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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameSaxena
First nameAnjana
InitialsA
AffiliationNYU School of Medicine, Department of Biochemistry
Author of summation(s)
5-methylcytosine G/T mismatch specific DNA glycosylase is th...
53BP1-deficient DT40 chicken cells exhibit elevated sensitiv...
A DNA double strand break results when two single strand bre...
A functional immune system depends on the production of a wi...
Although ATM is dispensable for Chk1 phosphorylation, caffei...
ATM, a serine-threonine kinase, belongs to a large family wi...
Before rejoining of the broken DNA ends can occur, endonucle...
Binding of XP-C:RAD23B complex to the damaged site on the DN...
BRCA1 phosphorylation occurs at multiple sites by ATM and is...
BRIP1 (also called BACH1) is a DEAH helicase that interacts ...
BRIP1, a DNA helicase also known as FANCJ, provides evidence...
c-Abl is a ubiquitously-expressed non-receptor tyrosine kina...
Cellular DNA is susceptible to different types of cytotoxic ...
Cellular insults causing DNA damage can be of varied origins...
Centrosomal abnormalities are frequently observed in cancers...
Chicken B lymphocyte precursors and DT40 cells diversify the...
Chicken DT40 cells lacking FANCG (one of the proteins of the...
Chicken SNM1A (DNA cross-link repair 1A protein) is not epis...
Chk1 phosphorylation on Ser-345 is mediated by ATR kinase up...
Chk2 phosphorylation by ATM requires NBS1 following DSB form...
Chromatin loading of the proliferating cell nuclear antigen ...
Contains 1 RING-type zinc finger and hence works as an E3-ub...
Damage to single nucleotides in a DNA duplex is common, ofte...
Defects in Brca1 confer susceptibility to breast cancer and ...
Depyrimidination of a damaged nucleotide is mediated by a py...
DNA ligase seals the newly synthesized repair patch to the i...
DNA-dependent protein kinase (DNA-PK), a member of PI3-kinas...
FA protein FANCI has been identified as an ATM/ATR kinase su...
Fanconi anemia (FA) is a rare hereditary disorder characteri...
Following cleavage of the damaged base, DNA glycosylase is d...
Gamma-H2AX formation by activated ATM kinase is one of the f...
Genetic recombination and the repair of double strand DNA br...
Homologous recombination in vertebrates is catalyzed by Rad5...
HRR is a major DNA repair pathway that acts on DSBs and inte...
In nucleotide excision repair (NER) endonucleases incise the...
Just before final end joining, the bound repair proteins mus...
Microcephalin (MCPH1/BRIT1) forms ionizing radiation-induced...
Mono-ubiquitination of FANCD2 promotes DNA repair. This modi...
MRE11 and RAD50 are homologs of proteins first identified in...
MRE11-RAD50-NBS1 (MRN) is a ubiquitous and conserved nucleas...
NBS1 via its BRCA1 C terminus domain (aa 665-693) interacts ...
Non homologous end joining (NHEJ) requires DNA dependent pro...
Nucleoplasmic polymerase zeta complex binds to the damaged D...
Nucleoplasmic REV1 protein binds to Pol kappa (Okada et al. ...
Pol eta binds to damaged DNA in the nucleus (Kawamoto et al....
Pol kappa bypasses the lesion and restores DNA replication i...
Pol kappa inserts the correct base in the complement strand ...
Polymerase activity of Pol zeta is attributed to its REV3L s...
Polymerase eta inserts the correct base in the complement st...
Polymerase eta-mediated DNA replication continues past the D...
Proliferating cell nuclear antigen (PCNA) is a DNA polymeras...
RAD18 catalyzes mono ubiquitination of PCNA by its RING zinc...
Rad51, a eukaryotic ortholog of bacterial RecA, is essential...
Reactive cellular catabolites can cause DNA damage by methyl...
Replication protein A (RPA) is a heterotrimeric single stran...
Replication Protein A (RPA), the primary single strand DNA-b...
Replication-independent HRR is critical in order to eliminat...
Stalling of DNA replication forks can be caused by replicati...
