In version V57, topics with new or revised pathways include: Developmental biology (RET signaling), Disease (Signaling by FGFR in disease and Defective CFTR causes cystic fibrosis), Gene expression (rRNA modification in the mitochondrion and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors), Immune system (ER-Phagosome pathway, Interleukin-7 signaling, Regulation by endogenous TLR ligand, and TCR signaling), Metabolism (Lipid digestion, mobilization, and transport and Phosphate bond hydrolysis by NTPDase proteins). Metabolism of proteins (Deubiquitination), Neuronal system (Interactions of neurexins and neuroligins at synapses and SALM protein interactions at synapse). Signal transduction (EGFR downregulation, Signaling by FGFR1, and FGFRL1 modulation of FGFR1 signaling), Transmembrane transport of small molecules (ABC-family proteins mediated transport) and Vesicle-mediated transport (Clathrin-mediated endocytosis).
Our external author is Alba Sanchis. Costin Antonescu, John Bergeron, Daniel Bogenhagen, Nunzio Bottini, Guang-Chao Chen, Igor Dawid, Regina Fluhrer, Noriko Gotoh, Francesca Granucci, Richard Grose, Paul Heppenstall, Jing Hu, Jan Huertas, Wenqin Luo, Malay Mandal, Birgit Meldal, Daniel Morales, Tatsunori Nishimura, Ronald Petralia, Gail Seabold, Sunny Sharma, Stephanie Stanford, Jean Sévigny, Philip Washbourne, Ivan Zanoni, and Valeria Zarelli are our external reviewers.