BioPAX pathway converted from "Histamine receptors" in the Reactome database. Histamine receptors This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT HRH1 binds hist This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Hrh1 HRH1 P70174 Reactome DB_ID: 9800241 plasma membrane GENE ONTOLOGY GO:0005886 UniProt:P70174 Hrh1 Mus musculus NCBI Taxonomy 10090 UniProt P70174 1 EQUAL 487 EQUAL Reactome Database ID Release 81 9800241 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9800241 Reactome R-MMU-390908 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390908.1 Reactome http://www.reactome.org Hist histamine Reactome DB_ID: 390899 extracellular region GENE ONTOLOGY GO:0005576 histaminium [ChEBI:58432] histaminium 2-(1H-imidazol-4-yl)ethanaminium histamine histaminium cation ChEBI CHEBI:58432 Reactome Database ID Release 81 390899 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390899 Reactome R-ALL-390899 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-390899.4 COMPOUND C00388 additional information MI MI:0361 HRH1:Hist Reactome DB_ID: 9800243 1 1 Reactome Database ID Release 81 9800243 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9800243 Reactome R-MMU-390885 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390885.1 Reactome Database ID Release 81 9802912 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9802912 Reactome R-MMU-390912 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390912.1 The histamine H1 receptor (De Backer MD et al, 1993) is found on smooth muscle, endothelium and the CNS. Histamine released from neurons binds to the H1 receptor and causes systemic vasodilation and increased endothelial cell permeability. The effects are modulated by the activated receptor binding to the G protein alpha-q/11 subtype which can activate phospholipase C and the phosphatidylinositol (PIP2) signaling pathway (Tilly BC et al, 1990). The classical antihistamines (histamine H1 receptor antagonists) were developed in the early 1930s and were shown to reduce the effects of histamine on many tissues. 2155607 Pubmed 1990 Histamine-H1-receptor-mediated phosphoinositide hydrolysis, Ca2+ signalling and membrane-potential oscillations in human HeLa carcinoma cells Tilly, BC Tertoolen, LG Lambrechts, AC Remorie, R de Laat, SW Moolenaar, WH Biochem J 266:235-43 8280179 Pubmed 1993 Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor De Backer, MD Gommeren, W Moereels, H Nobels, G Van Gompel, P Leysen, JE Luyten, WH Biochem Biophys Res Commun 197:1601-8 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT HRH1 binds HRH1 inverse agonists This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome HRH1 inverse agonists Reactome DB_ID: 9692532 alimemazine Reactome DB_ID: 9692548 alimemazine [Guide to Pharmacology:7237] alimemazine Nedeltran&reg; trimeprazine Guide to Pharmacology 7237 Reactome Database ID Release 81 9692548 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692548 Reactome R-ALL-9692548 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692548.1 Endep&reg; amitriptyline amitryptiline Elavil&reg; Reactome DB_ID: 9704199 amitriptyline [Guide to Pharmacology:200] amitriptyline amitryptiline Elavil&reg; Endep&reg; Guide to Pharmacology 200 Reactome Database ID Release 81 9704199 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9704199 Reactome R-ALL-9704199 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9704199.1 aripiprazole Reactome DB_ID: 9692527 aripiprazole [Guide to Pharmacology:34] aripiprazole Abilify&reg; Aripiprex&reg; Aristada&reg; (aripiprazole lauroxil) OPC 14597 OPC-14597 Guide to Pharmacology 34 Reactome Database ID Release 81 9692527 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692527 Reactome R-ALL-9692527 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692527.1 astemizole Reactome DB_ID: 9692524 astemizole [Guide to Pharmacology:2603] astemizole Hismanal&reg; Guide to Pharmacology 2603 Reactome Database ID Release 81 9692524 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692524 Reactome R-ALL-9692524 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692524.1 