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Reactome: A Curated Pathway Database
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Transport of MHC II:Ii complex along Golgi to TGN
Stable identifierREACT_121309.2
AuthoredGarapati, P V, 2012-02-21
ReviewedNeefjes, J, 2012-05-14
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Nonameric MHC II:Ii complex move through the various cisternae to reach the trans-golgi network (TGN), a tubulo-vesicular organelle located at the trans-face of Golgi stacks. From the TGN, MHC II:Ii complexes are targeted to the endocytic pathway for peptide loading. [Davidson 1999, Landsverk et al 2009]
Input (present at start of reaction)Nonameric complex [Golgi membrane]
Output (present at end of reaction)Nonameric complex [trans-Golgi network membrane]
Preceding event(s)Fusion of COPII vesicle with Golgi complex [Homo sapiens]
Formation of COPII vesicle [Homo sapiens]
Following event(s)Transport of MHC II:Ii complex to plasma membrane [Homo sapiens]
TGN-lysosomal vesicle coat assembly [Homo sapiens]
OrganismHomo sapiens
Cellular compartmenttrans-Golgi network membrane GO
Golgi membrane GO
References

Davidson, HW Direct transport of newly synthesized HLA-DR from the trans-Golgi network to major histocompatibility complex class II containing compartments (MIICS) demonstrated using a novel tyrosine-sulfated chimera 1999 J Biol Chem PubMed

Hiltbold, EM, Roche, PA Trafficking of MHC class II molecules in the late secretory pathway 2002 Curr Opin Immunol PubMed

Gu, F, Crump, CM, Thomas, G Trans-Golgi network sorting 2001 Cell Mol Life Sci PubMed

Equivalent event(s) in other organism(s)Transport of MHC II:Ii complex along Golgi to TGN [Bos taurus]
Transport of MHC II:Ii complex along Golgi to TGN [Canis familiaris]
Transport of MHC II:Ii complex along Golgi to TGN [Mus musculus]
Transport of MHC II:Ii complex along Golgi to TGN [Rattus norvegicus]
Transport of MHC II:Ii complex along Golgi to TGN [Gallus gallus]
Transport of MHC II:Ii complex along Golgi to TGN [Xenopus tropicalis]
Transport of MHC II:Ii complex along Golgi to TGN [Danio rerio]
Participating molecules
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REACT_121309