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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
First nameNicholas J
AffiliationUniversity of Cambridge, Department of Biochemistry
Núñez Miguel, R, Wong, J, Westoll, JF, Brooks, HJ, O'Neill, LA, Gay, NJ, Bryant, CE, Monie, TP A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins 2007 PLoS One PubMed
Nagpal, K, Plantinga, TS, Wong, J, Monks, BG, Gay, NJ, Netea, MG, Fitzgerald, KA, Golenbock, DT A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling 2009 J. Biol. Chem. PubMed
Motshwene, PG, Moncrieffe, MC, Grossmann, JG, Kao, C, Ayaluru, M, Sandercock, AM, Robinson, CV, Latz, E, Gay, NJ An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4 2009 J Biol Chem PubMed
Moncrieffe, MC, Grossmann, JG, Gay, NJ Assembly of oligomeric death domain complexes during Toll receptor signaling 2008 J. Biol. Chem. PubMed
Gibbard, RJ, Morley, PJ, Gay, NJ Conserved features in the extracellular domain of human toll-like receptor 8 are essential for pH-dependent signaling 2006 J Biol Chem PubMed
Valkov, E, Stamp, A, Dimaio, F, Baker, D, Verstak, B, Roversi, P, Kellie, S, Sweet, MJ, Mansell, A, Gay, NJ, Martin, JL, Kobe, B Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection 2011 Proc. Natl. Acad. Sci. U.S.A. PubMed
Gangloff, M, Gay, NJ MD-2: the Toll 'gatekeeper' in endotoxin signalling 2004 Trends Biochem Sci PubMed
Dunne, A, Ejdeback, M, Ludidi, PL, O'Neill, LA, Gay, NJ Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88 2003 J. Biol. Chem. PubMed
McGettrick, AF, Brint, EK, Palsson-McDermott, EM, Rowe, DC, Golenbock, DT, Gay, NJ, Fitzgerald, KA, O'Neill, LA Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling 2006 Proc Natl Acad Sci U S A PubMed
George, J, Motshwene, PG, Wang, H, Kubarenko, AV, Rautanen, A, Mills, TC, Hill, AV, Gay, NJ, Weber, AN Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly 2011 J. Biol. Chem. PubMed