BioPAX pathway converted from "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen" in the Reactome database.LEFT-TO-RIGHT1.14.11.7Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagenThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Prolyl 3-hydroxylases:Fe2+:4-Hyp collagen propeptidesReactome DB_ID: 9980505endoplasmic reticulum lumenGENE ONTOLOGYGO:0005788Converted from EntitySet in Reactome4-Hyp collagen propeptidesReactome DB_ID: 9980477COL2A13x4Hyp-COL2A1(26-1487)F1PS24Reactome DB_ID: 9980382UniProt:F1PS24COL2A1Canis familiarisNCBI Taxonomy9615UniProtF1PS24(2S,4R)-4-hydroxyprolineMODMOD:0003926EQUAL1487EQUALReactome Database ID Release 759980382Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980382ReactomeR-CFA-20220961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022096.1Reactomehttp://www.reactome.orgCOL3A13x4Hyp-COL3A1(24-1466)F1PG69Reactome DB_ID: 9980384UniProt:F1PG69COL3A1UniProtF1PG6924EQUAL1466EQUALReactome Database ID Release 759980384Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980384ReactomeR-CFA-20221081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022108.1COL9A13x4Hyp-COL9A1F1PPQ7Reactome DB_ID: 9980387UniProt:F1PPQ7COL9A1UniProtF1PPQ724EQUAL921EQUALReactome Database ID Release 759980387Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980387ReactomeR-CFA-21729501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172950.1COL5A13x4Hyp-COL5A1(38-1838)F1PHX8Reactome DB_ID: 9980389UniProt:F1PHX8COL5A1UniProtF1PHX838EQUAL1838EQUALReactome Database ID Release 759980389Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980389ReactomeR-CFA-20225101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022510.1COL6A13x4Hyp-COL6A1F1PFM6Reactome DB_ID: 9980392UniProt:F1PFM6COL6A1UniProtF1PFM620EQUAL1028EQUALReactome Database ID Release 759980392Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980392ReactomeR-CFA-20225081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022508.1COL7A13x4Hyp-COL7A1F1PIP7Reactome DB_ID: 9952863UniProt:F1PIP7COL7A1UniProtF1PIP717EQUAL2944EQUALReactome Database ID Release 759952863Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9952863ReactomeR-CFA-20221341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022134.1COL8A13x4Hyp-COL8A1(28-744)J9JHM4Reactome DB_ID: 9980394UniProt:J9JHM4COL8A1UniProtJ9JHM428EQUAL744EQUALReactome Database ID Release 759980394Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980394ReactomeR-CFA-21729481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172948.1J9P1I7COL10A13x4Hyp-COL10A1Reactome DB_ID: 9980396UniProt:J9P1I7COL10A1UniProtJ9P1I719EQUAL680EQUALReactome Database ID Release 759980396Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980396ReactomeR-CFA-21729591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172959.1J9NYK4COL11A13x4Hyp-COL11A1(36-1806)Reactome DB_ID: 9980398UniProt:J9NYK4COL11A1UniProtJ9NYK436EQUAL1806EQUALReactome Database ID Release 759980398Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980398ReactomeR-CFA-21729601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172960.1J9P6G0COL12A13x4Hyp-COL12A1Reactome DB_ID: 9980401UniProt:J9P6G0COL12A1UniProtJ9P6G024EQUAL3063EQUALReactome Database ID Release 759980401Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980401ReactomeR-CFA-21729211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172921.1F1PJH3COL13A13x4Hyp-COL13A1Reactome DB_ID: 9980404UniProt:F1PJH3COL13A1UniProtF1PJH31EQUAL717EQUALReactome Database ID Release 759980404Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980404ReactomeR-CFA-21729281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172928.1E2RT85COL14A13x4Hyp-COL14A1Reactome DB_ID: 9980407UniProt:E2RT85COL14A1UniProtE2RT8529EQUAL1796EQUALReactome Database ID Release 759980407Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980407ReactomeR-CFA-21729411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172941.1E2R0E5COL19A13x4Hyp-COL19A1Reactome DB_ID: 9980410UniProt:E2R0E5COL19A1UniProtE2R0E524EQUAL1142EQUALReactome