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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameAkira
First nameShizuo
InitialsS
AffiliationOsaka University, Laboratory of Host Defense
Publication(s)
Hemmi, H, Takeuchi, O, Kawai, T, Kaisho, T, Sato, S, Sanjo, H, Matsumoto, M, Hoshino, K, Wagner, H, Takeda, K, Akira, S A Toll-like receptor recognizes bacterial DNA 2000 Nature PubMed
Kawai, T, Akira, S Antiviral signaling through pattern recognition receptors 2007 J Biochem PubMed
Saitoh, T, Fujita, N, Hayashi, T, Takahara, K, Satoh, T, Lee, H, Matsunaga, K, Kageyama, S, Omori, H, Noda, T, Yamamoto, N, Kawai, T, Ishii, K, Takeuchi, O, Yoshimori, T, Akira, S Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response 2009 Proc. Natl. Acad. Sci. U.S.A. PubMed
Lee, KG, Xu, S, Kang, ZH, Huo, J, Huang, M, Liu, D, Takeuchi, O, Akira, S, Lam, KP Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response 2012 Proc Natl Acad Sci U S A PubMed
Tanaka, T, Yoshida, N, Kishimoto, T, Akira, S Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene 1997 EMBO J PubMed
Akaishi, H, Takeda, K, Kaisho, T, Shineha, R, Satomi, S, Takeda, J, Akira, S Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes 1998 Int Immunol PubMed
Kato, H, Takeuchi, O, Sato, S, Yoneyama, M, Yamamoto, M, Matsui, K, Uematsu, S, Jung, A, Kawai, T, Ishii, KJ, Yamaguchi, O, Otsu, K, Tsujimura, T, Koh, CS, Reis e Sousa, C, Matsuura, Y, Fujita, T, Akira, S Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses 2006 Nature PubMed
Takeuchi, O, Hoshino, K, Kawai, T, Sanjo, H, Takada, H, Ogawa, T, Takeda, K, Akira, S Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components 1999 Immunity PubMed
Takeuchi, O, Kawai, T, Muhlradt, PF, Morr, M, Radolf, JD, Zychlinsky, A, Takeda, K, Akira, S Discrimination of bacterial lipoproteins by Toll-like receptor 6 2001 Int Immunol PubMed
Loo, YM, Fornek, J, Crochet, N, Bajwa, G, Perwitasari, O, Martinez-Sobrido, L, Akira, S, Gill, MA, Garcia-Sastre, A, Katze, MG, Gale M, Jr Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity 2008 J Virol PubMed
Kondo, T, Kobayashi, J, Saitoh, T, Maruyama, K, Ishii, KJ, Barber, GN, Komatsu, K, Akira, S, Kawai, T DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking 2013 Proc. Natl. Acad. Sci. U.S.A. PubMed
Sato, S, Sanjo, H, Takeda, K, Ninomiya-Tsuji, J, Yamamoto, M, Kawai, T, Matsumoto, K, Takeuchi, O, Akira, S Essential function for the kinase TAK1 in innate and adaptive immune responses 2005 Nat Immunol PubMed
Yamamoto, M, Sato, S, Hemmi, H, Sanjo, H, Uematsu, S, Kaisho, T, Hoshino, K, Takeuchi, O, Kobayashi, M, Fujita, T, Takeda, K, Akira, S Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 2002 Nature PubMed
Kawagoe, T, Sato, S, Jung, A, Yamamoto, M, Matsui, K, Kato, H, Uematsu, S, Takeuchi, O, Akira, S Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling 2007 J Exp Med PubMed
Bauer, S, Kirschning, CJ, Hacker, H, Redecke, V, Hausmann, S, Akira, S, Wagner, H, Lipford, GB Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition 2001 Proc Natl Acad Sci U S A PubMed
Hoshino, K, Sugiyama, T, Matsumoto, M, Tanaka, T, Saito, M, Hemmi, H, Ohara, O, Akira, S, Kaisho, T IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9 2006 Nature PubMed
Tsuchida, T, Kawai, T, Akira, S Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins 2009 Cell Res PubMed
