Reactome: NADE modulates death signalling

NADE modulates death signalling [Homo sapiens]

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NADE modulates death signalling
Stable identifier	REACT_13526.2
Authored	Nasi, S, Annibali, D, 2006-10-10
Reviewed	Friedman, WJ, 2008-05-20 Chao, MV, 2008-05-28
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NADE protein (p75NTR-associated cell death executor) may induce cell death upon NGF binding, but not BDNF, NT3, or NT4/5 binding, to p75NTR. The NADE-dependent apoptosis is modulated by the 14-3-3-epsilon protein (Kimura MT et al, 2001). [Kimura et al 2001]
Organism	Homo sapiens
Kimura, MT, Irie, S, Shoji-Hoshino, S, Mukai, J, Nadano, D, Oshimura, M, Sato, TA 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction 2001 J Biol Chem PubMed
Represents GO biological process	apoptosis GO
Equivalent event(s) in other organism(s)	NADE modulates death signalling [Canis familiaris] NADE modulates death signalling [Bos taurus] NADE modulates death signalling [Sus scrofa] NADE modulates death signalling [Mus musculus] NADE modulates death signalling [Rattus norvegicus]
Participating molecules
14-3-3 protein epsilon [cytosol] U K E G G B B C C d d O R H U R P active Caspase2/3 [cytosol] Caspase-2 p12 subunit [cytosol] Caspase-2 p18 subunit [cytosol] Caspase-2 precursor [cytosol] Caspase-2-1 p12 subunit [cytosol] U K E G B C d O R H U R R P Caspase-2-1 p18 subunit [cytosol] U K E G B C d O R H U R R P Caspase-2-1 precursor [cytosol] U K E G B C d O R H U R R P Caspase-2-2 p12 subunit [cytosol] U K E G B C d O R H U R R P Caspase-2-2 p18 subunit [cytosol] U K E G B C d O R H U R R P ... List all 18 participating molecules

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