Reactome: Transport (influx) of glycocholate and taurocholate by OATP-C

Transport (influx) of glycocholate and taurocholate by OATP-C [Homo sapiens]

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Transport (influx) of glycocholate and taurocholate by OATP-C
Stable identifier	REACT_10091.1
Authored	D'Eustachio, P, 2007-03-09
Reviewed	D'Eustachio, P, 2007-04-30
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A molecule of extracellular glycocholate or taurocholate is transported into the cytosol, mediated by OATP-C (SLCO1B1) in the plasma membrane. Glyco- and taurocholate exist in the blood as complexes with serum albumin, and its uptake by OATP-C must involve disruption of this complex, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-C is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of glyco- and taurocholate by the liver under physiological conditions (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). [Kullak-Ublick et al 2004, Boyer & Trauner 2003]
Input (present at start of reaction)	albumin:cholate bile salt complex [extracellular region]
Output (present at end of reaction)	Serum albumin [extracellular region] U K E G B C d O O R H U R P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P cholate bile salts [cytosol]
Catalyst	OATP-C [plasma membrane] U K E G B C d O R H U R
GO molecular function	bile acid transmembrane transporter activity GO
Preceding event(s)	Transport (efflux) of bile salts by ABCC3 (MRP3) [Homo sapiens]
Following event(s)	Transport (efflux) of bile salts by ABCB11 (bile salt export pump) [Homo sapiens]
Organism	Homo sapiens
Cellular compartment	plasma membrane GO
Abe, T, Kakyo, M, Tokui, T, Nakagomi, R, Nishio, T, Nakai, D, Nomura, H, Unno, M, Suzuki, M, Naitoh, T, Matsuno, S, Yawo, H Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 1999 J Biol Chem PubMed Kullak-Ublick, GA, Ismair, MG, Stieger, B, Landmann, L, Huber, R, Pizzagalli, F, Fattinger, K, Meier, PJ, Hagenbuch, B Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver 2001 Gastroenterology PubMed Konig, J, Cui, Y, Nies, AT, Keppler, D A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane 2000 Am J Physiol Gastrointest Liver Physiol PubMed
Equivalent event(s) in other organism(s)	Transport (influx) of glycocholate and taurocholate by OATP-C [Canis familiaris] Transport (influx) of glycocholate and taurocholate by OATP-C [Bos taurus] Transport (influx) of glycocholate and taurocholate by OATP-C [Mus musculus] Transport (influx) of glycocholate and taurocholate by OATP-C [Rattus norvegicus]
Participating molecules
cholate bile salts [cytosol] cholate bile salts [extracellular region] glycocholate [cytosol] C C P glycocholate [extracellular region] C C P OATP-C [plasma membrane] U K E G B C d O R H U R Serum albumin [extracellular region] U K E G B C d O O R H U R P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P taurocholate [cytosol] C C taurocholate [extracellular region] C C

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