azelastine Reactome DB_ID: 9692551 azelastine [Guide to Pharmacology:7121] azelastine A-5610 Astelin&reg; E-0659 Rhinolast&reg; W-2979M Guide to Pharmacology 7121 Reactome Database ID Release 81 9692551 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692551 Reactome R-ALL-9692551 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692551.1 cetirizine Reactome DB_ID: 9692577 cetirizine [Guide to Pharmacology:1222] cetirizine Reactine&reg; Zyrtec&reg; Guide to Pharmacology 1222 Reactome Database ID Release 81 9692577 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692577 Reactome R-ALL-9692577 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692577.1 chlorpheniramine Reactome DB_ID: 9692538 chlorpheniramine [Guide to Pharmacology:6976] chlorpheniramine chlorprophenpyridamine maleate Phenetron&reg; Teldrin&reg; Guide to Pharmacology 6976 Reactome Database ID Release 81 9692538 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692538 Reactome R-ALL-9692538 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692538.1 chlorpromazine chlorpromazine HCl Largactil&reg; Thorazine&reg; Reactome DB_ID: 9654093 chlorpromazine [Guide to Pharmacology:83] chlorpromazine chlorpromazine HCl Largactil&reg; Thorazine&reg; Guide to Pharmacology 83 Reactome Database ID Release 81 9654093 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9654093 Reactome R-ALL-9654093 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9654093.1 clemastine Reactome DB_ID: 9692574 clemastine [Guide to Pharmacology:6063] clemastine HS-592 meclastin Tavegil&reg; Tavist&reg; Guide to Pharmacology 6063 Reactome Database ID Release 81 9692574 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692574 Reactome R-ALL-9692574 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692574.1 cyclizine Reactome DB_ID: 9692556 cyclizine [Guide to Pharmacology:7151] cyclizine Marezine&reg; Guide to Pharmacology 7151 Reactome Database ID Release 81 9692556 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692556 Reactome R-ALL-9692556 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692556.1 cyproheptadine Reactome DB_ID: 9692566 cyproheptadine [Guide to Pharmacology:277] cyproheptadine cyproheptidine Periactin&reg; Peritol&reg; Guide to Pharmacology 277 Reactome Database ID Release 81 9692566 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692566 Reactome R-ALL-9692566 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692566.1 desloratadine Reactome DB_ID: 9692545 desloratadine [Guide to Pharmacology:7157] desloratadine Clarinex&reg; SCH-34117 Guide to Pharmacology 7157 Reactome Database ID Release 81 9692545 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692545 Reactome R-ALL-9692545 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692545.1 diphenhydramine Reactome DB_ID: 9692535 diphenhydramine [Guide to Pharmacology:1224] diphenhydramine Benadryl&reg; benzhydramine dimehydrinate Guide to Pharmacology 1224 Reactome Database ID Release 81 9692535 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692535 Reactome R-ALL-9692535 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692535.1 dosulepin Dothep&reg; dothiepin Prothiaden&reg; Reactome DB_ID: 9704175 dosulepin [Guide to Pharmacology:7549] dosulepin Dothep&reg; dothiepin Prothiaden&reg; Guide to Pharmacology 7549 Reactome Database ID Release 81 9704175 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9704175 Reactome R-ALL-9704175 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9704175.1 doxepin Reactome DB_ID: 9692546 doxepin [Guide to Pharmacology:1225] doxepin Deptran&reg; P-3693A Sinequan&reg; Guide to Pharmacology 1225 Reactome Database ID Release 81 9692546 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692546 Reactome R-ALL-9692546 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692546.1 epinastine Reactome DB_ID: 9692581 epinastine [Guide to Pharmacology:7176] epinastine Elestat&reg; epinastine hydrochloride Guide to Pharmacology 7176 Reactome Database ID Release 81 9692581 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692581 Reactome R-ALL-9692581 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692581.1 