Diebold, SS, Kaisho, T, Hemmi, H, Akira, S, Reis e Sousa, C Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA 2004 Science PubMed
Delaloye, J, Roger, T, Steiner-Tardivel, QG, Le Roy, D, Knaup Reymond, M, Akira, S, Petrilli, V, Gomez, CE, Perdiguero, B, Tschopp, J, Pantaleo, G, Esteban, M, Calandra, T Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome 2009 PLoS Pathog PubMed
Kawai, T, Sato, S, Ishii, KJ, Coban, C, Hemmi, H, Yamamoto, M, Terai, K, Matsuda, M, Inoue, J, Uematsu, S, Takeuchi, O, Akira, S Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 2004 Nat Immunol PubMed
Uematsu, S, Sato, S, Yamamoto, M, Hirotani, T, Kato, H, Takeshita, F, Matsuda, M, Coban, C, Ishii, KJ, Kawai, T, Takeuchi, O, Akira, S Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction 2005 J Exp Med PubMed
Tokunaga, F, Sakata, S, Saeki, Y, Satomi, Y, Kirisako, T, Kamei, K, Nakagawa, T, Kato, M, Murata, S, Yamaoka, S, Yamamoto, M, Akira, S, Takao, T, Tanaka, K, Iwai, K Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation 2009 Nat. Cell Biol. PubMed
Ikeda, F, Hecker, CM, Rozenknop, A, Nordmeier, RD, Rogov, V, Hofmann, K, Akira, S, Dötsch, V, Dikic, I Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes 2007 EMBO J PubMed
Oishi, Y, Manabe, I, Tobe, K, Tsushima, K, Shindo, T, Fujiu, K, Nishimura, G, Maemura, K, Yamauchi, T, Kubota, N, Suzuki, R, Kitamura, T, Akira, S, Kadowaki, T, Nagai, R Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation 2005 Cell Metab PubMed
Kato, H, Takeuchi, O, Mikamo-Satoh, E, Hirai, R, Kawai, T, Matsushita, K, Hiiragi, A, Dermody, TS, Fujita, T, Akira, S Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 2008 J Exp Med PubMed
Satoh, T, Kato, H, Kumagai, Y, Yoneyama, M, Sato, S, Matsushita, K, Tsujimura, T, Fujita, T, Akira, S, Takeuchi, O LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses 2010 Proc Natl Acad Sci U S A PubMed
Akira, S, Nishio, Y, Inoue, M, Wang, XJ, Wei, S, Matsusaka, T, Yoshida, K, Sudo, T, Naruto, M, Kishimoto, T Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway 1994 Cell PubMed
Saitoh, T, Tun-Kyi, A, Ryo, A, Yamamoto, M, Finn, G, Fujita, T, Akira, S, Yamamoto, N, Lu, KP, Yamaoka, S Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1 2006 Nat Immunol PubMed
Akira, S, Uematsu, S, Takeuchi, O Pathogen recognition and innate immunity 2006 Cell PubMed
Takegahara, N, Takamatsu, H, Toyofuku, T, Tsujimura, T, Okuno, T, Yukawa, K, Mizui, M, Yamamoto, M, Prasad, DV, Suzuki, K, Ishii, M, Terai, K, Moriya, M, Nakatsuji, Y, Sakoda, S, Sato, S, Akira, S, Takeda, K, Inui, M, Takai, T, Ikawa, M, Okabe, M, Kumanogoh, A, Kikutani, H Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis 2006 Nat Cell Biol PubMed
Saito, T, Hirai, R, Loo, YM, Owen, D, Johnson, CL, Sinha, SC, Akira, S, Fujita, T, Gale M, Jr Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2 2007 Proc Natl Acad Sci U S A PubMed
Amer, A, Franchi, L, Kanneganti, TD, Body-Malapel, M, Ozören, N, Brady, G, Meshinchi, S, Jagirdar, R, Gewirtz, A, Akira, S, Nunez, G Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf 2006 J Biol Chem PubMed
Takahashi, K, Kawai, T, Kumar, H, Sato, S, Yonehara, S, Akira, S Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA 2006 J Immunol PubMed
Kawagoe, T, Sato, S, Matsushita, K, Kato, H, Matsui, K, Kumagai, Y, Saitoh, T, Kawai, T, Takeuchi, O, Akira, S Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 2008 Nat Immunol PubMed
