Reactome: A Curated Pathway Database

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Pathways reviewed by Widlak, Piotr (141904)

DB_ID Name
140342 Apoptosis induced DNA fragmentation
211227 Activation of DNA fragmentation factor

Details on Person Widlak, Piotr

_displayNameWidlak, Piotr
_timestamp2017-08-22 20:37:39
affiliation[Affiliation:1243093] Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
modified[InstanceEdit:1243092] D'Eustachio, P, 2011-03-31
[InstanceEdit:8932050] D'Eustachio, Peter, 2016-07-20
(author)[InstanceEdit:266205] Widlak, P, 2008-04-25 14:11:44
[InstanceEdit:349495] Widlak, P, 2008-05-07 23:54:18
[LiteratureReference:211197] Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1
[LiteratureReference:211244] The histone H1 C-terminal domain binds to the apoptotic nuclease, DNA fragmentation factor (DFF40/CAD) and stimulates DNA cleavage
[LiteratureReference:266155] Discovery, regulation, and action of the major apoptotic nucleases DFF40/CAD and endonuclease G
[LiteratureReference:266156] Subunit structures and stoichiometries of human DNA fragmentation factor proteins before and after induction of apoptosis
[LiteratureReference:266220] The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis
[LiteratureReference:350295] The major apoptotic endonuclease DFF40/CAD is a deoxyribose-specific and double-strand-specific enzyme
[LiteratureReference:350299] Cleavage preferences of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease) on naked DNA and chromatin substrates
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