Reactome: Thiamin diphosphate [mitochondrial matrix]

Details

Participates in processes
Name	Thiamin diphosphate Thiamine diphosphate Thiamin pyrophosphate TPP ThPP
Stable identifier	REACT_2518.2
Reference entity	Thiamin diphosphate [ChEBI:18290]
Links to compound in external databases	ChEBI:18290 COMPOUND:C00068 PubChem Substance:8143825
Cellular compartment	mitochondrial matrix GO
Component of	pyruvate dehydrogenase E1 complex [mitochondrial matrix] alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] branched-chain alpha-ketoacid dehydrogenase E1 complex [mitochondrial matrix] phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] branched-chain alpha-ketoacid dehydrogenase E1 complex (name copied from entity in Homo sapiens) [mitochondrial matrix] alpha-ketoglutarate dehydrogenase E1 holoenzyme (name copied from entity in Homo sapiens) [mitochondrial matrix] pyruvate dehydrogenase E1 complex (name copied from entity in Homo sapiens) [mitochondrial matrix] phosphorylated pyruvate dehydrogenase E1 complex (name copied from entity in Homo sapiens) [mitochondrial matrix] branched-chain alpha-ketoacid dehydrogenase E1 complex (name copied from entity in Homo sapiens) [mitochondrial matrix] alpha-ketoglutarate dehydrogenase E1 holoenzyme (name copied from entity in Homo sapiens) [mitochondrial matrix] ... List all 150 items
Pyruvate metabolism and Citric Acid (TCA) cycle - Pyruvate metabolism - pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+ [Homo sapiens] - Regulation of pyruvate dehydrogenase (PDH) complex - PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit [Homo sapiens] - PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit [Homo sapiens] - Citric acid cycle (TCA cycle) - alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ [Homo sapiens] Metabolism of amino acids and derivatives - Branched-chain amino acid catabolism - a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+ [Homo sapiens] - Lysine catabolism - alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ [Homo sapiens]
Other forms of this molecule	Thiamin pyrophosphate [peroxisomal matrix] Thiamin diphosphate [intracellular]

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