Database ID Release 759980410Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980410ReactomeR-CFA-21729311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172931.1J9P689COL15A13x4Hyp-COL15A1(28-1388)Reactome DB_ID: 9980413UniProt:J9P689COL15A1UniProtJ9P68928EQUAL1388EQUALReactome Database ID Release 759980413Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980413ReactomeR-CFA-21729581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172958.1E2R466COL16A13x4Hyp-COL16A1Reactome DB_ID: 9980416UniProt:E2R466COL16A1UniProtE2R46622EQUAL1604EQUALReactome Database ID Release 759980416Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980416ReactomeR-CFA-21729251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172925.1Q9N281COL17A13x4Hyp-COL17A1(1-1497)Reactome DB_ID: 9980419UniProt:Q9N281COL17A1UniProtQ9N2811EQUAL1497EQUALReactome Database ID Release 759980419Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980419ReactomeR-CFA-21729341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172934.1F6Y3U73x4Hyp-COL18A1(24-1754)Reactome DB_ID: 9980422UniProt:F6Y3U7UniProtF6Y3U724EQUAL1754EQUALReactome Database ID Release 759980422Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980422ReactomeR-CFA-21729441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172944.1F1PVR6COL20A13x4Hyp-COL20A1Reactome DB_ID: 9980425UniProt:F1PVR6COL20A1UniProtF1PVR623EQUAL1284EQUALReactome Database ID Release 759980425Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980425ReactomeR-CFA-21729361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172936.1F1PTE4COL22A13x4Hyp-COL22A1Reactome DB_ID: 9980428UniProt:F1PTE4COL22A1UniProtF1PTE428EQUAL1626EQUALReactome Database ID Release 759980428Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980428ReactomeR-CFA-21729511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172951.1J9P717COL23A13x4Hyp-COL23A1Reactome DB_ID: 9980431UniProt:J9P717COL23A1UniProtJ9P7171EQUAL540EQUALReactome Database ID Release 759980431Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980431ReactomeR-CFA-21729271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172927.1F1PXE8COL27A13x4Hyp-COL24A1Reactome DB_ID: 9980433UniProt:F1PXE8COL27A1UniProtF1PXE836EQUAL1714EQUALReactome Database ID Release 759980433Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980433ReactomeR-CFA-21729301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172930.1J9NV06COL28A13x4Hyp-COL28A1Reactome DB_ID: 9980440UniProt:J9NV06COL28A1UniProtJ9NV0624EQUAL1125EQUALReactome Database ID Release 759980440Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980440ReactomeR-CFA-21729461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172946.1COL4A23x4Hyp-COL4A2(26-1712)F1Q129Reactome DB_ID: 9980442UniProt:F1Q129COL4A2UniProtF1Q12926EQUAL1712EQUALReactome Database ID Release 759980442Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980442ReactomeR-CFA-20220891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022089.1J9P0L63x4Hyp-COL9A2Reactome DB_ID: 9980445UniProt:J9P0L6UniProtJ9P0L624EQUAL689EQUALReactome Database ID Release 759980445Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980445ReactomeR-CFA-21732991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2173299.1COL5A23x4Hyp-COL5A2(27-1499)F1PG08Reactome DB_ID: 9980447UniProt:F1PG08COL5A2UniProtF1PG0827EQUAL1499EQUALReactome Database ID Release 759980447Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980447ReactomeR-CFA-20224411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022441.1COL8A23x4Hyp-COL8A2J9NY38Reactome DB_ID: 9980449UniProt:J9NY38COL8A2UniProtJ9NY3829EQUAL703EQUALReactome Database ID Release 759980449Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980449ReactomeR-CFA-21793431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2179343.1F1PQD5COL11A23x4Hyp-COL11A2Reactome DB_ID: 9980451UniProt:F1PQD5COL11A2UniProtF1PQD528EQUAL1736EQUALReactome Database ID Release 