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Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P05067
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Amyloid beta A4 protein alternativeName: ABPP alternativeName: APPI shortName:APP alternativeName: Alzheimer disease amyloid protein alternativeName: Cerebral vascular amyloid peptide shortName:CVAP alternativeName: PreA4 alternativeName: Protease nexin-II shortName:PN-II component recommendedName: N-APP /component component recommendedName: Soluble APP-alpha shortName:S-APP-alpha /component component recommendedName: Soluble APP-beta shortName:S-APP-beta /component component recommendedName: C99 /component component recommendedName: Beta-amyloid protein 42 alternativeName: Beta-APP42 /component component recommendedName: Beta-amyloid protein 40 alternativeName: Beta-APP40 /component component recommendedName: C83 /component component recommendedName: P3(42) /component component recommendedName: P3(40) /component component recommendedName: C80 /component component recommendedName: Gamma-secretase C-terminal fragment 59 alternativeName: Amyloid intracellular domain 59 shortName:AICD-59 shortName:AID(59) alternativeName: Gamma-CTF(59) /component component recommendedName: Gamma-secretase C-terminal fragment 57 alternativeName: Amyloid intracellular domain 57 shortName:AICD-57 shortName:AID(57) alternativeName: Gamma-CTF(57) /component component recommendedName: Gamma-secretase C-terminal fragment 50 alternativeName: Amyloid intracellular domain 50 shortName:AICD-50 shortName:AID(50) alternativeName: Gamma-CTF(50) /component component recommendedName: C31 /component
Links to corresponding entries in other databasesBioGPS Gene:351
CTD Gene:351
DOCK Blaster:1AAP
DOCK Blaster:1AMB
DOCK Blaster:1AMC
DOCK Blaster:1AML
DOCK Blaster:1BA4
DOCK Blaster:1BA6
DOCK Blaster:1BJB
DOCK Blaster:1BJC
DOCK Blaster:1BRC
DOCK Blaster:1CA0
DOCK Blaster:1HZ3
DOCK Blaster:1IYT
DOCK Blaster:1MWP
DOCK Blaster:1OWT
DOCK Blaster:1QCM
DOCK Blaster:1QWP
DOCK Blaster:1QXC
DOCK Blaster:1QYT
DOCK Blaster:1TAW
DOCK Blaster:1TKN
DOCK Blaster:1UO7
DOCK Blaster:1UO8
DOCK Blaster:1UOA
DOCK Blaster:1UOI
DOCK Blaster:1ZE7
DOCK Blaster:1ZE9
DOCK Blaster:1ZJD
DOCK Blaster:2BEG
DOCK Blaster:2BP4
ENSEMBL:ENSG00000142192
GeneCards:P05067
HapMap:NM_000484
KEGG Gene:351
NCBI Gene:351
OMIM:104300
OMIM:104760
OMIM:605714
OMIM:609065
Protein Data Bank:1AAP
Protein Data Bank:1AMB
Protein Data Bank:1AMC
Protein Data Bank:1AML
Protein Data Bank:1BA4
Protein Data Bank:1BA6
Protein Data Bank:1BJB
Protein Data Bank:1BJC
Protein Data Bank:1BRC
Protein Data Bank:1CA0
Protein Data Bank:1HZ3
Protein Data Bank:1IYT
Protein Data Bank:1MWP
Protein Data Bank:1OWT
Protein Data Bank:1QCM
Protein Data Bank:1QWP
Protein Data Bank:1QXC
Protein Data Bank:1QYT
Protein Data Bank:1TAW
Protein Data Bank:1TKN
Protein Data Bank:1UO7
Protein Data Bank:1UO8
Protein Data Bank:1UOA
Protein Data Bank:1UOI
Protein Data Bank:1ZE7
Protein Data Bank:1ZE9
Protein Data Bank:1ZJD
Protein Data Bank:2BEG
Protein Data Bank:2BP4
RefSeq:NM_000484
RefSeq:NP_000475
UCSC human:P05067
UniProt:P05067
dbSNP Gene:351