fexofenadine Reactome DB_ID: 9692562 fexofenadine [Guide to Pharmacology:4819] fexofenadine Allegra&reg; fexofenadine HCl Guide to Pharmacology 4819 Reactome Database ID Release 81 9692562 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692562 Reactome R-ALL-9692562 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692562.1 hydroxyzine Reactome DB_ID: 9692588 hydroxyzine [Guide to Pharmacology:7199] hydroxyzine Atarax&reg; hydroxyzine hydrochloride hydroxyzine pamoate Vistaril&reg; Guide to Pharmacology 7199 Reactome Database ID Release 81 9692588 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692588 Reactome R-ALL-9692588 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692588.1 ketotifen Reactome DB_ID: 9692569 ketotifen [Guide to Pharmacology:7206] ketotifen HC-20511 Zaditor&reg; Guide to Pharmacology 7206 Reactome Database ID Release 81 9692569 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692569 Reactome R-ALL-9692569 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692569.1 loratadine Reactome DB_ID: 9692531 loratadine [Guide to Pharmacology:7216] loratadine Claritin&reg; SCH-29851 Guide to Pharmacology 7216 Reactome Database ID Release 81 9692531 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692531 Reactome R-ALL-9692531 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692531.1 mepyramine Reactome DB_ID: 9692541 mepyramine [Guide to Pharmacology:1227] mepyramine Anthisan&reg; mepiramine mepyramine maleate pyrilamine pyrilamine tannate Pyrlex&reg; Guide to Pharmacology 1227 Reactome Database ID Release 81 9692541 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692541 Reactome R-ALL-9692541 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692541.1 mizolastine Reactome DB_ID: 9692520 mizolastine [Guide to Pharmacology:10102] mizolastine Mizollen&reg; MKC431 MKC-431 SL850324 SL 85.0324 SL-850324 Guide to Pharmacology 10102 Reactome Database ID Release 81 9692520 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692520 Reactome R-ALL-9692520 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692520.1 molindone Reactome DB_ID: 9692555 molindone [Guide to Pharmacology:207] molindone EN-1733A Moban&reg; (+-)-molindone Guide to Pharmacology 207 Reactome Database ID Release 81 9692555 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692555 Reactome R-ALL-9692555 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692555.1 perphenazine Decentan&reg; Fentazin&reg; Trilafon&reg; Reactome DB_ID: 9653931 perphenazine [Guide to Pharmacology:209] perphenazine Decentan&reg; Fentazin&reg; Trilafon&reg; Guide to Pharmacology 209 Reactome Database ID Release 81 9653931 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9653931 Reactome R-ALL-9653931 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9653931.1 pitolisant Reactome DB_ID: 9692536 pitolisant [Guide to Pharmacology:8924] pitolisant BF2.649 tiprolisant [USAN] Wakix&reg; Guide to Pharmacology 8924 Reactome Database ID Release 81 9692536 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692536 Reactome R-ALL-9692536 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692536.1 promethazine Reactome DB_ID: 9692518 promethazine [Guide to Pharmacology:7282] promethazine Phenergan&reg; Sominex&reg; Guide to Pharmacology 7282 Reactome Database ID Release 81 9692518 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692518 Reactome R-ALL-9692518 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692518.1 rupatadine Reactome DB_ID: 9692522 rupatadine [Guide to Pharmacology:10103] rupatadine Rinialer&reg; Rupafin&reg; UR12592 UR-12592 Guide to Pharmacology 10103 Reactome Database ID Release 81 9692522 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692522 Reactome R-ALL-9692522 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692522.1 terfenadine Reactome DB_ID: 9692519 terfenadine [Guide to Pharmacology:2608] terfenadine RMI-9918 Seldane&reg; Triludan&reg; Guide to Pharmacology 2608 Reactome Database ID Release 81 9692519 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692519 Reactome R-ALL-9692519 