The ability of cells to tolerate DNA damage, even at the cos...
The c-Abl and Arg proteins in DT-40 cells gets activated by ...
The direct reversal of DNA damage is obviously the most stra...
The DNA double strand break triggers various checkpoint swit...
The DNA-PK-Ku complex translocates away from the DSB. Subseq...
The evidence for chicken genes, XP-C (Xeroderma pigmentosum ...
The G/T mismatch specific thymine DNA glycosylase (EC 3.2.2....
The heterotrimeric Rad9-Hus1-Rad1 (9-1-1) complex is structu...
The NHEJ pathway is initiated in response to the formation o...
The resultant gap is filled by polymerase activities of Pol ...
The REV3L and MAD2L2 (REV7) proteins combine to form the Pol...
The two family members c-Abl and Arg share high homology bet...
The vertebrate Rad17 protein is structurally related to larg...
This reaction takes place in the 'nucleus' and is mediated b...
This reaction takes place in the 'nucleus' and is mediated b...
This reaction takes place in the nucleus and is mediated by ...
This reaction takes place in the nucleus and is mediated by ...
To ensure the equal transmission of genetic material to both...
TopBP1, DNA topoisomerase II-binding protein 1 is the molecu...
Unpaired DNA damage or damage that, is improperly repaired b...
Upon DNA damage, the inactive ATM dimer auto-phosphorylates,...
Upon formation of a double-strand DNA breaks, ssDNA can be f...
Upon formation of DSBs, MRN (MRE11-RAD50-NBS1) complex is tr...
Various DNA damage conditions generate DNA double-strand bre...
Vertebrate Pol kappa belongs to the DNA polymerase Y family,...
Author of entries
'BRCA1 [nucleoplasm]' positively regulates 'Rad51 assembly at the DNA-damage sites on the chromatin'
'BRCA2 [nucleoplasm]' positively regulates 'Rad51 assembly at the DNA-damage sites on the chromatin'
'MRE11-RAD50-NBS1 complex [nucleoplasm]' is required for 'Activation and association of ATM kinase at the DNA damage sites'
'NBS, Nijmegen breakage syndrome protein 1 homolog [nucleoplasm]' is required for 'Activation and association of ATM kinase at the DNA damage sites'
'PCNA-homotrimer [nucleoplasm]' is required for 'Repair of ~27-30 bp long patch by DNA Pol Epsilon'
'Rad17-replication factor C (RFC), the clamp loader [nucleoplasm]' is required for 'Phosphorylation of Chk1 by ATR'
'Rad9-Hus1-Rad1(9-1-1) clamp [nucleoplasm]' is required for 'Phosphorylation of Chk1 by ATR'
'RFC2_CHICK [nucleoplasm]' is required for 'Repair of ~27-30 bp long patch by DNA Pol Epsilon'
'RPA, heterotrimer [nucleoplasm]' is required for 'Repair of ~27-30 bp long patch by DNA Pol Epsilon'
'UBC13, Ubiquitin-conjugating enzyme E2 N [nucleoplasm]' is required for 'Association of RAD51 with BRCA1'
5-methylcytosine G/T mismatch specific DNA glycosylase mediated recognition and binding of thymine opposite guanine at CpG sequences [Gallus gallus]
5-methylcytosine glycosylase:thymine complex [nucleoplasm]
53BP1 and gamma H2AX complex at the site of double strand DNA break [nucleoplasm]
Ableson family members [nucleoplasm]
Activated-ATM kinase [nucleoplasm] UEP
Activation and association of ATM kinase at the DNA damage sites [Gallus gallus]
Activation of ATR by interaction with RAD9-TopBP1 complex [Gallus gallus]