759980451Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980451ReactomeR-CFA-21792171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2179217.1COL4A33x4Hyp-COL4A3(29-1670)F1PM98Reactome DB_ID: 9980454UniProt:F1PM98COL4A3UniProtF1PM9829EQUAL1670EQUALReactome Database ID Release 759980454Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980454ReactomeR-CFA-20220821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022082.1COL5A33x4Hyp-COL5A3F1P6C9Reactome DB_ID: 9980456UniProt:F1P6C9COL5A3UniProtF1P6C930EQUAL1745EQUALReactome Database ID Release 759980456Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980456ReactomeR-CFA-20225131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022513.1COL6A33x4Hyp-COL6A3(26-3176)F1PR31Reactome DB_ID: 9980459UniProt:F1PR31COL6A3UniProtF1PR3126EQUAL3176EQUALReactome Database ID Release 759980459Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980459ReactomeR-CFA-20224581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022458.1COL9A33x4Hyp-COL9A3F1PLU6Reactome DB_ID: 9980462UniProt:F1PLU6COL9A3UniProtF1PLU626EQUAL684EQUALReactome Database ID Release 759980462Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980462ReactomeR-CFA-21792081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2179208.1COL4A43x4Hyp-COL4A4F1PM99Reactome DB_ID: 9980465UniProt:F1PM99COL4A4UniProtF1PM9939EQUAL1690EQUALReactome Database ID Release 759980465Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980465ReactomeR-CFA-20221291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022129.1COL6A54Hyp-COL6A5F1Q2F7Reactome DB_ID: 9980468UniProt:F1Q2F7COL6A5UniProtF1Q2F719EQUAL2615EQUALReactome Database ID Release 759980468Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980468ReactomeR-CFA-20234991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2023499.1COL4A63x4Hyp-COL4A6J9NW83Reactome DB_ID: 9980470UniProt:J9NW83COL4A6UniProtJ9NW8323EQUAL1691EQUALReactome Database ID Release 759980470Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980470ReactomeR-CFA-20221251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022125.1COL6A64Hyp-COL6A6E2R0D7Reactome DB_ID: 9980473UniProt:E2R0D7COL6A6UniProtE2R0D720EQUAL2263EQUALReactome Database ID Release 759980473Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980473ReactomeR-CFA-20235011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2023501.1COL4A13x4Hyp-COL4A1(24-1669)F1Q133Reactome DB_ID: 9980475UniProt:F1Q133COL4A1UniProtF1Q13324EQUAL1669EQUALReactome Database ID Release 759980475Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980475ReactomeR-CFA-20657071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2065707.1Reactome Database ID Release 759980477Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980477ReactomeR-CFA-16507671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1650767.11Prolyl 3-hydroxylases:Fe2+Reactome DB_ID: 9980503Converted from EntitySet in ReactomeProlyl 3-hydroxylasesReactome DB_ID: 9980501P3H2LEPREL1F1PJH5Reactome DB_ID: 9980481UniProt:F1PJH5P3H2UniProtF1PJH525EQUAL708EQUALReactome Database ID Release 759980481Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980481ReactomeR-CFA-16507681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1650768.1LEPRE1:PPIB:CRTAPReactome DB_ID: 9980495PPIBJ9NVL9Reactome DB_ID: 9980493UniProt:J9NVL9UniProtJ9NVL934EQUAL216EQUALReactome Database ID Release 759980493Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980493ReactomeR-CFA-19802621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1980262.11CRTAPCRTAPJ9NTX5Reactome DB_ID: 9980485UniProt:J9NTX5CRTAPUniProtJ9NTX527EQUAL401EQUALReactome Database ID Release 759980485Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980485ReactomeR-CFA-19802611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1980261.11P3H1LEPRE1F1PS57Reactome DB_ID: 9980489UniProt:F1PS57P3H1UniProtF1PS5723EQUAL736EQUALReactome Database ID Release 759980489Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980489ReactomeR-CFA-16503181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1650318.11Reactome Database ID