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692519.1 thiothixene Reactome DB_ID: 9692572 thiothixene [Guide to Pharmacology:212] thiothixene Navane&reg; Guide to Pharmacology 212 Reactome Database ID Release 81 9692572 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692572 Reactome R-ALL-9692572 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692572.1 tripelennamine Reactome DB_ID: 9692560 tripelennamine [Guide to Pharmacology:7318] tripelennamine Pyribenzamine&reg; Guide to Pharmacology 7318 Reactome Database ID Release 81 9692560 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692560 Reactome R-ALL-9692560 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692560.1 triprolidine Reactome DB_ID: 9692553 triprolidine [Guide to Pharmacology:1228] triprolidine Actidil&reg; Guide to Pharmacology 1228 Reactome Database ID Release 81 9692553 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692553 Reactome R-ALL-9692553 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692553.1 ORG-5222 asenapine Saphris&reg; Sycrest&reg; Reactome DB_ID: 9654012 asenapine [Guide to Pharmacology:22] asenapine ORG-5222 Saphris&reg; Sycrest&reg; Guide to Pharmacology 22 Reactome Database ID Release 81 9654012 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9654012 Reactome R-ALL-9654012 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9654012.1 ChEBI 71253 HF-1854 clozapine Clorazil&reg; Reactome DB_ID: 9654089 clozapine [Guide to Pharmacology:38] clozapine Clorazil&reg; HF-1854 Guide to Pharmacology 38 Reactome Database ID Release 81 9654089 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9654089 Reactome R-ALL-9654089 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9654089.1 ChEBI 3766 fluphenazine Prolixin&reg; Reactome DB_ID: 9654064 fluphenazine [Guide to Pharmacology:204] fluphenazine Prolixin&reg; Guide to Pharmacology 204 Reactome Database ID Release 81 9654064 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9654064 Reactome R-ALL-9654064 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9654064.1 R-6218 fluspirilene Imap&reg; MCN-JR-6218 Redeptin&reg; Reactome DB_ID: 9648223 fluspirilene [Guide to Pharmacology:85] fluspirilene Imap&reg; MCN-JR-6218 R-6218 Redeptin&reg; Guide to Pharmacology 85 Reactome Database ID Release 81 9648223 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9648223 Reactome R-ALL-9648223 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9648223.1 R-1625 haloperidol Haldol&reg; MCN-JR-1625 Serenace&reg; Reactome DB_ID: 9654039 haloperidol [Guide to Pharmacology:86] haloperidol Haldol&reg; MCN-JR-1625 R-1625 Serenace&reg; Guide to Pharmacology 86 Reactome Database ID Release 81 9654039 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9654039 Reactome R-ALL-9654039 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9654039.1 loxapine Adasuve&reg; CL-62362 CL-71563 Loxapac&reg; Loxitane&reg; SUM-3170 Reactome DB_ID: 9654086 loxapine [Guide to Pharmacology:205] loxapine Adasuve&reg; CL-62362 CL-71563 Loxapac&reg; Loxitane&reg; SUM-3170 Guide to Pharmacology 205 Reactome Database ID Release 81 9654086 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9654086 Reactome R-ALL-9654086 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9654086.1 LY-170053 olanzapine Zyprexa&reg; Reactome DB_ID: 9654045 olanzapine [Guide to Pharmacology:47] olanzapine LY-170053 Zyprexa&reg; Guide to Pharmacology 47 Reactome Database ID Release 81 9654045 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9654045 Reactome R-ALL-9654045 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9654045.1 ChEBI 7735 ZM-204636 quetiapine Seroquel&reg; Reactome DB_ID: 9654028 quetiapine [Guide to Pharmacology:50] quetiapine Seroquel&reg; ZM-204636 Guide to Pharmacology 50 Reactome Database ID Release 81 9654028 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9654028 Reactome R-ALL-9654028 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9654028.1 ChEBI 8707 TP-21 thioridazine Mellaril&reg; thioridazin Reactome DB_ID: 9648262 thioridazine [Guide to Pharmacology:100] thioridazine Mellaril&reg; thioridazin TP-21 Guide to Pharmacology 