BioPAX pathway converted from "Beta-catenin recruits TRRAP/KAT5 HAT components" in the Reactome database.LEFT-TO-RIGHTBeta-catenin recruits TRRAP/KAT5 HAT componentsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>RUVBL1RUVBL1E2RQC9Reactome DB_ID: 9967636nucleoplasmGENE ONTOLOGYGO:0005654UniProt:E2RQC9RUVBL1Canis familiarisNCBI Taxonomy9615UniProtE2RQC91EQUAL456EQUALReactome Database ID Release 759967636Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967636ReactomeR-CFA-4183231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-418323.1Reactomehttp://www.reactome.orgTCF/LEF:CTNNB1Reactome DB_ID: 9951809CTNNB1CTNNB1B6V8E6Reactome DB_ID: 9951676UniProt:B6V8E6CTNNB1UniProtB6V8E61EQUAL781EQUALReactome Database ID Release 759951676Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9951676ReactomeR-CFA-34511681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3451168.11Converted from EntitySet in ReactomeTCF/LEFReactome DB_ID: 9951807TCF7L2TCF7L2E2QXK1Reactome DB_ID: 9951793UniProt:E2QXK1TCF7L2UniProtE2QXK11EQUAL619EQUALReactome Database ID Release 759951793Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9951793ReactomeR-CFA-2019231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-201923.1LEF1LEF1F1Q334Reactome DB_ID: 9951797UniProt:F1Q334LEF1UniProtF1Q3341EQUAL399EQUALReactome Database ID Release 759951797Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9951797ReactomeR-CFA-32149721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3214972.1TCF7TCF7E2RRW8Reactome DB_ID: 9951801UniProt:E2RRW8TCF7UniProtE2RRW81EQUAL384EQUALReactome Database ID Release 759951801Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9951801ReactomeR-CFA-32995431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3299543.1TCF7L1TCF7L1F1PX33Reactome DB_ID: 9951805UniProt:F1PX33TCF7L1UniProtF1PX331EQUAL598EQUALReactome Database ID Release 759951805Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9951805ReactomeR-CFA-52286491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5228649.1Reactome Database ID Release 759951807Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9951807ReactomeR-CFA-32995461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3299546.11Reactome Database ID Release 759951809Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9951809ReactomeR-CFA-32995481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3299548.1TRRAPTRRAPE2RJS8Reactome DB_ID: 9990946UniProt:E2RJS8TRRAPUniProtE2RJS81EQUAL3859EQUALReactome Database ID Release 759990946Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9990946ReactomeR-CFA-33229511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3322951.1KAT5KAT5E2RE71Reactome DB_ID: 9934539UniProt:E2RE71KAT5UniProtE2RE711EQUAL513EQUALReactome Database ID Release 759934539Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9934539ReactomeR-CFA-33219791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3321979.1TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5Reactome DB_ID: 99909481111Reactome Database ID Release 759990948Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9990948ReactomeR-CFA-34511291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3451129.1Reactome Database ID Release 759990950Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9990950ReactomeR-CFA-34511531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3451153.1Pulldown experiments in colorectal cancer cells show an interaction between the C-terminal region of beta-catenin (ARM domains 11 and 12 through the C terminal) with a number of TRRAP-KAT5 HAT complex members including TRRAP, TIP49, p400 and KAT5 (TIP60), among others (Sierra et al, 2006; Bauer et al, 1998; Bauer et al, 2000; Feng et al, 2003). KAT5 and TIP49 have been shown to directly regulate WNT target genes in vivo and are associated with increased H4 acetylation (Bauer et al, 2000; Feng et al, 2003; Kim et al, 2005).9843967Pubmed1998Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding proteinBauer, AHuber, OtmarKemler, RolfProc. Natl. Acad. Sci. U.S.A. 95:14787-9214695187Pubmed2003TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodelingFeng, YingLee, NanaFearon, Eric RCancer Res. 63:8726-3411080158Pubmed2000Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activityBauer, AChauvet, SophieHuber, OtmarUsseglio, FabriceRothbächer, UteAragnol, DeniseKemler, RolfPradel, JacquesEMBO J. 19:6121-3016510874Pubmed2006The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genesSierra, JoseYoshida, TomonoriJoazeiro, Claudio AJones, Katherine AGenes Dev. 20:586-60015829968Pubmed2005Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexesKim, Jung HwaKim, BogyouCai, LingChoi, Hee JuneOhgi, Kenneth ATran, ChrisChen, CharlieChung, Chin HaHuber, OtmarRose, David WSawyers, Charles LRosenfeld, Michael GBaek, Sung HeeNature 434:921-6inferred from electronic annotationEVIDENCE CODEECO:0000203