Reactome: alpha-ketoglutarate dehydrogenase E2 [mitochondrial matrix]

Details

Participates in processes
Name	alpha-ketoglutarate dehydrogenase E2 DLST Dihydrolipoamide succinyltransferase
Stable identifier	REACT_2967.2
Links to corresponding entries in other databases	BioGPS Gene:1743 CTD Gene:1743 ENSEMBL:ENSG00000119689 Entrez Gene:1743 HapMap:NM_001933 KEGG Gene:1743 OMIM:126063 RefSeq:NM_001933 RefSeq:NP_001924 UCSC human:P36957 UniProt:P36957 dbSNP Gene:1743
Other identifiers related to this sequence	ODO2_HUMAN, Q7LDY7, Q9BQ32, ENSG00000119689, ENST00000334220, ENSP00000335304, 215210_s_at, 33257_at, 33258_g_at, 45545_at, D26535_s_at, Hs.296348.0.S1_3p_s_at, A_24_P13572, A_23_P205697, CCDS9833, GE61495, S72422, CR456727, AC006530, D17297, D16373, D26535, L37418, BC000302, BC001922, BX248774, BX248276, BX248764, EntrezGene:1743, GI_32307170-S, ILMN_22174, IPI00033034, IPI00420108, IPI00384016, IPI00384122, MIM:126063, AAB31066, CAG33008, BAA04130, AAD30181, BAA03871, BAA05536, AAB59629, AAH00302, AAH01922, CAD66581, CAD62604, CAD66571, NM_001933, NP_001924, Hs.525459, Hs.619283, Q16187, Q6IBS5, Q6LEQ7, Q7LDY7, P36957, Q86SW4, Q86TW7, Q86TQ8, Q16187_HUMAN, Q6IBS5_HUMAN, Q6LEQ7_HUMAN, Q7LDY7_HUMAN, ODO2_HUMAN, Q86SW4_HUMAN, Q86TW7_HUMAN, Q86TQ8_HUMAN, IPR003016, IPR000089, IPR001078, IPR000694
Reference entity	UniProt:P36957 DLST
Post-translational modification(s)	N6-lipoyl-L-lysine at 110
Cellular compartment	mitochondrial matrix GO
Organism	Homo sapiens
Component of	alpha-ketoglutarate dehydrogenase complex [mitochondrial matrix] alpha-ketoglutarate dehydrogenase E2 holoenzyme [mitochondrial matrix]
Pyruvate metabolism and Citric Acid (TCA) cycle - Citric acid cycle (TCA cycle) - alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ [Homo sapiens] Metabolism of amino acids and derivatives - Lysine catabolism - alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ [Homo sapiens]
Entities deduced on the basis of this entity	ENSCAFP00000025011 [mitochondrial matrix] E E [Canis familiaris] ENSCAFP00000032131 [mitochondrial matrix] E E [Canis familiaris] Homologues of alpha-ketoglutarate dehydrogenase E2 [mitochondrial matrix] [Canis familiaris] P11179 [mitochondrial matrix] U K E E G B C d R H R [Bos taurus] Q9N0F1 [mitochondrial matrix] U K E [Sus scrofa] Q9D2G2 [mitochondrial matrix] U K E E G B C d R H R [Mus musculus] Q01205 [mitochondrial matrix] U K E E G B C d R H R [Rattus norvegicus] Q5F326 [mitochondrial matrix] U K E E G B C d R H R [Gallus gallus] ENSTGUP00000012548 [mitochondrial matrix] E E [Taeniopygia guttata] Q6DIZ2 [mitochondrial matrix] U K E E [Xenopus tropicalis] Q6NZW7 [mitochondrial matrix] U E E G G G G G B B B B B C C C C C d d d d d R H R [Danio rerio] Q7ZVL3 [mitochondrial matrix] U K E E G G G G G B B B B B C C C C C d d d d d R H R [Danio rerio] Homologues of alpha-ketoglutarate dehydrogenase E2 [mitochondrial matrix] [Danio rerio] Q9VGQ1 [mitochondrial matrix] U K E E G B C d F R [Drosophila melanogaster] O45148 [mitochondrial matrix] U K E W E G B C d R H R [Caenorhabditis elegans] Q9FLQ4 [mitochondrial matrix] U K E T [Arabidopsis thaliana] Q8LGI7 [mitochondrial matrix] U E T [Arabidopsis thaliana] Q8H107 [mitochondrial matrix] U E T [Arabidopsis thaliana] Q9ZRQ1 [mitochondrial matrix] U E T [Arabidopsis thaliana] Q3E9W2 [mitochondrial matrix] U E T [Arabidopsis thaliana] Homologues of alpha-ketoglutarate dehydrogenase E2 [mitochondrial matrix] [Arabidopsis thaliana] B8AIM2 [mitochondrial matrix] U E [Oryza sativa] Q7XVM2 [mitochondrial matrix] U K E [Oryza sativa] Q0E0X4 [mitochondrial matrix] U E [Oryza sativa] B8ATA3 [mitochondrial matrix] U E [Oryza sativa] Q01LB1 [mitochondrial matrix] U E [Oryza sativa] B9F081 [mitochondrial matrix] U E [Oryza sativa] Homologues of alpha-ketoglutarate dehydrogenase E2 [mitochondrial matrix] [Oryza sativa] Q869Y7 [mitochondrial matrix] U E d [Dictyostelium discoideum] P19262 [mitochondrial matrix] U K E S E G B C d R [Saccharomyces cerevisiae] O94681 [mitochondrial matrix] U K E G [Schizosaccharomyces pombe] Q8IEA6 [mitochondrial matrix] U K E P [Plasmodium falciparum] P0AFG6 [intracellular] U K K E [Escherichia coli] P65633 [intracellular] U K K E [Mycobacterium tuberculosis] Q7A5N4 [intracellular] U K E [Staphylococcus aureus N315]

Click on the map:		shifts focus		zooms in		zooms out