Reactome: A Curated Pathway Database

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Pathways reviewed by Lopez, Angel (450033)

DB_ID Name
512988 Interleukin-3, 5 and GM-CSF signaling
912631 Regulation of signaling by CBL

Details on Person Lopez, Angel

_displayNameLopez, Angel
_timestamp2017-08-22 20:42:05
created[InstanceEdit:450083] Jupe, S, 2009-12-11
modified[InstanceEdit:941871] Jupe, S, 2010-09-06
[InstanceEdit:8932050] D'Eustachio, Peter, 2016-07-20
(author)[LiteratureReference:450043] Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding
[LiteratureReference:879903] The structural and functional basis of cytokine receptor activation: lessons from the common beta subunit of the granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 receptors
[LiteratureReference:879924] Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors
[LiteratureReference:893513] Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors
[LiteratureReference:913385] The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation
[LiteratureReference:913396] Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF
[LiteratureReference:913402] The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-kappaB and induction of bcl-2
[LiteratureReference:914172] Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival
[LiteratureReference:914184] The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease
[InstanceEdit:941869] Lopez, AF, 2010-09-06
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