Reactome: A Curated Pathway Database

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Pathways reviewed by Leppla, Stephen H (5205698)

DB_ID Name
5210891 Uptake and function of anthrax toxins

Details on Person Leppla, Stephen H

Class:IdPerson:5205698
_displayNameLeppla, Stephen H
_timestamp2017-08-22 20:45:31
affiliation[Affiliation:5490364] National Institutes of Health,National Institute of Allergy and Infectious Diseases
created[InstanceEdit:5205725] D'Eustachio, Peter, 2013-12-05
firstnameStephen H
initialSH
modified[InstanceEdit:5490365] D'Eustachio, Peter, 2014-05-19
surnameLeppla
(author)[InstanceEdit:5490366] Leppla, Stephen H, 2014-05-19
[LiteratureReference:874007] Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome
[LiteratureReference:5205695] Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase
[LiteratureReference:5205696] Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen
[LiteratureReference:5205714] Crystal structure of the anthrax toxin protective antigen
[LiteratureReference:5205729] Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin
[LiteratureReference:5209988] Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization
[LiteratureReference:5209992] Crystal structure of a complex between anthrax toxin and its host cell receptor
[LiteratureReference:5210014] The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin
[LiteratureReference:5211226] Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells
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