Release 759980495Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980495ReactomeR-CFA-19802341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1980234.1J9NXQ0LEPREL2Reactome DB_ID: 9980499UniProt:J9NXQ0UniProtJ9NXQ021EQUAL736EQUALReactome Database ID Release 759980499Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980499ReactomeR-CFA-16508211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1650821.1Reactome Database ID Release 759980501Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980501ReactomeR-CFA-19802361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1980236.11Fe2+iron (ferrous)Fe(II)Fe++Reactome DB_ID: 1650774iron(2+) [ChEBI:29033]iron(2+)FE (II) IONFe2+Fe(2+)iron ion(2+)Fe(II)Ferrous ionChEBICHEBI:29033Reactome Database ID Release 751650774Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1650774ReactomeR-ALL-16507744Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1650774.4COMPOUNDC00023additional informationMIMI:03611VitCAscorbateL-ascorbic acidReactome DB_ID: 1981146L-ascorbic acid [ChEBI:29073]L-ascorbic acidChEBICHEBI:29073Reactome Database ID Release 751981146Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1981146ReactomeR-ALL-19811463Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1981146.31Reactome Database ID Release 759980503Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980503ReactomeR-CFA-19811601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1981160.11Reactome Database ID Release 759980505Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980505ReactomeR-CFA-89482331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8948233.12OG2-Oxoglutarate2-oxoglutaric acidalpha-ketoglutarate2-oxoglutarate(2-)Reactome DB_ID: 16507792-oxoglutarate(2-) [ChEBI:16810]2-oxoglutarate(2-)2-ketoglutaratealpha-ketoglutarate2-oxopentanedioic acid, ion(2-)2-oxoglutarateChEBICHEBI:16810Reactome Database ID Release 751650779Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1650779ReactomeR-ALL-16507794Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1650779.4COMPOUNDC00026O2OxygendioxygenReactome DB_ID: 113534dioxygen [ChEBI:15379]dioxygenChEBICHEBI:15379Reactome Database ID Release 75113534Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113534ReactomeR-ALL-1135343Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113534.3COMPOUNDC00007Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptidesReactome DB_ID: 9980604Converted from EntitySet in Reactome3,4-Hyp collagen propeptidesReactome DB_ID: 9980602COL2A13x4Hyp-3Hyp-COL2A1(26-1487)F1PS24Reactome DB_ID: 9980507(2S,3S)-3-hydroxyprolineMODMOD:0003826EQUAL1487EQUALReactome Database ID Release 759980507Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980507ReactomeR-CFA-20224251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022425.1COL3A13x4Hyp-3Hyp-COL3A1(24-1466)F1PG69Reactome DB_ID: 998050924EQUAL1466EQUALReactome Database ID Release 759980509Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980509ReactomeR-CFA-20224631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022463.1COL5A13x4Hyp-3Hyp-COL5A1(38-1838)F1PHX8Reactome DB_ID: 998051138EQUAL1838EQUALReactome Database ID Release 759980511Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980511ReactomeR-CFA-20224831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022483.1COL6A13x4Hyp-3Hyp-COL6A1F1PFM6Reactome DB_ID: 998051420EQUAL1028EQUALReactome Database ID Release 759980514Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980514ReactomeR-CFA-20225071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022507.1COL7A13x4Hyp-3Hyp-COL7A1F1PIP7Reactome DB_ID: 995285517EQUAL2944EQUALReactome Database ID Release 759952855Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9952855ReactomeR-CFA-20225111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022511.1COL4A23x4Hyp-3Hyp-COL4A2(26-1712)F1Q129Reactome DB_ID: 998051626EQUAL1712EQUALReactome Database ID Release 759980516Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980516ReactomeR-CFA-20225241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022524.1COL5A23x4Hyp-3Hyp-COL5A2(27-1499)F1PG08Reactome