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Reactome: A Curated Pathway Database
Phosphorylation of gp130
Stable identifierREACT_27189.1
AuthoredRay, KP, 2010-12-13
ReviewedRose-John, S, 2011-02-11
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Activated JAKs are believed to be responsible for phosphorylating the cytoplasmic region of gp130 (Wang & Fuller 1994, Reich & Liu 2006) creating docking sites for adaptor and downstream signaling molecules, in particular the STAT factors STAT1 and STAT3. Several phosphotyrosine residues of gp130 are docking sites for STAT factors (Stahl et al. 1995, Gerhartz et al. 1996), Tyr-759 phosphorylation allows recruitment of the phosphatase SHP2. [Wang & Fuller 1994, Reich & Liu 2006, Stahl et al 1995, Gerhartz et al 1996]
Input (present at start of reaction)IL6 receptor hexamer:Activated JAKs [plasma membrane]
ATP [cytosol] CCPZHH x 20
Output (present at end of reaction)Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]
ADP [cytosol] CCPZH x 20
Preceding event(s)JAK activation [Homo sapiens]
Following event(s)STATs bind gp130 phosphotyrosines [Homo sapiens]
SHP2 binds gp130 phosphotyrosine-759 [Homo sapiens]
SOCS3 binds gp130 [Homo sapiens]
OrganismHomo sapiens
Cellular compartmentplasma membrane GO
cytosol GO

Reich, NC, Liu, L Tracking STAT nuclear traffic 2006 Nat Rev Immunol PubMed

Wang, Y, Fuller, GM Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes 1994 Mol Biol Cell PubMed

Equivalent event(s) in other organism(s)Phosphorylation of gp130 [Sus scrofa]
Phosphorylation of gp130 [Bos taurus]
Phosphorylation of gp130 [Canis familiaris]
Phosphorylation of gp130 [Mus musculus]
Phosphorylation of gp130 [Rattus norvegicus]
Phosphorylation of gp130 [Gallus gallus]
Phosphorylation of gp130 [Taeniopygia guttata]
Phosphorylation of gp130 [Xenopus tropicalis]
Phosphorylation of gp130 [Danio rerio]
Participating molecules
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