100 Reactome Database ID Release 81 9648262 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9648262 Reactome R-ALL-9648262 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9648262.1 Eskazinyl&reg; trifluoperazine Stelazine&reg; trifluoperazine hydrochloride Reactome DB_ID: 9653951 trifluoperazine [Guide to Pharmacology:214] trifluoperazine Eskazinyl&reg; Stelazine&reg; trifluoperazine hydrochloride Guide to Pharmacology 214 Reactome Database ID Release 81 9653951 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9653951 Reactome R-ALL-9653951 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9653951.1 CP-88059 ziprasidone CP-88059-27 CP-880591 CP-8805927 Geodon&reg; Reactome DB_ID: 9654080 ziprasidone [Guide to Pharmacology:59] ziprasidone CP-88059 CP-88059-27 CP-880591 CP-8805927 Geodon&reg; Guide to Pharmacology 59 Reactome Database ID Release 81 9654080 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9654080 Reactome R-ALL-9654080 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9654080.1 ChEBI 10119 bilastine Reactome DB_ID: 9692684 bilastine [Guide to Pharmacology:11579] bilastine Bilaxten&reg; Ilaxten&reg; Guide to Pharmacology 11579 Reactome Database ID Release 81 9692684 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692684 Reactome R-ALL-9692684 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692684.1 Reactome Database ID Release 81 9692532 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692532 Reactome R-ALL-9692532 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692532.1 HRH1:HRH1 inverse agonists Reactome DB_ID: 9881129 1 1 Reactome Database ID Release 81 9881129 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9881129 Reactome R-MMU-9692576 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9692576.1 Reactome Database ID Release 81 9881131 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9881131 Reactome R-MMU-9692539 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9692539.1 Histamine is a biogenic amine involved in local immune responses, regulation of gut function and neurotransmission. It exerts its actions by binding to one of four human histamine receptors (HRHs). They belong to the family of rhodopsin-like G-protein-coupled receptors (Panula et al. 2015). Histamine binding to HRHs brings about many physiologic changes, including neurotransmission, inflammation, smooth muscle contraction, dilatation of capillaries, chemotaxis, cytokine production and gastric acid secretion. The histamine H1 receptor (HRH1) is found on smooth muscle and the vascular endothelium, and in the heart and the CNS. Histamine released from neurons binds to HRH1 and causes systemic vasodilation and increased endothelial cell permeability. HRH1 displays constitutive receptor activation in the absence of agonists (Bakker et al. 2000).<br><br>More than 40 HRH1 antihistamines are available worldwide, comprising the largest class of medications used in the treatment of allergic diseases. For more than 50 years these drugs were thought to act as antagonists of HRH1 but it is now known that most of these drugs act as inverse agonists that combine with and stabilize the inactive conformation of HRH1, shifting the equilibrium toward the inactive state (Bakker et al. 2000, Nijmeijer et al. 2010). HRH1 antihistamines are functionally classified as first (old) generation and second (new) generation. First (old)–generation HRH1 antihistamines may cross the blood-brain barrier and interfere with neurotransmission in the CNS, with adverse affects, even resulting in death in overdose cases. First-generation HRH1 antihistamines include chlorpheniramine, diphenhydramine and hydroxyzine, amongst others. Second (new)–generation HRH1 antihistamines are used to treat allergic rhinitis, allergic conjunctivitis, and urticaria. These drugs minimally cross the blood-brain barrier and do not impair alertness, learning, memory, or multitasking and are minimally sedative. Overdose does not cause toxicity or death. Second-generation HRH1 antihistamines include bilastine, ceterizine, fexofenadine, loratadine and reupatadine, amongst others (Yanai et al. 2012, Simons & Akdis 2014, Fein et al. 2019). 