Phosphorylation of the SA2 Cohesion Complex [Homo sapiens]
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Phosphorylation of the SA2 Cohesion Complex
Stable identifier
REACT_1481.1
Authored
Lee, KS
, 2004-12-08
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Prior to anaphase onset, sister-chromatids are held together by cohesin complexes. Plk1-dependent phosphorylation of the cohesin subunit SA2 promotes dissociation of cohesins in early mitosis. [
Sumara
et al
2002
,
Hornig & Uhlmann 2004
]
Input (present at start of reaction)
Cohesin Complex [nucleoplasm]
Output (present at end of reaction)
Cohesin Complex with a phosphorylated SA2 Subunit [nucleoplasm]
Catalyst
PLK1 [nucleoplasm]
U
K
E
G
B
C
d
O
R
H
U
R
P
P
P
GO molecular function
kinase activity
GO
Following event(s)
Phosphorylation of the Scc1:Cohesion Complex [Homo sapiens]
Organism
Homo sapiens
Cellular compartment
nucleoplasm
GO
References
Hauf, S
,
Waizenegger, IC
,
Peters, JM
Cohesin cleavage by separase required for anaphase and cytokinesis in human cells
2001
Science
PubMed
Hauf, S
,
Roitinger, E
,
Koch, B
,
Dittrich, CM
,
Mechtler, K
,
Peters, JM
Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2
2005
PLoS Biol
PubMed
Represents GO biological process
sister chromatid cohesion
GO
Equivalent event(s) in other organism(s)
Phosphorylation of the SA2 Cohesion Complex [Mus musculus]
Phosphorylation of the SA2 Cohesion Complex [Rattus norvegicus]
Phosphorylation of the SA2 Cohesion Complex [Xenopus tropicalis]
Phosphorylation of the SA2 Cohesion Complex [Danio rerio]
Phosphorylation of the SA2 Cohesion Complex [Drosophila melanogaster]
Phosphorylation of the SA2 Cohesion Complex [Caenorhabditis elegans]
Phosphorylation of the SA2 Cohesion Complex [Dictyostelium discoideum]
Phosphorylation of the SA2 Cohesion Complex [Schizosaccharomyces pombe]
Participating molecules
phospho-SA2 [nucleoplasm]
U
K
E
G
B
C
d
O
R
R
H
H
U
R
R
PLK1 [nucleoplasm]
U
K
E
G
B
C
d
O
R
H
U
R
P
P
P
Rad21 [nucleoplasm]
U
K
E
G
B
C
d
O
R
H
U
R
Rec8 [nucleoplasm]
U
K
E
G
B
C
d
O
R
R
H
H
U
R
R
SA1 [nucleoplasm]
U
K
E
G
B
C
d
O
R
H
U
R
SA2 [nucleoplasm]
U
K
E
G
B
C
d
O
R
R
H
H
U
R
R
SMC1 (BAA11495) [nucleoplasm]
U
K
E
G
B
C
d
O
O
R
H
U
R
SMC3 [nucleoplasm]
U
K
E
G
B
C
d
O
O
R
H
U
R
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Date: 2010-09-02 22:22:53
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