dynll2 DYNLL2 Q9D0M5 Reactome DB_ID: 9825247 UniProt:Q9D0M5 Dynll2 UniProt Q9D0M5 1 EQUAL 89 EQUAL Reactome Database ID Release 82 9825247 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825247 Reactome R-MMU-2029024 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2029024.1 Reactome Database ID Release 82 9825249 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825249 Reactome R-MMU-2029105 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2029105.1 2 DHC dimer Reactome DB_ID: 9825233 Q9JHU4 DYNC1H1 Reactome DB_ID: 9825231 UniProt:Q9JHU4 UniProt Q9JHU4 1 EQUAL 4646 EQUAL Reactome Database ID Release 82 9825231 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825231 Reactome R-MMU-380285 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-380285.1 2 Reactome Database ID Release 82 9825233 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825233 Reactome R-MMU-2029144 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2029144.1 1 Converted from EntitySet in Reactome DICs Dynein intermediate chains Reactome DB_ID: 9825243 O88485 Dync1i1 DYNC1I1 Reactome DB_ID: 9825237 UniProt:O88485 Dync1i1 UniProt O88485 1 EQUAL 645 EQUAL Reactome Database ID Release 82 9825237 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825237 Reactome R-MMU-201578 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-201578.1 O88487 Dync1i2 DYNC1I2 Reactome DB_ID: 9825241 UniProt:O88487 Dync1i2 UniProt O88487 1 EQUAL 638 EQUAL Reactome Database ID Release 82 9825241 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825241 Reactome R-MMU-201607 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-201607.1 Reactome Database ID Release 82 9825243 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825243 Reactome R-MMU-2029119 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2029119.1 2 Converted from EntitySet in Reactome DLIs Dynein-1 light intermediate chain Reactome DB_ID: 9825259 Q6PDL0 DYNC1LI2 Reactome DB_ID: 9825253 UniProt:Q6PDL0 UniProt Q6PDL0 1 EQUAL 492 EQUAL Reactome Database ID Release 82 9825253 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825253 Reactome R-MMU-2029025 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2029025.1 Q8R1Q8 DYNC1LI1 Reactome DB_ID: 9825257 UniProt:Q8R1Q8 UniProt Q8R1Q8 1 EQUAL 523 EQUAL Reactome Database ID Release 82 9825257 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825257 Reactome R-MMU-8943213 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8943213.1 Reactome Database ID Release 82 9825259 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825259 Reactome R-MMU-2029122 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2029122.1 2 Reactome Database ID Release 82 9825261 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825261 Reactome R-MMU-2029145 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2029145.1 1 Ckap5 CKAP5 A2AGT5 Reactome DB_ID: 9825056 UniProt:A2AGT5 Ckap5 UniProt A2AGT5 1 EQUAL 2032 EQUAL Reactome Database ID Release 82 9825056 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825056 Reactome R-MMU-377729 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-377729.1 1 Cenpa CENPA O35216 Reactome DB_ID: 9824924 UniProt:O35216 Cenpa UniProt O35216 1 EQUAL 140 EQUAL Reactome Database ID Release 82 9824924 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824924 Reactome R-MMU-375317 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375317.1 1 Ska2 SKA2 Q9CR46 Reactome DB_ID: 9824992 UniProt:Q9CR46 Ska2 UniProt Q9CR46 1 EQUAL 121 EQUAL Reactome Database ID Release 82 9824992 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9824992 Reactome R-MMU-376231 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376231.1 1 KIF2B Q8C0N1 Reactome DB_ID: 9825048 UniProt:Q8C0N1 UniProt Q8C0N1 1 EQUAL 673 EQUAL Reactome Database ID Release 82 9825048 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825048 Reactome R-MMU-376259 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-376259.1 1 Reactome Database ID Release 82 9825263 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825263 Reactome R-MMU-375305 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375305.1 1 Microtubule Reactome DB_ID: 9831814 Microtubule protofilament Reactome DB_ID: 9831812 Reactome Database ID Release 82 9831812 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9831812 Reactome R-MMU-8982424 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8982424.1 13 Reactome Database ID Release 82 9831814 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9831814 Reactome R-MMU-190599 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-190599.1 15 Reactome Database ID Release 82 9840752 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9840752 Reactome R-MMU-375303 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-375303.1 2 Converted from EntitySet in Reactome PDS5 PDS5A/B PDS5A/PDS5B Reactome DB_ID: 9867653 Pds5a PDS5A Q6A026 Reactome DB_ID: 9867647 UniProt:Q6A026 Pds5a UniProt Q6A026 1 EQUAL 1337 EQUAL Reactome Database ID Release 82 9867647 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867647 Reactome R-MMU-2468259 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2468259.1 Pds5b PDS5B Q4VA53 Reactome DB_ID: 9867651 UniProt:Q4VA53 Pds5b UniProt Q4VA53 1 EQUAL 1447 EQUAL Reactome Database ID Release 82 9867651 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867651 Reactome R-MMU-2468263 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2468263.1 Reactome Database ID Release 82 9867653 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867653 Reactome R-MMU-2468261 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2468261.1 1 Sister Centromere