978-0-323-08593-9 ISBN 2014 94 - Histamine and H1 Antihistamines Simons, Estelle Akdis, Cesmi Middleton's Allergy (Eighth Edition) (Book): 1503-1533 31582993 Pubmed 2019 CSACI position statement: Newer generation H<sub>1</sub>-antihistamines are safer than first-generation H<sub>1</sub>-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria Fein, Michael N Fischer, David A O'Keefe, Andrew W Sussman, Gord L Allergy Asthma Clin Immunol 15:61 26084539 Pubmed 2015 International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors Panula, Pertti Chazot, Paul L Cowart, Marlon Gutzmer, Ralf Leurs, Rob Liu, Wai L S Stark, Holger Thurmond, Robin L Haas, Helmut L Pharmacol. Rev. 67:601-55 10633171 Pubmed 2000 Constitutive activity of the histamine H(1) receptor reveals inverse agonism of histamine H(1) receptor antagonists Bakker, R A Wieland, K Timmerman, H Leurs, R Eur. J. Pharmacol. 387:R5-7 21036230 Pubmed 2010 Constitutive activity of the histamine H(1) receptor Nijmeijer, Saskia Leurs, Rob Vischer, Henry F Meth. Enzymol. 484:127-47 22455874 Pubmed 2012 Safety considerations in the management of allergic diseases: focus on antihistamines Yanai, K Rogala, B Chugh, K Paraskakis, E Pampura, A N Boev, R Curr Med Res Opin 28:623-42 LEFT-TO-RIGHT HRH2 binds hist This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Hrh2 HRH2 P97292 Reactome DB_ID: 9799728 UniProt:P97292 Hrh2 UniProt P97292 1 EQUAL 359 EQUAL Reactome Database ID Release 81 9799728 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799728 Reactome R-MMU-390907 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390907.1 HRH2:histamine Reactome DB_ID: 9799730 1 1 Reactome Database ID Release 81 9799730 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799730 Reactome R-MMU-390881 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390881.1 Reactome Database ID Release 81 9802910 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9802910 Reactome R-MMU-390909 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390909.1 Histamine H2 receptors (Gantz I et al, 1991) are primarily located on parietal cells (oxyntic cells) which are the stomach epithelium cells that secrete gastric acid in response to histamine. This action is modulated by coupling of the activated receptor with the G protein alpha-s subtype which can stimulate adenylate cyclase (Mitsuhashi M et al, 1989). Through a separate mechanism, the activated receptor can also couple with the G protein alpha-q/11 to stimulate phospholipase C (Mitsuhashi M et al, 1989). H2-receptor antagonists (H2RA) are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells.They are used in the treatment of dyspepsia. 2553705 Pubmed 1989 Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells Mitsuhashi, M Mitsuhashi, T Payan, DG J Biol Chem 264:18356-62 1714721 Pubmed 1991 Molecular cloning of the human histamine H2 receptor Gantz, I Munzert, G Tashiro, T Schäffer, M Wang, L DelValle, J Yamada, T Biochem Biophys Res Commun 178:1386-92 LEFT-TO-RIGHT HRH2 binds HRH2 antagonists This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome HRH2 antagonists Reactome DB_ID: 9692737 CIM cimetidine Reactome DB_ID: 446609 cimetidine [Guide to Pharmacology:1231] cimetidine cimetidine HCl Tagamet&reg; Guide to Pharmacology 1231 Reactome Database ID Release 81 446609 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446609 Reactome R-ALL-446609 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-446609.5 COMPOUND C06952 ChEBI 3699 ranitidine Reactome DB_ID: 9692735 ranitidine [Guide to Pharmacology:1234] ranitidine AH-19065 Gavilast&reg; GR-122311X Zantac&reg; Guide to Pharmacology 1234 Reactome Database ID Release 81 9692735 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692735 Reactome R-ALL-9692735 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692735.1 famotidine Reactome DB_ID: 9692740 famotidine [Guide to Pharmacology:7074] famotidine Gaster&reg; MK-208 Pepcid&reg; Guide to Pharmacology 7074 Reactome Database ID Release 81 9692740 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692740 