DB_ID: 998051827EQUAL1499EQUALReactome Database ID Release 759980518Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980518ReactomeR-CFA-20224441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022444.1COL8A23x4Hyp-3Hyp-COL8A2J9NY38Reactome DB_ID: 998052029EQUAL703EQUALReactome Database ID Release 759980520Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980520ReactomeR-CFA-21793491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2179349.1F1PQD5COL11A23x4Hyp-3Hyp-COL11A2Reactome DB_ID: 998052228EQUAL1736EQUALReactome Database ID Release 759980522Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980522ReactomeR-CFA-21792151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2179215.1COL4A33x4Hyp-3Hyp-COL4A3(29-1670)F1PM98Reactome DB_ID: 998052529EQUAL1670EQUALReactome Database ID Release 759980525Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980525ReactomeR-CFA-20224521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022452.1COL9A33Hyp-4Hyp-COL9A3F1PLU6Reactome DB_ID: 998052826EQUAL684EQUALReactome Database ID Release 759980528Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980528ReactomeR-CFA-21791921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2179192.1COL5A33x4Hyp-3Hyp-COL5A3F1P6C9Reactome DB_ID: 998053030EQUAL1745EQUALReactome Database ID Release 759980530Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980530ReactomeR-CFA-20224751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022475.1COL6A33x4Hyp-3Hyp-COL6A3(26-3176)F1PR31Reactome DB_ID: 998053326EQUAL3176EQUALReactome Database ID Release 759980533Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980533ReactomeR-CFA-20224721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022472.1COL4A43x4Hyp-3Hyp-COL4A4F1PM99Reactome DB_ID: 998053639EQUAL1690EQUALReactome Database ID Release 759980536Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980536ReactomeR-CFA-20225211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022521.1COL6A53Hyp-4Hyp-COL6A5F1Q2F7Reactome DB_ID: 998053919EQUAL2615EQUALReactome Database ID Release 759980539Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980539ReactomeR-CFA-20234981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2023498.1COL4A63x4Hyp-3Hyp-COL4A6J9NW83Reactome DB_ID: 998054123EQUAL1691EQUALReactome Database ID Release 759980541Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980541ReactomeR-CFA-20224861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022486.1COL6A63Hyp-4Hyp-COL6A6E2R0D7Reactome DB_ID: 998054420EQUAL2263EQUALReactome Database ID Release 759980544Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980544ReactomeR-CFA-20234961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2023496.1COL9A13x4Hyp-3Hyp-COL9A1F1PPQ7Reactome DB_ID: 998054724EQUAL921EQUALReactome Database ID Release 759980547Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980547ReactomeR-CFA-21729991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172999.1COL8A13x4Hyp-3Hyp-COL8A1(28-744)J9JHM4Reactome DB_ID: 998054928EQUAL744EQUALReactome Database ID Release 759980549Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980549ReactomeR-CFA-21729761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172976.1J9P1I7COL10A13x4Hyp-3Hyp-COL10A1Reactome DB_ID: 998055119EQUAL680EQUALReactome Database ID Release 759980551Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980551ReactomeR-CFA-21729641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172964.1J9NYK4COL11A13x4Hyp-3Hyp-COL11A1(36-1806)Reactome DB_ID: 998055336EQUAL1806EQUALReactome Database ID Release 759980553Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980553ReactomeR-CFA-21729921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172992.1J9P6G0COL12A13x4Hyp-3Hyp-COL12A1Reactome DB_ID: 998055624EQUAL3063EQUALReactome Database ID Release 759980556Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980556ReactomeR-CFA-21730041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2173004.1F1PJH3COL13A13x4Hyp-3Hyp-COL13A1Reactome