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Details
IdentifierUniProt:Q13485
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Mothers against decapentaplegic homolog 4 shortName:MAD homolog 4 shortName:Mothers against DPP homolog 4 alternativeName: Deletion target in pancreatic carcinoma 4 alternativeName: SMAD family member 4 shortName:SMAD 4 shortName:Smad4 shortName:hSMAD4
Links to corresponding entries in other databasesBioGPS Gene:4089
CTD Gene:4089
DOCK Blaster:1DD1
DOCK Blaster:1G88
DOCK Blaster:1MR1
DOCK Blaster:1U7F
DOCK Blaster:1U7V
DOCK Blaster:1YGS
ENSEMBL:ENSG00000141646
GeneCards:Q13485
HapMap:NM_005359
KEGG Gene:4089
NCBI Gene:4089
OMIM:174900
OMIM:175050
OMIM:260350
OMIM:600993
Orphanet:15524
PRO:Q13485
Protein Data Bank:1DD1
Protein Data Bank:1G88
Protein Data Bank:1MR1
Protein Data Bank:1U7F
Protein Data Bank:1U7V
Protein Data Bank:1YGS
RefSeq:NM_005359
RefSeq:NP_005350
UCSC human:Q13485
UniProt:Q13485
dbSNP Gene:4089
Other identifiers related to this sequenceSMAD4_HUMAN, A8K405, 3788350, IPR008984, MIM:175050, AB043547, 3788346, SMAD4-001, 3788318, EAW62985, 1YGS, 510_g_at, 1G88, Hs.75862, 3788330, 3788320, AK290770, 46885_at, 8021228, 11725360_a_at, MIM:139210, UPI0000053431, K7ENG1, MIM:174900, 11750827_a_at, EntrezGene:4089, Hs.707908, Hs.75862.0.S2_3p_at, HGNC:6770, OTTHUMP00000163548, 202526_at, 3788347, AAC03051, IPR013019, 202527_s_at, SM00523, A_23_P27346, g4885456_3p_a_at, 3788351, Hs.610854, A_19_P00812250, 11744679_a_at, LRG_318, BAF83459, K7EL15, ENSP00000381452, 3788357, 11725363_s_at, 58962_at, 3788353, 509_at, AF045441, Q9BYG6, 3788349, IPR001132, Hs.50438.0.A1_3p_at, U44378_at, BAB40977, 11725361_s_at, AAA91041, MIM:114500, AF045442, AF045438, 3788337, SMAD4, MIM:260350, 4089, HPA019154, 8553070, AF045443, 1U7V, 3788328, AF045445, 1DD1, 3788344, AC087687, 36953_at, AF045440, A_19_P00804817, 16852354, AAH02379, 3788315, ILMN_1842785, K7ENG8, AF045446, 3788359, 3788348, 8774881, ENSG00000141646, 235725_at, K7EL18, A_19_P00323665, 1MR1, 57902_at, 11753117_a_at, PF03166, ILMN_1741477, Hs.621831, 1U7F, PH_hs_0004380, 11725362_x_at, K7EIJ2, NM_005359, SM00524, 3788324, 3788358, AF045447, AC091551, CCDS11950, AF045444, uc010xdp.2, GE59174, PF03165, 3788355, 0000540341, 3788335, CH471096, MIM:600993, 3788327, AF045439, 74813_at, 3788316, U44378, A_14_P134632, IPR003619, CAB002312, GE887174, BC002379, NP_005350, ENSP00000341551, 3788308, 3788304, 3788305, SMAD4-201, 3788306, ENST00000342988, 3788307, LRG_318t1
Molecules with this sequenceSMAD4 [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 [nucleoplasm] UKENBCdOOOOORHPGPPPPPPURDDDDDD
RibC-SMAD4 [nucleoplasm] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 D351H [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 D351G [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 D351Y [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 D351del [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 R361C [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 R361H [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 P356L [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 P356R [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 R361G [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 R361S [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 K428R [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 A406T [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 K428T [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 R515T [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
SMAD4 R515* [cytosol] UKENBCdOOOOORHPGPPPPPPURDDDDDD
Component ofp-2S-SMAD2/3:SMAD4 [cytosol]
p-2S-SMAD1/5/8:SMAD4 [cytosol]
Ub-SMAD4 [cytosol]
Ub-SMAD4:USP9X [cytosol]
p-2S-SMAD2/3:SMAD4 [nucleoplasm]
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm]
p-2S-SMAD1/5/8:SMAD4:SKI [nucleoplasm]
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm]
SMAD4:p-SMAD2:p-SMAD2 [nucleoplasm]
Ub-SMAD4 [nucleoplasm]
...
List all 30 items
Represented by generalisation(s)SMAD4 MH2 domain mutants [cytosol]
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Ubiquitination of SKI/SKIL by Rnf11 [Homo sapiens]

Gene Expression

Rnf111 binds SKI/SKIL in complex with SMAD2/3:SMAD4 upon TGF-beta stimulation [Homo sapiens]

Developmental Biology

Disease

Modifications in molecules with this sequenceadenosine diphosphoribosyl (ADP-ribosyl) modified residue at unknown position
L-aspartic acid residue 351 replaced with glycine
L-aspartic acid residue 351 replaced with L-histidine
Deletion of residues 351 to 351
L-aspartic acid residue 351 replaced with L-tyrosine
L-proline residue 356 replaced with L-leucine
L-proline residue 356 replaced with L-arginine
L-arginine residue 361 replaced with L-histidine
L-arginine residue 361 replaced with L-cysteine
L-arginine residue 361 replaced with glycine
L-arginine residue 361 replaced with L-serine
L-lysine residue 428 replaced with L-threonine
L-lysine residue 428 replaced with L-arginine
L-alanine residue 406 replaced with L-threonine
L-arginine residue 515 replaced with L-threonine
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