Reactome R-ALL-9692740 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692740.1 nizatidine Reactome DB_ID: 9692736 nizatidine [Guide to Pharmacology:7248] nizatidine Axid&reg; LY-139037 Guide to Pharmacology 7248 Reactome Database ID Release 81 9692736 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692736 Reactome R-ALL-9692736 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9692736.1 Reactome Database ID Release 81 9692737 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9692737 Reactome R-HSA-9692737 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9692737.1 HRH2:HRH2 antagonists Reactome DB_ID: 9881133 1 1 Reactome Database ID Release 81 9881133 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9881133 Reactome R-MMU-9692725 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9692725.1 Reactome Database ID Release 81 9881135 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9881135 Reactome R-MMU-9692738 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9692738.1 When bound to its endogenous ligand histamine, the histamine H2 receptor (HRH2) mediates mediates gastric acid secretion, gastrointestinal motility and intestinal secretion. HRH2 is also thought to be involved in regulating cell growth and differentiation (Panula et al. 2015). The HRH2 antagonists cimetidine (Black et al. 1972, Ganellin 1981), ranitidine (Brogden et al. 1982), nizatidine (Price & Brogden 1988) and famotidine (Campoli-Richards & Clissold 1986) are well established treatments (Baker et al. 2008) for patients presenting with dyspepsia, gastric or duodenal ulcers, or gastroesophageal reflux disease (Sigterman et al. 2013). 4401751 Pubmed 1972 Definition and antagonism of histamine H 2 -receptors BLACK, J W Duncan, W A Durant, C J Ganellin, C R Parsons, E M Nature 236:385-90 6128216 Pubmed 1982 Ranitidine: a review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases Brogden, R N Carmine, A A Heel, R C Speight, T M Avery, G S Drugs 24:267-303 18157166 Pubmed 2008 A study of antagonist affinities for the human histamine H2 receptor Baker, J G Br. J. Pharmacol. 153:1011-21 6120235 Pubmed 1981 1980 Award in Medicinal Chemistry: Medicinal chemistry and dynamic structure-activity analysis in the discovery of drugs acting at histamine H2 receptors Ganellin, R J. Med. Chem. 24:913-20 2875864 Pubmed 1986 Famotidine. Pharmacodynamic and pharmacokinetic properties and a preliminary review of its therapeutic use in peptic ulcer disease and Zollinger-Ellison syndrome Campoli-Richards, D M Clissold, S P Drugs 32:197-221 9311023 Pubmed 1997 International Union of Pharmacology. XIII. Classification of histamine receptors Hill, SJ Ganellin, CR Timmerman, H Schwartz, JC Shankley, NP Young, JM Schunack, W Levi, R Haas, HL Pharmacol Rev 49:253-78 23728637 Pubmed 2013 Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease Sigterman, Kirsten E van Pinxteren, Bart Bonis, Peter A Lau, Joseph Numans, Mattijs E Cochrane Database Syst RevCD002095 2905640 Pubmed 1988 Nizatidine. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in peptic ulcer disease Price, A H Brogden, R N Drugs 36:521-39 LEFT-TO-RIGHT HRH3 binds Hist This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Hrh3 HRH3 P58406 Reactome DB_ID: 9881149 UniProt:P58406 Hrh3 UniProt P58406 1 EQUAL 445 EQUAL Reactome Database ID Release 81 9881149 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9881149 Reactome R-MMU-390866 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390866.1 HRH3:Hist Reactome DB_ID: 9881155 1 1 Reactome Database ID Release 81 9881155 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9881155 Reactome R-MMU-9692866 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9692866.1 Reactome Database ID Release 81 9881157 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9881157 Reactome R-MMU-9692880 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9692880.1 Histamine H3 receptor (HRH3) (Lovenberg et al. 1999) is predominantly expressed in the CNS and is involved in decreasing the release of neurotransmitters such as histamine, acetylcholine, norepinephrine and serotonin. There are currently at least six isoforms of the H3 receptor in humans of which isoforms 1,2 and 4 encode functional proteins (Wellendorph et al. 2002). 