Reactome: NF-kB migrates to the nucleus and turns on transcription

NF-kB migrates to the nucleus and turns on transcription [Homo sapiens]

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NF-kB migrates to the nucleus and turns on transcription
Stable identifier	REACT_13816.1
Authored	Nasi, S, Annibali, D, 2006-10-10
Reviewed	Friedman, WJ, 2008-05-20 Chao, MV, 2008-05-28
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Once dissociated from IkB, NF-kB moves to the nucleus. Once in the nucleus, NF-kB binds DNA at promoters of target genes. This entails transcription of several genes including the two HLH transcriptional regulators HES1 and HES5. HES1 and HES5 transcription can also be activated via NOTCH signalling. Increased production of HES1 and HES5 reduces the number of primary dendrites and promotes dendrite elongation.
Input (present at start of reaction)	NF-kB complex [cytosol]
Output (present at end of reaction)	NF-kB complex [nucleoplasm]
Preceding event(s)	IKKbeta phosphorylates IkB causing NF-kB to dissociate [Homo sapiens] Activation of NF-kB complex [Homo sapiens]
Organism	Homo sapiens
Cellular compartment	nuclear envelope GO
Salama-Cohen, P, Arévalo, MA, Meier, J, Grantyn, R, Rodríguez-Tébar, A NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch 2005 Mol Biol Cell PubMed
Equivalent event(s) in other organism(s)	NF-kB migrates to the nucleus and turns on transcription [Canis familiaris] NF-kB migrates to the nucleus and turns on transcription [Bos taurus] NF-kB migrates to the nucleus and turns on transcription [Sus scrofa] NF-kB migrates to the nucleus and turns on transcription [Mus musculus] NF-kB migrates to the nucleus and turns on transcription [Rattus norvegicus] NF-kB migrates to the nucleus and turns on transcription [Taeniopygia guttata] NF-kB migrates to the nucleus and turns on transcription [Xenopus tropicalis] NF-kB migrates to the nucleus and turns on transcription [Drosophila melanogaster]
Participating molecules
NFkB1 [nucleoplasm] U K E O U P P P P P NFkB1 p50 [cytosol] U K E O U P P P P P NFkB3 [nucleoplasm] U K E G B C d O R H U R P Transcription factor p65 [cytosol] U K E G B C d O R H U R P

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