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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameConaway
First nameRon C
InitialsRC
AffiliationStowers Institute for Medical Research
Author of summation(s)
The mechanisms governing the process of elongation during eu...
Transcription by RNA Polymerase I, RNA Polymerase III and t...
Author of entries
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing [Homo sapiens]
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest [Homo sapiens]
Abortive termination of early transcription elongation by DSIF:NELF [Homo sapiens]
Abortive termination of elongation after arrest [Homo sapiens]
Addition of nucleotides leads to transcript elongation [Homo sapiens]
DSIF complex binds to RNA Pol II (hypophosphorylated) [Homo sapiens]
Formation of DSIF:NELF:early elongation complex [Homo sapiens]
Formation of NELF complex [Homo sapiens]
Formation of RNA Pol II elongation complex [Homo sapiens]
Formation of the Early Elongation Complex [Homo sapiens]
Hypophosphorylation of RNA Pol II CTD by FCP1P protein [Homo sapiens]
Pol II elongation complex moves on the template as transcript elongates [Homo sapiens]
Recruitment of elongation factors to form elongation complex [Homo sapiens]
Resumption of elongation after recovery from pausing [Homo sapiens]
RNA Polymerase II Transcription [Homo sapiens]
RNA Polymerase II Transcription Elongation [Homo sapiens]
Separation of elongating transcript from template [Homo sapiens]
Publication(s)
Dvir, A, Conaway, RC, Conaway, JW A role for TFIIH in controlling the activity of early RNA polymerase II elongation complexes. 1997 Proc Natl Acad Sci U S A PubMed
Sato, S, Tomomori-Sato, C, Parmely, TJ, Florens, LA, Zybailov, B, Swanson, SK, Banks, CA, Jin, J, Cai, Y, Washburn, MP, Conaway, JW, Conaway, RC A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology 2004 Mol Cell PubMed
Bourbon, HM, Aguilera, A, Ansari, AZ, Asturias, FJ, Berk, AJ, Bjorklund, S, Blackwell, TK, Borggrefe, T, Carey, M, Carlson, M, Conaway, JW, Conaway, RC, Emmons, SW, Fondell, JD, Freedman, LP, Fukasawa, T, Gustafsson, CM, Han, M, He, X, Herman, PK, Hinnebusch, AG, Holmberg, S, Holstege, FC, Jaehning, JA, Kim, YJ, Kuras, L, Leutz, A, Lis, JT, Meisterernest, M, Naar, AM, Nasmyth, K, Parvin, JD, Ptashne, M, Reinberg, D, Ronne, H, Sadowski, I, Sakurai, H, Sipiczki, M, Sternberg, PW, Stillman, DJ, Strich, R, Struhl, K, Svejstrup, JQ, Tuck, S, Winston, F, Roeder, RG, Kornberg, RD A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II 2004 Mol Cell PubMed
Kamura, T, Sato, S, Iwai, K, Czyzyk-Krzeska, M, Conaway, RC, Conaway, JW Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex 2000 Proc Natl Acad Sci U S A PubMed
Conaway, RC, Conaway, JW ATP activates transcription initiation from promoters by RNA polymerase II in a reversible step prior to RNA synthesis. 1988 J Biol Chem PubMed
Ivan, M, Haberberger, T, Gervasi, DC, Michelson, KS, G├╝nzler, V, Kondo, K, Yang, H, Sorokina, I, Conaway, RC, Conaway, JW, Kaelin WG, Jr Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor 2002 Proc Natl Acad Sci U S A PubMed
Conaway, JW, Shilatifard, A, Dvir, A, Conaway, RC Control of elongation by RNA polymerase II. 2000 Trends Biochem Sci PubMed
Iwai, K, Yamanaka, K, Kamura, T, Minato, N, Conaway, RC, Conaway, JW, Klausner, RD, Pause, A Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex 1999 Proc Natl Acad Sci U S A PubMed
Maynard, MA, Qi, H, Chung, J, Lee, EH, Kondo, Y, Hara, S, Conaway, RC, Conaway, JW, Ohh, M Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex 2003 J Biol Chem PubMed
Koutelou, E, Sato, S, Tomomori-Sato, C, Florens, L, Swanson, SK, Washburn, MP, Kokkinaki, M, Conaway, RC, Conaway, JW, Moschonas, NK Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1 2008 J Biol Chem PubMed
Dvir, A, Tan, S, Conaway, JW, Conaway, RC Promoter escape by RNA polymerase II. Formation of an escape-competent transcriptional intermediate is a prerequisite for exit of polymerase from the promoter. 1997 J Biol Chem PubMed
Kamura, T, Sato, S, Haque, D, Liu, L, Kaelin WG, Jr, Conaway, RC, Conaway, JW The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families 1998 Genes Dev PubMed
Conaway, JW, Florens, LA, Sato, S, Tomomori-Sato, C, Parmely, TJ, Yao, T, Swanson, SK, Banks, CA, Washburn, MP, Conaway, RC The mammalian Mediator complex 2005 FEBS Lett PubMed
Shilatifard, A, Conaway, RC, Conaway, JW The RNA polymerase II elongation complex. 2003 Annu Rev Biochem PubMed
Kamura, T, Maenaka, K, Kotoshiba, S, Matsumoto, M, Kohda, D, Conaway, RC, Conaway, JW, Nakayama, KI VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases 2004 Genes Dev PubMed