BioPAX pathway converted from "Activation of conventional Protein Kinase C" in the Reactome database. LEFT-TO-RIGHT Activation of conventional Protein Kinase C This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PS 3-sn-phosphatidyl-L-serine Phosphatidylserine phosphatidyl-L-serine 1,2-Diacyl-sn-glycerol 3-phospho-L-serine 3-O-sn-Phosphatidyl-L-serine O3-Phosphatidyl-L-serine Reactome DB_ID: 33625 plasma membrane GENE ONTOLOGY GO:0005886 3-sn-phosphatidyl-L-serine [ChEBI:11750] 3-sn-phosphatidyl-L-serine L-alpha-phosphatidylserine 3-O-sn-phosphatidyl-L-serine 3-sn-phosphatidyl-L-serines 3-L-phosphatidyl-L-serine 1-D-phosphatidyl-L-serine 1,2-diacyl-sn-glycerol 3-phospho-L-serine ChEBI CHEBI:11750 Reactome Database ID Release 82 33625 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=33625 Reactome R-ALL-33625 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-33625.5 Reactome http://www.reactome.org Ca2+ Calcium calcium(2+) Reactome DB_ID: 74016 cytosol GENE ONTOLOGY GO:0005829 calcium(2+) [ChEBI:29108] calcium(2+) ChEBI CHEBI:29108 Reactome Database ID Release 82 74016 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74016 Reactome R-ALL-74016 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74016.3 COMPOUND C00076 additional information MI MI:0361 DAG 1,2-Diacylglycerol 1,2-diacyl-sn-glycerol Reactome DB_ID: 114519 1,2-diacyl-sn-glycerol [ChEBI:17815] 1,2-diacyl-sn-glycerol ChEBI CHEBI:17815 Reactome Database ID Release 82 114519 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114519 Reactome R-ALL-114519 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-114519.4 Converted from EntitySet in Reactome Protein Kinase C, conventional Reactome DB_ID: 9938282 PRKCA P05696 Reactome DB_ID: 9937578 UniProt:P05696 Rattus norvegicus NCBI Taxonomy 10116 UniProt P05696 2 EQUAL 672 EQUAL Reactome Database ID Release 82 9937578 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9937578 Reactome R-RNO-58196 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-58196.1 PRKCB P68403 Reactome DB_ID: 9938280 UniProt:P68403 UniProt P68403 2 EQUAL 671 EQUAL Reactome Database ID Release 82 9938280 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9938280 Reactome R-RNO-58198 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-58198.1 PRKCG P63319 Reactome DB_ID: 9937585 UniProt:P63319 UniProt P63319 1 EQUAL 697 EQUAL Reactome Database ID Release 82 9937585 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9937585 Reactome R-RNO-58204 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-58204.1 Reactome Database ID Release 82 9938282 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9938282 Reactome R-RNO-114528 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-114528.1 Converted from EntitySet in Reactome Activated conventional protein kinase C Reactome DB_ID: 9938294 Activated PKC alpha Reactome DB_ID: 9938286 1 1 Ca2+ Calcium calcium(2+) Reactome DB_ID: 140648 Reactome Database ID Release 82 140648 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=140648 Reactome R-ALL-140648 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-140648.4 COMPOUND C00076 2 PRKCA P05696 Reactome DB_ID: 9938284 2 EQUAL 672 EQUAL Reactome Database ID Release 82 9938284 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9938284 Reactome R-RNO-156469 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-156469.1 1 Reactome Database ID Release 82 9938286 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9938286 Reactome R-RNO-139828 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-139828.1 Activated PKC beta Reactome DB_ID: 9938290 1 1 3 PRKCB P68403 Reactome DB_ID: 9938288 2 EQUAL 671 EQUAL Reactome Database ID Release 82 9938288 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9938288 Reactome R-RNO-156467 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-156467.1 1 Reactome Database ID Release 82 9938290 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9938290 Reactome R-RNO-139829 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-139829.1 Activated PKC gamma Reactome DB_ID: 9938292 1 1 1 3 Reactome Database ID Release 82 9938292 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9938292 Reactome R-RNO-426343 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-426343.1 Reactome Database ID Release 82 9938294 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9938294 Reactome R-RNO-139830 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-139830.1 Reactome Database ID Release 82 9938296 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9938296 Reactome R-RNO-114553 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-114553.1 The conventional Protein Kinase C (cPKC) isoforms have two membrane-targetting domains, a C1 domain which binds to the membrane lipid diacylglycerol (DAG) and a C2 domain which binds membrane phospholipids such as phosphatidylserine, in a calcium-dependent manner. Association of both domains with the plasma membrane produces a conformational change that releases an autoinhibitory pseudosubstrate segment from the substrate-binding cavity, allowing substrate binding and downstream signaling. 9601053 Pubmed 1998 The extended protein kinase C superfamily Mellor, H Parker, PJ Biochem J 332:281-92 9814702 Pubmed 1998 Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals Oancea, E Meyer, T Cell 95:307-18 19033211 Pubmed 2009 Lipid activation of protein kinases Newton, AC J Lipid Res 50:S266-71 9780306478635 ISBN 2004 Protein Kinase C 2nd ed Dekker, L Protein Kinase C 2nd ed (Book) inferred from electronic annotation EVIDENCE CODE ECO:0000203 ACTIVATION Reactome Database ID Release 82 425851 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425851 Reactome R-HSA-425851 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425851.1