BioPAX pathway converted from "GGPS1 hexamer transfers IPPP to DMAPP" in the Reactome database. LEFT-TO-RIGHT 2.5.1.1 GGPS1 hexamer transfers IPPP to DMAPP Addition of isopentenyl pyrophosphate to DMAPP This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> IPPP delta3-isopentenyl-PP isopentenyl diphosphate delta3-isopentenyl pyrophosphate Reactome DB_ID: 191362 cytosol GENE ONTOLOGY GO:0005829 isopentenyl diphosphate [ChEBI:16584] isopentenyl diphosphate ChEBI CHEBI:16584 Reactome Database ID Release 81 191362 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191362 Reactome R-ALL-191362 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-191362.3 Reactome http://www.reactome.org COMPOUND C00129 additional information MI MI:0361 DMAPP Dimethylallyl pyrophosphate prenyl diphosphate Reactome DB_ID: 191324 prenyl diphosphate [ChEBI:16057] prenyl diphosphate ChEBI CHEBI:16057 Reactome Database ID Release 81 191324 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191324 Reactome R-ALL-191324 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-191324.3 COMPOUND C00235 GPP Geranyl pyrophosphate geranyl diphosphate Reactome DB_ID: 191409 geranyl diphosphate [ChEBI:17211] geranyl diphosphate ChEBI CHEBI:17211 Reactome Database ID Release 81 191409 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191409 Reactome R-ALL-191409 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-191409.3 COMPOUND C00341 PPi pyrophosphate diphosphoric acid pyrophosphoric acid diphosphate Reactome DB_ID: 111294 diphosphate(3-) [ChEBI:33019] diphosphate(3-) ChEBI CHEBI:33019 Reactome Database ID Release 81 111294 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111294 Reactome R-ALL-111294 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-111294.4 COMPOUND C00013 ACTIVATION holo-GGPS1 hexamer Reactome DB_ID: 9991333 GGPS1:3Mg2+ Reactome DB_ID: 9991331 Mg2+ Magnesium magnesium(2+) Mg++ Reactome DB_ID: 29926 magnesium(2+) [ChEBI:18420] magnesium(2+) ChEBI CHEBI:18420 Reactome Database ID Release 81 29926 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29926 Reactome R-ALL-29926 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29926.5 COMPOUND C00305 3 Ggps1 GGPS1 Q6F596 Reactome DB_ID: 9991329 UniProt:Q6F596 Ggps1 Rattus norvegicus NCBI Taxonomy 10116 UniProt Q6F596 1 EQUAL 300 EQUAL Reactome Database ID Release 81 9991329 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9991329 Reactome R-RNO-191415 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-191415.1 1 Reactome Database ID Release 81 9991331 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9991331 Reactome R-RNO-981557 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-981557.1 6 Reactome Database ID Release 81 9991333 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9991333 Reactome R-RNO-981569 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-981569.1 GENE ONTOLOGY GO:0004161 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 81 9991337 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9991337 Reactome Database ID Release 81 9991339 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9991339 Reactome R-RNO-9717834 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-9717834.1 The family of enzymes called prenyltransferases is involved in the biosynthesis of isoprenoids. Two members of this family are known to catalyse the sequential condensation of isopentenyl pyrophosphate (IPPP) to DMAPP: farnesyl pyrophosphate synthase dimer (FPPS dimer) and geranylgeranyl pyrophosphate synthetase hexamer (GGPPS hexamer) (Kavanaugh et al, 2006). Both enzymes utlise Mg2+ as cofactor (Chang et al. 2021). 16684881 Pubmed 2006 The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs Kavanagh, KL Guo, K Dunford, JE Wu, X Knapp, S Ebetino, FH Rogers, MJ Russell, RG Oppermann, U Proc Natl Acad Sci U S A 103:7829-34 10026212 Pubmed 1999 Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. Kuzuguchi, T Morita, Y Sagami, I Sagami, H Ogura, K J Biol Chem 274:5888-94 9741684 Pubmed 1998 Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression Ericsson, J Greene, JM Carter, KC Shell, BK Duan, DR Florence, C Edwards, PA J Lipid Res 39:1731-9 33246356 Pubmed 2021 Structure, catalysis, and inhibition mechanism of prenyltransferase Chang, Hsin-Yang Cheng, Tien-Hsing Wang, Andrew H-J IUBMB Life 73:40-63 inferred from electronic annotation EVIDENCE CODE ECO:0000203