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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameCharalambous
First nameMarika
InitialsM
AffiliationUniversity of Cambridge, Center for Trophoblast Research
Author of summation(s)
14-3-3 has been displaced from Ser259. 14-3-3 may now bind i...
Activated MEK1 phosphorylates and activates ERK1.
Activated MEK2 phosphorylates and activates ERK2.
Activated p21ras (the GTP-bound form) is associated with the...
Active Raf-1 phosphorylates MEK-1/2 on Serine residues, conv...
An unidentified protein tyrosine kinase located in the plasm...
In the cytoplasm activated MEK1 (Serine phosphorylated) may ...
In the cytoplasm activated MEK2 (Serine phosphorylated) may ...
In the cytoplasm of unstimulated cells, SOS1 is found in a c...
Inactive p21ras-GDP is found anchored to the plasma membrane...
Inactive Raf-1 is associated in the cytoplasm with 14-3-3. 1...
MEK-1/2 have a proline rich domain (P) and critical Serine r...
MEK1 dissociates from phospho-ERK1, allowing phospho-ERK1 to...
MEK1 phosphorylates the critical Tyrosine and Threonine on E...
MEK2 dissociates from phospho-ERK2, allowing phospho-ERK2 to...
MEK2 phosphorylates the critical Tyrosine and Threonine on E...
SOS promotes the formation of GTP-bound RAS, thus activating...
Two phospho-ERK1 molecules dimerise and enter the nucleus, w...
Two phospho-ERK2 molecules dimerise and enter the nucleus, w...
Tyrosine receptor kinase stimulation phosphorylates Shc whic...
Author of entries
Activated Raf complex binds MEK [Rattus norvegicus]
Activated RAF1 complex binds MEK [Homo sapiens]
Binding of Grb10 to the insulin receptor [Homo sapiens]
Dimerisation of phospho-ERK-1 [Homo sapiens]
Dimerisation of phospho-ERK-2 [Homo sapiens]
Dimerisation of phospho-ERK-2 [Rattus norvegicus]
Dissociation of phospho-ERK-1:MEK1 [Homo sapiens]
Dissociation of phospho-ERK-2:MEK2 [Homo sapiens]
ERK activation [Homo sapiens]
ERK1 activation [Homo sapiens]
ERK2 activation [Homo sapiens]
GRB2 binds SOS1 [Homo sapiens]
GRB2:SOS binds IRS-P [Homo sapiens]
GRB2:SOS binds to SHC-P [Homo sapiens]
Inactivation of MEK1 by p34cdc2 [Homo sapiens]
IRS-mediated signalling [Homo sapiens]
MEK activation [Homo sapiens]
MEK1 binds ERK-1 [Homo sapiens]
MEK1 phosphorylates ERK-1 [Homo sapiens]
MEK2 binds ERK-2 [Homo sapiens]
MEK2 phosphorylates ERK-2 [Homo sapiens]
Nuclear translocation of phospho-ERK-1 dimer [Homo sapiens]
Nuclear translocation of phospho-ERK-2 dimer [Homo sapiens]
Nuclear translocation of phospho-ERK-2 dimer [Rattus norvegicus]
p-RAF binds 14-3-3 beta/alpha [Homo sapiens]
RAF activation [Homo sapiens]
RAF phosphorylates MEK [Homo sapiens]
RAF/MAP kinase cascade [Homo sapiens]
RAF1 phosphorylates MEK1 [Homo sapiens]
Raf1 phosphorylates MEK1 [Rattus norvegicus]
Raf1 phosphorylates MEK2 [Rattus norvegicus]
RAF1 phosphorylates MEK2 [Homo sapiens]
SHC-mediated signalling [Homo sapiens]
SOS mediated nucleotide exchange of RAS (IRS) [Homo sapiens]
SOS mediated nucleotide exchange of RAS (IRS) [Rattus norvegicus]
SOS mediated nucleotide exchange of RAS (SHC) [Rattus norvegicus]
SOS mediated nucleotide exchange of RAS (SHC) [Homo sapiens]
SOS phosphorylation and dissociation (IRS) [Homo sapiens]
SOS phosphorylation and dissociation (IRS, Crk) [Homo sapiens]
SOS phosphorylation and dissociation (SHC) [Homo sapiens]
SOS-mediated signalling [Homo sapiens]
Stabilisation of RAF by further phosphorylation [Homo sapiens]
Stabilisation of RAS:RAF by 14-3-3 [Homo sapiens]
Transient dissociation of 14-3-3 upon Ras binding [Homo sapiens]