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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameFarndale
First nameRichard
InitialsR
AffiliationUniversity of Cambridge, Department of Biochemistry
Author of summation(s)
Hemostasis is a physiological response that culminates in th...
Author of entries
Activation of conventional Protein Kinase C [Homo sapiens]
Adhesion of integrin alphaIIbbeta3 to fibrin network [Homo sapiens]
Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen [Homo sapiens]
Binding of IP3 to IP3 receptor [Homo sapiens]
Binding of Syk tyrosine kinase [Homo sapiens]
Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 [Homo sapiens]
Disinhibition of SNARE formation [Homo sapiens]
Effects of PIP2 hydrolysis [Homo sapiens]
Elevation of cytosolic Ca2+ levels [Homo sapiens]
Fyn/Lyn-mediated phosphorylation of FcR1 gamma [Homo sapiens]
G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) [Homo sapiens]
G12/13 activation by PAR [Homo sapiens]
GPIb-IX-V binds to vWF:Collagen complex [Homo sapiens]
GPVI-mediated activation cascade [Homo sapiens]
Gq activation by PAR [Homo sapiens]
Hemostasis [Homo sapiens]
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol [Homo sapiens]
p115-RhoGEF activation of Rac1 [Homo sapiens]
P2X1-mediated entry of Ca++ from plasma [Homo sapiens]
Phosphorylation of Platelet Sec-1 [Homo sapiens]
Phosphorylation of Syntaxin-4 [Homo sapiens]
Platelet activation, signaling and aggregation [Homo sapiens]
Platelet Adhesion to exposed collagen [Homo sapiens]
Platelet Aggregation (Plug Formation) [Homo sapiens]
Platelet degranulation [Homo sapiens]
PLC beta-mediated PIP2 hydrolysis [Homo sapiens]
PLC gamma 2-mediated PIP2 hydrolysis [Homo sapiens]
PLC-mediated hydrolysis of PIP2 [Homo sapiens]
Rac1 activation of PI3K [Homo sapiens]
Response to elevated platelet cytosolic Ca2+ [Homo sapiens]
Thrombin-mediated activation of Proteinase-activated receptors [Homo sapiens]
vWF binds to collagen [Homo sapiens]
Publication(s)
Gibbins, JM, Okuma, M, Farndale, R, Barnes, M, Watson, SP Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain 1997 FEBS Lett PubMed