Reactome: Release of Cytochrome c from mitochondria

Release of Cytochrome c from mitochondria [Homo sapiens]

Reactionmap

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Diagram

Details

References
Release of Cytochrome c from mitochondria
Stable identifier	REACT_535.3
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In this reaction, 1 molecule of 'Cytochrome c' is translocated from mitochondrial intermembrane space to cytosol. This reaction takes place in the 'mitochondrial outer membrane'.
Input (present at start of reaction)	Cytochrome c [mitochondrial intermembrane space] U K E G B C d O R H U R P
Output (present at end of reaction)	Cytochrome c [cytosol] U K E G B C d O R H U R P
Preceding event(s)	Oligomerization of BAK at the mitochondrial membrane [Homo sapiens] Oligomerization of BAX at the mitochondrial membrane [Homo sapiens] Translocation of tBID to mitochondria [Homo sapiens] Association of Vpr with ANT1 [Homo sapiens, Human immunodeficiency virus 1]
Following event(s)	Formation of apoptosome [Homo sapiens] Cytochrome c-mediated apoptotic response [Homo sapiens]
Organism	Homo sapiens
Cellular compartment	mitochondrial outer membrane GO
Arnoult, D, Gaume, B, Karbowski, M, Sharpe, JC, Cecconi, F, Youle, RJ Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. 2003 EMBO J PubMed Song, Z, Yao, X, Wu, M Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. 2003 J Biol Chem PubMed
Equivalent event(s) in other organism(s)	Release of Cytochrome c from mitochondria [Gallus gallus] Release of Cytochrome c from mitochondria [Taeniopygia guttata] Release of Cytochrome c from mitochondria [Xenopus tropicalis] Release of Cytochrome c from mitochondria [Caenorhabditis elegans] Release of Cytochrome c from mitochondria [Arabidopsis thaliana] Release of Cytochrome c from mitochondria [Oryza sativa] Release of Cytochrome c from mitochondria [Dictyostelium discoideum] Release of Cytochrome c from mitochondria [Saccharomyces cerevisiae] Release of Cytochrome c from mitochondria [Schizosaccharomyces pombe] Release of Cytochrome c from mitochondria [Plasmodium falciparum]
Participating molecules
Cytochrome c [cytosol] U K E G B C d O R H U R P Cytochrome c [mitochondrial intermembrane space] U K E G B C d O R H U R P

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