Inactivation of Myt1 kinase [Homo sapiens]
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Inactivation of Myt1 kinase
Stable identifier
REACT_414.2
Authored
Lee, KS
, 2004-12-08
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At mitotic entry Plk1 phosphorylates and inhibits Myt1 activity. Cyclin B1-bound Cdc2, which is the target of Myt1, functions in a feedback loop and phosphorylates and further inhibits Myt1. [
Sagata 2005
]
Input (present at start of reaction)
Myt1 kinase [nucleoplasm]
U
K
E
G
B
C
d
O
R
R
H
H
U
R
Output (present at end of reaction)
phospho-Myt1 [nucleoplasm]
U
K
E
G
B
C
d
O
R
R
H
H
U
R
Catalyst
PLK1 [nucleoplasm]
U
K
E
G
B
C
d
O
R
H
U
R
P
P
P
GO molecular function
kinase activity
GO
Following event(s)
Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases [Homo sapiens]
Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25 [Homo sapiens]
Organism
Homo sapiens
Cellular compartment
nucleus
GO
References
Nakajima, H
,
Toyoshima-Morimoto, F
,
Taniguchi, E
,
Nishida, E
Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate
2003
J Biol Chem
PubMed
Represents GO biological process
regulation of cell cycle
GO
Equivalent event(s) in other organism(s)
Inactivation of Myt1 kinase [Mus musculus]
Inactivation of Myt1 kinase [Rattus norvegicus]
Inactivation of Myt1 kinase [Xenopus tropicalis]
Inactivation of Myt1 kinase [Danio rerio]
Inactivation of Myt1 kinase [Drosophila melanogaster]
Inactivation of Myt1 kinase [Caenorhabditis elegans]
Inactivation of Myt1 kinase [Dictyostelium discoideum]
Inactivation of Myt1 kinase [Saccharomyces cerevisiae]
Inactivation of Myt1 kinase [Schizosaccharomyces pombe]
Participating molecules
Myt1 kinase [nucleoplasm]
U
K
E
G
B
C
d
O
R
R
H
H
U
R
phospho-Myt1 [nucleoplasm]
U
K
E
G
B
C
d
O
R
R
H
H
U
R
PLK1 [nucleoplasm]
U
K
E
G
B
C
d
O
R
H
U
R
P
P
P
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Date: 2010-09-02 22:53:18
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