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Details
IdentifierUniProt:Q13485
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Mothers against decapentaplegic homolog 4 shortName:MAD homolog 4 shortName:Mothers against DPP homolog 4 alternativeName: Deletion target in pancreatic carcinoma 4 alternativeName: SMAD family member 4 shortName:SMAD 4 shortName:Smad4 shortName:hSMAD4
Links to corresponding entries in other databasesBioGPS Gene:4089
CTD Gene:4089
DOCK Blaster:1DD1
DOCK Blaster:1G88
DOCK Blaster:1MR1
DOCK Blaster:1U7F
DOCK Blaster:1U7V
DOCK Blaster:1YGS
ENSEMBL:ENSG00000141646
GeneCards:Q13485
HapMap:NM_005359
KEGG Gene:4089
NCBI Gene:4089
OMIM:174900
OMIM:175050
OMIM:260350
OMIM:600993
Protein Data Bank:1DD1
Protein Data Bank:1G88
Protein Data Bank:1MR1
Protein Data Bank:1U7F
Protein Data Bank:1U7V
Protein Data Bank:1YGS
RefSeq:NM_005359
RefSeq:NP_005350
UCSC human:Q13485
UniProt:Q13485
dbSNP Gene:4089
Other identifiers related to this sequenceSMAD4_HUMAN, A8K405, ENSG00000141646, ENST00000342988, ENSP00000341551, ENST00000398417, ENSP00000381452, 509_at, 510_g_at, 202527_s_at, 202526_at, 235725_at, 36953_at, 46885_at, 57902_at, 58962_at, 74813_at, U44378_at, Hs.75862.0.S2_3p_at, g4885456_3p_a_at, Hs.50438.0.A1_3p_at, A_14_P134632, A_23_P27346, CCDS11950, GE59174, GE769362, GE887174, AB043547, AF045447, AF045438, AF045439, AF045440, AF045441, AF045442, AF045443, AF045444, AF045445, AF045446, U44378, BC002379, EntrezGene:4089, GI_34147555-S, ILMN_20018, IPI00013404, IPI00644112, MIM:600993, MIM:174900, MIM:175050, MIM:260350, OTTHUMP00000163548, OTTHUMT00000255993, 1MR1, 1U7V, 1U7F, 1DD1, 1G88, 1YGS, BAB40977, AAC03051, AAA91041, AAH02379, NM_005359, NP_005350, Hs.610854, Hs.621831, Hs.628328, Q9BYG6, Q13485, Q9BYG6_HUMAN, SMAD4_HUMAN, IPR001132, IPR003619, IPR013019
Molecules with this sequenceSMAD4 [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 [nucleoplasm] UKENBCdOOOORHGURPPPPPPDDDDDD
RibC-SMAD4 [nucleoplasm] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 D351H [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 D351G [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 D351Y [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 D351del [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 R361C [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 R361H [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 P356L [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 P356R [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 R361G [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 R361S [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 K428R [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 A406T [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 K428T [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 R515T [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
SMAD4 R515* [cytosol] UKENBCdOOOORHGURPPPPPPDDDDDD
Component ofp-2S-SMAD2/3:SMAD4 [cytosol]
p-2S-SMAD1/5/8:SMAD4 [cytosol]
Ub-SMAD4 [cytosol]
Ub-SMAD4:USP9X [cytosol]
p-2S-SMAD2/3:SMAD4 [nucleoplasm]
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm]
p-2S-SMAD1/5/8:SMAD4:SKI [nucleoplasm]
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm]
SMAD4:p-SMAD2:p-SMAD2 [nucleoplasm]
Ub-SMAD4 [nucleoplasm]
...
List all 30 items
Represented by generalisation(s)SMAD4 MH2 domain mutants [cytosol]
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Ubiquitination of SKI/SKIL by Rnf11 [Homo sapiens]

Gene Expression

Rnf111 binds SKI/SKIL in complex with SMAD2/3:SMAD4 upon TGF-beta stimulation [Homo sapiens]

Developmental Biology

Disease

Modifications in molecules with this sequenceadenosine diphosphoribosyl (ADP-ribosyl) modified residue at unknown position
L-aspartic acid residue 351 replaced with glycine
L-aspartic acid residue 351 replaced with L-histidine
Deletion of residues 351 to 351
L-aspartic acid residue 351 replaced with L-tyrosine
L-proline residue 356 replaced with L-leucine
L-proline residue 356 replaced with L-arginine
L-arginine residue 361 replaced with L-histidine
L-arginine residue 361 replaced with L-cysteine
L-arginine residue 361 replaced with glycine
L-arginine residue 361 replaced with L-serine
L-lysine residue 428 replaced with L-threonine
L-lysine residue 428 replaced with L-arginine
L-alanine residue 406 replaced with L-threonine
L-arginine residue 515 replaced with L-threonine
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