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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
First nameTim
AffiliationFox Chase Cancer Center - University of Pennsylvania
Author of summation(s)
A hallmark of the human cell cycle in normal somatic cells i...
Author of entries
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal [Homo sapiens]
Amplification of signal from the kinetochores [Homo sapiens]
Binding of the MCC complex to the APC/C complex [Homo sapiens]
Cell Cycle Checkpoints [Homo sapiens]
Formation of the MCC complex [Homo sapiens]
Inactivation of APC/C via CDC20 sequestration [Homo sapiens]
Inactivation of APC/C via direct inhibition of the APC/C complex [Homo sapiens]
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components [Homo sapiens]
Mad1 binds kinetochore [Homo sapiens]
MAD2 associates with the Mad1 kinetochore complex [Homo sapiens]
MAD2 converted to an inhibitory state via interaction with Mad1 [Homo sapiens]
Mitotic Spindle Checkpoint [Homo sapiens]
Release of activated MAD2 from kinetochores [Homo sapiens]
McEwen, BF, Chan, GK, Zubrowski, B, Savoian, MS, Sauer, MT, Yen, TJ CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells 2001 Mol Biol Cell PubMed
Yen, TJ, Compton, DA, Wise, D, Zinkowski, RP, Brinkley, BR, Earnshaw, WC, Cleveland, DW CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase 1991 EMBO J PubMed
Sudakin, V, Chan, GK, Yen, TJ Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 2001 J Cell Biol PubMed
Liu, ST, Rattner, JB, Jablonski, SA, Yen, TJ Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells 2006 J Cell Biol PubMed
Campbell, MS, Chan, GK, Yen, TJ Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase 2001 J Cell Sci PubMed
Chan, GK, Yen, TJ The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit 2003 Prog Cell Cycle Res PubMed