ALKBH2 [nucleoplasm] E
ALKBH3 [nucleoplasm] E
Arg (Abl-related gene) [nucleoplasm]
Association between RAD9 and TopBP1 [Gallus gallus]
Association of 53BP1 with gamma H2AX at double strand break [Gallus gallus]
Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks [Gallus gallus]
Association of gamma H2AX and NBS1 [Gallus gallus]
Association of gamma-H2AX with MCPH1 [Gallus gallus]
Association of Ku heterodimer with ends of DNA double-strand breaks [Gallus gallus]
Association of MRE11 and NBS1 leads to nuclear localization of MRN complex [Gallus gallus]
Association of MRE11 with RAD50 [Gallus gallus]
Association of RAD51 with BRCA1 [Gallus gallus]
Association of RAD51 with BRCA2 [Gallus gallus]
Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex [Gallus gallus]
ATM [nucleoplasm] UEP
ATM mediated phosphorylation of repair proteins [Gallus gallus]
ATM mediated response to DNA double-strand break [Gallus gallus]
ATR [nucleoplasm] E
ATRIP [nucleoplasm] E
ATRIP-ATR complex [nucleoplasm]
Autophosphorylation of DNA-PKcs [Gallus gallus]
Base Excision Repair [Gallus gallus]
Base Excision Repair, AP site formation [Gallus gallus]
Binding of Pol eta to a DNA template containing a lesion [Gallus gallus]
Binding of Pol kappa and REV1 complex to the lesion on the template DNA strand [Gallus gallus]
Binding of Pol zeta complex to a DNA template containing lesions [Gallus gallus]
Binding of RPA heterotrimer to 3' double stranded DNA break [Gallus gallus]
BRCA1 [nucleoplasm] UENBCdRHPR
BRCA2 [nucleoplasm] UEP
BRIP1 (FANCJ) helicase functions in direct unwinding of DNA [Gallus gallus]
C-terminal PI3-kinase [nucleoplasm] UEP
CABL [nucleoplasm] UEP
CDC2 kinase, Cell division control protein 2 homolog [nucleoplasm] UENBCdRHPR
CHEK2 [nucleoplasm] UENBCdP
Chk1-controlled and DNA-damage induced centrosome duplication [Gallus gallus]
chSNM1A, DNA cross-link repair 1A protein [nucleoplasm] UENBCdRHPR
chSNM1A-PIAS1 complex [nucleoplasm]
Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase [Gallus gallus]
Cleavage of thymine by TDG glycosylase [Gallus gallus]
Cleavage of uracil by Uracil-glycosylase [Gallus gallus]
Cohesin complex [nucleoplasm]
DDB1, DNA damage-binding protein 1 [nucleoplasm] UENNBBCCddPR
Depyrimidination [Gallus gallus]
Deubiquitination of FancD2 [Gallus gallus]
Dimeric ATM [nucleoplasm]
Displacement of DNA glycosylase and endonucleolytic cleavage by DNA-lyase [Gallus gallus]
DNA containing a 5-methylcytosine glycosylase-bound apurinic/apyrimidinic site [nucleoplasm]
DNA containing a TDG-bound apurinic/apyrimidinic site [nucleoplasm]
DNA containing Uracil-glycosylase-bound apurinic/apyrimidinic site [nucleoplasm]
DNA damage bypass [Gallus gallus]
DNA damage recognition in global genomic repair [Gallus gallus]
DNA Damage Reversal [Gallus gallus]
DNA helicase activity of FANCJ (BRIP1), Fanconi anemia group J protein homolog [nucleoplasm]
DNA ligase IV [nucleoplasm] UENBCdRHPR
DNA Pol kappa-REV1 complex [nucleoplasm]
DNA polymerase activity of Pol zeta complex [nucleoplasm]
DNA polymerase activity of POLE2, DNA polymerase epsilon subunit 2 [nucleoplasm]
DNA polymerase activity of POLH [nucleoplasm]
