Reactome: A Curated Pathway Database

Query author contributions in Reactome

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Pathways reviewed by Silverman, N (207774)

DB_ID Name
209171 Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE
209266 Peptidoglycan bound PGRP-LC/LE oligomerises
209394 Transcriptional activtion and repression of REL-68 target genes
209397 Formation of the cytosolic BSK 'scaffolding complex'
209400 Transcriptional activtion by phosphorylated DL/DIF dimer
209406 Degradation of NF-kappa-B inhibitor, CACT
209409 Formation of the nuclear AP-1 transcription factor 'scaffolding complex'
209425 Transcriptional activtion by AP-1 transcription factor
209438 Formation of the PGN:PGRP-LC/LE receptor 'signalling complex'
209442 Formation of the trans-membrane 'signalling complex'
209447 Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY
209449 Toll pathway
209459 Imd pathway
209465 Catalytic processing of the nuclear factor, REL
209478 Dephosphorylation of BSK
214399 Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'
214397 Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'
214411 REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'
214416 Phosphorylated REL is cleaved by and dissociates from DREDD
214842 DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'
214844 DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'
214863 Adaptor protein complex binds to TL receptor at the plasma membrane
214862 Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'
214869 Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'
214874 PLL kinase binds to TUB in the TL receptor 'signalling complex'

Details on Person Silverman, N

_displayNameSilverman, N
_timestamp2017-08-22 20:38:59
created[InstanceEdit:205654] Williams, MG, 2007-07-12 09:20:19
crossReference[DatabaseIdentifier:5662807] ORCID:0000-0002-4259-456X
modified[InstanceEdit:5662814] Matthews, Lisa, 2015-01-13
(author)[LiteratureReference:208034] A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity
[LiteratureReference:208086] Caspase-mediated processing of the Drosophila NF-kappaB factor Relish
[LiteratureReference:208094] The role of ubiquitination in Drosophila innate immunity
[LiteratureReference:208121] Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway
[LiteratureReference:208161] Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins
[LiteratureReference:208216] Bacterial recognition and signalling by the Drosophila IMD pathway
[LiteratureReference:208221] PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan
[LiteratureReference:208348] Immune activation of NF-kappaB and JNK requires Drosophila TAK1
[LiteratureReference:214914] Role of Drosophila IKK gamma in a toll-independent antibacterial immune response
[InstanceEdit:386956] Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
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