DB_ID: 99805591EQUAL717EQUALReactome Database ID Release 759980559Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980559ReactomeR-CFA-21729711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172971.1E2RT85COL14A13x4Hyp-3Hyp-COL14A1Reactome DB_ID: 998056229EQUAL1796EQUALReactome Database ID Release 759980562Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980562ReactomeR-CFA-21729651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172965.1E2R0E5COL19A13x4Hyp-3Hyp-COL19A1Reactome DB_ID: 998056524EQUAL1142EQUALReactome Database ID Release 759980565Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980565ReactomeR-CFA-21729751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172975.1J9P689COL15A13x4Hyp-3Hyp-COL15A1(28-1388)Reactome DB_ID: 998056828EQUAL1388EQUALReactome Database ID Release 759980568Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980568ReactomeR-CFA-21729671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172967.1E2R466COL16A13x4Hyp-3Hyp-COL16A1Reactome DB_ID: 998057122EQUAL1604EQUALReactome Database ID Release 759980571Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980571ReactomeR-CFA-21730001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2173000.1Q9N281COL17A13x4Hyp-3Hyp-COL17A1(1-1497)Reactome DB_ID: 99805741EQUAL1497EQUALReactome Database ID Release 759980574Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980574ReactomeR-CFA-21729891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172989.1F6Y3U73x4Hyp-3Hyp-COL18A1(24-1754)Reactome DB_ID: 998057724EQUAL1754EQUALReactome Database ID Release 759980577Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980577ReactomeR-CFA-21729971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172997.1F1PVR6COL20A13x4Hyp-3Hyp-COL20A1Reactome DB_ID: 998058023EQUAL1284EQUALReactome Database ID Release 759980580Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980580ReactomeR-CFA-21729791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172979.1F1PTE4COL22A13x4Hyp-3Hyp-COL22A1Reactome DB_ID: 998058328EQUAL1626EQUALReactome Database ID Release 759980583Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980583ReactomeR-CFA-21729661Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172966.1J9P717COL23A13x4Hyp-3Hyp-COL23A1Reactome DB_ID: 99805861EQUAL540EQUALReactome Database ID Release 759980586Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980586ReactomeR-CFA-21729981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172998.1F1PXE8COL27A13x4Hyp-3Hyp-COL24A1Reactome DB_ID: 998058836EQUAL1714EQUALReactome Database ID Release 759980588Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980588ReactomeR-CFA-21729831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172983.1J9NV06COL28A13x4Hyp-3Hyp-COL28A1Reactome DB_ID: 998059524EQUAL1125EQUALReactome Database ID Release 759980595Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980595ReactomeR-CFA-21729781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2172978.1J9P0L63x4Hyp-3Hyp-COL9A2Reactome DB_ID: 998059824EQUAL689EQUALReactome Database ID Release 759980598Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980598ReactomeR-CFA-21732871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2173287.1COL4A13x4Hyp-3Hyp-COL4A1(24-1669)F1Q133Reactome DB_ID: 998060024EQUAL1669EQUALReactome Database ID Release 759980600Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980600ReactomeR-CFA-20656241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2065624.1Reactome Database ID Release 759980602Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980602ReactomeR-CFA-20224921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022492.111Reactome Database ID Release 759980604Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980604ReactomeR-CFA-20224261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2022426.1CO2carbon dioxideReactome DB_ID: 159751carbon dioxide [ChEBI:16526]carbon dioxideChEBICHEBI:16526Reactome