DNA polymerase activity of POLK [nucleoplasm]
DNA repair [Gallus gallus]
DNA repair intermediates [nucleoplasm]
DNA-dependent protein kinase activity of DNA-PKcs, DNA-dependent protein kinase catalytic subunit [nucleoplasm]
DNA-glycosylase [nucleoplasm]
DNA-glycosylase and DNA-lyase complex [nucleoplasm]
DNA-PK synaptic complex [nucleoplasm]
DNA-PK-Ku-DNA complex [nucleoplasm]
DNA-PK: DNA synaptic complex with processed (ligatable) DNA [nucleoplasm]
DNA-PK:XRCC4:DNA ligase IV:DNA complex associated with ligatable DNA ends [nucleoplasm]
DNA-PKcs, DNA-dependent protein kinase catalytic subunit [nucleoplasm] UENNNNNNNBBBBBBBCCCCCCCdddddddRHPR
Double strand break repair [Gallus gallus]
Elongation by Pol eta [Gallus gallus]
Elongation by Pol kappa [Gallus gallus]
Elongation by Pol zeta complex [Gallus gallus]
endonuclease activity of NEIL2 [nucleoplasm]
endonuclease activity of TDP1 [nucleoplasm]
ERCC3, TFIIH basal transcription factor complex helicase XPB subunit [nucleoplasm] UENBCdRHPR
ERCC5 [nucleoplasm] E
FANCD2 [nucleoplasm] UENBCdRHPR
FANCG, Fanconi anemia group G protein [nucleoplasm] UENBCdRHPR
FANCI, Fanconi anemia complementation group I [nucleoplasm] UP
FANCJ (BRIP1), Fanconi anemia group J protein homolog [nucleoplasm] UENBCdRHPR
FancL [nucleoplasm] UENBCdRHPR
Fanconi Anemia Pathway in DNA repair [Gallus gallus]
Formation of a multi-protein complex, cohesin [Gallus gallus]
Formation of Pol zeta complex [Gallus gallus]
Formation of RPA-heterotrimer [Gallus gallus]
Formation of the Rad17-RFC alternate clamp-loader complex [Gallus gallus]
G/T specific TDG glycosylase:thymine complex [nucleoplasm]
gamma H2Ax and phospho-NBS1 at the double strand break [nucleoplasm]
gamma H2AX foci at the DNA double strand breaks [nucleoplasm]
gamma-H2AX-MCPH1 complex [nucleoplasm]
Generation of a DNA double strand break [Gallus gallus]
H2AX [nucleoplasm]
half cystine at unknown position
Homologous DNA pairing and strand exchange [Gallus gallus]
Homologous recombination repair [Gallus gallus]
Homologous recombination repair (HRR) of replication-independent double-strand breaks [Gallus gallus]
Homologous recombination repair of replication-dependent double-strand breaks [Gallus gallus]
HUS1 [nucleoplasm] E
Insertion of correct bases opposite to the lesion by Pol eta [Gallus gallus]
Insertion of correct bases opposite to the lesion by Pol kappa [Gallus gallus]
Interaction between two DNA-PK:DNA complexes at opposing ends of DNA DSB [Gallus gallus]
kinase activity of CABL [nucleoplasm]
kinase activity of PI3-kinase family [nucleoplasm]
Ku-heterodimer complex [nucleoplasm]
Ku70, XRCC6, Ku autoantigen protein p70 homolog [nucleoplasm] UENBCdRHPR
Ku:DNA DSB ends [nucleoplasm]
LIG3 [nucleoplasm] UENBCdRHPR
ligase activity of LIG3 [nucleoplasm]
Ligation of DNA at sites of patch replacement [Gallus gallus]
Ligation of newly synthesized repair patch to incised DNA in GG-NER [Gallus gallus]
MAD2L2 [nucleoplasm] UENBCdRHPR
MBD4 [nucleoplasm] UENBCdRHPR
methylated-DNA-[protein]-cysteine S-methyltransferase activity of MGMT [nucleoplasm]
methylcysteine-MGMT [nucleoplasm] E
MGMT [nucleoplasm] E
MGMT mediated DNA Damage Reversal [Gallus gallus]
Microcephalin [nucleoplasm] UP
