Reactome: Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix]

Details

Participates in processes
Name	Dihydrolipoamide dehydrogenase, mitochondrial DLD Glycine cleavage system L protein
Stable identifier	REACT_2744.2
Links to corresponding entries in other databases	BioGPS Gene:1738 Brenda:1.8.1.4 CTD Gene:1738 EC:1.8.1.4 ENSEMBL:ENSG00000091140 Entrez Gene:1738 HapMap:NM_000108 IntEnz:1.8.1.4 KEGG Gene:1738 OMIM:238331 OMIM:248600 Protein Data Bank:1ZMC Protein Data Bank:1ZMD Protein Data Bank:1ZY8 Protein Data Bank:2F5Z RefSeq:NM_000108 RefSeq:NP_000099 UCSC human:P09622 UniProt:P09622 dbSNP Gene:1738
Other identifiers related to this sequence	DLDH_HUMAN, B2R5X0, Q14131, Q14167, Q59EV8, Q8WTS4, ENSG00000091140, ENST00000205402, ENSP00000205402, 209095_at, 230426_at, 36163_at, L13761_rna1_at, Hs.74635.1.A1_3p_at, g181574_3p_at, A_14_P103503, A_14_P134041, A_23_P111835, CCDS5749, GE60491, CH236947, J03490, J03620, L13761, L13749, L13750, L13751, L13752, L13753, L13754, L13748, L13755, L13759, L13760, L13756, L13757, L13758, AB209703, BC018648, BC018696, M99384, EntrezGene:1738, GI_5016092-S, ILMN_18159, IPI00015911, MIM:238331, MIM:248600, 1ZMC, 1ZMD, 1ZY8, 2F5Z, AAA59527, AAA35764, AAB01381, BAD92940, EAL24389, AAH18648, AAH18696, AAA35759, NM_000108, NP_000099, Hs.131711, Hs.614218, P09622, DLDH_HUMAN, IPR012999, IPR000103, IPR000815, IPR001100, IPR013027, IPR001327, IPR002218, IPR004099
Reference entity	UniProt:P09622 DLD
Coordinates in the reference sequence	36 .. 509
Cellular compartment	mitochondrial matrix GO
Organism	Homo sapiens
Component of	alpha-keto acid dehydrogenase E3 holoenzyme [mitochondrial matrix] alpha-keto acid dehydrogenase E3 homodimer [mitochondrial matrix] alpha-ketoglutarate dehydrogenase complex [mitochondrial matrix] branched-chain alpha-ketoacid dehydrogenase complex [mitochondrial matrix] phosphorylated pyruvate dehydrogenase complex [mitochondrial matrix] pyruvate dehydrogenase complex [mitochondrial matrix]
Pyruvate metabolism and Citric Acid (TCA) cycle - Pyruvate metabolism - pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+ [Homo sapiens] - Regulation of pyruvate dehydrogenase (PDH) complex - PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit [Homo sapiens] - PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit [Homo sapiens] - Citric acid cycle (TCA cycle) - alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ [Homo sapiens] Metabolism of amino acids and derivatives - Branched-chain amino acid catabolism - a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+ [Homo sapiens] - Lysine catabolism - alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ [Homo sapiens]
References
Brautigam, CA, Chuang, JL, Tomchick, DR, Machius, M, Chuang, DT Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations 2005 J Mol Biol PubMed
Entities deduced on the basis of this entity	Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E E G B C d [Canis familiaris] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] E E [Bos taurus] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E [Sus scrofa] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E E G B C d R H R [Mus musculus] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E E G B C d R H R [Rattus norvegicus] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E E G B C d R H R [Gallus gallus] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] E E [Taeniopygia guttata] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] E E [Xenopus tropicalis] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U E E G B C d R H R [Danio rerio] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E E G B C d R H R [Danio rerio] Homologues of Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] [Danio rerio] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E E G B C d F R [Drosophila melanogaster] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E W E G B C d R H R [Caenorhabditis elegans] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E T [Arabidopsis thaliana] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E T [Arabidopsis thaliana] Homologues of Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] [Arabidopsis thaliana] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U E [Oryza sativa] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U E [Oryza sativa] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E [Oryza sativa] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U E [Oryza sativa] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U E [Oryza sativa] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E [Oryza sativa] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U E [Oryza sativa] Homologues of Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] [Oryza sativa] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U E d [Dictyostelium discoideum] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E S E G B C d R P P [Saccharomyces cerevisiae] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E G [Schizosaccharomyces pombe] Dihydrolipoamide dehydrogenase, mitochondrial [mitochondrial matrix] U K E P [Plasmodium falciparum] Dihydrolipoamide dehydrogenase, mitochondrial [intracellular] U K K E [Escherichia coli] Dihydrolipoamide dehydrogenase, mitochondrial [intracellular] U K K E [Mycobacterium tuberculosis] Dihydrolipoamide dehydrogenase, mitochondrial [intracellular] U K E [Staphylococcus aureus N315]

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