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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
First nameChristopher M
Starr, AE, Bellac, CL, Dufour, A, Goebeler, V, Overall, CM Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities 2012 J. Biol. Chem. PubMed
Morrison, CJ, Butler, GS, Bigg, HF, Roberts, CR, Soloway, PD, Overall, CM Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway 2001 J Biol Chem PubMed
Tam, EM, Wu, YI, Butler, GS, Stack, MS, Overall, CM Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage 2002 J Biol Chem PubMed
Overall, CM, Sodek, J Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases 1990 J Biol Chem PubMed
Overall, CM, Tam, E, McQuibban, GA, Morrison, C, Wallon, UM, Bigg, HF, King, AE, Roberts, CR Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation 2000 J Biol Chem PubMed
Overall, CM, King, AE, Sam, DK, Ong, AD, Lau, TT, Wallon, UM, DeClerck, YA, Atherstone, J Identification of the tissue inhibitor of metalloproteinases-2 (TIMP-2) binding site on the hemopexin carboxyl domain of human gelatinase A by site-directed mutagenesis. The hierarchical role in binding TIMP-2 of the unique cationic clusters of hemopexin modules III and IV 1999 J Biol Chem PubMed
McQuibban, GA, Gong, JH, Tam, EM, McCulloch, CA, Clark-Lewis, I, Overall, CM Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3 2000 Science PubMed
Morrison, CJ, Butler, GS, Rodríguez, D, Overall, CM Matrix metalloproteinase proteomics: substrates, targets, and therapy 2009 Curr Opin Cell Biol PubMed
Rodríguez, D, Morrison, CJ, Overall, CM Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics 2010 Biochim Biophys Acta PubMed
Overall, CM Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites 2002 Mol Biotechnol PubMed
Bigg, HF, Shi, YE, Liu, YE, Steffensen, B, Overall, CM Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2 1997 J Biol Chem PubMed
Brayer, GD, Sidhu, G, Maurus, R, Rydberg, EH, Braun, C, Wang, Y, Nguyen, NT, Overall, CM, Withers, SG Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques 2000 Biochemistry PubMed
Steffensen, B, Bigg, HF, Overall, CM The involvement of the fibronectin type II-like modules of human gelatinase A in cell surface localization and activation 1998 J Biol Chem PubMed
Morrison, CJ, Overall, CM TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains 2006 J Biol Chem PubMed
Bigg, HF, Morrison, CJ, Butler, GS, Bogoyevitch, MA, Wang, Z, Soloway, PD, Overall, CM Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase 2001 Cancer Res PubMed
Butler, GS, Overall, CM Updated biological roles for matrix metalloproteinases and new "intracellular" substrates revealed by degradomics 2009 Biochemistry PubMed
Kai, HS, Butler, GS, Morrison, CJ, King, AE, Pelman, GR, Overall, CM Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain 2002 J Biol Chem PubMed