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Reactome: A Curated Pathway Database
Class:IdBlackBoxEvent:1112510
_displayNamePhosphorylation of gp130
_doReleaseTRUE
_timestamp2014-09-11 06:53:07
authored[InstanceEdit:1164950] Ray, K, 2010-12-13
compartment[EntityCompartment:876] plasma membrane
[EntityCompartment:70101] cytosol
created[InstanceEdit:1112527] Jupe, S, 2010-12-03
edited[InstanceEdit:1112767] Jupe, S, 2010-12-10
input[Complex:1112515] IL6 receptor hexamer:Activated JAKs [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:1164952] Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes
[LiteratureReference:1112534] Tracking STAT nuclear traffic
modified[InstanceEdit:1164953] Jupe, S, 2010-12-13
[InstanceEdit:1214160] Jupe, S, 2011-02-11
[InstanceEdit:5702526] Schmidt, EE
[InstanceEdit:5762839] Schmidt, EE
[InstanceEdit:5820760] Schmidt, EE
[InstanceEdit:5883983] Schmidt, EE
[InstanceEdit:5944311] Schmidt, EE
[InstanceEdit:6004688] Schmidt, EE
[InstanceEdit:6051207] Schmidt, EE
[InstanceEdit:6094796] Schmidt, EE
[InstanceEdit:6150212] Schmidt, EE
namePhosphorylation of gp130
orthologousEvent
output[Complex:1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2011-03-15
reviewed[InstanceEdit:1214159] Rose-John, S, 2011-02-11
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1224950]
summation[Summation:1112600] Activated JAKs are believed to be responsible for phosphoryl...
(hasEvent)[Pathway:1059683] Interleukin-6 signaling [Homo sapiens]
(inferredFrom)[BlackBoxEvent:5738988] Phosphorylation of gp130 [Sus scrofa]
[BlackBoxEvent:5797387] Phosphorylation of gp130 [Bos taurus]
[BlackBoxEvent:5857615] Phosphorylation of gp130 [Canis familiaris]
[BlackBoxEvent:5921224] Phosphorylation of gp130 [Mus musculus]
[BlackBoxEvent:5980639] Phosphorylation of gp130 [Rattus norvegicus]
[BlackBoxEvent:6031956] Phosphorylation of gp130 [Gallus gallus]
[BlackBoxEvent:6077144] Phosphorylation of gp130 [Taeniopygia guttata]
[BlackBoxEvent:6128549] Phosphorylation of gp130 [Xenopus tropicalis]
[BlackBoxEvent:6197716] Phosphorylation of gp130 [Danio rerio]
(orthologousEvent)[BlackBoxEvent:5738988] Phosphorylation of gp130 [Sus scrofa]
[BlackBoxEvent:5797387] Phosphorylation of gp130 [Bos taurus]
[BlackBoxEvent:5857615] Phosphorylation of gp130 [Canis familiaris]
[BlackBoxEvent:5921224] Phosphorylation of gp130 [Mus musculus]
[BlackBoxEvent:5980639] Phosphorylation of gp130 [Rattus norvegicus]
[BlackBoxEvent:6031956] Phosphorylation of gp130 [Gallus gallus]
[BlackBoxEvent:6077144] Phosphorylation of gp130 [Taeniopygia guttata]
[BlackBoxEvent:6128549] Phosphorylation of gp130 [Xenopus tropicalis]
[BlackBoxEvent:6197716] Phosphorylation of gp130 [Danio rerio]
(precedingEvent)[Reaction:1112565] STATs bind gp130 phosphotyrosines [Homo sapiens]
[Reaction:1112708] SHP2 binds gp130 phosphotyrosine-759 [Homo sapiens]
[Reaction:1112755] SOCS3 binds gp130 [Homo sapiens]
(representedInstance)[ReactionVertex:6832283]
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