Yoneyama, M, Kikuchi, M, Matsumoto, K, Imaizumi, T, Miyagishi, M, Taira, K, Foy, E, Loo, YM, Gale M, Jr, Akira, S, Yonehara, S, Kato, A, Fujita, T Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity 2005 J Immunol PubMed
Hemmi, H, Kaisho, T, Takeuchi, O, Sato, S, Sanjo, H, Hoshino, K, Horiuchi, T, Tomizawa, H, Takeda, K, Akira, S Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway 2002 Nat Immunol PubMed
Heil, F, Hemmi, H, Hochrein, H, Ampenberger, F, Kirschning, C, Akira, S, Lipford, G, Wagner, H, Bauer, S Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8 2004 Science PubMed
Shim, JH, Xiao, C, Paschal, AE, Bailey, ST, Rao, P, Hayden, MS, Lee, KY, Bussey, C, Steckel, M, Tanaka, N, Yamada, G, Akira, S, Matsumoto, K, Ghosh, S TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo 2005 Genes Dev PubMed
Kishida, S, Sanjo, H, Akira, S, Matsumoto, K, Ninomiya-Tsuji, J TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway 2005 Genes Cells PubMed
Kawagoe, T, Takeuchi, O, Takabatake, Y, Kato, H, Isaka, Y, Tsujimura, T, Akira, S TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis 2009 Nat Immunol PubMed
Jounai, N, Takeshita, F, Kobiyama, K, Sawano, A, Miyawaki, A, Xin, KQ, Ishii, KJ, Kawai, T, Akira, S, Suzuki, K, Okuda, K The Atg5 Atg12 conjugate associates with innate antiviral immune responses 2007 Proc Natl Acad Sci U S A PubMed
Hayashi, F, Smith, KD, Ozinsky, A, Hawn, TR, Yi, EC, Goodlett, DR, Eng, JK, Akira, S, Underhill, DM, Aderem, A The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 2001 Nature PubMed
Tsuchida, T, Zou, J, Saitoh, T, Kumar, H, Abe, T, Matsuura, Y, Kawai, T, Akira, S The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA 2010 Immunity PubMed
Takeda, K, Akira, S TIR domains, which are conserved among all TLRs. Recent accumulating 2004 Semin Immunol PubMed
Takeda, K, Akira, S TIRAP/Mal, TRIF and TRAM. Differential utilization of these TIR 2005 Int Immunol PubMed
Kawai, T, Akira, S TLR signaling 2006 Cell Death Differ PubMed
Akira, S Toll-like receptor signaling 2003 J Biol Chem PubMed
Akira, S Toll-like receptors: lessons from knockout mice 2000 Biochem Soc Trans PubMed
Sato, S, Sugiyama, M, Yamamoto, M, Watanabe, Y, Kawai, T, Takeda, K, Akira, S Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling 2003 J. Immunol. PubMed
Yoshida, R, Takaesu, G, Yoshida, H, Okamoto, F, Yoshioka, T, Choi, Y, Akira, S, Kawai, T, Yoshimura, A, Kobayashi, T TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway 2008 J Biol Chem PubMed
Konno, H, Yamamoto, T, Yamazaki, K, Gohda, J, Akiyama, T, Semba, K, Goto, H, Kato, A, Yujiri, T, Imai, T, Kawaguchi, Y, Su, B, Takeuchi, O, Akira, S, Tsunetsugu-Yokota, Y, Inoue, J TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA 2009 PLoS One PubMed
Kagan, JC, Su, T, Horng, T, Chow, A, Akira, S, Medzhitov, R TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta 2008 Nat Immunol PubMed
Broglie, P, Matsumoto, K, Akira, S, Brautigan, DL, Ninomiya-Tsuji, J Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway 2010 J. Biol. Chem. PubMed
Gack, MU, Shin, YC, Joo, CH, Urano, T, Liang, C, Sun, L, Takeuchi, O, Akira, S, Chen, Z, Inoue, S, Jung, JU TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity 2007 Nature PubMed
Takahasi, K, Suzuki, NN, Horiuchi, M, Mori, M, Suhara, W, Okabe, Y, Fukuhara, Y, Terasawa, H, Akira, S, Fujita, T, Inagaki, F X-ray crystal structure of IRF-3 and its functional implications 2003 Nat Struct Biol PubMed