12069903 Pubmed 2002 Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H(3) receptor Wellendorph, P Goodman, MW Burstein, ES Nash, NR Brann, MR Weiner, DM Neuropharmacology 42:929-40 10347254 Pubmed 1999 Cloning and functional expression of the human histamine H3 receptor Lovenberg, TW Roland, BL Wilson, SJ Jiang, X Pyati, J Huvar, A Jackson, MR Erlander, MG Mol Pharmacol 55:1101-7 LEFT-TO-RIGHT HRH3 binds pitosilant This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> HRH3:pitosilant Reactome DB_ID: 9881151 1 1 Reactome Database ID Release 81 9881151 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9881151 Reactome R-MMU-9692855 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9692855.1 Reactome Database ID Release 81 9881153 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9881153 Reactome R-MMU-9692867 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9692867.1 The histamine H3 receptors (HRH3) mediate the histamine signals in the CNS and peripheral nervous system. It signals through the inhibition of adenylate cyclase and displays high constitutive activity. It functions as an auto- and a hetero-receptor at pre- and post-synaptic membranes and has a profound influence on different neurotransmitter balances (Arrang et al. 1983).<br><br>Pitolisant is a selective inverse/agonist/antagonist of HRH3 (Ligneau et al. 2007) and is used to treat type 1 or 2 narcolepsy (Dauvilliers et al. 2013). 6188956 Pubmed 1983 Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor Arrang, J M Garbarg, M Schwartz, J C Nature 302:832-7 17005916 Pubmed 2007 BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology Ligneau, X Perrin, D Landais, L Camelin, J-C Calmels, T P G Berrebi-Bertrand, I Lecomte, J-M Parmentier, R Anaclet, C Lin, J-S Bertaina-Anglade, V la Rochelle, C Drieu d'Aniello, F Rouleau, A Gbahou, F Arrang, J-M Ganellin, C R Stark, H Schunack, W Schwartz, J-C J. Pharmacol. Exp. Ther. 320:365-75 24107292 Pubmed 2013 Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial Dauvilliers, Yves Bassetti, Claudio Lammers, Gert Jan Arnulf, Isabelle Mayer, Geert Rodenbeck, Andrea Lehert, Philippe Ding, Claire-Li Lecomte, Jeanne-Marie Schwartz, Jean-Charles HARMONY I study group, - Lancet Neurol 12:1068-75 LEFT-TO-RIGHT HRH4 binds Hist This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Hrh4 HRH4 Q91ZY2 Reactome DB_ID: 9800847 UniProt:Q91ZY2 Hrh4 UniProt Q91ZY2 1 EQUAL 390 EQUAL Reactome Database ID Release 81 9800847 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9800847 Reactome R-MMU-390910 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390910.1 HRH4:Hist Reactome DB_ID: 9800849 1 1 Reactome Database ID Release 81 9800849 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9800849 Reactome R-MMU-390876 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390876.1 Reactome Database ID Release 81 9802908 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9802908 Reactome R-MMU-390886 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390886.1 Histamine H4 receptor (HRH4) (Nakamura et al. 2000) is highly expressed in bone marrow and white blood cells. It is also found in other tissues such as colon, liver, lungs and thymus. HRH4 mediates mast cell chemotaxis. Both the H3 and H4 receptors mediate their actions by coupling with the G protein alpha-i subtype, decreasing intracellular cAMP. 11118334 Pubmed 2000 Molecular cloning and characterization of a new human histamine receptor, HH4R Nakamura, T Itadani, H Hidaka, Y Ohta, M Tanaka, K Biochem Biophys Res Commun 279:615-20 Reactome Database ID Release 81 9885086 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9885086 Reactome R-MMU-390650 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390650.1 Histamine is a biogenic amine involved in local immune responses, regulation of gut function and neurotransmission. It exerts its actions by binding to histamine receptors. There are four receptors in humans, H1-H4 (Hill SJ et al, 1997).