BioPAX pathway converted from "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA" in the Reactome database.LEFT-TO-RIGHT1.3.3.6Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoAThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>O2OxygendioxygenReactome DB_ID: 113535peroxisomal matrixGENE ONTOLOGYGO:0005782dioxygen [ChEBI:15379]dioxygenChEBICHEBI:15379Reactome Database ID Release 75113535Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113535ReactomeR-ALL-1135353Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113535.3Reactomehttp://www.reactome.orgCOMPOUNDC00007additional informationMIMI:0361THA-CoA6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl-CoA (THA-CoA)(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA6,9,12,15,18,21-24:6(n-3)Reactome DB_ID: 2046047(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA [ChEBI:63540](6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAChEBICHEBI:63540Reactome Database ID Release 752046047Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046047ReactomeR-ALL-20460473Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2046047.3delta2-THA-CoA1-(2E,6Z,9Z,12Z,15Z,18Z,21Z-tetracosaheptaenoyl)-CoA(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoAReactome DB_ID: 2066767(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA [ChEBI:65139](2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoAChEBICHEBI:65139Reactome Database ID Release 752066767Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066767ReactomeR-ALL-20667673Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2066767.3H2O2hydrogen peroxideReactome DB_ID: 113575hydrogen peroxide [ChEBI:16240]hydrogen peroxideChEBICHEBI:16240Reactome Database ID Release 75113575Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113575ReactomeR-ALL-1135753Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113575.3COMPOUNDC00027ACTIVATIONACOX1 dimerReactome DB_ID: 9851966ACOX1:FAD complexReactome DB_ID: 9851964Acox1ACOX1-2P07872Reactome DB_ID: 9851962UniProt:P07872 Acox1Acox1AcoxFUNCTION Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (PubMed:7462191, PubMed:1400324, PubMed:7503725). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (PubMed:7503725). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (PubMed:7503725). Isoform 1 shows optimum activity with a chain length of 10 carbons while isoform 2 exhibits optimum activity with 14 carbons (PubMed:7503725).PATHWAY Lipid metabolism; peroxisomal fatty acid beta-oxidation.SUBUNIT Homodimer. The enzyme contains three components A, B and C, the latter two being produced from the first by a proteolytic cleavage. Interacts with LONP2 (By similarity).SIMILARITY Belongs to the acyl-CoA oxidase family.Rattus norvegicusNCBI Taxonomy10116UniProtP078721EQUAL660EQUALReactome Database ID Release 759851962Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9851962ReactomeR-RNO-3902631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-390263.11FADReactome DB_ID: 141335FAD [ChEBI:16238]FADFlavin adenine dinucleotideChEBICHEBI:16238Reactome Database ID Release 75141335Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=141335ReactomeR-ALL-1413352Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-141335.21Reactome Database ID Release 759851964Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9851964ReactomeR-RNO-3902371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-390237.12Reactome Database ID Release 759851966Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9851966ReactomeR-RNO-3902321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-390232.1GENE ONTOLOGYGO:0003997gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 759851967Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9851967Reactome Database ID Release 759880283Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9880283ReactomeR-RNO-20667871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-2066787.1Retroconversion of C24:6(n-3) to docosahexaenoic acid (22:6(n-3) involves the initial oxidation of tetracosahexaenoyl-CoA to an intermediate 1-(2E,6Z,9Z,12Z,15Z,18Z,21Z-tetracosaheptaenoyl)-CoA (delta2-THA-CoA). This step is catalysed by the peroxisomal enzyme Straight-chain acyl-CoA oxidase (SCOX) (Ferdinandusse et al. 2001).11734571Pubmed2001Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acidFerdinandusse, SachaDenis, SimoneMooijer, PAZhang, ZReddy, Janardan KSpector, AAWanders, Ronald J AJ Lipid Res 42:1987-958656081Pubmed1995Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acidMoore, SAHurt, EYoder, ESprecher, HSpector, AAJ Lipid Res 36:2433-4311500517Pubmed2001Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesisSu, HMMoser, ABMoser, HWWatkins, PAJ Biol Chem 276:38115-20inferred from electronic annotationEVIDENCE CODEECO:0000203