monoubiquitinated FancD2 [nucleoplasm]
monoubiquitinated FANCI [nucleoplasm]
monoubiquitinated PCNA [nucleoplasm]
Monoubiquitination of FancD2 [Gallus gallus]
Monoubiquitination of FANCI [Gallus gallus]
Monoubiquitination of PCNA [Gallus gallus]
Monoubiquitunated PCNA mediates recruitment of the translesion polymerase to the DNA damaged site. [Gallus gallus]
MRE11-RAD50 complex [nucleoplasm]
MRE11-RAD50-NBS1 complex [nucleoplasm]
MRE11A [nucleoplasm] UENBCdRHPR
NBS, Nijmegen breakage syndrome protein 1 homolog [nucleoplasm] UENBCdRHPR
NEIL2 [nucleoplasm] E
NHEJ1 [nucleoplasm] E
Non-homologous end joining (NHEJ) [Gallus gallus]
Nuclear focus formation by interaction of chSNM1A with PIAS1 upon DNA lesion [Gallus gallus]
Nucleotide Excision Repair [Gallus gallus]
O-phospho-L-serine at 1189
O-phospho-L-serine at 1542
O-phospho-L-serine at 345
O-phospho-L-serine at 7
O-phospho-L-serine at unknown position
O-phospho-L-threonine at 68
O4'-phospho-L-tyrosine at 46
PCNA, Proliferating cell nuclear antigen [nucleoplasm] UENBCdRHPR
PCNA-homotrimer [nucleoplasm]
phospho-CABL [nucleoplasm] UEP
Phospho-CHEK2 [nucleoplasm] UENBCdP
Phospho-DNA-PKcs [nucleoplasm] UENNNNNNNBBBBBBBCCCCCCCdddddddRHPR
phospho-FANCG, Fanconi anemia group G protein [nucleoplasm] UENBCdRHPR
phospho-NBS1 [nucleoplasm] UENBCdRHPR
phospho-RAD51 [nucleoplasm] UENBCdRHPR
phospho-RCF4 [nucleoplasm] UENBCdRHPR
phospho-STT3 [nucleoplasm] UEP
phosphorylated Abl and Arg [nucleoplasm]
Phosphorylated Arg (Abl-related gene) [nucleoplasm]
phosphorylated BRCA1 at S1189 and S1542 [nucleoplasm] UENBCdRHPR
phosphorylated H2AX (ser139) [nucleoplasm]
phosphorylated residue at unknown position
phosphorylated residue at unknown position
phosphorylated residue at unknown position
Phosphorylation of BRCA1 [Gallus gallus]
Phosphorylation of c-Abl and Arg by ATM [Gallus gallus]
Phosphorylation of Chk1 by ATM upon DNA damage [Gallus gallus]
Phosphorylation of Chk1 by ATR [Gallus gallus]
Phosphorylation of Chk2 by ATM upon DNA damage [Gallus gallus]
Phosphorylation of FANCG at S7 [Gallus gallus]
Phosphorylation of H2AX at S139 by ATM at the site of DSB [Gallus gallus]
Phosphorylation of NBS1 by ATM [Gallus gallus]
Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members [Gallus gallus]
Phosphorylation of RPA2 by CDC2 kinase [Gallus gallus]
PI3-kinase family [nucleoplasm]
PIAS1, protein inhibitor of activated STAT, 1 [nucleoplasm] UENBCdRHPR
Pol eta -DNA damage complex [nucleoplasm]
Pol eta:lesioned DNA template inserted with correct base complement [nucleoplasm]
Pol kappa-damaged DNA [nucleoplasm]
Pol kappa:lesioned DNA template inserted with correct base complement [nucleoplasm]
Pol zeta complex [nucleoplasm]
Pol zeta-damaged DNA complex [nucleoplasm]
POLE2, DNA polymerase epsilon subunit 2 [nucleoplasm] UENBCdRHPR
POLH [nucleoplasm] UENBCdRHPR
POLK [nucleoplasm] UENBCdRHPR
Polymerization of phospho-RAD51as foci [nucleoplasm]
Pre-incision complex in GG-NER [nucleoplasm]
Processing of DNA double-strand break ends [Gallus gallus]
protein serine/threonine kinase activity of ATM [nucleoplasm]
protein serine/threonine kinase activity of ATR [nucleoplasm]