Database ID Release 75159751Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159751ReactomeR-ALL-1597513Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-159751.3COMPOUNDC00011SUCCASuccinatesuccinic acidButanedionic acidEthylenesuccinic acidsuccinate(2-)Reactome DB_ID: 1650769succinate(2-) [ChEBI:30031]succinate(2-)(-)OOC-CH2-CH2-COO(-)succinatebutanedioic acid, ion(2-)butanedioateChEBICHEBI:30031Reactome Database ID Release 751650769Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1650769ReactomeR-ALL-16507694Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1650769.4COMPOUNDC00042ACTIVATIONGENE ONTOLOGYGO:0019797gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 759980605Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980605Reactome Database ID Release 759980607Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9980607ReactomeR-CFA-19802331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1980233.1Collagen contains (2S,3S)-3-hydroxyproline (3-Hyp), though much less abundantly than 4-Hyp (Rhodes and Miller 1978). The 3-Hyp content of collagen is much more variable than that of 4-Hyp, varying between collagen types, tissues, developmental stages and pathological states (Kivirikko et al. 1992). It is more prevalent in type IV and V collagens at 10-15 3-Hyp residues (Bentz et al. 1983) than in Type I-III fibrillar collagens which have a single 3-Hyp residue per chain; the alpha-1 chain of type I collagen has 3-Hyp at residue 986 (Fietzek et al. 1972, Marini et al. 2007). 3-Hyp is formed from Pro in the Xaa position of Xaa-Hyp-Gly triplets (Gryder et al. 1975, Kivirikko et al. 1992). It is likely that 4-Hyp is a requirement at the second position of the triplet as 4-Hyp rich substrates are more active than 4-Hyp poor (Adams & Frank 1980). 3-Hyp has a modest effect on triple-helix stability (Jenkins et al. 2003; Mizuno et al. 2008). 3-Hyp may adjust the stability of basement membranes to enable formation of the meshwork structure, or serve as a ligand for other proteins. It is suggested to have a role in the self-assembly of collagen supramolecular structures (Weis et al. 2010). <br>3-Hyp is formed by prolyl 3-hydroxylase (P3H; EC 1.14.11.7), which has 3 isoforms in vertebrates. All contain an ER-retention signal but vary in their tissue expression (Vranka et al. 2009). P3H can hydroxylate prolines that precede 4-Hyp residues (Tryggvason et al. 1976) but not those that precede an unhydroxylated proline (Kivirikko & Myllla 1982, Myllyharju 2005). Like P4H, P3H requires molecular oxygen, alpha-ketoglutarate, iron(II), and ascorbate for activity. P3H1 is homologous to mammalian leprecan or growth suppressor 1 (Gros1), and forms a 3-prolyl hydroxylation complex with cartilage-associated protein (CRTAP) and a peptidyl-prolyl cis-trans isomerase, cyclophilin B (CypB), which is encoded by the PPIB gene (Vranka et al. 2004). Lack of 3-Hyp in Type I and II collagens leads to an osteogenesis imperfecta (OI)-like disease, as demonstrated by CRTAP and PPIB knock-out mice (Morello et al. 2006, Choi et al. 2009) and by mutations in human LEPRE1 (which encodes P3H1), CRTAP, and PPIB (Barnes et al. 2006, Cabral et al. 2007, van Dijk et al. 2009). The P3H1/CRTAP/CypB complex has also been shown to have chaperone activity (Ishikawa et al. 2009). P3H2 hydroxylates peptides derived from Type IV collagen more efficiently than Type I peptides and is localized to tissues that are rich in basement membrane (Tiainen et al. 2008). The effect of prolyl 3-hydroxylation on basement membrane collagens remains unknown.<br><br> In this generalized reaction, all collagen subtypes are represented as having one 3-Hyp residue. 