DILP binds to Drosophila insulin receptor (DINR) [Drosophila melanogaster]
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DILP binds to Drosophila insulin receptor (DINR)
Stable identifier
REACT_6290.1
Authored
Jassal, B
, 2004-02-11
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Drosophila contains seven insulin-like genes which encode for DILP (Drosophila Insulin-like peptide)1-7. These DILPs can bind to the Drosophila Insulin receptor (DINR) to initiate intracellular signaling.
Input (present at start of reaction)
insulin receptor (DINR) [plasma membrane]
DILP [extracellular region]
Output (present at end of reaction)
DILP:DINR [plasma membrane]
Preceding event(s)
Re-integration of insulin receptor into plasma membrane [Drosophila melanogaster]
Following event(s)
Autophosphorylation of DINR [Drosophila melanogaster]
Organism
Drosophila melanogaster
Cellular compartment
plasma membrane
GO
References
Brogiolo, W
,
Stocker, H
,
Ikeya, T
,
Rintelen, F
,
Fernandez, R
,
Hafen, E
An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control.
2001
Curr Biol
PubMed
Represents GO biological process
cell surface receptor linked signaling pathway
GO
Equivalent event(s) in other organism(s)
Insulin binding [Homo sapiens]
Participating molecules
DILP A chain [extracellular region]
DILP B chain [extracellular region]
ILP1 alpha chain [extracellular region]
U
K
E
G
B
C
d
F
R
ILP1 beta chain [extracellular region]
U
K
E
G
B
C
d
F
R
ILP2 alpha chain [extracellular region]
U
K
E
G
B
C
d
F
R
ILP2 beta chain [extracellular region]
U
K
E
G
B
C
d
F
R
ILP3 alpha chain [extracellular region]
U
K
E
G
B
C
d
F
R
ILP3 beta chain [extracellular region]
U
K
E
G
B
C
d
F
R
ILP4 alpha chain [extracellular region]
U
K
E
G
B
C
d
F
R
ILP4 beta chain [extracellular region]
U
K
E
G
B
C
d
F
R
...
List all 18 participating molecules
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Protein identifiers
ChEBI identifiers
KEGG COMPOUND identifiers
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Date: 2010-09-02 22:25:06
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