Reactome is a free, online, open-source, curated resource of core pathways and reactions in human biology. Information is authored by expert biological researchers, maintained by the Reactome editorial staff and cross-referenced to the NCBI Entrez Gene, Ensembl and UniProt databases, the UCSC and HapMap Genome Browsers, the KEGG Compound and ChEBI small molecule databases, PubMed, and GO. The curated human data are used to infer orthologous events in 22 non-human species including mouse, rat, chicken, puffer fish, worm, fly, yeast, two plants and E.coli. Tools for data analysis include Skypainter and Biomart. A description of Reactome has been published in Genome Biology and Nucleic Acids Research.
Protein-protein interaction datasets, statistics and the editorial calendar are available. The Reactome team thanks users for their comments on the pathway visualization tool.
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