19419969Pubmed2009Biochemical characterization of the prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B complexIshikawa, YWirz, JVranka, JANagata, KBächinger, HPJ Biol Chem 284:17641-73-540-23272-9ISBN2005Intracellular Post Translational Modifications of CollagensMyllyharju, JCollagen: primer in structure, processing and assembly (Book)17277775Pubmed2007Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfectaCabral, WAChang, WBarnes, AMWeis, MScott, MALeikin, SMakareeva, EKuznetsova, NVRosenbaum, KNTifft, CJBulas, DIKozma, CSmith, PAEyre, DRMarini, JCNat Genet 39:359-6519652424Pubmed2009Expression of prolyl 3-hydroxylase genes in embryonic and adult mouse tissuesVranka, JStadler, HSBächinger, HPCell Struct Funct 34:97-10412785781Pubmed2003Effect of 3-hydroxyproline residues on collagen stabilityJenkins, CLBretscher, LEGuzei, IARaines, RTJ Am Chem Soc 125:6422-717055431Pubmed2006CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfectaMorello, RBertin, TKChen, YHicks, JTonachini, LMonticone, MCastagnola, PRauch, FGlorieux, FHVranka, JBächinger, HPPace, JMSchwarze, UByers, PHWeis, MFernandes, RJEyre, DRYao, ZBoyce, BFLee, BCell 127:291-30419781681Pubmed2009PPIB mutations cause severe osteogenesis imperfectavan Dijk, FSNesbitt, IMZwikstra, EHNikkels, PGPiersma, SRFratantoni, SAJimenez, CRHuizer, MMorsman, ACCobben, JMvan Roij, MHElting, MWVerbeke, JIWijnaendts, LCShaw, NJHögler, WMcKeown, CSistermans, EADalton, AMeijers-Heijboer, HPals, GAm J Hum Genet 85:521-715044469Pubmed2004Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymesVranka, JASakai, LYBächinger, HPJ Biol Chem 279:23615-2119997487Pubmed2009Severe osteogenesis imperfecta in cyclophilin B-deficient miceChoi, JWSutor, SLLindquist, LEvans, GLMadden, BJBergen HR, 3rdHefferan, TEYaszemski, MJBram, RJPLoS Genet 5:e100075018487197Pubmed2008Characterization of recombinant human prolyl 3-hydroxylase isoenzyme 2, an enzyme modifying the basement membrane collagen IVTiainen, PPasanen, ASormunen, RMyllyharju, JJ Biol Chem 283:19432-96574478Pubmed1983Isolation and partial characterization of a new human collagen with an extended triple-helical structural domainBentz, HMorris, NPMurray, LWSakai, LYHollister, DWBurgeson, REProc Natl Acad Sci U S A 80:3168-726250440Pubmed1980Metabolism of proline and the hydroxyprolinesAdams, ElijahFrank, LeonardAnnu Rev Biochem 49:1005-61164442Pubmed1975Sequence position of 3-hydroxyproline in basement membrane collagen. Isolation of glycyl-3-hydroxyprolyl-4-hydroxyproline from swine kidneyGryder, RMLamon, MAdams, ElijahJ Biol Chem 250:2470-4194596Pubmed1976Separation of prolyl 3-hydroxylase and 4-hydroxylase activities and the 4-hydroxyproline requirement for synthesis of 3-hydroxyprolineTryggvason, KRisteli, JKivirikko, KIBiochem Biophys Res Commun 76:275-816210830Pubmed1982Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymesKivirikko, KIMyllylä, RMethods Enzymol 82:245-3044343807Pubmed1972The covalent structure of collagen. Amino-acid sequence of peptide 1-CB6-C2Fietzek, PPRexrodt, FWWendt, PStark, MKühn, KEur J Biochem 30:163-81992Hydroxylation of proline and lysine residues in collagens and other animal and plant proteins.Kivirikko, KIMyllylä, RPihlajaniemi, TPost-translational modification of proteins (Book): 1-5117192541Pubmed2006Deficiency of cartilage-associated protein in recessive lethal osteogenesis imperfectaBarnes, AMChang, WMorello, RCabral, WAWeis, MEyre, DRLeikin, SMakareeva, EKuznetsova, NUveges, TEAshok, AFlor, AWMulvihill, JJWilson, PLSundaram, UTLee, BMarini, JCN Engl J Med 355:2757-64687595Pubmed1978Physicochemical characterization and molecular organization of the collagen A and B chainsRhodes, RKMiller, EJBiochemistry 17:3442-819021759Pubmed2008Effect of the -Gly-3(S)-hydroxyprolyl-4(R)-hydroxyprolyl- tripeptide unit on the stability of collagen model peptidesMizuno, KPeyton, DHHayashi, TEngel, JBächinger, HPFEBS J 275:5830-4017630507Pubmed2007Components of the collagen prolyl 3-hydroxylation complex are crucial for normal bone developmentMarini, JCCabral, WABarnes, AMChang, WCell Cycle 6:1675-8119940144Pubmed2010Location of 3-hydroxyproline residues in collagen types I, II, III, and V/XI implies a role in fibril supramolecular assemblyWeis, MAHudson, DMKim, LScott, MWu, JJEyre, DRJ Biol Chem 285:2580-90inferred from electronic annotationEVIDENCE CODEECO:0000203