Reactome: A Curated Pathway Database

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Name Email address

Pathways authored by Borowiec, James A (69375)

DB_ID Name
176187 Activation of ATR in response to replication stress

Pathways reviewed by Borowiec, James A (69375)

DB_ID Name
217106 Chk1-controlled and DNA-damage induced centrosome duplication
265976 Homologous DNA pairing and strand exchange
351433 ATM mediated phosphorylation of repair proteins
351444 Recruitment of repair and signaling proteins to double-strand breaks
351442 ATM mediated response to DNA double-strand break
351451 Homologous recombination repair of replication-dependent double-strand breaks
351468 Processing of DNA double-strand break ends
351470 Homologous recombination repair (HRR) of replication-independent double-strand breaks
351465 Fanconi Anemia Pathway in DNA repair
353239 DNA Damage Reversal
353234 Base Excision Repair, AP site formation
353248 DNA damage recognition in global genomic repair
353295 Homologous recombination repair
353303 Nucleotide Excision Repair
353299 RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases
353357 Base Excision Repair
353371 Double strand break repair
353382 Translesion synthesis by Pol eta
353377 DNA repair
353423 Non-homologous end joining (NHEJ)
353416 Resolution of Abasic Sites (AP sites)
353446 Depyrimidination
353473 Translesion synthesis by Pol zeta
353488 DNA damage bypass
353503 Translesion synthesis by Pol kappa
353496 Translesion synthesis by DNA polymerases bypassing lesion on DNA template
73893 DNA Damage Bypass
110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
110312 Translesion synthesis by REV1
110314 Recognition of DNA damage by PCNA-containing replication complex
110320 Translesion Synthesis by POLH
5655862 Translesion synthesis by POLK
5656169 Termination of translesion DNA synthesis
5656121 Translesion synthesis by POLI
73884 Base Excision Repair
73927 Depurination
73929 Base-Excision Repair, AP Site Formation
73928 Depyrimidination
73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
73933 Resolution of Abasic Sites (AP sites)
110329 Cleavage of the damaged pyrimidine
110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine
110331 Cleavage of the damaged purine
110330 Recognition and association of DNA glycosylase with site containing an affected purine
110357 Displacement of DNA glycosylase by APEX1
110362 POLB-Dependent Long Patch Base Excision Repair
110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
110381 Resolution of AP sites via the single-nucleotide replacement pathway
5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
5651801 PCNA-Dependent Long Patch Base Excision Repair
5685942 HDR through Homologous Recombination (HRR)
5685938 HDR through Single Strand Annealing (SSA)
5685939 HDR through MMEJ (alt-NHEJ)
5693532 DNA Double-Strand Break Repair
5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
5693538 Homology Directed Repair
5693537 Resolution of D-Loop Structures
5693548 Sensing of DNA Double Strand Breaks
5693571 Nonhomologous End-Joining (NHEJ)
5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
5693579 Homologous DNA Pairing and Strand Exchange
5693616 Presynaptic phase of homologous DNA pairing and strand exchange
5693606 DNA Double Strand Break Response
5693607 Processing of DNA double-strand break ends

Details on Person Borowiec, James A

_displayNameBorowiec, James A
_timestamp2017-08-22 20:36:38
affiliation[Affiliation:69324] NYU School of Medicine, Department of Biochemistry
firstnameJames A
modified[InstanceEdit:176246] D'Eustachio, P, 2006-03-03 16:44:08
[InstanceEdit:5663081] Orlic-Milacic, Marija, 2015-01-15
[InstanceEdit:6793048] Matthews, Lisa, 2015-08-28
[InstanceEdit:6797374] Orlic-Milacic, Marija, 2015-09-09
(author)[LiteratureReference:69372] Replication protein A (RPA): the eukaryotic SSB.
[LiteratureReference:176266] Human replication protein A binds single-stranded DNA in two distinct complexes
[LiteratureReference:391632] Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair
[LiteratureReference:5685175] Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery
[LiteratureReference:5687752] A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
[InstanceEdit:176227] Borowiec, JA, 2006-02-25 17:40:15
[InstanceEdit:176977] Borowiec, JA, Tye, BK, Mendez, J, Aladjem, M, 2005-09-07
[InstanceEdit:418616] Borowiec, JA, 2009-04-23 20:19:22
[InstanceEdit:5663080] Borowiec, James, 2015-01-07
[InstanceEdit:5673689] Borowiec, James, 2014-12-22
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