Reactome DB_ID: 1638792 chromosome GENE ONTOLOGY GO:0005694 Reactome Database ID Release 82 1638792 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1638792 Reactome R-ALL-1638792 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1638792.3 ChEBI 23367 additional information MI MI:0361 2 Q9CPY3 phospho-Cdca5 p-S21,S75,T159-CDCA5 Reactome DB_ID: 9867660 UniProt:Q9CPY3 Cdca5 UniProt Q9CPY3 159 EQUAL O-phospho-L-threonine MOD MOD:00047 21 EQUAL 75 EQUAL 1 EQUAL 252 EQUAL Reactome Database ID Release 82 9867660 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867660 Reactome R-MMU-2468269 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2468269.1 1 Wapl WAPAL Q65Z40 Reactome DB_ID: 9867664 UniProt:Q65Z40 Wapl UniProt Q65Z40 1 EQUAL 1190 EQUAL Reactome Database ID Release 82 9867664 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867664 Reactome R-MMU-2577088 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2577088.1 1 Reactome Database ID Release 82 9867683 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867683 Reactome R-MMU-2500242 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2500242.1 Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules Reactome DB_ID: 9878021 1 2 2 Cleaved Cohesin Reactome DB_ID: 9878019 1 Rad21 RAD21(1-172) Q61550 Reactome DB_ID: 9878015 1 EQUAL 172 EQUAL Reactome Database ID Release 82 9878015 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9878015 Reactome R-MMU-2467793 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2467793.1 1 Q61550 phospho-Rad21 p-S454-RAD21(451-631) Reactome DB_ID: 9878013 451 EQUAL 631 EQUAL Reactome Database ID Release 82 9878013 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9878013 Reactome R-MMU-2467790 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2467790.1 1 1 1 Rad21 RAD21(173-450) Q61550 Reactome DB_ID: 9878017 173 EQUAL 450 EQUAL Reactome Database ID Release 82 9878017 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9878017 Reactome R-MMU-2500296 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2500296.1 1 1 Reactome Database ID Release 82 9878019 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9878019 Reactome R-MMU-2467801 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2467801.1 1 1 1 30 Reactome Database ID Release 82 9878021 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9878021 Reactome R-MMU-2467806 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2467806.1 ACTIVATION ESPL1 Autocleaved Reactome DB_ID: 9877978 Espl1 ESPL1(1507-1535) P60330 Reactome DB_ID: 9877976 UniProt:P60330 Espl1 UniProt P60330 1507 EQUAL 1535 EQUAL Reactome Database ID Release 82 9877976 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9877976 Reactome R-MMU-2500272 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2500272.1 1 Espl1 ESPL1(1536-2120) P60330 Reactome DB_ID: 9877972 1536 EQUAL 2120 EQUAL Reactome Database ID Release 82 9877972 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9877972 Reactome R-MMU-2467767 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2467767.1 1 Espl1 ESPL1(1-1506) P60330 Reactome DB_ID: 9877974 1 EQUAL 1506 EQUAL Reactome Database ID Release 82 9877974 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9877974 Reactome R-MMU-2467768 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2467768.1 1 Reactome Database ID Release 82 9877978 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9877978 Reactome R-MMU-2467770 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2467770.1 GENE ONTOLOGY GO:0008234 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 9878022 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9878022 Reactome Database ID Release 82 9878024 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9878024 Reactome R-MMU-2467809 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2467809.1 ESPL1 (separin i.e. separase) cleaves RAD21 (SCC1) subunit of centromeric cohesin at two sites that conform to the consensus separase recognition site E-X-X-R: after arginine residue R172 and after arginine residue R450 (Hauf et al. 2001). Phosphorylation of RAD21 at the serine residue S454 by PLK1 in prometaphase facilitates ESPL1-mediated cleavage of RAD21 at the C-terminal cleavage site R450 (Hauf et al. 2005). The N-terminal and C-terminal RAD21 cleavage fragments remain bound to the rest of the cohesin complex (Deardorff et al. 2012). It is not clear whether RAD21 middle fragment also continues to be associated with cohesin. 22885700 Pubmed 2012 HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle Deardorff, Matthew A Bando, Masashige Nakato, Ryuichiro Watrin, Erwan Itoh, Takehiko Minamino, Masashi Saitoh, Katsuya Komata, Makiko Katou, Yuki Clark, Dinah Cole, Kathryn E De Baere, Elfride Decroos, Christophe Di Donato, Nataliya Ernst, Sarah Francey, Lauren J Gyftodimou, Yolanda Hirashima, Kyotaro Hullings, Melanie Ishikawa, Yuuichi Jaulin, Christian Kaur, Maninder Kiyono, T Lombardi, Patrick M Magnaghi-Jaulin, L Mortier, Geert R Nozaki, Naohito Petersen, Michael B Seimiya, Hiroyuki Siu, Victoria M Suzuki, Yutaka Takagaki, Kentaro Wilde, Jonathan J Willems, Patrick J Prigent, Claude Gillessen-Kaesbach, Gabriele Christianson, DW Kaiser, Frank J Jackson, Laird G Hirota, Toru Krantz, Ian D Shirahige, Katsuhiko Nature 489:313-7 11509732 Pubmed 2001 Cohesin cleavage by separase required for anaphase and cytokinesis in human cells Hauf, S Waizenegger, IC Peters, JM Science 293:1320-3 15737063 Pubmed 2005 Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2 Hauf, S Roitinger, E Koch, B Dittrich, CM Mechtler, K Peters, JM PLoS Biol 3:e69 inferred from electronic annotation EVIDENCE CODE ECO:0000203