Other identifiers related to this sequenceA4_HUMAN, B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q6GSC0, Q8WZ99, Q9BT38, Q9UC33, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58, ENSG00000142192, ENST00000346798, ENSP00000284981, 200602_at, 214953_s_at, 211277_x_at, 41136_s_at, 64309_f_at, 92102_f_at, Y00264_at, 211277_3p_x_at, g4502166_3p_at, Hs.177486.2.A1_3p_a_at, g13325111_3p_at, g13325111_3p_x_at, A_24_P314159, A_32_P167000, A_23_P6216, A_32_P166995, CCDS13576, CCDS33523, CCDS13577, GE57419, BC065523, AB066441, Y00264, X13466, X13467, X13468, X13469, X13470, X13471, X13472, X13473, X13474, X13475, X13476, X13477, X13478, X13479, X13487, X13488, X06989, M33112, M34862, M34863, M34864, M34865, M34866, M34867, M34868, M34869, M34870, M34871, M34872, M34873, M34874, M34876, M34877, M34878, M34879, M34875, D87675, AY919674, BC004369, M35675, M24547, M24546, M28373, M16765, X06982, X06981, M18734, M29270, M29269, M15533, M15532, M37896, M37895, S45136, S60317, AF282245, S60721, S61380, S61383, BC065529, EntrezGene:351, GI_41406053-S, ILMN_23272, ILMN_30235, IPI00006608, IPI00412681, IPI00412924, IPI00219186, IPI00412568, IPI00394658, IPI00219182, MIM:104760, MIM:104300, MIM:605714, MIM:609065, 1AAP, 1AMB, 1AMC, 1AML, 1BA4, 1BA6, 1BJB, 1BJC, 1BRC, 1CA0, 1HZ3, 1IYT, 1MWP, 1OWT, 1QCM, 1QWP, 1QXC, 1QYT, 1TAW, 1TKN, 1UO7, 1UO8, 1UOA, 1UOI, 1ZE7, 1ZE9, 1ZJD, 2BEG, 2BP4, AAH65523, BAB71958, CAA68374, CAA31830, CAA30050, AAB59502, AAB59501, BAA22264, AAW82435, AAH04369, AAA60163, AAC13654, AAA58727, AAA51722, CAA30042, CAA30041, AAA51726, AAA51768, AAA35540, AAA51564, AAA51727, AAB23646, AAC60601, AAQ14327, AAB26263, AAB26264, AAB26265, AAH65529, NM_000484, NM_201413, NM_201414, NP_000475, NP_958816, NP_958817, OTTHUMT00000171340, OTTHUMT00000171337, OTTHUMT00000171339, OTTHUMT00000171338, Hs.695922, Hs.698014, Q9UC33, Q6P0P4, Q8WZ99, P05067, Q6GSC0, Q9UC33_HUMAN, Q6P0P4_HUMAN, Q8WZ99_HUMAN, A4_HUMAN, Q6GSC0_HUMAN, P05067-9, P05067-8, P05067-6, P05067-4, P05067-10, P05067-2, IPR002223, IPR008155, IPR013803, IPR008154
Molecules with this sequenceAPP(18-770) [extracellular region] UKENBCdOOOORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
APP(18-770) [platelet alpha granule lumen] UKENBCdOOOORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
APP(672-711) [cytosol] UKENBCdOOOORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
APP(672-713) [extracellular region] UKENBCdOOOORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
APP(672-711) [extracellular region] UKENBCdOOOORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
Component ofNLRP3 elicitor proteins:NLRP3 [cytosol]
FPRL1:FPRL1 ligands [plasma membrane]
AGER ligands:AGER [plasma membrane]
Beta amyloid fibril [extracellular region]
AGER ligands:AGER:ERK [plasma membrane]
AGER ligands:AGER:Erk [cytosol]
AGRN:Beta amyloid fibril [extracellular region]
NLRP3 elicitors:NLRP3 oligomer [cytosol]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane]
...
List all 15 items
Represented by generalisation(s)Platelet alpha granule contents [extracellular region]
Platelet alpha granule contents [platelet alpha granule lumen]
NLRP3 elicitor proteins [cytosol]
FPRL1 ligands [extracellular region]
AGER ligands [extracellular region]
Beta-amyloid [extracellular region]
Ligands of GPCRs that activate Gi [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region]
Localized amyloid fibril monomers [extracellular region]
Amyloid fibril monomers [extracellular region]
Processes where molecules and complexes with this sequence are involved

Immune System

Signal Transduction

AGER binds rat ERK1/2 [Homo sapiens]

Extracellular matrix organization

Hemostasis

Disease

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