BioPAX pathway converted from "PIN1 binds p-S345-NCF1" in the Reactome database. LEFT-TO-RIGHT 5.2.1.8 PIN1 binds p-S345-NCF1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> p-S-345-NCF1:NCF2:NCF4 Reactome DB_ID: 9926061 cytosol GENE ONTOLOGY GO:0005829 Ncf2 NCF2 O70145 Reactome DB_ID: 9865338 UniProt:O70145 Ncf2 Mus musculus NCBI Taxonomy 10090 UniProt O70145 1 EQUAL 526 EQUAL Reactome Database ID Release 83 9865338 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9865338 Reactome R-MMU-1222600 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1222600.1 Reactome http://www.reactome.org 1 Q09014 phospho-Ncf1 p-S345-NCF1 Reactome DB_ID: 9926059 UniProt:Q09014 Ncf1 UniProt Q09014 345 EQUAL O-phospho-L-serine MOD MOD:00046 1 EQUAL 390 EQUAL Reactome Database ID Release 83 9926059 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9926059 Reactome R-MMU-9626824 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9626824.1 1 NCF4 P97369 Reactome DB_ID: 9865342 UniProt:P97369 UniProt P97369 1 EQUAL 339 EQUAL Reactome Database ID Release 83 9865342 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9865342 Reactome R-MMU-1222707 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1222707.1 1 Reactome Database ID Release 83 9926061 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9926061 Reactome R-MMU-9626850 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9626850.1 Pin1 PIN1 Q9QUR7 Reactome DB_ID: 9926063 UniProt:Q9QUR7 Pin1 UniProt Q9QUR7 1 EQUAL 163 EQUAL Reactome Database ID Release 83 9926063 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9926063 Reactome R-MMU-9626823 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9626823.1 PIN1:p-S-345-NCF1:NCF2:NCF4 Reactome DB_ID: 9926065 1 1 1 1 Reactome Database ID Release 83 9926065 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9926065 Reactome R-MMU-9626778 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9626778.1 ACTIVATION GENE ONTOLOGY GO:0003755 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 83 9926066 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9926066 Reactome Database ID Release 83 9926068 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9926068 Reactome R-MMU-9626816 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9626816.1 Priming agents such as tumor necrosis factor-α (TNFα) and toll like receptor 7 (TLR7)/TLR8 agonists induced the activation of the peptidyl-prolyl cis/trans isomerase PIN1 in human neutrophils (Boussetta T et al. 2010; Makni-Maalej K et al. 2015). PIN1 is an enzyme that binds to phosphorylated Ser‐Pro or Thr‐Pro sequences, and subsequently catalyzes their conformational changes (Liou YC et al. 2011). In intact neutrophils, PIN1 was found to bind to the neutrophil cytosol factor 1 (NCF1 or p47phox) via the phosphorylated residue of Ser345 (Boussetta T et al. 2010). PIN1 then catalyzed a conformational change of NCF1 that facilitated subsequent phosphorylation of the protein on other sites by protein kinase C (PKC) (Boussetta T et al. 2010; El-Benna J et al. 2016). Extensive phosphorylation of the subunit NCF1 (p47phox) occurs during the activation of the NADPH oxidase (NOX2) in intact cells. 21852138 Pubmed 2011 Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins Liou, Yih-Cherng Zhou, Xiao Zhen Lu, Kun Ping Trends Biochem. Sci. 36:501-14 25877926 Pubmed 2015 TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils Makni-Maalej, Karama Marzaioli, Viviana Boussetta, Tarek Belambri, Sahra Amel Gougerot-Pocidalo, Marie-Anne Hurtado-Nedelec, Margarita Dang, Pham My-Chan El-Benna, Jamel J. Leukoc. Biol. 97:1081-7 20956805 Pubmed 2010 The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils Boussetta, Tarek Gougerot-Pocidalo, Marie-Anne Hayem, Gilles Ciappelloni, Silvia Raad, Houssam Arabi Derkawi, Riad Bournier, Odile Kroviarski, Yolande Zhou, Xiao Zhen Malter, James S Lu, Ping K Bartegi, Aghleb Dang, Pham My-Chan El-Benna, Jamel Blood 116:5795-802 27558335 Pubmed 2016 Priming of the neutrophil respiratory burst: role in host defense and inflammation El-Benna, Jamel Hurtado-Nedelec, Margarita Marzaioli, Viviana Marie, Jean-Claude Gougerot-Pocidalo, Marie-Anne Dang, Pham My-Chan Immunol. Rev. 273:180-93 inferred from electronic annotation EVIDENCE CODE ECO:0000203