BioPAX pathway converted from "PRMT1,PRMT6 methylate arginine-4 of histone H4" in the Reactome database.LEFT-TO-RIGHT2.1.1PRMT1,PRMT6 methylate arginine-4 of histone H4This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>SAMAdoMetS-adenosylmethionineS-adenosyl-L-methionineReactome DB_ID: 77087nucleoplasmGENE ONTOLOGYGO:0005654S-adenosyl-L-methionine [ChEBI:15414]S-adenosyl-L-methionineChEBICHEBI:15414Reactome Database ID Release 7077087Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77087ReactomeR-ALL-770873Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-77087.3Reactomehttp://www.reactome.orgF2Z4N2HIST1H4Reactome DB_ID: 9885729UniProt:F2Z4N2Canis familiarisNCBI Taxonomy9615UniProtF2Z4N22EQUAL103EQUALReactome Database ID Release 709885729Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9885729ReactomeR-CFA-1819021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181902.1SAHAdoHcyS-adenosylhomocysteineS-adenosyl-L-homocysteineReactome DB_ID: 77502S-adenosyl-L-homocysteine [ChEBI:16680]S-adenosyl-L-homocysteineChEBICHEBI:16680Reactome Database ID Release 7077502Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77502ReactomeR-ALL-775023Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-77502.3F2Z4N2MeR4-HIST1H4Reactome DB_ID: 99454874EQUALomega-N-methyl-L-arginineMODMOD:000782EQUAL103EQUALReactome Database ID Release 709945487Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9945487ReactomeR-CFA-47542401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-4754240.1ACTIVATIONConverted from EntitySet in ReactomePRMT1,PRMT6Reactome DB_ID: 9945493PRMT1F6XFY9Reactome DB_ID: 9939701UniProt:F6XFY9UniProtF6XFY91EQUAL361EQUALReactome Database ID Release 709939701Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9939701ReactomeR-CFA-32151401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3215140.1PRMT6E2QWI7Reactome DB_ID: 9945491UniProt:E2QWI7UniProtE2QWI71EQUAL375EQUALReactome Database ID Release 709945491Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9945491ReactomeR-CFA-52268841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5226884.1Reactome Database ID Release 709945493Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9945493ReactomeR-CFA-52268851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5226885.1GENE ONTOLOGYGO:0016274gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 709945494Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9945494Reactome Database ID Release 709945496Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9945496ReactomeR-CFA-52057981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5205798.1PRMT1 (Wang et al. 2001, Strahl et al. 2001, Wagner et al. 2006) and PRMT6 (Hyllus et al. 2007) can asymmetrically dimethylate histone H4 at arginine-3 (H4R3me2a). This functions as a transcriptional activation mark that can result in either the recruitment of methyl-binding proteins or the deposition of other posttranslational marks. PRMT1 is the best studied. It is recruited to promoters by a number of different transcription factors (Bedford & Richard 2005). PRMT1-knockout mice die shortly after implantation (Pawlak et al. 2000). In vitro PRMT1 can also methylate histone H2A at arginine-3 (Strahl et al. 2001). 18079182Pubmed2007PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylationHyllus, DawinStein, ClaudiaSchnabel, KristinSchiltz, EmileImhof, AxelDou, YaliHsieh, JamesBauer, Uta-MariaGenes Dev. 21:3369-8011448779Pubmed2001Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1Strahl, B DBriggs, S DBrame, C JCaldwell, J AKoh, S SMa, HCook, RGShabanowitz, JHunt, D FStallcup, M RAllis, C DCurr. Biol. 11:996-100010848611Pubmed2000Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viablePawlak, M RScherer, C AChen, JRoshon, M JRuley, H EMol. Cell. Biol. 20:4859-6911387442Pubmed2001Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptorWang, HHuang, Z QXia, LFeng, QErdjument-Bromage, HStrahl, B DBriggs, S DAllis, C DWong, JTempst, PZhang, YScience 293:853-715866169Pubmed2005Arginine methylation an emerging regulator of protein functionBedford, Mark TRichard, SMol. Cell 18:263-7216861234Pubmed2006SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1Wagner, SabineWeber, SusanneKleinschmidt, Markus ANagata, KyosukeBauer, Uta-MariaJ. Biol. Chem. 281:27242-50inferred from electronic annotationEVIDENCE CODEECO:0000203