protein serine/threonine kinase activity of CDC2 kinase, Cell division control protein 2 homolog [nucleoplasm]
RAD1 [nucleoplasm] E
RAD17 [nucleoplasm] UENBCdPR
Rad17-replication factor C (RFC), the clamp loader [nucleoplasm]
RAD18 [nucleoplasm] UENBCdRHPR
RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases [Gallus gallus]
RAD21 [nucleoplasm] E
RAD23B [nucleoplasm] E
RAD50 [nucleoplasm] UEP
RAD51 [nucleoplasm] UENBCdRHPR
Rad51 assembly at the DNA-damage sites on the chromatin [Gallus gallus]
RAD51-BRCA1 complex [nucleoplasm]
RAD51-BRCA2 complex [nucleoplasm]
RAD51C [nucleoplasm] UKENBCdOORRHHPGURR
Rad9-Hus1-Rad1(9-1-1) clamp [nucleoplasm]
RAD9-TopBP1 association [nucleoplasm]
RAD9A [nucleoplasm] UENBCdRHPR
RCF4 [nucleoplasm] UENBCdRHPR
Recruitment of repair and signaling proteins to double-strand breaks [Gallus gallus]
Recruitment of repair factors to form the preincision complex [Gallus gallus]
Removal of 3'-phosphoglycolate (PG) moiety from DSB ends [Gallus gallus]
Removal of repair proteins and ligation of the processed ends of the DNA double-strand break [Gallus gallus]
Repair of ~27-30 bp long patch by DNA Pol Epsilon [Gallus gallus]
Resolution of Abasic Sites (AP sites) [Gallus gallus]
REV1 [nucleoplasm] UENBCdRHPR
REV1-Pol kappa complex formation [Gallus gallus]
REV3L [nucleoplasm] E
Reversal of Alkylation Damage By DNA Dioxygenases [Gallus gallus]
RFC2 [nucleoplasm] UENBCdRHPR
RPA heterotrimer [nucleoplasm]
RPA-coated 3' end of DNA double strand break [nucleoplasm]
RPA1 (Replication protein A1) [nucleoplasm] UENBCdRHPR
RPA3 [nucleoplasm] E
S-methyl-L-cysteine at unknown position
SMC1 protein cohesin subunit [nucleoplasm] UP
SMC3, Cohesin complex subunit [nucleoplasm] UENBCdRHPR
STAG1 [nucleoplasm] E
STT3 [nucleoplasm] UEP
TDG [nucleoplasm] UENBCdRHPR
TDG glycosylase mediated recognition and binding of thymine opposite guanine [Gallus gallus]
TDP1 [nucleoplasm] E
TFIIH, General transcription factor IIH subunit 5 [nucleoplasm] UENBCdP
TOPBP1 [nucleoplasm] E
TopBP1 association with ATR via its activation domain (AD) [nucleoplasm]
TP53BP1 [nucleoplasm] E
Translesion synthesis by DNA polymerases bypassing lesion on DNA template [Gallus gallus]
Translesion synthesis by Pol eta [Gallus gallus]
Translesion synthesis by Pol kappa [Gallus gallus]
Translesion synthesis by Pol zeta [Gallus gallus]
UBE2N [nucleoplasm] E
Ubiquitin [nucleoplasm]
ubiquitin-protein ligase activity of FancL [nucleoplasm]
ubiquitin-protein ligase activity of RAD18 [nucleoplasm]
UNG [nucleoplasm] UENBCdRHPR
Uracil glycosylase mediated recognition and binding of uracil opposite guanine [Gallus gallus]
uracil-glycosylase:uracil complex [nucleoplasm]
XP-A, DNA-repair protein complementing XP-A cells homolog [nucleoplasm] UP
XP-C binds to RAD23B forming a heterodimer [Gallus gallus]
XP-C-RAD23B complex to damaged DNA site [nucleoplasm]
XP-C-RAD23B heterodimer [nucleoplasm]
XP-C-RAD23B heterodimer binds to damaged DNA site with lesion [Gallus gallus]
XPC [nucleoplasm] E
XRCC4:DNA ligase IV complex [nucleoplasm]
XRCC5 [nucleoplasm] E
Publication(s)
Zhou, B, McGary, CT, Weigel, JA, Saxena, A, Weigel, PH Purification and molecular identification of the human hyaluronan receptor for endocytosis 2003 Glycobiology PubMed